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On One Page

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Gene |

Product(s) |

Expression|

Evolution |

References |

Quickview

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Standard Name	yedZ
Gene Synonym(s)	ECK1968, b1972, JW1955^[1], JW1955
Product Desc.	conserved inner membrane protein^[2]^[3] Inner membrane heme subunit for periplasmic YedYZ reductase^[4]
Product Synonyms(s)	conserved inner membrane protein^[1], YedZ^[2]^[1], B1972^[2]^[1] , ECK1968, JW1955, b1972
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): yedY^[2]
Regulation/Activity
Quick Links
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Notes

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YedY is anchored to the membrane by the YedZ subunit. Topology mapped using protein fusions. EPR spectroscopy shows that YedZ has a HALS-type low-spin heme.^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	yedZ
Mnemonic	Systematic nomenclature
Synonyms	ECK1968, b1972, JW1955^[1], JW1955
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	43.94 minutes	MG1655: 2038507..2039142 <gbrowseImage> name=NC_000913:2038507..2039142 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 1978482..1979117 <gbrowseImage> name=NC_012967:1978482..1979117 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 1930990..1931625 <gbrowseImage> name=NC_012759:1930990..1931625 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 2042620..2043255 <gbrowseImage> name=NC_007779:2042620..2043255 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 2129515..2130150 <gbrowseImage> name=NC_010473:2129515..2130150 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability	Comments
ΔyedZ (Keio:JW1955)	deletion	deletion	PMID:16738554	Shigen
zed-3069::Tn10	Insertion at 2,038,764 bp in MG1655 (NC_000913)		adapted from Nichols et al.^[5]	CAG18451 = CGSC7395^[6]	Synonyms:
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW1955	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCCGTCTGACAGCAAAACAGGT Primer 2:CCTACAGATAATTTGTTGTGAAC
9G6	Kohara Phage	Genobase	PMID:3038334
uvrC279::Tn10	Linked marker	CAG12156 = CGSC7394^[6]	est. P1 cotransduction: 11% ^[5]
zef-3129::Tn10	Linked marker	CAG12099 = CGSC7397^[6]	est. P1 cotransduction: 14% ^[5] Synonyms:zee-3129::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G7060	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG14048	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003646	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:946483	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3801	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0006542	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	YedZ
Synonyms	conserved inner membrane protein^[1], YedZ^[2]^[1], B1972^[2]^[1] , ECK1968, JW1955, b1972
Product description	conserved inner membrane protein^[2]^[3] Inner membrane heme subunit for periplasmic YedYZ reductase^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005887	integral to plasma membrane	PMID:11867724	IDA: Inferred from Direct Assay		C		complete
	GO:0005506	iron ion binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013130	F	Seeded from EcoCyc (v14.0)	complete
	GO:0009055	electron carrier activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013130	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016491	oxidoreductase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013130	F	Seeded from EcoCyc (v14.0)	complete
	GO:0050660	FAD binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013130	F	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence
plasma membrane	C-terminus localized in the cytoplasm with 6 predicted transmembrane domains	Daley et al. (2005) ^[7]
plasma membrane
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MRLTAKQVTW LKVCLHLAGL LPFLWLVWAI NHGGLGADPV KDIQHFTGRT ALKFLLATLL ITPLARYAKQ PLLIRTRRLL GLWCFAWATL HLTSYALLEL GVNNLALLGK ELITRPYLTL GIISWVILLA LAFTSTQAMQ RKLGKHWQQL HNFVYLVAIL APIHYLWSVK IISPQPLIYA GLAVLLLALR YKKLRSLFNR LRKQVHNKLS V
Length	211
Mol. Wt	24.069 kDa
pI	11.2 (calculated)
Extinction coefficient	54,430 - 54,680 (calc based on 7 Y, 8 W, and 2 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	18..162	PF01794 Ferric reductase like transmembrane component		PMID:19920124
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<motif_map/>

Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=yedZ taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16129918	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:946483	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0006542	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P76343	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G7060	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG14048	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:946483	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003646	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3801	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MG1655	15^a	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
Protein	E. coli K-12 MG1655	27	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	0^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
yedY
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:2038487..2038527 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b1972 (EcoliWiki Page)	NCBI GEO profiles for yedZ
microarray	GenExpDB:b1972 (EcoliWiki Page)	Summary of data for yedZ from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to yedZ Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G7060	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3801	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b1972
EcoGene	EcoGene:EG14048	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003646	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0006542	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Anopheles gambiae	ENSANGP00000000008 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Shigella flexneri	S2116	From SHIGELLACYC
E. coli O157	Z3064	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF01794 Ferric reductase like transmembrane component
EcoCyc	EcoCyc:G7060	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG14048	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003646	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3801	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0006542	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ ^6.0 ^6.1 ^6.2 CGSC: The Coli Genetics Stock Center
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed

yedZ:On One Page

Quickview

Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to yedZ Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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