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Expression|

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Standard Name	folP
Gene Synonym(s)	ECK3166, b3177, JW3144, dhpS^[1], dhpS
Product Desc.	FolP^[2]^[3]; Component of dihydropteroate synthase^[2]^[3]
Product Synonyms(s)	7,8-dihydropteroate synthase^[1], B3177^[2]^[1], DhpS^[2]^[1], FolP^[2]^[1] , dhpS, ECK3166, JW3144, b3177
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): glmM^[2]
Regulation/Activity
Quick Links
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	folP
Mnemonic	Folate
Synonyms	ECK3166, b3177, JW3144, dhpS^[1], dhpS
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	71.6 minutes	MG1655: 3322933..3322085 <gbrowseImage> name=NC_000913:3322085..3322933 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 3260145..3259297 <gbrowseImage> name=NC_012967:3259297..3260145 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 3209233..3210081 <gbrowseImage> name=NC_012759:3209233..3210081 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 3324766..3323918 <gbrowseImage> name=NC_007779:3323918..3324766 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 3420678..3419830 <gbrowseImage> name=NC_010473:3419830..3420678 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
Coding Start (SO:0000323)	MG1655	3322085	Edman degradation	PMID:1657875
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Description	Reference	Availability	Comments
folPF28I		F28I	(in TS20; resistant to sulfonamide and temperature-sensitive)			Strain variation; seeded from UniProt:P0AC13
ΔfolP (Keio:JW3144)	deletion	deletion		PMID:16738554	Shigen CGSC10389^[4]
folP::Tn5KAN-I-SceI (FB21059)	Insertion at nt 838 in Minus orientation			PMID:15262929	E. coli Genome Project:FB21059	contains pKD46
ΔfolP775::kan				PMID:16738554	CGSC:100986
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Notes

The Keio collection^[5] lists a deletion of folP. The insertion in this strain is a duplication of the folP region.^[6]

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW3144	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCAAACTCTTTGCCCAGGGTAC Primer 2:CCtTCATAGCGTTTGTTTTCCTT
18H7	Kohara Phage	Genobase	PMID:3038334
14F11	Kohara Phage	Genobase	PMID:3038334
aer-3075::Tn10	Linked marker	CAG12152 = CGSC7438^[4]	est. P1 cotransduction: % ^[7] Synonyms:zgh-3075::Tn10, zgj-3075::Tn10
sfsB203::Tn10	Linked marker	CAG12072 = CGSC7440^[4]	est. P1 cotransduction: 73% ^[7] Synonyms:zgj-203::Tn10, zha-203::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG50011	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG50011	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002570	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:947691	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB4304	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0010441	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	FolP
Synonyms	7,8-dihydropteroate synthase^[1], B3177^[2]^[1], DhpS^[2]^[1], FolP^[2]^[1] , dhpS, ECK3166, JW3144, b3177
Product description	FolP^[2]^[3]; Component of dihydropteroate synthase^[2]^[3]
EC number (for enzymes)	2.5.1.15^[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm	PMID:1522070	IDA: Inferred from Direct Assay		C	Seeded from Riley et al 2006 ^[1].	complete
	GO:0004156	dihydropteroate synthase activity	PMID:1522070	IDA: Inferred from Direct Assay		F		complete
	GO:0042493	response to drug	PMID:9449266	IMP: Inferred from Mutant Phenotype		P	sulfonamides	complete
	GO:0004156	dihydropteroate synthase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000489	F	Seeded from EcoCyc (v14.0)	complete
	GO:0004156	dihydropteroate synthase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006390	F	Seeded from EcoCyc (v14.0)	complete
	GO:0004156	dihydropteroate synthase activity	GOA:spec GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.5.1.15	F	Seeded from EcoCyc (v14.0)	complete
	GO:0046656	folic acid biosynthetic process	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0289	P	Seeded from EcoCyc (v14.0)	complete
	GO:0046677	response to antibiotic	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0046	P	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of dihydropteroate synthase	could be indirect
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MLRGFFLSIH TRDNIMKLFA QGTSLDLSHP HVMGILNVTP DSFSDGGTHN SLIDAVKHAN LMINAGATII DVGGESTRPG AAEVSVEEEL QRVIPVVEAI AQRFEVWISV DTSKPEVIRE SAKVGAHIIN DIRSLSEPGA LEAAAETGLP VCLMHMQGNP KTMQEAPKYD DVFAEVNRYF IEQIARCEQA GIAKEKLLLD PGFGFGKNLS HNYSLLARLA EFHHFNLPLL VGMSRKSMIG QLLNVGPSER LSGSLACAVI AAMQGAHIIR VHDVKETVEA MRVVEATLSA KENKRYE
Length	297
Mol. Wt	32.417 kDa
pI	6.2 (calculated)
Extinction coefficient	11,460 - 11,835 (calc based on 4 Y, 1 W, and 3 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	20..225	PF00809 Pterin binding enzyme		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=folP taxon=562,83333 </beststructure>

Models

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Structure figures

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:90111553	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:947691	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0010441	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P0AC13	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG50011	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG50011	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:947691	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002570	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB4304	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MC4100	1.76E+02	molecules/cell	Medium: median data from rich and minimal media Temperature (°C): 37 Doubling time (min): Growth Rate(min): Growth phase: other:	emPAI	PMID:18304323
Protein	E. coli K-12 MG1655	1139	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	345	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	720	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
glmM
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Figure courtesy of RegulonDB

</protect>

Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:3322913..3322953 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b3177 (EcoliWiki Page)	NCBI GEO profiles for folP
microarray	GenExpDB:b3177 (EcoliWiki Page)	Summary of data for folP from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to folP Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG50011	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB4304	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b3177
EcoGene	EcoGene:EG50011	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002570	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0010441	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Anopheles gambiae	ENSANGP00000026154 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Arabidopsis thaliana	AT4G30000 (score: 1.000; bootstrap: 100%) AT1G69190 (score: 0.618)	From Inparanoid:20070104
Dictyostelium discoideum	DDB0230139 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Oryza gramene	Q69V07 (score: 1.000; bootstrap: 100%) Q7X7X0 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Saccharomyces cerevisiae	YNL256W (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Schizosaccharomyces pombe	SPBC17343 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000005020 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Shigella flexneri	FOLP	From SHIGELLACYC
E. coli O157	FOLP	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Superfamily (EcoliWiki Page)	SUPERFAMILY:51717
Panther (EcoliWiki Page)	PTHR20941:SF1
Pfam (EcoliWiki Page)	PF00809 Pterin binding enzyme
EcoCyc	EcoCyc:EG50011	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG50011	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002570	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB4304	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0010441	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 CGSC: The Coli Genetics Stock Center
↑ Baba, T et al. (2006) Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol. Syst. Biol. 2 2006.0008 PubMed
↑ Yamamoto, N et al. (2009) Update on the Keio collection of Escherichia coli single-gene deletion mutants. Mol. Syst. Biol. 5 335 PubMed
↑ ^7.0 ^7.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

folP:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to folP Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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