ahpC:On One Page
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Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
Quickview | | Gene | | Product(s) | | Expression| | Evolution | | References | |
Quickview
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Standard Name |
ahpC |
---|---|
Gene Synonym(s) | |
Product Desc. |
Component of alkylhydroperoxide reductase[3] Alkyl hydroperoxide reductase, subunit C; reduced by the AhpF subunit[4] |
Product Synonyms(s) |
alkyl hydroperoxide reductase, C22 subunit[1], B0605[2][1], AhpC[2][1], Ssi8[2][1] , ECK0599, JW0598, tpx, b0605 |
Function from GO |
<GO_nr /> |
Knock-Out Phenotype | |
Regulation/Expression | |
Regulation/Activity | |
Quick Links | |
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</protect> See Help:Quickview for help with entering information in the Quickview table. <protect></protect>
Notes
AhpCF protects aerobic, phosphate-starved cells from oxidative damage. Binds TrxA (Kumar, 2004).[4]
Gene
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Nomenclature
See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.
Standard name |
ahpC |
---|---|
Mnemonic |
Alkyl hydroperoxide |
Synonyms | |
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Notes
Location(s) and DNA Sequence
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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.
Strain | Map location | Genome coordinates | Genome browsers | Sequence links |
---|---|---|---|---|
MG1655 |
13.75 minutes |
MG1655: 638168..638731 |
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NC_012967: 620996..621559 |
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NC_012759: 540928..541491 |
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W3110 |
|
W3110: 638168..638731 |
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DH10B: 577500..578063 |
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DH10B: 690760..691323 |
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Notes
Sequence Features
See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.
Feature Type | Strain | Genomic Location | Evidence | Reference | Notes |
---|---|---|---|---|---|
Coding Start (SO:0000323) |
638171 |
Edman degradation |
PMID:1575737 |
| |
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Notes
Alleles and Phenotypes
See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.
Allele | Nt change(s) | AA change(s) | Phenotype: Type | Phenotype: Description | Reference | Availability | Comments |
---|---|---|---|---|---|---|---|
ΔahpC (Keio:JW0598) |
deletion |
deletion |
PMID:16738554 |
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ahpC* |
triplet repeat expansion |
PMID: 18206967 |
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ΔahpC744::kan |
PMID:16738554 |
| |||||
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Notes
Genetic Interactions
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Interactor | Interaction | Allele | Score(s) | Reference(s) | Accessions | Notes |
---|---|---|---|---|---|---|
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Notes
Genetic Resources
See Help:Gene_resources for help entering information into the Genetic Resources table.
Resource | Resource Type | Source | Notes/Reference |
---|---|---|---|
JW0598 |
Plasmid clone |
PMID:16769691 Status:Clone OK Primer 1:GCCTCCTTGATTAACACCAAAAT Primer 2:CCGATTTTACCAACCAGGTCCAG | |
Kohara Phage |
PMID:3038334 | ||
Kohara Phage |
PMID:3038334 | ||
Linked marker |
est. P1 cotransduction: 92% [6] | ||
Linked marker |
est. P1 cotransduction: 57% [6] | ||
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Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
Database | Accession | Notes |
---|---|---|
EcoCyc:EG11384 |
Escherichia coli str. K-12 substr. MG1655 | |
EcoGene:EG11384 |
Escherichia coli str. K-12 substr. MG1655 | |
RegulonDB:ECK120001351 |
Escherichia coli str. K-12 substr. MG1655 | |
Escherichia coli str. K-12 substr. MG1655 | ||
EchoBASE:EB1357 |
Escherichia coli str. K-12 substr. MG1655 | |
ASAP:ABE-0002090 |
Escherichia coli str. K-12 substr. MG1655 | |
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Notes
Links
Name | URL | Comments |
---|---|---|
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Product(s)
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Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
Standard name |
AhpC |
---|---|
Synonyms |
alkyl hydroperoxide reductase, C22 subunit[1], B0605[2][1], AhpC[2][1], Ssi8[2][1] , ECK0599, JW0598, tpx, b0605 |
Product description |
Component of alkylhydroperoxide reductase[3] Alkyl hydroperoxide reductase, subunit C; reduced by the AhpF subunit[4] |
EC number (for enzymes) | |
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Notes
Function
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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
---|---|---|---|---|---|---|---|---|
GO:0005737 |
cytoplasm |
C |
Seeded from Riley et al 2006 [1]. |
Missing: evidence, reference | ||||
GO:0005829 |
cytosol |
PMID:16858726 |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
GO:0016020 |
membrane |
PMID:16858726 |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
GO:0045454 |
cell redox homeostasis |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
InterPro:IPR017936 |
P |
Seeded from EcoCyc (v14.0) |
complete | |
GO:0051920 |
peroxiredoxin activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
InterPro:IPR017559 |
F |
Seeded from EcoCyc (v14.0) |
complete | |
GO:0051920 |
peroxiredoxin activity |
GOA:spec |
IEA: Inferred from Electronic Annotation |
EC:1.11.1.15 |
F |
Seeded from EcoCyc (v14.0) |
complete | |
GO:0055114 |
oxidation reduction |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
InterPro:IPR017559 |
P |
Seeded from EcoCyc (v14.0) |
complete | |
GO:0004601 |
peroxidase activity |
PMID:11717276 |
IGI: Inferred from Genetic Interaction |
EcoliWiki:katG |
F |
complete | ||
GO:0055114 |
oxidation reduction |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
SP_KW:KW-0560 |
P |
Seeded from EcoCyc (v14.0) |
complete | |
GO:0005737 |
cytoplasm |
PMID:7499381 |
IDA: Inferred from Direct Assay |
C |
complete | |||
GO:0009970 |
cellular response to sulfate starvation |
PMID:8774726 |
IDA: Inferred from Direct Assay |
P |
complete | |||
GO:0032843 |
hydroperoxide reductase activity |
PMID:7644465 |
IDA: Inferred from Direct Assay |
F |
complete | |||
GO:0016684 |
oxidoreductase activity, acting on peroxide as acceptor |
PMID:7644465 |
IMP: Inferred from Mutant Phenotype |
F |
complete | |||
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
Partner Type | Partner | Notes | References | Evidence |
---|---|---|---|---|
Protein |
Subunits of alkylhydroperoxide reductase |
could be indirect |
||
Protein |
rhsC |
PMID:16606699 |
Experiment(s):EBI-1137372 | |
Protein |
lacZ |
PMID:16606699 |
Experiment(s):EBI-1137372 | |
Protein |
rhsE |
PMID:16606699 |
Experiment(s):EBI-1137372 | |
Protein |
rtcB |
PMID:16606699 |
Experiment(s):EBI-1137372 | |
Protein |
recB |
PMID:16606699 |
Experiment(s):EBI-1137372 | |
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Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
Compartment | Description | Evidence | Reference/Source | Notes |
---|---|---|---|---|
cytoplasm |
| |||
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Notes
Structure and Physical Properties
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Physical Properties
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
Name | |
---|---|
Sequence |
MSLINTKIKP FKNQAFKNGE FIEITEKDTE GRWSVFFFYP ADFTFVCPTE LGDVADHYEE LQKLGVDVYA VSTDTHFTHK AWHSSSETIA KIKYAMIGDP TGALTRNFDN MREDEGLADR ATFVVDPQGI IQAIEVTAEG IGRDASDLLR KIKAAQYVAS HPGEVCPAKW KEGEATLAPS LDLVGKI |
Length |
187 |
Mol. Wt |
20.761 kDa |
pI |
5.0 (calculated) |
Extinction coefficient |
23,950 - 24,200 (calc based on 5 Y, 3 W, and 2 C residues) |
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Domains/Motifs/Modification Sites
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
|
<motif_map/> |
Structure
| </protect>
Structure figures<protect> | ||||||
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
Resource type | Source | Notes/Reference |
---|---|---|
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Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
Database | Accession | Notes |
---|---|---|
Escherichia coli str. K-12 substr. MG1655 | ||
Escherichia coli str. K-12 substr. MG1655 | ||
ASAP:ABE-0002090 |
Escherichia coli str. K-12 substr. MG1655 | |
Escherichia coli str. K-12 substr. MG1655 | ||
EcoCyc:EG11384 |
Escherichia coli str. K-12 substr. MG1655 | |
EcoGene:EG11384 |
Escherichia coli str. K-12 substr. MG1655 | |
Escherichia coli str. K-12 substr. MG1655 | ||
RegulonDB:ECK120001351 |
Escherichia coli str. K-12 substr. MG1655 | |
EchoBASE:EB1357 |
Escherichia coli str. K-12 substr. MG1655 | |
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Notes
Links
Name | URL | Comments |
---|---|---|
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Expression
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Overview
This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.
Cellular Levels
Molecule | Organism or Strain | Value | Units | Experimental Conditions | Assay used | Notes | Reference(s) |
---|---|---|---|---|---|---|---|
Protein |
E. coli K-12 MC4100 |
1.97E+05 |
molecules/cell |
|
emPAI |
PMID:18304323 | |
Protein |
E. coli K-12 EMG2 |
300 |
molecules/cell |
|
Quantitative protein sequencing |
Spot ID: M97-2 |
PMID: 9298646 |
Protein |
E. coli K-12 EMG2 |
2250 |
molecules/cell |
|
Quantitative protein sequencing |
Spot ID: M2-J |
PMID: 9298646 |
Protein |
E. coli K-12 EMG2 |
6040 |
molecules/cell |
|
Quantitative protein sequencing |
Spot ID: M3J.l |
PMID: 9298646 |
Protein |
E. coli K-12 MG1655 |
92449 |
molecules/cell/generation |
|
Ribosome Profiling |
PMID: 24766808 | |
Protein |
E. coli K-12 MG1655 |
37153 |
molecules/cell/generation |
|
Ribosome Profiling |
PMID: 24766808 | |
Protein |
E. coli K-12 MG1655 |
76357 |
molecules/cell/generation |
|
Ribosome Profiling |
PMID: 24766808 | |
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Notes
Transcription and Transcriptional Regulation
<protect>
See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.
|
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Notes
This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.
Translation and Regulation of Translation
<protect><gbrowseImage>
name=NC_000913:638148..638188
source=MG1655
type=Gene+DNA_+Protein
preset=Nterminus
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This picture shows the sequence around the N-terminus.
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Notes
This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.
Turnover and Regulation of Turnover
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Notes
This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.
Experimental
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Mutations Affecting Expression
See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.
Allele Name | Mutation | Phenotype | Reference |
---|---|---|---|
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Expression Studies
See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.
Type | Reference | Notes |
---|---|---|
microarray |
NCBI GEO profiles for ahpC | |
microarray |
Summary of data for ahpC from multiple microarray studies | |
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Expression Resources
See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.
Resource Name | Resource Type | Description | Source | Notes |
---|---|---|---|---|
GFP Fusion |
Intergenic region (637759..638206) fused to gfpmut2. |
GFP fusion described in Zaslaver, et al. | ||
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Notes
Accessions Related to ahpC Expression
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
Database | Accession | Notes |
---|---|---|
EcoCyc:EG11384 |
Escherichia coli str. K-12 substr. MG1655 | |
EchoBASE:EB1357 |
Escherichia coli str. K-12 substr. MG1655 | |
EcoGene:EG11384 |
Escherichia coli str. K-12 substr. MG1655 | |
RegulonDB:ECK120001351 |
Escherichia coli str. K-12 substr. MG1655 | |
ASAP:ABE-0002090 |
Escherichia coli str. K-12 substr. MG1655 | |
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Notes
Links
Name | URL | Comments |
---|---|---|
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Evolution
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Homologs in Other Organisms
See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.
Organism | Homologs (Statistics) | Comments |
---|---|---|
Anopheles gambiae |
|
From Inparanoid:20070104 |
Apis mellifera |
|
From Inparanoid:20070104 |
Arabidopsis thaliana |
|
From Inparanoid:20070104 |
Bos taurus |
|
From Inparanoid:20070104 |
Caenorhabditis briggsae |
|
From Inparanoid:20070104 |
Caenorhabditis elegans |
|
From Inparanoid:20070104 |
Canis familiaris |
|
From Inparanoid:20070104 |
Ciona intestinalis |
|
From Inparanoid:20070104 |
Danio rerio |
|
From Inparanoid:20070104 |
Dictyostelium discoideum |
|
From Inparanoid:20070104 |
Drosophila melanogaster |
|
From Inparanoid:20070104 |
Drosophila pseudoobscura |
|
From Inparanoid:20070104 |
Gallus gallus |
|
From Inparanoid:20070104 |
Homo sapiens |
|
From Inparanoid:20070104 |
Macaca mulatta |
|
From Inparanoid:20070104 |
Monodelphis domestica |
|
From Inparanoid:20070104 |
Mus musculus |
|
From Inparanoid:20070104 |
Oryza gramene |
|
From Inparanoid:20070104 |
Pan troglodytes |
|
From Inparanoid:20070104 |
Rattus norvegicus |
|
From Inparanoid:20070104 |
Saccharomyces cerevisiae |
|
From Inparanoid:20070104 |
Schizosaccharomyces pombe |
|
From Inparanoid:20070104 |
Takifugu rubripes |
|
From Inparanoid:20070104 |
Tetraodon nigroviridis |
|
From Inparanoid:20070104 |
Xenopus tropicalis |
|
From Inparanoid:20070104 |
Shigella flexneri |
AHPC |
From SHIGELLACYC |
E. coli O157 |
AHPC |
From ECOO157CYC |
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Do-It-Yourself Web Tools
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Notes
Families
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
Database | Accession | Notes |
---|---|---|
EcoCyc:EG11384 |
Escherichia coli str. K-12 substr. MG1655 | |
EcoGene:EG11384 |
Escherichia coli str. K-12 substr. MG1655 | |
RegulonDB:ECK120001351 |
Escherichia coli str. K-12 substr. MG1655 | |
EchoBASE:EB1357 |
Escherichia coli str. K-12 substr. MG1655 | |
ASAP:ABE-0002090 |
Escherichia coli str. K-12 substr. MG1655 | |
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Notes
Links
Name | URL | Comments |
---|---|---|
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References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.0 5.1 5.2 CGSC: The Coli Genetics Stock Center
- ↑ 6.0 6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
- ↑ Zaslaver, A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat. Methods 3 623-8 PubMed
Categories
- Genes in OpenBioSystems with Promoter Fusions
- Genes with homologs in Anopheles gambiae
- Genes with homologs in Apis mellifera
- Genes with homologs in Arabidopsis thaliana
- Genes with homologs in Bos taurus
- Genes with homologs in Caenorhabditis briggsae
- Genes with homologs in Caenorhabditis elegans
- Genes with homologs in Canis familiaris
- Genes with homologs in Ciona intestinalis
- Genes with homologs in Danio rerio
- Genes with homologs in Dictyostelium discoideum
- Genes with homologs in Drosophila melanogaster
- Genes with homologs in Drosophila pseudoobscura
- Genes with homologs in Gallus gallus
- Genes with homologs in Homo sapiens
- Genes with homologs in Macaca mulatta
- Genes with homologs in Monodelphis domestica
- Genes with homologs in Mus musculus
- Genes with homologs in Oryza gramene
- Genes with homologs in Pan troglodytes
- Genes with homologs in Rattus norvegicus
- Genes with homologs in Saccharomyces cerevisiae
- Genes with homologs in Schizosaccharomyces pombe
- Genes with homologs in Takifugu rubripes
- Genes with homologs in Tetraodon nigroviridis
- Genes with homologs in Xenopus tropicalis
- Genes with homologs in Shigella flexneri
- Genes with homologs in E. coli O157