{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

On One Page

Quickview |

Gene |

Product(s) |

Expression|

Evolution |

References |

Quickview

[back to top]

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Standard Name	fliG
Gene Synonym(s)	ECK1937, b1939, JW1923, flaBII, flaAII 2, flaAII.2, AII.2, flaAII, 2, flaAll.2^[1]^[2]
Product Desc.	flagellar motor switch protein FliG^[2]^[3]; Component of Flagellar Motor Switch Complex^[3]; Flagellar Motor Complex^[2]^[3]; Flagellum^[3] Rotor protein for flagellar motor switching and energizing; role in flagellar assembly^[4]
Product Synonyms(s)	flagellar motor switching and energizing component^[1], B1939^[2]^[1], FliG^[2]^[1] , ECK1937, flaAII.2, flaBII, JW1923, b1939
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): fliFGHIJK^[2]
Regulation/Activity
Quick Links
edit table

</protect> See Help:Quickview for help with entering information in the Quickview table. <protect></protect>

Notes

[back to top]

FliGMN switch complex on the rotor of the bacterial flagellum. FliG interacts with the stator protein MotA.^[4]

Gene

[back to top]

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css> <protect>

Nomenclature

[back to top]

See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	fliG
Mnemonic	Flagella
Synonyms	ECK1937, b1939, JW1923, flaBII, flaAII 2, flaAII.2, AII.2, flaAII, 2, flaAll.2^[1]^[2]
edit table

</protect>

Notes

Location(s) and DNA Sequence

[back to top]

<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	43.38 minutes	MG1655: 2012904..2013899 <gbrowseImage> name=NC_000913:2012904..2013899 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
BW2952		NC_012759: 1905387..1906382 <gbrowseImage> name=NC_012759:1905387..1906382 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 2017017..2018012 <gbrowseImage> name=NC_007779:2017017..2018012 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 2103912..2104907 <gbrowseImage> name=NC_010473:2103912..2104907 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
edit table

</protect>

Notes

Sequence Features

[back to top]

See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
edit table

Notes

Alleles and Phenotypes

[back to top]

See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability
ΔfliG (Keio:JW1923)	deletion	deletion	PMID:16738554	Shigen CGSC9599^[5]
ΔfliG785::kan			PMID:16738554	CGSC:100938
edit table

Notes

Genetic Interactions

[back to top]

Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
edit table

</protect>

Notes

Genetic Resources

[back to top]

See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW1923	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCAGTAACCTGACAGGCACCGA Primer 2:CCGACATAGGTATCCTCGCCGCT
3B3	Kohara Phage	Genobase	PMID:3038334
uvrC279::Tn10	Linked marker	CAG12156 = CGSC7394^[5]	est. P1 cotransduction: 44% ^[6]
zed-3069::Tn10	Linked marker	CAG18451 = CGSC7395^[5]	est. P1 cotransduction: 41% ^[6]
edit table

Notes

Accessions in Other Databases

[back to top]

See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11654	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11654	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001598	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:946451	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1607	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0006456	Escherichia coli str. K-12 substr. MG1655
edit table

Notes

Links

[back to top]

Name	URL	Comments
edit table

Product(s)

[back to top]

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	FliG
Synonyms	flagellar motor switching and energizing component^[1], B1939^[2]^[1], FliG^[2]^[1] , ECK1937, flaAII.2, flaBII, JW1923, b1939
Product description	flagellar motor switch protein FliG^[2]^[3]; Component of Flagellar Motor Switch Complex^[3]; Flagellar Motor Complex^[2]^[3]; Flagellum^[3] Rotor protein for flagellar motor switching and energizing; role in flagellar assembly^[4]
EC number (for enzymes)
edit table

Notes

Function

[back to top]

<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0001539	ciliary or flagellar motility	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000090	P	Seeded from EcoCyc (v14.0)	complete
	GO:0001539	ciliary or flagellar motility	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0283	P	Seeded from EcoCyc (v14.0)	complete
	GO:0003774	motor activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000090	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0997	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C	Seeded from EcoCyc (v14.0)	complete
	GO:0006935	chemotaxis	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000090	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006935	chemotaxis	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0145	P	Seeded from EcoCyc (v14.0)	complete
	GO:0071973	bacterial-type flagellar cell motility	PMID:8550421	IMP: Inferred from Mutant Phenotype		P	Fig. 5	complete
	GO:0009288	bacterial-type flagellum	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000090	C	Seeded from EcoCyc (v14.0)	complete
	GO:0009296	flagellum assembly	PMID:8550421	IMP: Inferred from Mutant Phenotype		P	Table 3	complete
	GO:0009288	bacterial-type flagellum	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0975	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005515	protein binding	PMID:17085573	IPI: Inferred from Physical Interaction	UniProtKB:P06974	F	Fig. 4	complete
	GO:0009425	bacterial-type flagellum basal body	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0142	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016020	membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005515	protein binding	PMID:8604139	IPI: Inferred from Physical Interaction	UniProtKB:P25798	F	Fig. 3	complete
	GO:0005515	protein binding	PMID:8631704	IPI: Inferred from Physical Interaction	UniProtKB:P06974	F		complete
edit table

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of Flagellar Motor Switch Complex	could be indirect
Protein	nadE		PMID:16606699	Experiment(s):EBI-1141425
Protein	uvrY		PMID:16606699	Experiment(s):EBI-1141425
Protein	rplB		PMID:16606699	Experiment(s):EBI-1141425
Protein	rsuA		PMID:16606699	Experiment(s):EBI-1141425
Protein	mukB		PMID:16606699	Experiment(s):EBI-1141425
Protein	rplD		PMID:16606699	Experiment(s):EBI-1141425
Protein	Subunits of Flagellar Motor Complex	could be indirect
Protein	Subunits of Flagellum	could be indirect
edit table

</protect>

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
edit table

Notes

Structure and Physical Properties

[back to top]

<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MSNLTGTDKS VILLMTIGED RAAEVFKHLS QREVQTLSAA MANVTQISNK QLTDVLAEFE QEAEQFAALN INANDYLRSV LVKALGEERA ASLLEDILET RDTASGIETL NFMEPQSAAD LIRDEHPQII ATILVHLKRA QAADILALFD ERLRHDVMLR IATFGGVQPA ALAELTEVLN GLLDGQNLKR SKMGGVRTAA EIINLMKTQQ EEAVITAVRE FDGELAQKII DEMFLFENLV DVDDRSIQRL LQEVDSESLL IALKGAEQPL REKFLRNMSQ RAADILRDDL ANRGPVRLSQ VENEQKAILL IVRRLAETGE MVIGSGEDTY V
Length	331
Mol. Wt	36.776 kDa
pI	4.5 (calculated)
Extinction coefficient	2,980 (calc based on 2 Y, 0 W, and 0 C residues)
edit table

Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	215..324	PF01706 FliG C-terminal domain		PMID:19920124
edit table

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=fliG taxon=562,83333 </beststructure>

Models

View models at:

edit table

</protect>

Structure figures

</protect>

Notes

Gene Product Resources

[back to top]

See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
edit table

Notes

Accessions in Other Databases

[back to top]

See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16129886	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:946451	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0006456	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P0ABZ1	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG11654	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11654	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:946451	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001598	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1607	Escherichia coli str. K-12 substr. MG1655
edit table

Notes

Links

[back to top]

Name	URL	Comments
edit table

Expression

[back to top]

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

[back to top]

See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MG1655	17	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	2^a	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
Protein	E. coli K-12 MG1655	0^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
edit table

Notes

Transcription and Transcriptional Regulation

[back to top]

See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
fliFGHIJK
edit table

Figure courtesy of RegulonDB

</protect>

Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

[back to top]

<protect><gbrowseImage> name=NC_000913:2012884..2012924 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

</protect>

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

</protect>

Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

[back to top]

<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
edit table

Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b1939 (EcoliWiki Page)	NCBI GEO profiles for fliG
microarray	GenExpDB:b1939 (EcoliWiki Page)	Summary of data for fliG from multiple microarray studies
edit table

Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
edit table

Notes

Accessions Related to fliG Expression

[back to top]

See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11654	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1607	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b1939
EcoGene	EcoGene:EG11654	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001598	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0006456	Escherichia coli str. K-12 substr. MG1655
edit table

Notes

Links

[back to top]

Name	URL	Comments
edit table

Evolution

[back to top]

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Homologs in Other Organisms

[back to top]

See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Shigella flexneri	FLIG	From SHIGELLACYC
E. coli O157	FLIG	From ECOO157CYC
edit table

Do-It-Yourself Web Tools

Notes

Families

[back to top]

See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF01706 FliG C-terminal domain
Superfamily (EcoliWiki Page)	SUPERFAMILY:48029
Superfamily (EcoliWiki Page)	SUPERFAMILY:48029
EcoCyc	EcoCyc:EG11654	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11654	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001598	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1607	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0006456	Escherichia coli str. K-12 substr. MG1655
edit table

Notes

Links

[back to top]

Name	URL	Comments
edit table

References

[back to top]

See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

fliG:On One Page

Quickview

Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to fliG Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

Categories

Navigation menu

Search