uvrC:On One Page

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Quickview | Gene | Product(s) | Expression| Evolution | References |

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<protect>

Standard Name

uvrC

Gene Synonym(s)

ECK1912, b1913, JW1898[1], JW1898

Product Desc.

excinuclease ABC, subunit C; repair of UV damage to DNA[2][3];

Component of UvrABC Nucleotide Excision Repair Complex[2][3]

Excision nuclease subunit C; repair of UV damage to DNA; multicopy causes mucoidy[4]

Product Synonyms(s)

excinuclease UvrABC, endonuclease subunit[1], B1913[2][1], UvrC[2][1] , ECK1912, JW1898, b1913

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): uvrYC[2], uvrC[2]

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

uvrC

Mnemonic

UV resistant

Synonyms

ECK1912, b1913, JW1898[1], JW1898

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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain Map location Genome coordinates Genome browsers Sequence links

MG1655

42.91 minutes 

MG1655: 1992730..1990898
<gbrowseImage> name=NC_000913:1990898..1992730 source=MG1655 preset=GeneLocation </gbrowseImage>

REL606

NC_012967: 1972633..1970867
<gbrowseImage> name=NC_012967:1970867..1972633 source=REL606 preset=GeneLocation </gbrowseImage>

BW2952

NC_012759: 1883381..1885213
<gbrowseImage> name=NC_012759:1883381..1885213 source=BW2952 preset=GeneLocation </gbrowseImage>

W3110

 

W3110: 1996843..1995011
<gbrowseImage> name=NC_007779:1995011..1996843 source=W3110 preset=GeneLocation </gbrowseImage>

DH10B

DH10B: 2083738..2081906
<gbrowseImage> name=NC_010473:2081906..2083738 source=DH10B preset=GeneLocation </gbrowseImage>

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type Strain Genomic Location Evidence Reference Notes

Coding Start (SO:0000323)

MG1655

1990901

Edman degradation

PMID:11056168


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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele Nt change(s) AA change(s) Phenotype: Type Phenotype: Description Reference Availability Comments

uvrC(del) (Keio:JW1898)

deletion

deletion

PMID:16738554

Shigen

CGSC9579[5]

uvrC::Tn5KAN-2 (FB20521)

Insertion at nt 569 in Minus orientation

PMID:15262929

E. coli Genome Project:FB20521

contains pKD46

uvrCR42A

R42A

Defective in 3' incision but not in 5' incision

seeded from UniProt:P0A8G0

uvrCD399A,N

D399A,N

Defective in 5' incision but not in 3' incision

seeded from UniProt:P0A8G0

uvrCD438A,N

D438A,N

Defective in 5' incision but not in 3' incision

seeded from UniProt:P0A8G0

uvrCD466A,N

D466A,N

Defective in 5' incision but not in 3' incision

seeded from UniProt:P0A8G0

uvrCH538F,Y

H538F,Y

Defective in 5' incision but not in 3' incision

seeded from UniProt:P0A8G0

uvrC279::Tn10

Insertion at 1,991,245 bp in MG1655 (NC_000913)

adapted from Nichols et al.[6]

CAG12156 = CGSC7394[5]

Synonyms:

uvrC34

CGSC:7529

uvrC279::Tn10

CGSC:8860

uvrC33

CGSC:9250

uvrC152

CGSC:16908

uvrC759(del)::kan

PMID:16738554

CGSC:103346

uvrC(del)::Tn10

deletion

deletion

Sensitivity to

Deletion mutants are more sensitive to DNA damaging agent Mitomycin C, figure 1 & 2.

PMID:17040104

Experimental strain: RJF574

uvrA::Tn10 uvrC34

Sensitivity to

Double mutation increased sensitivity to mitomycin C but at a slower rate than single deletions, figure 1.

PMID:17040104

uvrC(del)

deletion

deletion

Sensitivity to

Deletion mutation causes hypersensitive to UV when irradiated and incubated in non-photoreactivating conditions, figure 2.

PMID:16970815

uvrA::Tn10 uvrC34

DNA repair

Double mutation was able to recover high molecular weight DNA, though at a much slower rate than wild type.

PMID:17040104

Figure 4.

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Notes

Genetic Interactions

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<protect>

Interactor Interaction Allele Score(s) Reference(s) Accessions Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource Resource Type Source Notes/Reference

JW1898

Plasmid clone

Shigen

PMID:16769691

Status:Clone OK

Primer 1:GCCAGTGATCAGTTTGACGCAAA

Primer 2:CCATGTTTCAACGACCAGAAGAT

16B12

Kohara Phage

Genobase

PMID:3038334

eda-51::Tn10

Linked marker

CAG18486 = CGSC7392[5]

est. P1 cotransduction: 4% [6]

zed-3069::Tn10

Linked marker

CAG18451 = CGSC7395[5]

est. P1 cotransduction: 13% [6]

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:EG11063

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11063

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001052

Escherichia coli str. K-12 substr. MG1655

NCBI (EcoliWiki Page)

GeneID:947203

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1056

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006370

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

UvrC

Synonyms

excinuclease UvrABC, endonuclease subunit[1], B1913[2][1], UvrC[2][1] , ECK1912, JW1898, b1913

Product description

excinuclease ABC, subunit C; repair of UV damage to DNA[2][3];

Component of UvrABC Nucleotide Excision Repair Complex[2][3]

Excision nuclease subunit C; repair of UV damage to DNA; multicopy causes mucoidy[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status

GO:0003677

DNA binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00203

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000445

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001162

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001943

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003583

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009055

F

Seeded from EcoCyc (v14.0)

complete

GO:0004518

nuclease activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000305

F

Seeded from EcoCyc (v14.0)

complete

GO:0004518

nuclease activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001162

F

Seeded from EcoCyc (v14.0)

complete

GO:0004518

nuclease activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001943

F

Seeded from EcoCyc (v14.0)

complete

GO:0004518

nuclease activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009055

F

Seeded from EcoCyc (v14.0)

complete

GO:0004518

nuclease activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0267

F

Seeded from EcoCyc (v14.0)

complete

GO:0005622

intracellular

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000305

C

Seeded from EcoCyc (v14.0)

complete

GO:0005622

intracellular

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000445

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00203

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004791

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0006281

DNA repair

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00203

P

Seeded from EcoCyc (v14.0)

complete

GO:0006281

DNA repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000305

P

Seeded from EcoCyc (v14.0)

complete

GO:0006281

DNA repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003583

P

Seeded from EcoCyc (v14.0)

complete

GO:0006281

DNA repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004791

P

Seeded from EcoCyc (v14.0)

complete

GO:0006281

DNA repair

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0228

P

Seeded from EcoCyc (v14.0)

complete

GO:0006281

DNA repair

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0234

P

Seeded from EcoCyc (v14.0)

complete

GO:0006289

nucleotide-excision repair

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00203

P

Seeded from EcoCyc (v14.0)

complete

GO:0006289

nucleotide-excision repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001162

P

Seeded from EcoCyc (v14.0)

complete

GO:0006289

nucleotide-excision repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001943

P

Seeded from EcoCyc (v14.0)

complete

GO:0006289

nucleotide-excision repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009055

P

Seeded from EcoCyc (v14.0)

complete

GO:0006974

response to DNA damage stimulus

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0227

P

Seeded from EcoCyc (v14.0)

complete

GO:0009380

excinuclease repair complex

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004791

C

Seeded from EcoCyc (v14.0)

complete

GO:0009381

excinuclease ABC activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00203

F

Seeded from EcoCyc (v14.0)

complete

GO:0009381

excinuclease ABC activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004791

F

Seeded from EcoCyc (v14.0)

complete

GO:0009432

SOS response

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00203

P

Seeded from EcoCyc (v14.0)

complete

GO:0009432

SOS response

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0742

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of UvrABC Nucleotide Excision Repair Complex

could be indirect

Protein

aceE

PMID:15690043

Experiment(s):EBI-880917

Protein

lpdA

PMID:15690043

Experiment(s):EBI-880917, EBI-887152

Protein

rplA

PMID:15690043

Experiment(s):EBI-880917, EBI-887152

Protein

rplB

PMID:15690043

Experiment(s):EBI-880917, EBI-887152

Protein

rplC

PMID:15690043

Experiment(s):EBI-880917, EBI-887152

Protein

rpsB

PMID:15690043

Experiment(s):EBI-880917

Protein

rpsD

PMID:15690043

Experiment(s):EBI-880917, EBI-887152

Protein

rpsG

PMID:15690043

Experiment(s):EBI-880917, EBI-887152

Protein

rpsK

PMID:15690043

Experiment(s):EBI-880917

Protein

rpsM

PMID:15690043

Experiment(s):EBI-880917, EBI-887152

Protein

yfiB

PMID:15690043

Experiment(s):EBI-880917

Protein

yjeF

PMID:15690043

Experiment(s):EBI-880917

Protein

rpsC

PMID:15690043

Experiment(s):EBI-880917, EBI-887152

Protein

ddpA

PMID:15690043

Experiment(s):EBI-887152

Protein

yfgF

PMID:15690043

Experiment(s):EBI-887152

Protein

cspC

PMID:15690043

Experiment(s):EBI-887152

Protein

glnK

PMID:15690043

Experiment(s):EBI-887152

Protein

hupA

PMID:15690043

Experiment(s):EBI-887152

Protein

pntA

PMID:15690043

Experiment(s):EBI-887152

Protein

rplD

PMID:15690043

Experiment(s):EBI-887152

Protein

rplI

PMID:15690043

Experiment(s):EBI-887152

Protein

rplM

PMID:15690043

Experiment(s):EBI-887152

Protein

rplN

PMID:15690043

Experiment(s):EBI-887152

Protein

rplS

PMID:15690043

Experiment(s):EBI-887152

Protein

rplT

PMID:15690043

Experiment(s):EBI-887152

Protein

rplU

PMID:15690043

Experiment(s):EBI-887152

Protein

rplV

PMID:15690043

Experiment(s):EBI-887152

Protein

rpsA

PMID:15690043

Experiment(s):EBI-887152

Protein

rpsE

PMID:15690043

Experiment(s):EBI-887152

Protein

rpsF

PMID:15690043

Experiment(s):EBI-887152

Protein

rpsH

PMID:15690043

Experiment(s):EBI-887152

Protein

rpsJ

PMID:15690043

Experiment(s):EBI-887152

Protein

rpsN

PMID:15690043

Experiment(s):EBI-887152

Protein

rpsO

PMID:15690043

Experiment(s):EBI-887152

Protein

rpsR

PMID:15690043

Experiment(s):EBI-887152

Protein

rpsS

PMID:15690043

Experiment(s):EBI-887152

Protein

rpsT

PMID:15690043

Experiment(s):EBI-887152

Protein

sucA

PMID:15690043

Experiment(s):EBI-887152

Protein

sucB

PMID:15690043

Experiment(s):EBI-887152

Protein

yfiF

PMID:15690043

Experiment(s):EBI-887152

Protein

yhbY

PMID:15690043

Experiment(s):EBI-887152

Protein

rplY

PMID:15690043

Experiment(s):EBI-887152

Protein

rpmB

PMID:15690043

Experiment(s):EBI-887152

Protein

rpsL

PMID:15690043

Experiment(s):EBI-887152

Protein

rpmB

PMID:19402753

LCMS(ID Probability):99.6

Protein

rpsS

PMID:19402753

LCMS(ID Probability):99.6

Protein

rpsH

PMID:19402753

LCMS(ID Probability):99.6

Protein

rplT

PMID:19402753

LCMS(ID Probability):99.6

Protein

rplS

PMID:19402753

LCMS(ID Probability):99.6 MALDI(Z-score):5.210219

Protein

rpsL

PMID:19402753

LCMS(ID Probability):99.6

Protein

rplU

PMID:19402753

LCMS(ID Probability):99.6

Protein

rpsN

PMID:19402753

LCMS(ID Probability):99.6

Protein

rpsT

PMID:19402753

LCMS(ID Probability):99.6

Protein

hupA

PMID:19402753

LCMS(ID Probability):99.6

Protein

rpsF

PMID:19402753

LCMS(ID Probability):99.6

Protein

rpsM

PMID:19402753

LCMS(ID Probability):99.0 MALDI(Z-score):17.053160

Protein

rplA

PMID:19402753

LCMS(ID Probability):99.6 MALDI(Z-score):8.116641

Protein

rpsC

PMID:19402753

LCMS(ID Probability):99.6 MALDI(Z-score):29.295881

Protein

rpsO

PMID:19402753

LCMS(ID Probability):99.4

Protein

rplM

PMID:19402753

LCMS(ID Probability):99.6

Protein

rplB

PMID:19402753

LCMS(ID Probability):99.6 MALDI(Z-score):8.451958

Protein

rpsD

PMID:19402753

LCMS(ID Probability):99.6 MALDI(Z-score):36.225093

Protein

yjeF

PMID:19402753

MALDI(Z-score):17.053160

Protein

sucB

PMID:19402753

LCMS(ID Probability):99.6

Protein

sucA

PMID:19402753

LCMS(ID Probability):99.6

Protein

rplD

PMID:19402753

LCMS(ID Probability):99.2 MALDI(Z-score):3.129348

Protein

ddpA

PMID:19402753

LCMS(ID Probability):99.0

Protein

yhbY

PMID:19402753

LCMS(ID Probability):99.6

Protein

pntA

PMID:19402753

LCMS(ID Probability):99.0

Protein

yfiF

PMID:19402753

LCMS(ID Probability):99.6

Protein

yfiB

PMID:19402753

MALDI(Z-score):17.053160

Protein

yfgF

PMID:19402753

LCMS(ID Probability):99.0

Protein

glnK

PMID:19402753

LCMS(ID Probability):99.0

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MYDAGGTVIY VGKAKDLKKR LSSYFRSNLA SRKTEALVAQ IQQIDVTVTH TETEALLLEH
NYIKLYQPRY NVLLRDDKSY PFIFLSGDTH PRLAMHRGAK HAKGEYFGPF PNGYAVRETL
ALLQKIFPIR QCENSVYRNR SRPCLQYQIG RCLGPCVEGL VSEEEYAQQV EYVRLFLSGK
DDQVLTQLIS RMETASQNLE FEEAARIRDQ IQAVRRVTEK QFVSNTGDDL DVIGVAFDAG
MACVHVLFIR QGKVLGSRSY FPKVPGGTEL SEVVETFVGQ FYLQGSQMRT LPGEILLDFN
LSDKTLLADS LSELAGRKIN VQTKPRGDRA RYLKLARTNA ATALTSKLSQ QSTVHQRLTA
LASVLKLPEV KRMECFDISH TMGEQTVASC VVFDANGPLR AEYRRYNITG ITPGDDYAAM
NQVLRRRYGK AIDDSKIPDV ILIDGGKGQL AQAKNVFAEL DVSWDKNHPL LLGVAKGADR
KAGLETLFFE PEGEGFSLPP DSPALHVIQH IRDESHDHAI GGHRKKRAKV KNTSSLETIE
GVGPKRRQML LKYMGGLQGL RNASVEEIAK VPGISQGLAE KIFWSLKH
Length

588

Mol. Wt

65.717 kDa

pI

9.2 (calculated)

Extinction coefficient

42,290 - 43,165 (calc based on 21 Y, 2 W, and 7 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

578..607

PF00633 Helix-hairpin-helix motif

PMID:19920124

Domain

204..239

PF02151 UvrB/uvrC motif

PMID:19920124

Domain

17..93

PF01541 GIY-YIG catalytic domain

PMID:19920124

Domain

383..542

PF08459 UvrC Helix-hairpin-helix N-terminal

PMID:19920124

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=uvrC taxon=562,83333 </beststructure>

Models

View models at:

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</protect>

Structure figures

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</protect>

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111354

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947203

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006370

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A8G0

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11063

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11063

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947203

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001052

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1056

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

Molecule Organism or Strain Value Units Experimental Conditions Assay used Notes Reference(s)

Protein

Ecoli K-12

9.982+/-0.048

Molecules/cell

  • Medium:
  • Temperature (°C):
  • Doubling time (min): Growth Rate(min): *
  • Growth phase: other: *

Single Molecule Fluorescence

PMID:20671182

mRNA

Ecoli K-12

0.050491266

Molecules/cell

  • Medium:
  • Temperature (°C):
  • Doubling time (min): Growth Rate(min): *
  • Growth phase: other: *

by RNA_Seq

PMID:20671182

Protein

E. coli K-12 MG1655

269

molecules/cell/generation

  • Medium: MOPS Complete
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Protein

E. coli K-12 MG1655

156

molecules/cell/generation

  • Medium: MOPS Minimal
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Protein

E. coli K-12 MG1655

205

molecules/cell/generation

  • Medium: MOPS Complete without Methionine
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

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Notes

Transcription and Transcriptional Regulation

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<protect>

See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

uvrYC

uvrC

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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:1992710..1992750 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name Mutation Phenotype Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type Reference Notes

microarray

GEO Profiles:b1913 (EcoliWiki Page)

NCBI GEO profiles for uvrC

microarray

GenExpDB:b1913 (EcoliWiki Page)

Summary of data for uvrC from multiple microarray studies

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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name Resource Type Description Source Notes

GFP Fusion

Intergenic region (1992575..1992783) fused to gfpmut2.

OpenBioSystems

GFP fusion described in Zaslaver, et al.
Plate:109-AZ20; Well:B5[7]

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Notes

Accessions Related to uvrC Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:EG11063

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1056

Escherichia coli str. K-12 substr. MG1655

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b1913

EcoGene

EcoGene:EG11063

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001052

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006370

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism Homologs (Statistics) Comments

Apis mellifera

  • ENSAPMP00000030171 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Shigella flexneri

UVRC

From SHIGELLACYC

E. coli O157

UVRC

From ECOO157CYC

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Do-It-Yourself Web Tools

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Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

Pfam (EcoliWiki Page)

PF01541 GIY-YIG catalytic domain

Pfam (EcoliWiki Page)

PF00633 Helix-hairpin-helix motif

Pfam (EcoliWiki Page)

PF02151 UvrB/uvrC motif

Superfamily (EcoliWiki Page)

SUPERFAMILY:46600

Superfamily (EcoliWiki Page)

SUPERFAMILY:47781

Superfamily (EcoliWiki Page)

SUPERFAMILY:82771

Pfam (EcoliWiki Page)

PF08459 UvrC Helix-hairpin-helix N-terminal

EcoCyc

EcoCyc:EG11063

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11063

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001052

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1056

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006370

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 CGSC: The Coli Genetics Stock Center
  6. ↑ 6.0 6.1 6.2 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
  7. ↑ Zaslaver, A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat. Methods 3 623-8 PubMed

Categories

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