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Expression|

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Standard Name	fes
Gene Synonym(s)	ECK0577, b0585, JW0576^[1], JW0576
Product Desc.	enterochelin esterase^[2]^[3] Enterochelin esterase^[4]
Product Synonyms(s)	enterobactin/ferric enterobactin esterase^[1], B0585^[2]^[1], Fes^[2]^[1], enterobactin esterase^[2]^[1] , ECK0577, JW0576, b0585
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): fes-ybdZ-entF-fepE^[2]
Regulation/Activity
Quick Links
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	fes
Mnemonic	Iron
Synonyms	ECK0577, b0585, JW0576^[1], JW0576
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	13.19 minutes	MG1655: 612038..613162 <gbrowseImage> name=NC_000913:612038..613162 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 595523..596647 <gbrowseImage> name=NC_012967:595523..596647 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 514798..515922 <gbrowseImage> name=NC_012759:514798..515922 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 612038..613162 <gbrowseImage> name=NC_007779:612038..613162 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 551370..552494 <gbrowseImage> name=NC_010473:551370..552494 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
DH10B		DH10B: 664630..665754 <gbrowseImage> name=NC_010473:664630..665754 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
Coding Start (SO:0000323)	MG1655	612038	Edman degradation	PMID:2974033
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability
Δfes (Keio:JW0576)	deletion	deletion	PMID:16738554	Shigen CGSC8695^[5]
Δfes-722::kan			PMID:16738554	CGSC:100846
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW0576	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCTTTGAGGTCACTTTCTGGTG Primer 2:CCACTCCTGTCATGGAAAAGTGG
21A9S	Kohara Phage	Genobase	PMID:3038334
2D12	Kohara Phage	Genobase	PMID:3038334
purK79::Tn10	Linked marker	CAG12171 = CGSC7342^[5]	est. P1 cotransduction: 4% ^[6] Synonyms:purE79::Tn10
dsbG601::Tn10	Linked marker	CAG12149 = CGSC7346^[5]	est. P1 cotransduction: 41% ^[6] Synonyms:zbd-601::Tn10, zbe-601::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10299	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10299	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000293	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:945181	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0295	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0002019	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	Fes
Synonyms	enterobactin/ferric enterobactin esterase^[1], B0585^[2]^[1], Fes^[2]^[1], enterobactin esterase^[2]^[1] , ECK0577, JW0576, b0585
Product description	enterochelin esterase^[2]^[3] Enterochelin esterase^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
NOT	GO:0005506	iron ion binding	GOA:spkw SP_KW:GO_REF	IEA: Inferred from Electronic Annotation	SP_KW:KW-0408	F	Fes binds enterochelin and ferric-enterochelin.^[7] There is no experimental evidence that Fes binds iron. 127.0.0.1 14:27, 17 February 2015 (CST)	complete
	GO:0008849	enterochelin esterase activity	PMID:150859	IDA: Inferred from Direct Assay		F		complete
	GO:0005737	cytoplasm	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C	Seeded from EcoCyc (v14.0)	complete
NOT	GO:0006826	iron ion transport	SP_KW:GO_REF GOA:spkw	IEA: Inferred from Electronic Annotation	SP_KW:KW-0410	P	Fes is involved in iron ion transport; it cleaves ferric-enterochelin after it has been transported into the cytoplasm.^[7] 127.0.0.1 14:27, 17 February 2015 (CST)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	xseA	PMID:16606699	Experiment(s):EBI-1137234
Protein	hcaE	PMID:16606699	Experiment(s):EBI-1137234
Protein	nuoF	PMID:16606699	Experiment(s):EBI-1137234
Protein	groL	PMID:16606699	Experiment(s):EBI-1137234
Protein	ahpF	PMID:19402753	MALDI(Z-score):28.802552
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MFEVTFWWRD PQGSEEYSTI KRVWVYITGV TDHHQNSQPQ SMQRIAGTNV WQWTTQLNAN WRGSYCFIPT ERDDIFSVPS PDRLELREGW RKLLPQAIAD PLNLQSWKGG RGHAVSALEM PQAPLQPGWD CPQAPEIPAK EIIWKSERLK KSRRVWIFTT GDATAEERPL AVLLDGEFWA QSMPVWPVLT SLTHRQQLPP AVYVLIDAID TTHRAHELPC NADFWLAVQQ ELLPLVKAIA PFSDRADRTV VAGQSFGGLS ALYAGLHWPE RFGCVLSQSG SYWWPHRGGQ QEGVLLEKLK AGEVSAEGLR IVLEAGIREP MIMRANQALY AQLHPIKESI FWRQVDGGHD ALCWRGGLMQ GLIDLWQPLF HDRS
Length	374
Mol. Wt	42.569 kDa
pI	6.6 (calculated)
Extinction coefficient	120,430 - 121,055 (calc based on 7 Y, 20 W, and 5 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	References
Domain	146..365	PF00756 Putative esterase	PMID:19920124
Domain	1..131	PF11806 Domain of unknown function (DUF3327)	PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=fes taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16128568	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:945181	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0002019	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P13039	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG10299	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10299	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:945181	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000293	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0295	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MG1655	7^a	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
Protein	E. coli K-12 MG1655	9	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	0^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
fes-ybdZ-entF-fepE
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:612018..612058 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b0585 (EcoliWiki Page)	NCBI GEO profiles for fes
microarray	GenExpDB:b0585 (EcoliWiki Page)	Summary of data for fes from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
	GFP Fusion	Intergenic region (611640..612087) fused to gfpmut2.	OpenBioSystems	GFP fusion described in Zaslaver, et al. Plate:109-AZ16; Well:E2^[8]
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Notes

Accessions Related to fes Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10299	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0295	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b0585
EcoGene	EcoGene:EG10299	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000293	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0002019	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Shigella flexneri	FES	From SHIGELLACYC
E. coli O157	FES	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF00756 Putative esterase
Superfamily (EcoliWiki Page)	SUPERFAMILY:53474
Panther (EcoliWiki Page)	PTHR10907:SF2
Superfamily (EcoliWiki Page)	SUPERFAMILY:81296
Pfam (EcoliWiki Page)	PF11806 Domain of unknown function (DUF3327)
PFAM (EcoliWiki Page)	PFAM:PF00756
EcoCyc	EcoCyc:EG10299	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10299	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000293	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0295	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0002019	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ ^7.0 ^7.1 Greenwood, KT & Luke, RK (1978) Enzymatic hydrolysis of enterochelin and its iron complex in Escherichia Coli K-12. Properties of enterochelin esterase. Biochim. Biophys. Acta 525 209-18 PubMed
↑ Zaslaver, A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat. Methods 3 623-8 PubMed

fes:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to fes Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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