mrcA:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
<protect>
| Standard Name |
mrcA |
|---|---|
| Gene Synonym(s) |
ECK3383, b3396, JW3359, ponA[1], ponA |
| Product Desc. |
peptidoglycan synthetase; penicillin-binding protein 1A[2][3] Murein polymerase, PBP1A; bifunctional murein transglycosylase and transpeptidase; penicillin-binding protein 1A; dimeric[4] |
| Product Synonyms(s) |
fused penicillin-binding protein 1a: murein transglycosylase[1], murein transpeptidase[1], B3396[2][1], PonA[2][1], MrcA[2][1], PBP1A[2][1] , ECK3383, JW3359, ponA, b3396 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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| edit table |
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Notes
The N-terminal transglycosylase activity polymerizes the glycan backbone and is penicillin-insensitive. The C-terminal transpeptidase activity crosslinks the muramic peptides and is penicillin-sensitive. Several phenotypes were associated with an mrcA deletion strain that inadvertantly deleted two neighboring genes, nudE(yrfE) and yrfF. One or both of these other genes turned out to be responsible for the observed mrcA-associated phenotypes. Murein polymerase is an essential function satisfied by either MrcA or MrcB. MrcA contains a PDZ domain involved in substrate recognition. MrcA is a membrane-bound periplasmic enzyme that has an uncleaved signal anchor.[4]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
