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On One Page

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Gene |

Product(s) |

Expression|

Evolution |

References |

Quickview

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Standard Name	ypdE
Gene Synonym(s)	ECK2380, b2384, JW2381^[1], JW2381
Product Desc.	broad-specificity examinopeptidase^[2]^[3] Aminopeptidase^[4]
Product Synonyms(s)	predicted peptidase^[1], B2384^[2]^[1], YpdE^[2]^[1] , ECK2380, JW2381, b2384
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): ypdD^[2]
Regulation/Activity
Quick Links
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Notes

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ypdE, frvX and sgcX are paralogs.^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	ypdE
Mnemonic	Systematic nomenclature
Synonyms	ECK2380, b2384, JW2381^[1], JW2381
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	53.94 minutes	MG1655: 2503569..2502532 <gbrowseImage> name=NC_000913:2502532..2503569 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 2439772..2438735 <gbrowseImage> name=NC_012967:2438735..2439772 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 2388337..2389374 <gbrowseImage> name=NC_012759:2388337..2389374 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 2510993..2509956 <gbrowseImage> name=NC_007779:2509956..2510993 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 2595334..2594297 <gbrowseImage> name=NC_010473:2594297..2595334 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability
ΔypdE (Keio:JW2381)	deletion	deletion	PMID:16738554	Shigen CGSC9902^[5]
ΔypdE722::kan			PMID:16738554	CGSC:105904
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW2381	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCGATTTATCGCTATTAAAAGC Primer 2:CCTCTGAAATCCGTCAGTTGAAC
10D3	Kohara Phage	Genobase	PMID:3038334
12H4	Kohara Phage	Genobase	PMID:3038334
zfd-1::Tn10	Linked marker	CAG18467 = CGSC7408^[5]	est. P1 cotransduction: 68% ^[6] Synonyms:zfb-1::Tn10
nupC510::Tn10	Linked marker	CAG18468 = CGSC7410^[5]	est. P1 cotransduction: 78% ^[6]
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G7247	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG14152	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003822	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:946848	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3904	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007864	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	YpdE
Synonyms	predicted peptidase^[1], B2384^[2]^[1], YpdE^[2]^[1] , ECK2380, JW2381, b2384
Product description	broad-specificity examinopeptidase^[2]^[3] Aminopeptidase^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0004177	aminopeptidase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0031	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008233	peptidase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008237	metallopeptidase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0482	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016787	hydrolase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F	Seeded from EcoCyc (v14.0)	complete
	GO:0004177	aminopeptidase activity	PMID:15901689	IDA: Inferred from Direct Assay		F		complete
	GO:0008237	metallopeptidase activity	PMID:15901689	IDA: Inferred from Direct Assay		F	Fig 5b: YpdE activity dependent on presence of divalent metal ions	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	nadE	PMID:16606699	Experiment(s):EBI-1142702
Protein	hflB	PMID:16606699	Experiment(s):EBI-1142702
Protein	moeB	PMID:16606699	Experiment(s):EBI-1142702
Protein	yfdZ	PMID:16606699	Experiment(s):EBI-1142702
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MDLSLLKALS EADAIASSEQ EVRQILLEEA DRLQKEVRFD GLGSVLIRLN ESTGPKVMIC AHMDEVGFMV RSISREGAID VLPVGNVRMA ARQLQPVRIT TREECKIPGL LDGDRQGNDV SAMRVDIGAR SYDEVMQAGI RPGDRVTFDT TFQVLPHQRV MGKAFDDRLG CYLLVTLLRE LHDAELPAEV WLVASSSEEV GLRGGQTATR AVSPDVAIVL DTACWAKNFD YGAANHRQIG NGPMLVLSDK SLIAPPKLTA WVETVAAEIG VPLQADMFSN GGTDGGAVHL TGTGVPTVVM GPATRHGHCA ASIADCRDIL QMQQLLSALI QRLTRETVVQ LTDFR
Length	345
Mol. Wt	37.408 kDa
pI	5.1 (calculated)
Extinction coefficient	20,970 - 21,720 (calc based on 3 Y, 3 W, and 6 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	43..325	PF05343 M42 glutamyl aminopeptidase		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=ypdE taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16130316	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:946848	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007864	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P77585	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G7247	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG14152	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:946848	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003822	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3904	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MG1655	3^a	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
Protein	E. coli K-12 MG1655	3^a	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
Protein	E. coli K-12 MG1655	0^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
ypdD
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:2503549..2503589 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b2384 (EcoliWiki Page)	NCBI GEO profiles for ypdE
microarray	GenExpDB:b2384 (EcoliWiki Page)	Summary of data for ypdE from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to ypdE Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G7247	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3904	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b2384
EcoGene	EcoGene:EG14152	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003822	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007864	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Shigella flexneri	S2589	From SHIGELLACYC
E. coli O157	Z3649	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Superfamily (EcoliWiki Page)	SUPERFAMILY:53187
Superfamily (EcoliWiki Page)	SUPERFAMILY:101821
Pfam (EcoliWiki Page)	PF05343 M42 glutamyl aminopeptidase
EcoCyc	EcoCyc:G7247	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG14152	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003822	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3904	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007864	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

ypdE:On One Page

Quickview

Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to ypdE Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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