ftsZ:On One Page

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Quickview | Gene | Product(s) | Expression| Evolution | References |

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Standard Name

ftsZ

Gene Synonym(s)

ECK0096, b0095, JW0093, sfiB, sulB[1], sulB

Product Desc.

essential cell division protein FtsZ[2][3]

Septal ring GTPase required for cell division and growth; initiation of septation[4]

Product Synonyms(s)

GTP-binding tubulin-like cell division protein[1], B0095[2][1], SulB[2][1], SfiB[2][1], FtsZ[2][1] , ECK0096, JW0093, sfiB, sulB, b0095

Function from GO

<GO_nr />

Knock-Out Phenotype

Essential[5]

Regulation/Expression

transcription unit(s): mraZW-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ[2], ftsZ[2], ftsAZ[2], ftsQAZ[2], OP00295

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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ZapA binding promotes FtsZ polymer bundling and inhibits the GTPase activity of FtsZ (Small, 2007). FtsZ is stored in a dynamic helical FtsZ cytoskeleton upon disassembly of the Z ring in daughter cells. Overexpression causes filamentous biofilm formation. Binds TrxA (Kumar, 2004). Divisome.[4]



Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

ftsZ

Mnemonic

Filamentation, temperature sensitive

Synonyms

ECK0096, b0095, JW0093, sfiB, sulB[1], sulB

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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain Map location Genome coordinates Genome browsers Sequence links

MG1655

2.27 minutes 

MG1655: 105305..106456
<gbrowseImage> name=NC_000913:105305..106456 source=MG1655 preset=GeneLocation </gbrowseImage>

REL606

NC_012967: 108109..109260
<gbrowseImage> name=NC_012967:108109..109260 source=REL606 preset=GeneLocation </gbrowseImage>

BW2952

NC_012759: 105304..106455
<gbrowseImage> name=NC_012759:105304..106455 source=BW2952 preset=GeneLocation </gbrowseImage>

W3110

 

W3110: 105305..106456
<gbrowseImage> name=NC_007779:105305..106456 source=W3110 preset=GeneLocation </gbrowseImage>

DH10B

DH10B: 79409..80560
<gbrowseImage> name=NC_010473:79409..80560 source=DH10B preset=GeneLocation </gbrowseImage>

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type Strain Genomic Location Evidence Reference Notes

Coding Start (SO:0000323)

MG1655

105305

Edman degradation

PMID:9298646


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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele Nt change(s) AA change(s) Phenotype: Type Phenotype: Description Reference Availability Comments

ftsZG105F

G105F

In ftsZ-84; loss of GTPase-activity and conversion to an ATPase

seeded from UniProt:P0A9A6

ftsZT108A

T108A

In ftsZ-Z3; lethal; greatly reduced GTP binding

seeded from UniProt:P0A9A6

ftsZ844(ts)

temperature sensitive

PMID:6991482 PMID:4583216

CGSC:10684

ftsZ26(ts)

Growth Phenotype

cell division is blocked and filaments with smooth morphology are formed

abnormal geometry of z ring is formed

PMID:1644768

PMID:8682793

CGSC:6956

unable to localize FtsZ at non-permissive temp.

at permissive temp. cells have altered polar morphology

ftsZ25(ts)

temperature sensitive

CGSC:12145

ftsZ103

TTC to TGC

Phe to Cys at amino acid 268

Resistant to

resistant to SulA

PMID:7012641 PMID:1107802 PMID:2145263

CGSC:70085

same phenotype as ftsZ114

ftsZ1

GCT to ACT

Ala to Thr at amino acid 70

Resistant to

resistant to SulA

PMID:8752322

PMID:2145263

ftsZ9

Insertion of TC GGC G

Insertion of Val-Gly after amino acid 18

Resistant to

resistant to SulA

PMID:8752322

PMID:2145263

same phenotype as ftsZ25

ftsZ100

GCT to GTT and TTC to TGC

Ala to Val at amino acid 81 and Phe to Cys at amino acid 268

Resistant to

resistant to SulA and partially resistant to minCD

PMID:8752322

PMID:11673433

PMID:2145263

participates in cell division regardless of SulA’s presence


ftsZ114

reduced affinity for SulA

PMID:8752322 PMID:9501185 PMID:6329742

previously known as sfiB114

ftsZ3

ACC to GAC

Thr to Ala at amino acid 108

Resistant to

resistant to SulA

PMID:8752322

PMID:2145263

unstable protein, unable to support cell growth and shows a deficiency in GTP interaction

ftsZ2

Growth Phenotype

reduces the activity of ftsZ, forms elongated nucleated cells with minicells

PMID:8752322 PMID:1644768

resistant to SulA's effect, but still shown to interact with it based on 2 Hybrid screen.

displays reduced GTP hydrolysis but is able to support cell growth

ftsZ84

Cell Shape

unable to form Z-ring at non-permissive temperature

PMID:1528267 PMID:8016071 PMID:8682793

reduced GTPase activity and a reduced ability to polymerize

ftsZ84

missense mutation

Growth Phenotype

at non-permissive temperature cell division is blocked and filaments with smooth morphology are formed

PMID:8083192

PMID:8682793

changed GTPase activity to ATPase activity instead

ftsZ2

GAC to GGC

Asp to Gly at amino acid 212

Resistant to

resistant to SulA

PMID:2145263

ftsZ84

GGT to AGT

Gly to Ser at amino acid 105

Growth Phenotype

temperature sensitive

PMID:2145263


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Notes

Genetic Interactions

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Interactor Interaction Allele Score(s) Reference(s) Accessions Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource Resource Type Source Notes/Reference

JW0093

Plasmid clone

Shigen

PMID:16769691

Status:Clone OK

Primer 1:GCCTTTGAACCAATGGAACTTAC

Primer 2:CCATCAGCTTGCTTACGCAGGAA

6F3

Kohara Phage

Genobase

PMID:3038334

15B8

Kohara Phage

Genobase

PMID:3038334

leuO3051::Tn10

Linked marker

CAG12095 = CGSC7324[6]

est. P1 cotransduction: 45% [7]
Synonyms:zab-3051::Tn10 nnnThe start of leuO was reannotated by Riley et al. (2006).

zad-220::Tn10

Linked marker

CAG12025 = CGSC7326[6]

est. P1 cotransduction: 15% [7]

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:EG10347

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10347

Escherichia coli str. K-12 substr. MG1655

NCBI (EcoliWiki Page)

GeneID:944786

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000341

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0343

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000333

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

FtsZ

Synonyms

GTP-binding tubulin-like cell division protein[1], B0095[2][1], SulB[2][1], SfiB[2][1], FtsZ[2][1] , ECK0096, JW0093, sfiB, sulB, b0095

Product description

essential cell division protein FtsZ[2][3]

Septal ring GTPase required for cell division and growth; initiation of septation[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status

GO:0003924

GTPase activity

PMID:1528267

IDA: Inferred from Direct Assay

F

complete

GO:0005737

cytoplasm

PMID:1943703

IDA: Inferred from Direct Assay

C

complete

GO:0051258

protein polymerization

PMID:8917533

IDA: Inferred from Direct Assay

P

complete

GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0000917

barrier septum formation

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0717

P

Seeded from EcoCyc (v14.0)

complete

GO:0003924

GTPase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008280

F

Seeded from EcoCyc (v14.0)

complete

GO:0003924

GTPase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018316

F

Seeded from EcoCyc (v14.0)

complete

GO:0032153

cell division site

PMID:9603865

IDA: Inferred from Direct Assay

C

complete

GO:0005515

protein binding

PMID:17307852

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0051301

cell division

PMID:2045370

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005515

protein binding

PMID:8752322

IPI: Inferred from Physical Interaction

F

Seeded from EcoCyc (v14.0)

Missing: with/from

GO:0005525

GTP binding

PMID:1528267

IDA: Inferred from Direct Assay

F

complete

GO:0005515

protein binding

PMID:9008158

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0005525

GTP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000158

F

Seeded from EcoCyc (v14.0)

complete

GO:0003924

GTPase activity

PMID:1528268

IDA: Inferred from Direct Assay

F

complete

GO:0005525

GTP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008280

F

Seeded from EcoCyc (v14.0)

complete

GO:0005525

GTP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018316

F

Seeded from EcoCyc (v14.0)

complete

GO:0005525

GTP binding

PMID:1528268

IDA: Inferred from Direct Assay

F

complete

GO:0005515

protein binding

PMID:17307852

IDA: Inferred from Direct Assay

F

EcoliWiki:ftsE

complete

GO:0005525

GTP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020805

F

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

PMID:8917533

IDA: Inferred from Direct Assay

F

EcoliWiki:ftsA

complete

GO:0005515

protein binding

PMID:9008158

IDA: Inferred from Direct Assay

F

EcoliWiki:zipA

complete

GO:0005525

GTP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0342

F

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

PMID:8752322

IPI: Inferred from Physical Interaction

EcoliWiki:sulA


F

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000158

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020805

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0007049

cell cycle

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0131

P

Seeded from EcoCyc (v14.0)

complete

GO:0043234

protein complex

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003008

C

Seeded from EcoCyc (v14.0)

complete

GO:0043234

protein complex

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008280

C

Seeded from EcoCyc (v14.0)

complete

GO:0043234

protein complex

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018316

C

Seeded from EcoCyc (v14.0)

complete

GO:0051258

protein polymerization

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003008

P

Seeded from EcoCyc (v14.0)

complete

GO:0051258

protein polymerization

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008280

P

Seeded from EcoCyc (v14.0)

complete

GO:0051258

protein polymerization

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018316

P

Seeded from EcoCyc (v14.0)

complete

GO:0051301

cell division

IEA: Inferred from Electronic Annotation

SP_KW:KW-0132


P

Seeded from EcoCyc (v14.0)

Missing: reference

GO:0005515

protein binding

PMID:20497333

IPI: Inferred from Physical Interaction

EcoliWiki:zapA


F

complete

GO:0005515

protein binding

PMID:20497333

IPI: Inferred from Physical Interaction

EcoliWiki:ftsZ


F

complete

GO:0051258

protein polymerization

PMID:21321206

IDA: Inferred from Direct Assay

P

Figure 3

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

add

PMID:15690043

Experiment(s):EBI-889279

Protein

dnaK

PMID:15690043

Experiment(s):EBI-889279

Protein

ftsK

PMID:15690043

Experiment(s):EBI-889279

Protein

fusA

PMID:15690043

Experiment(s):EBI-889279

Protein

gatY

PMID:15690043

Experiment(s):EBI-889279

Protein

malK

PMID:15690043

Experiment(s):EBI-889279

Protein

mreB

PMID:15690043

Experiment(s):EBI-889279

Protein

pstB

PMID:15690043

Experiment(s):EBI-889279

Protein

recA

PMID:15690043

Experiment(s):EBI-889279

Protein

rplE

PMID:15690043

Experiment(s):EBI-889279

Protein

rpsB

PMID:15690043

Experiment(s):EBI-889279

Protein

rpsE

PMID:15690043

Experiment(s):EBI-889279

Protein

rpsJ

PMID:15690043

Experiment(s):EBI-889279

Protein

secA

PMID:15690043

Experiment(s):EBI-889279

Protein

tufA

PMID:15690043

Experiment(s):EBI-889279

Protein

pflB

PMID:16606699

Experiment(s):EBI-1135563

Protein

rpsD

PMID:16606699

Experiment(s):EBI-1135563

Protein

uspG

PMID:16606699

Experiment(s):EBI-1135563

Protein

yedD

PMID:16606699

Experiment(s):EBI-1135563

Protein

moaC

PMID:16606699

Experiment(s):EBI-1135563

Protein

tatE

PMID:16606699

Experiment(s):EBI-1135563

Protein

rplN

PMID:16606699

Experiment(s):EBI-1135563

Protein

secA

PMID:19402753

MALDI(Z-score):18.856613

Protein

fusA

PMID:19402753

MALDI(Z-score):20.694080

Protein

ftsK

PMID:19402753

MALDI(Z-score):18.687667

Protein

recA

PMID:19402753

MALDI(Z-score):38.547831

Protein

malT

PMID:19402753

MALDI(Z-score):19.663296

Protein

pstB

PMID:19402753

MALDI(Z-score):38.846575

Protein

gatY

PMID:19402753

MALDI(Z-score):31.574250

Protein

add

PMID:19402753

MALDI(Z-score):27.158866

Protein

SulA

FtsZ full length and truncations

PMID:8752322

2 hybrid

Protein

FtsA

FtsA/FtsZ ratio is important for cell division


PMID:1400163

PMID:1400183


Genetic Interference

Protein

FtsA

FtsA may link Z-ring to septal specific peptidoglycan biosynthesis

PMID:6365891

Protein

SlmA

PMID:21321206

Bacterial 2 hybrid

Protein

MinCD

overproduction of MinCD blocks localization of FtsZ

PMID:8432706

Protein

sdiA

ftsZ84 strains grown at 42C showed restored ability to form colonies with introduction of sdiA plasmids

PMID:1915297


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Notes

  • FtsZ is a key player in Septation
  • FtsZ contains a fairly strong activation domain (AD) and cannot be used as the bait in 2 hybrid screens.[8]

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm

From EcoCyc[3]

cytoplasm

fractionation experiments

PMID:1943703

cytoplasm

fractionation

PMID:1528267

membrane-associated in the presence of GTP

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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MFEPMELTND AVIKVIGVGG GGGNAVEHMV RERIEGVEFF AVNTDAQALR KTAVGQTIQI
GSGITKGLGA GANPEVGRNA ADEDRDALRA ALEGADMVFI AAGMGGGTGT GAAPVVAEVA
KDLGILTVAV VTKPFNFEGK KRMAFAEQGI TELSKHVDSL ITIPNDKLLK VLGRGISLLD
AFGAANDVLK GAVQGIAELI TRPGLMNVDF ADVRTVMSEM GYAMMGSGVA SGEDRAEEAA
EMAISSPLLE DIDLSGARGV LVNITAGFDL RLDEFETVGN TIRAFASDNA TVVIGTSLDP
DMNDELRVTV VATGIGMDKR PEITLVTNKQ VQQPVMDRYQ QHGMAPLTQE QKPVAKVVND
NAPQTAKEPD YLDIPAFLRK QAD
Length

383

Mol. Wt

40.323 kDa

pI

4.5 (calculated)

Extinction coefficient

4,470 (calc based on 3 Y, 0 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

12..184

PF00091 Tubulin/FtsZ family, GTPase domain

PMID:19920124

Domain

221..318

PF12327 FtsZ family, C-terminal domain

PMID:19920124

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=ftsZ taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

  • The dynamics of FtsZ ring formation/constriction was investigated in Addinall et al.(1997)[9].
  • Aluminum fluoride abolishes FtsZ GTPase activity[10].

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

Purified protein

FtsZ D212N- defective GTPase activity

PMID: 21321206

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128088

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:944786

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000333

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A9A6

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10347

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10347

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:944786

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000341

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0343

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

Molecule Organism or Strain Value Units Experimental Conditions Assay used Notes Reference(s)

Protein

E. coli K-12 MC4100

9.66E+02

molecules/cell

  • Medium: median data from rich and minimal media
  • Temperature (°C): 37
  • Doubling time (min): Growth Rate(min):
  • Growth phase: other:

emPAI

PMID:18304323

Protein

E. coli K-12 EMG2

320

molecules/cell

  • Medium: MOPS glucose minimal
  • Temperature (°C): 37
  • Doubling time (min):
  • Growth phase: Exponential
  • OD: OD600 = 0.2 to 0.25
  • other: aerated

Quantitative protein sequencing

Spot ID: M49

PMID: 9298646

Protein

E. coli K-12 MG1655

6750

molecules/cell/generation

  • Medium: MOPS Complete
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Protein

E. coli K-12 MG1655

3335

molecules/cell/generation

  • Medium: MOPS Minimal
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Protein

E. coli K-12 MG1655

5290

molecules/cell/generation

  • Medium: MOPS Complete without Methionine
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

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Notes

Tetart et al. (1992) studied an E.coli strain that expressed ftsZ at one-fifth of its normal level, because of antisense regulation by DicF RNA[11].

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

mraZW-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ

ftsZ

ftsAZ

ftsQAZ

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Figure courtesy of RegulonDB

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Notes

Robin et al. (1990) studied the transcriptional regulation of ftsZ gene using a lacZ operon fusions[12]

An increase in FtsZ results in an induction of minicell phenotype and additional division events every cell cycle. [13]

The amount of cellular FtsZ was increased by sdiA expression. [14]

FtsZ ring assembly and constriction requires FtsI activity. [15]

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:105285..105325 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name Mutation Phenotype Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type Reference Notes

microarray

GEO Profiles:b0095 (EcoliWiki Page)

NCBI GEO profiles for ftsZ

microarray

GenExpDB:b0095 (EcoliWiki Page)

Summary of data for ftsZ from multiple microarray studies

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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name Resource Type Description Source Notes

GFP Fusion

Intergenic region (104953..105117) fused to gfpmut2.

OpenBioSystems

GFP fusion described in Zaslaver, et al.
Plate:109-AZ20; Well:A5[16]

λJFL100

lacZ fusion

ftsZ-lacZ fusion on lambda transducing phage PMID:2106510


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Notes

Accessions Related to ftsZ Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:EG10347

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0343

Escherichia coli str. K-12 substr. MG1655

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b0095

EcoGene

EcoGene:EG10347

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000341

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000333

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Evolution

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{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism Homologs (Statistics) Comments

Arabidopsis thaliana

  • AT5G55280 (score: 1.000; bootstrap: 100%)
  • AT3G52750 (score: 0.125)
  • AT2G36250 (score: 0.122)

From Inparanoid:20070104

Dictyostelium discoideum

  • DDB0219983 (score: 1.000; bootstrap: 89%)

From Inparanoid:20070104

Oryza gramene

  • Q6F2N1 (score: 1.000; bootstrap: 100%)
  • Q94F85 (score: 0.106)
  • Q7FAR6 (score: 0.106)

From Inparanoid:20070104

Xenopus tropicalis

  • ENSXETP00000038461 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Shigella flexneri

FTSZ

From SHIGELLACYC

E. coli O157

FTSZ

From ECOO157CYC

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Do-It-Yourself Web Tools

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Notes

FtsZ ring: the eubacterial division apparatus conserved in archaebacteria[17]

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

Superfamily (EcoliWiki Page)

SUPERFAMILY:52490

Superfamily (EcoliWiki Page)

SUPERFAMILY:55307

Pfam (EcoliWiki Page)

PF00091 Tubulin/FtsZ family, GTPase domain

Pfam (EcoliWiki Page)

PF12327 FtsZ family, C-terminal domain

EcoCyc

EcoCyc:EG10347

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10347

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000341

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0343

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000333

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Bi, E et al. () FtsZ and cell division. Res. Microbiol. 142 249-52 PubMed
  6. ↑ 6.0 6.1 CGSC: The Coli Genetics Stock Center
  7. ↑ 7.0 7.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
  8. ↑ Huang, J et al. (1996) Interaction between FtsZ and inhibitors of cell division. J. Bacteriol. 178 5080-5 PubMed
  9. ↑ Addinall, SG et al. (1997) Temperature shift experiments with an ftsZ84(Ts) strain reveal rapid dynamics of FtsZ localization and indicate that the Z ring is required throughout septation and cannot reoccupy division sites once constriction has initiated. J. Bacteriol. 179 4277-84 PubMed
  10. ↑ RayChaudhuri, D & Park, JT (1994) A point mutation converts Escherichia coli FtsZ septation GTPase to an ATPase. J. Biol. Chem. 269 22941-4 PubMed
  11. ↑ Tétart, F et al. (1992) Involvement of FtsZ in coupling of nucleoid separation with septation. Mol. Microbiol. 6 621-7 PubMed
  12. ↑ Robin, A et al. (1990) Transcription of the ftsZ gene and cell division in Escherichia coli. J. Bacteriol. 172 1392-9 PubMed
  13. ↑ Ward, JE Jr & Lutkenhaus, J (1985) Overproduction of FtsZ induces minicell formation in E. coli. Cell 42 941-9 PubMed
  14. ↑ Wang, XD et al. (1991) A factor that positively regulates cell division by activating transcription of the major cluster of essential cell division genes of Escherichia coli. EMBO J. 10 3363-72 PubMed
  15. ↑ Pogliano, J et al. (1997) Inactivation of FtsI inhibits constriction of the FtsZ cytokinetic ring and delays the assembly of FtsZ rings at potential division sites. Proc. Natl. Acad. Sci. U.S.A. 94 559-64 PubMed
  16. ↑ Zaslaver, A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat. Methods 3 623-8 PubMed
  17. ↑ Wang, X & Lutkenhaus, J (1996) FtsZ ring: the eubacterial division apparatus conserved in archaebacteria. Mol. Microbiol. 21 313-9 PubMed

Categories

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