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Standard Name	feaB
Gene Synonym(s)	ECK1382, b1385, JW1380, padA, ydbG, G6707^[1]^[2]
Product Desc.	FeaB^[2]^[3]; Component of phenylacetaldehyde dehydrogenase^[2]^[3] Catabolism of phenylethylamine^[4]
Product Synonyms(s)	phenylacetaldehyde dehydrogenase^[1], B1385^[2]^[1], YdbG^[2]^[1], PadA^[2]^[1], FeaB^[2]^[1] , ECK1382, JW1380, padA, ydbG, b1385
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): feaB^[2]
Regulation/Activity
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	feaB
Mnemonic	Phenylethylamine
Synonyms	ECK1382, b1385, JW1380, padA, ydbG, G6707^[1]^[2]
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	31.16 minutes	MG1655: 1445543..1447042 <gbrowseImage> name=NC_000913:1445543..1447042 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 1439125..1440624 <gbrowseImage> name=NC_012967:1439125..1440624 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 1337602..1339101 <gbrowseImage> name=NC_012759:1337602..1339101 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 1449233..1450732 <gbrowseImage> name=NC_007779:1449233..1450732 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 1536138..1537637 <gbrowseImage> name=NC_010473:1536138..1537637 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
Coding Start (SO:0000323)	MG1655	1445543	Edman degradation	PMID:9043126 PMID:9109378
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability
ΔfeaB (Keio:JW1380)	deletion	deletion	PMID:16738554	Shigen CGSC9220^[5]
ΔfeaB749::kan			PMID:16738554	CGSC:100814
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW1380	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCACAGAGCCGCATGTAGCAGT Primer 2:CCATACCGTACACACACCGACTT
1E7	Kohara Phage	Genobase	PMID:3038334
5F1	Kohara Phage	Genobase	PMID:3038334
zhj-3076::Tn10	Linked marker	CAG18640 = CGSC7453^[5]	est. P1 cotransduction: 66% ^[6]
trg-2::Tn10	Linked marker	CAG12026 = CGSC7376^[5]	est. P1 cotransduction: 11% ^[6]
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G7961	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13179	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120004448	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:945933	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2971	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004637	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	FeaB
Synonyms	phenylacetaldehyde dehydrogenase^[1], B1385^[2]^[1], YdbG^[2]^[1], PadA^[2]^[1], FeaB^[2]^[1] , ECK1382, JW1380, padA, ydbG, b1385
Product description	FeaB^[2]^[3]; Component of phenylacetaldehyde dehydrogenase^[2]^[3] Catabolism of phenylethylamine^[4]
EC number (for enzymes)	1.2.1.39^[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm				C	Seeded from Riley et al 2006 ^[1].	Missing: evidence, reference
	GO:0008957	phenylacetaldehyde dehydrogenase activity	GOA:spec GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.2.1.39	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008957	phenylacetaldehyde dehydrogenase activity	PMID:9109378	IDA: Inferred from Direct Assay		F	Seeded from EcoCyc (v14.0)	complete
	GO:0009435	NAD biosynthetic process	PMID:9109378	IDA: Inferred from Direct Assay		P	Seeded from EcoCyc (v14.0)	complete
	GO:0016491	oxidoreductase activity	PMID:16731973	IDA: Inferred from Direct Assay		F		complete
	GO:0046196	4-nitrophenol catabolic process	PMID:9109378	IDA: Inferred from Direct Assay		P	Seeded from EcoCyc (v14.0)	complete
	GO:0008957	phenylacetaldehyde dehydrogenase activity	PMID:16731973	IDA: Inferred from Direct Assay		F		complete
	GO:0055114	oxidation reduction	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015590	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009435	NAD biosynthetic process	PMID:16731973	IDA: Inferred from Direct Assay		P		complete
	GO:0055114	oxidation reduction	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016160	P	Seeded from EcoCyc (v14.0)	complete
	GO:0055114	oxidation reduction	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016161	P	Seeded from EcoCyc (v14.0)	complete
	GO:0055114	oxidation reduction	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016162	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009435	NAD biosynthetic process	PMID:9043126	IDA: Inferred from Direct Assay		P		complete
	GO:0046196	4-nitrophenol catabolic process	PMID:9109378	IDA: Inferred from Direct Assay		P	from E.coli W	complete
	GO:0055114	oxidation reduction	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P	Seeded from EcoCyc (v14.0)	complete
	GO:0047106	4-hydroxyphenylacetaldehyde dehydrogenase activity	PMID:9043126	IDA: Inferred from Direct Assay		F		complete
	GO:0009435	NAD biosynthetic process	PMID:9109378	IDA: Inferred from Direct Assay		P	from E.coli W	complete
	GO:0008957	phenylacetaldehyde dehydrogenase activity	PMID:9109378	IDA: Inferred from Direct Assay		F	from E.coli W	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of phenylacetaldehyde dehydrogenase	could be indirect
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Notes

Localization

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Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MMTEPHVAVL SQVQQFLDRQ HGLYIDGRPG PAQSEKRLAI FDPATGQEIA STADANEADV DNAVMSAWRA FVSRRWAGRL PAERERILLR FADLVEQHSE ELAQLETLEQ GKSIAISRAF EVGCTLNWMR YTAGLTTKIA GKTLDLSIPL PQGARYQAWT RKEPVGVVAG IVPWNFPLMI GMWKVMPALA AGCSIVIKPS ETTPLTMLRV AELASEAGIP DGVFNVVTGS GAVCGAALTS HPHVAKISFT GSTATGKGIA RTAADHLTRV TLELGGKNPA IVLKDADPQW VIEGLMTGSF LNQGQVCAAS SRIYIEAPLF DTLVSGFEQA VKSLQVGPGM SPVAQINPLV SRAHCDKVCS FLDDAQAQQA ELIRGSNGPA GEGYYVAPTL VVNPDAKLRL TREEVFGPVV NLVRVADGEE ALQLANDTEY GLTASVWTQN LSQALEYSDR LQAGTVWVNS HTLIDANLPF GGMKQSGTGR DFGPDWLDGW CETKSVCVRY
Length	500
Mol. Wt	53.829 kDa
pI	5.3 (calculated)
Extinction coefficient	73,910 - 74,910 (calc based on 9 Y, 11 W, and 8 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	30..495	PF00171 Aldehyde dehydrogenase family		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=feaB taxon=562,83333 </beststructure>

Models

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:90111264	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:945933	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004637	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P80668	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G7961	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13179	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:945933	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120004448	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2971	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MG1655	12	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	28	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	7^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
feaB
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:1445523..1445563 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b1385 (EcoliWiki Page)	NCBI GEO profiles for feaB
microarray	GenExpDB:b1385 (EcoliWiki Page)	Summary of data for feaB from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
	GFP Fusion	Intergenic region (1445214..1445541) fused to gfpmut2.	OpenBioSystems	GFP fusion described in Zaslaver, et al. Plate:109-AZ03; Well:D7^[7]
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Notes

Accessions Related to feaB Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G7961	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2971	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b1385
EcoGene	EcoGene:EG13179	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120004448	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004637	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Saccharomyces cerevisiae	YOR374W (score: 1.000; bootstrap: 100%) YPL061W (score: 0.293) YMR170C (score: 0.076)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000001826 (score: 1.000; bootstrap: 71%)	From Inparanoid:20070104
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Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF00171 Aldehyde dehydrogenase family
Superfamily (EcoliWiki Page)	SUPERFAMILY:53720
EcoCyc	EcoCyc:G7961	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13179	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120004448	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2971	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004637	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ Zaslaver, A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat. Methods 3 623-8 PubMed

feaB:On One Page

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Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

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Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

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Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to feaB Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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