ahpC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

AhpC

Synonyms

alkyl hydroperoxide reductase, C22 subunit[1], B0605[2][1], AhpC[2][1], Ssi8[2][1] , ECK0599, JW0598, tpx, b0605

Product description

AhpC component[2][3];

Component of alkylhydroperoxide reductase[3]

Alkyl hydroperoxide reductase, subunit C; reduced by the AhpF subunit[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0005829

cytosol

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0045454

cell redox homeostasis

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017936

P

Seeded from EcoCyc (v14.0)

complete

GO:0051920

peroxiredoxin activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017559

F

Seeded from EcoCyc (v14.0)

complete

GO:0051920

peroxiredoxin activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.11.1.15

F

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017559

P

Seeded from EcoCyc (v14.0)

complete

GO:0004601

peroxidase activity

PMID:11717276[6]

IGI: Inferred from Genetic Interaction

EcoliWiki:katG

F

complete

GO:0055114

oxidation reduction

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

PMID:7499381[7]

IDA: Inferred from Direct Assay

C

complete

GO:0009970

cellular response to sulfate starvation

PMID:8774726[8]

IDA: Inferred from Direct Assay

P

complete

GO:0032843

hydroperoxide reductase activity

PMID:7644465[9]

IDA: Inferred from Direct Assay

F

complete

GO:0016684

oxidoreductase activity, acting on peroxide as acceptor

PMID:7644465[9]

IMP: Inferred from Mutant Phenotype

F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of alkylhydroperoxide reductase

could be indirect

Protein

rhsC

PMID:16606699[10]

Experiment(s):EBI-1137372

Protein

lacZ

PMID:16606699[10]

Experiment(s):EBI-1137372

Protein

rhsE

PMID:16606699[10]

Experiment(s):EBI-1137372

Protein

rtcB

PMID:16606699[10]

Experiment(s):EBI-1137372

Protein

recB

PMID:16606699[10]

Experiment(s):EBI-1137372
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSLINTKIKP FKNQAFKNGE FIEITEKDTE GRWSVFFFYP ADFTFVCPTE LGDVADHYEE
LQKLGVDVYA VSTDTHFTHK AWHSSSETIA KIKYAMIGDP TGALTRNFDN MREDEGLADR
ATFVVDPQGI IQAIEVTAEG IGRDASDLLR KIKAAQYVAS HPGEVCPAKW KEGEATLAPS
LDLVGKI
Length

187

Mol. Wt

20.761 kDa

pI

5.0 (calculated)

Extinction coefficient

23,950 - 24,200 (calc based on 5 Y, 3 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0AE08

Modification Site

84

phosphorylation site at S84

probability greater than 75%

PMID:17938405[11]

Modification Site

146

phosphorylation site at S146

probability greater than 75%

PMID:17938405[11]

Domain

4..134

PF00578 AhpC/TSA family

PMID:19920124[12]

Domain

154..186

PF10417 C-terminal domain of 1-Cys peroxiredoxin

PMID:19920124[12]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=ahpC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128588

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945225

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0002090

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0AE08

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11384

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11384

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945225

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001351

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1357

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  6. ↑ Seaver, LC & Imlay, JA (2001) Alkyl hydroperoxide reductase is the primary scavenger of endogenous hydrogen peroxide in Escherichia coli. J. Bacteriol. 183 7173-81 PubMed
  7. ↑ Cha, MK et al. (1995) Thioredoxin-linked "thiol peroxidase" from periplasmic space of Escherichia coli. J. Biol. Chem. 270 28635-41 PubMed
  8. ↑ Quadroni, M et al. (1996) Analysis of global responses by protein and peptide fingerprinting of proteins isolated by two-dimensional gel electrophoresis. Application to the sulfate-starvation response of Escherichia coli. Eur. J. Biochem. 239 773-81 PubMed
  9. ↑ 9.0 9.1 Ferrante, AA et al. (1995) Cloning of an organic solvent-resistance gene in Escherichia coli: the unexpected role of alkylhydroperoxide reductase. Proc. Natl. Acad. Sci. U.S.A. 92 7617-21 PubMed
  10. ↑ 10.0 10.1 10.2 10.3 10.4 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  11. ↑ 11.0 11.1 Macek, B et al. (2008) Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation. Mol. Cell Proteomics 7 299-307 PubMed
  12. ↑ 12.0 12.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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