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On One Page

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Expression|

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Standard Name	glpR
Gene Synonym(s)	ECK3409, b3423, JW3386^[1], JW3386
Product Desc.	GlpR transcriptional repressor^[2]^[3] Repressor of glp regulon, induced by glycerol phophate; tetrameric^[4]
Product Synonyms(s)	DNA-binding transcriptional repressor^[1], B3423^[2]^[1], GlpR^[2]^[1], repressor of the glp operon^[2]^[1] , ECK3409, JW3386, b3423
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): glpR^[2], glpGR^[2], glpEGR^[2]
Regulation/Activity
Quick Links
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	glpR
Mnemonic	Glycerol phosphate
Synonyms	ECK3409, b3423, JW3386^[1], JW3386
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	76.68 minutes	MG1655: 3558628..3557870 <gbrowseImage> name=NC_000913:3557870..3558628 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 3489206..3488448 <gbrowseImage> name=NC_012967:3488448..3489206 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 3446364..3447122 <gbrowseImage> name=NC_012759:3446364..3447122 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 4079810..4080568 <gbrowseImage> name=NC_007779:4079810..4080568 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 3656373..3655615 <gbrowseImage> name=NC_010473:3655615..3656373 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
Coding Start (SO:0000323)	MG1655	3557870	Edman degradation	PMID:8955387
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Description	Reference	Availability	Comments
ΔglpR (Keio:JW3386)	deletion	deletion		PMID:16738554	Shigen CGSC10521^[5]
glpR::Tn5KAN-I-SceI (FB21194)	Insertion at nt 273 in Plus orientation			PMID:15262929	E. coli Genome Project:FB21194	does not contain pKD46
glpR2(glp^c)					CGSC:4919
glpR12(glpⁿ)					CGSC:6509
glpR8(glp^c)					CGSC:6607
glpR7(glpⁿ)					CGSC:6608
glpR200(glp^c)				PMID:3882662	CGSC:10441
glpR20(ts)			temperature sensitive	PMID:4866330	CGSC:14471
glpR28					CGSC:14595
glpR5					CGSC:16024
glpR201					CGSC:19381
glpR101					CGSC:71446
ΔglpR756::kan				PMID:16738554	CGSC:101192
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW3386	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCAAACAAACACAACGTCACAA Primer 2:CCGCACAGCTCCAGTTGAATATG
E5B4	Kohara Phage	Genobase	PMID:3038334
E4E4	Kohara Phage	Genobase	PMID:3038334
zhf-3084::Tn10	Linked marker	CAG18456 = CGSC7576^[5]	est. P1 cotransduction: 7% ^[6] Synonyms:zhe-3084::Tn10nnnCAG18456 also carries cysG0 (CGSC).
glgP721::Tn10	Linked marker	CAG18638 = CGSC7451^[5]	est. P1 cotransduction: 84% ^[6] Synonyms:zhg-3086::Tn10, zhh-21::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10400	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10400	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000393	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:947926	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0395	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0011176	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	GlpR
Synonyms	DNA-binding transcriptional repressor^[1], B3423^[2]^[1], GlpR^[2]^[1], repressor of the glp operon^[2]^[1] , ECK3409, JW3386, b3423
Product description	GlpR transcriptional repressor^[2]^[3] Repressor of glp regulon, induced by glycerol phophate; tetrameric^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0003677	DNA binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F	Seeded from EcoCyc (v14.0)	complete
	GO:0003700	transcription factor activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001034	F	Seeded from EcoCyc (v14.0)	complete
	GO:0003700	transcription factor activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018356	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005622	intracellular	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001034	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005622	intracellular	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018356	C	Seeded from EcoCyc (v14.0)	complete
	GO:0006071	glycerol metabolic process	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0319	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006350	transcription	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006355	regulation of transcription, DNA-dependent	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001034	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006355	regulation of transcription, DNA-dependent	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018356	P	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	ttdA		PMID:16606699	Experiment(s):EBI-1145856
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Notes

Localization

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Compartment	Description	Evidence	Reference/Source	Notes
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Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MKQTQRHNGI IELVKQQGYV STEELVEHFS VSPQTIRRDL NELAEQNLIL RHHGGAALPS SSVNTPWHDR KATQTEEKER IARKVAEQIP NGSTLFIDIG TTPEAVAHAL LNHSNLRIVT NNLNVANTLM VKEDFRIILA GGELRSRDGG IIGEATLDFI SQFRLDFGIL GISGIDSDGS LLEFDYHEVR TKRAIIENSR HVMLVVDHSK FGRNAMVNMG SISMVDAVYT DAPPPVSVMQ VLTDHHIQLE LC
Length	252
Mol. Wt	28.047 kDa
pI	6.3 (calculated)
Extinction coefficient	9,970 - 10,095 (calc based on 3 Y, 1 W, and 1 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	References
Domain	75..231	PF00455 Bacterial regulatory proteins, deoR family	PMID:19920124
Domain	6..62	PF08220 DeoR-like helix-turn-helix domain	PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=glpR taxon=562,83333 </beststructure>

Models

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Structure figures

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16131297	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:947926	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0011176	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P0ACL0	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG10400	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10400	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:947926	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000393	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0395	Escherichia coli str. K-12 substr. MG1655
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Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MG1655	1057	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	295	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	705	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
glpR
glpGR
glpEGR
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:3558608..3558648 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b3423 (EcoliWiki Page)	NCBI GEO profiles for glpR
microarray	GenExpDB:b3423 (EcoliWiki Page)	Summary of data for glpR from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to glpR Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10400	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0395	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b3423
EcoGene	EcoGene:EG10400	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000393	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0011176	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Anopheles gambiae	ENSANGP00000028641 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000036761 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Shigella flexneri	GLPR	From SHIGELLACYC
E. coli O157	GLPR	From ECOO157CYC
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Notes

Families

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<protect> See Help:Evolution_families for help entering or editing information in this section of EcoliWiki.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF08220 DeoR-like helix-turn-helix domain
Pfam (EcoliWiki Page)	PF00455 Bacterial regulatory proteins, deoR family
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

glpR:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to glpR Expression

Notes

Links

Evolution

Homologs in Other Organisms

Notes

Families

Notes

Links

References

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