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On One Page

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Gene |

Product(s) |

Expression|

Evolution |

References |

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Standard Name	mrcA
Gene Synonym(s)	ECK3383, b3396, JW3359, ponA^[1], ponA
Product Desc.	peptidoglycan synthetase; penicillin-binding protein 1A^[2]^[3] Murein polymerase, PBP1A; bifunctional murein transglycosylase and transpeptidase; penicillin-binding protein 1A; dimeric^[4]
Product Synonyms(s)	fused penicillin-binding protein 1a: murein transglycosylase^[1], murein transpeptidase^[1], B3396^[2]^[1], PonA^[2]^[1], MrcA^[2]^[1], PBP1A^[2]^[1] , ECK3383, JW3359, ponA, b3396
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): mrcA^[2]
Regulation/Activity
Quick Links
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Notes

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The N-terminal transglycosylase activity polymerizes the glycan backbone and is penicillin-insensitive. The C-terminal transpeptidase activity crosslinks the muramic peptides and is penicillin-sensitive. Several phenotypes were associated with an mrcA deletion strain that inadvertantly deleted two neighboring genes, nudE(yrfE) and yrfF. One or both of these other genes turned out to be responsible for the observed mrcA-associated phenotypes. Murein polymerase is an essential function satisfied by either MrcA or MrcB. MrcA contains a PDZ domain involved in substrate recognition. MrcA is a membrane-bound periplasmic enzyme that has an uncleaved signal anchor.^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	mrcA
Mnemonic	Murein cluster c
Synonyms	ECK3383, b3396, JW3359, ponA^[1], ponA
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Notes

Location(s) and DNA Sequence

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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	75.89 minutes, 75.89 minutes	MG1655: 3520893..3523445 <gbrowseImage> name=NC_000913:3520893..3523445 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 3451553..3454105 <gbrowseImage> name=NC_012967:3451553..3454105 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 3408050..3410602 <gbrowseImage> name=NC_012759:3408050..3410602 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 4117545..4114993 <gbrowseImage> name=NC_007779:4114993..4117545 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 3618638..3621190 <gbrowseImage> name=NC_010473:3618638..3621190 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
ΔmrcA (Keio:JW3359)	deletion	deletion			PMID:16738554	Shigen CGSC10505^[5]
mrcA::Tn5KAN-I-SceI (FB21157)	Insertion at nt 1872 in Minus orientation				PMID:15262929	E. coli Genome Project:FB21157	does not contain pKD46
ΔmrcA::kan	deletion		Biolog:respiration	unable to respire Acetate	PMID:16095938
ΔmrcA::kan	deletion		Biolog:respiration	unable to respire Bromosuccinate	PMID:16095938
mrcA980						CGSC:8782
ΔmrcA731::kan					PMID:16738554	CGSC:101946
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW3359	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCAAGTTCGTAAAGTATTTTTT Primer 2:CCGAACAATTCCTGTGCCTCGCC
1C9	Kohara Phage	Genobase	PMID:3038334
4D4	Kohara Phage	Genobase	PMID:3038334
zhf-3084::Tn10	Linked marker	CAG18456 = CGSC7576^[5]	est. P1 cotransduction: 52% ^[6] Synonyms:zhe-3084::Tn10nnnCAG18456 also carries cysG0 (CGSC).
glgP721::Tn10	Linked marker	CAG18638 = CGSC7451^[5]	est. P1 cotransduction: 16% ^[6] Synonyms:zhg-3086::Tn10, zhh-21::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10748	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10748	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000739	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:947907	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0741	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0011082	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	MrcA
Synonyms	fused penicillin-binding protein 1a: murein transglycosylase^[1], murein transpeptidase^[1], B3396^[2]^[1], PonA^[2]^[1], MrcA^[2]^[1], PBP1A^[2]^[1] , ECK3383, JW3359, ponA, b3396
Product description	peptidoglycan synthetase; penicillin-binding protein 1A^[2]^[3] Murein polymerase, PBP1A; bifunctional murein transglycosylase and transpeptidase; penicillin-binding protein 1A; dimeric^[4]
EC number (for enzymes)	2.4.1.-^[1] 3.4.-^[1]
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005887	integral to plasma membrane	PMID:319999^[7]	IDA: Inferred from Direct Assay		C	Seeded from Riley et al 2006 ^[1].	complete
	GO:0008955	peptidoglycan glycosyltransferase activity	PMID:7006606^[8]	IDA: Inferred from Direct Assay		F		complete
	GO:0008658	penicillin binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001460	F	Seeded from EcoCyc (v14.0)	complete
	GO:0009002	serine-type D-Ala-D-Ala carboxypeptidase activity	PMID:7006606^[8]	IDA: Inferred from Direct Assay		F		complete
	GO:0009252	peptidoglycan biosynthetic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001264	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009252	peptidoglycan biosynthetic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011816	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009252	peptidoglycan biosynthetic process	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0573	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009274	peptidoglycan-based cell wall	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001264	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016763	transferase activity, transferring pentosyl groups	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011816	F	Seeded from EcoCyc (v14.0)	complete
	GO:0046677	response to antibiotic	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011816	P	Seeded from EcoCyc (v14.0)	complete
	GO:0046677	response to antibiotic	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0046	P	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	hflB	PMID:16606699^[9]	Experiment(s):EBI-1145791
Protein	alaS	PMID:16606699^[9]	Experiment(s):EBI-1145791
Protein	rpsP	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rpsP	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rplP	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	hupA	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rplA	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rplK	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rplS	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rpsM	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rpsS	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rpsD	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rplO	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	groS	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rplR	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rpsK	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	eno	PMID:19402753^[10]	LCMS(ID Probability):99.6 MALDI(Z-score):14.416243
Protein	rplI	PMID:19402753^[10]	LCMS(ID Probability):99.6 MALDI(Z-score):5.817502
Protein	rplB	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rpsA	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rpmC	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rplX	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rpsN	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	ugpB	PMID:19402753^[10]	LCMS(ID Probability):99.3 MALDI(Z-score):8.104456
Protein	ahpC	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	tufB	PMID:19402753^[10]	MALDI(Z-score):20.804233
Protein	gadB	PMID:19402753^[10]	LCMS(ID Probability):99.6 MALDI(Z-score):11.890041
Protein	rplJ	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rpsJ	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	gapA	PMID:19402753^[10]	LCMS(ID Probability):99.6 MALDI(Z-score):26.091416
Protein	rplE	PMID:19402753^[10]	LCMS(ID Probability):99.6 MALDI(Z-score):2.650387
Protein	fusA	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	hns	PMID:19402753^[10]	LCMS(ID Probability):99.5
Protein	yfiD	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	dps	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	tig	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	pflB	PMID:19402753^[10]	LCMS(ID Probability):99.6 MALDI(Z-score):23.505319
Protein	hdeB	PMID:19402753^[10]	LCMS(ID Probability):99.4
Protein	gnd	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	glmS	PMID:19402753^[10]	LCMS(ID Probability):98.9
Protein	fur	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	yccJ	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	rplY	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	adk	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	pstS	PMID:19402753^[10]	MALDI(Z-score):19.273541
Protein	elaB	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	katG	PMID:19402753^[10]	LCMS(ID Probability):99.2
Protein	ribE	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	glyA	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	clpB	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	pgm	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	dhaM	PMID:19402753^[10]	LCMS(ID Probability):99.2
Protein	talB	PMID:19402753^[10]	LCMS(ID Probability):99.5
Protein	aspS	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	ihfA	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	luxS	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	fkpA	PMID:19402753^[10]	LCMS(ID Probability):98.6
Protein	manA	PMID:19402753^[10]	LCMS(ID Probability):99.0
Protein	cspC	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	mdh	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	uspD	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	pgk	PMID:19402753^[10]	LCMS(ID Probability):99.6 MALDI(Z-score):2.192678
Protein	tsf	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	wrbA	PMID:19402753^[10]	MALDI(Z-score):21.134951
Protein	yqjD	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	ybaB	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	efp	PMID:19402753^[10]	LCMS(ID Probability):99.5
Protein	greA	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	fabG	PMID:19402753^[10]	LCMS(ID Probability):99.5
Protein	yfcZ	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	lysU	PMID:19402753^[10]	LCMS(ID Probability):98.7 MALDI(Z-score):2.580915
Protein	ansB	PMID:19402753^[10]	LCMS(ID Probability):99.5
Protein	rfbB	PMID:19402753^[10]	LCMS(ID Probability):99.6
Protein	deoB	PMID:19402753^[10]	LCMS(ID Probability):99.0
Protein	osmC	PMID:19402753^[10]	LCMS(ID Probability):99.6
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Evidence	Reference/Source
Inner Membrane	PMID:3882429, PMID:3510188	EchoLocation:mrcA
plasma membrane
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MKLNGKFPVK FVKYFLILAV CCILLGAGSI YGLYRYIEPQ LPDVATLKDV RLQIPMQIYS ADGELIAQYG EKRRIPVTLD QIPPEMVKAF IATEDSRFYE HHGVDPVGIF RAASVALFSG HASQGASTIT QQLARNFFLS PERTLMRKIK EVFLAIRIEQ LLTKDEILEL YLNKIYLGYR AYGVGAAAQV YFGKTVDQLT LNEMAVIAGL PKAPSTFNPL YSMDRAVARR NVVLSRMLDE GYITQQQFDQ TRTEAINANY HAPEIAFSAP YLSEMVRQEM YNRYGESAYE DGYRIYTTIT RKVQQAAQQA VRNNVLDYDM RHGYRGPANV LWKVGESAWD NNKITDTLKA LPTYGPLLPA AVTSANPQQA TAMLADGSTV ALSMEGVRWA RPYRSDTQQG PTPRKVTDVL QTGQQIWVRQ VGDAWWLAQV PEVNSALVSI NPQNGAVMAL VGGFDFNQSK FNRATQALRQ VGSNIKPFLY TAAMDKGLTL ASMLNDVPIS RWDASAGSDW QPKNSPPQYA GPIRLRQGLG QSKNVVMVRA MRAMGVDYAA EYLQRFGFPA QNIVHTESLA LGSASFTPMQ VARGYAVMAN GGFLVDPWFI SKIENDQGGV IFEAKPKVAC PECDIPVIYG DTQKSNVLEN NDVEDVAISR EQQNVSVPMP QLEQANQALV AKTGAQEYAP HVINTPLAFL IKSALNTNIF GEPGWQGTGW RAGRDLQRRD IGGKTGTTNS SKDAWFSGYG PGVVTSVWIG FDDHRRNLGH TTASGAIKDQ ISGYEGGAKS AQPAWDAYMK AVLEGVPEQP LTPPPGIVTV NIDRSTGQLA NGGNSREEYF IEGTQPTQQA VHEVGTTIID NGEAQELF
Length	858
Mol. Wt	94.52 kDa
pI	6.9 (calculated)
Extinction coefficient	130,640 - 131,140 (calc based on 36 Y, 14 W, and 4 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	References
Domain	427..673	PF00905 Penicillin binding protein transpeptidase domain	PMID:19920124^[11]
Domain	54..230	PF00912 Transglycosylase	PMID:19920124^[11]
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=mrcA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:162135911	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:947907	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0011082	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P02918	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG10748	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10748	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:947907	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000739	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0741	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MC4100	8.04E+01	molecules/cell	Medium: median data from rich and minimal media Temperature (°C): 37 Doubling time (min): Growth Rate(min): Growth phase: other:	emPAI		PMID:18304323
Protein	Ecoli K-12	1.429+/-0.051	Molecules/cell	Medium: Temperature (°C): Doubling time (min): Growth Rate(min): * Growth phase: other: *		Single Molecule Fluorescence	PMID:20671182
mRNA	Ecoli K-12	0.02096395	Molecules/cell	Medium: Temperature (°C): Doubling time (min): Growth Rate(min): * Growth phase: other: *		by RNA_Seq	PMID:20671182
Protein	E. coli K-12 MG1655	554	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	116	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	135	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
mrcA
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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<gbrowseImage> name=NC_000913:3520873..3520913 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

</protect>

Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b3396 (EcoliWiki Page)	NCBI GEO profiles for mrcA
microarray	GenExpDB:b3396 (EcoliWiki Page)	Summary of data for mrcA from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to mrcA Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10748	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0741	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b3396
EcoGene	EcoGene:EG10748	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000739	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0011082	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Shigella flexneri	MRCA	From SHIGELLACYC
E. coli O157	MRCA	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF00905 Penicillin binding protein transpeptidase domain
Superfamily (EcoliWiki Page)	SUPERFAMILY:56601
Pfam (EcoliWiki Page)	PF00912 Transglycosylase
EcoCyc	EcoCyc:EG10748	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10748	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000739	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0741	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0011082	Escherichia coli str. K-12 substr. MG1655
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↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ Spratt, BG (1977) Properties of the penicillin-binding proteins of Escherichia coli K12,. Eur. J. Biochem. 72 341-52 PubMed
↑ ^8.0 ^8.1 Ishino, F et al. (1980) Dual enzyme activities of cell wall peptidoglycan synthesis, peptidoglycan transglycosylase and penicillin-sensitive transpeptidase, in purified preparations of Escherichia coli penicillin-binding protein 1A. Biochem. Biophys. Res. Commun. 97 287-93 PubMed
↑ ^9.0 ^9.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 ^10.17 ^10.18 ^10.19 ^10.20 ^10.21 ^10.22 ^10.23 ^10.24 ^10.25 ^10.26 ^10.27 ^10.28 ^10.29 ^10.30 ^10.31 ^10.32 ^10.33 ^10.34 ^10.35 ^10.36 ^10.37 ^10.38 ^10.39 ^10.40 ^10.41 ^10.42 ^10.43 ^10.44 ^10.45 ^10.46 ^10.47 ^10.48 ^10.49 ^10.50 ^10.51 ^10.52 ^10.53 ^10.54 ^10.55 ^10.56 ^10.57 ^10.58 ^10.59 ^10.60 ^10.61 ^10.62 ^10.63 ^10.64 ^10.65 ^10.66 ^10.67 ^10.68 ^10.69 ^10.70 ^10.71 ^10.72 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
↑ ^11.0 ^11.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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