{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

On One Page

Quickview |

Gene |

Product(s) |

Expression|

Evolution |

References |

Quickview

[back to top]

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Standard Name	yjcC
Gene Synonym(s)	ECK4053, b4061, JW4022^[1], JW4022
Product Desc.	conserved protein^[2]^[3] Putative cyclic-di-GMP phosphodiesterase, function unknown^[4]
Product Synonyms(s)	predicted signal transduction protein (EAL domain containing protein)^[1], B4061^[2]^[1], YjcC^[2]^[1] , ECK4053, JW4022, b4061
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): yjcC^[2]
Regulation/Activity
Quick Links
edit table

</protect> See Help:Quickview for help with entering information in the Quickview table. <protect></protect>

Notes

[back to top]

YjcC has a C-terminal putative cyclic-di-GMP phosphodiesterase EAL domain. Structural Genomics target No. 80 (http://afmb.cnrs-mrs.fr/article171.html^[4]

Gene

[back to top]

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css> <protect>

Nomenclature

[back to top]

See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	yjcC
Mnemonic	Systematic nomenclature
Synonyms	ECK4053, b4061, JW4022^[1], JW4022
edit table

</protect>

Notes

Location(s) and DNA Sequence

[back to top]

<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	92.11 minutes	MG1655: 4273494..4275080 <gbrowseImage> name=NC_000913:4273494..4275080 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
BW2952		NC_012759: 4212339..4213925 <gbrowseImage> name=NC_012759:4212339..4213925 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 4279061..4280647 <gbrowseImage> name=NC_007779:4279061..4280647 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
edit table

</protect>

Notes

Sequence Features

[back to top]

See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
edit table

Notes

Alleles and Phenotypes

[back to top]

See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
Strain DH10B		G416C		Nonsynonomous mutation	PMID:18245285	ASAP	This is a SNP in E. coli K-12 Strain DH10B
ΔyjcC (Keio:JW4022)	deletion	deletion			PMID:16738554	Shigen CGSC10890^[5]
ΔyjcC755::kan					PMID:16738554	CGSC:105474
yjcC755(del)::FRTKanFRT			Mutagenesis rate	Decreased stress-induced mutagenesis (SIM) phenotype.	PMID:23224554	Parental Strain: SMR4562 Experimental Strain: SMR12056	Mutation was comparatively weak with decrease only happening to 33-67% of population.
yicC750::FRTKanFRT			Mutagenesis rate	Decreased stress-induced mutagenesis (SIM) phenotype.	PMID:23224554	Parental Strain: SMR4562 Experimental Strain: SMR11978	Mutation was comparatively weak with decrease only happening to 33-67% of population.
yjcC755(del)::FRTKanFRT			Sensitivity to	An increase in UV Sensitivity	PMID:23224554	Parental Strain: SMR4562 Experimental Strain: SMR12056	supplemental Table S7 & S1
edit table

Notes

Genetic Interactions

[back to top]

Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
edit table

</protect>

Notes

Genetic Resources

[back to top]

See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW4022	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCAGTCATCGTGCACGACACCA Primer 2:CCTTGCCCGCGCGTTAACTCCCG
12D1	Kohara Phage	Genobase	PMID:3038334
3F12	Kohara Phage	Genobase	PMID:3038334
malF3089::Tn10	Linked marker	CAG12164 = CGSC7476^[5]	est. P1 cotransduction: 27% ^[6]
zje-2241::Tn10	Linked marker	CAG18427 = CGSC7481^[5]	est. P1 cotransduction: 28% ^[6]
edit table

Notes

Accessions in Other Databases

[back to top]

See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11938	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11938	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001866	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:948568	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1882	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0013309	Escherichia coli str. K-12 substr. MG1655
edit table

Notes

Links

[back to top]

Name	URL	Comments
edit table

Product(s)

[back to top]

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	YjcC
Synonyms	predicted signal transduction protein (EAL domain containing protein)^[1], B4061^[2]^[1], YjcC^[2]^[1] , ECK4053, JW4022, b4061
Product description	conserved protein^[2]^[3] Putative cyclic-di-GMP phosphodiesterase, function unknown^[4]
EC number (for enzymes)
edit table

Notes

Function

[back to top]

<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
edit table

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	rpsF	PMID:19402753	LCMS(ID Probability):99.6
Protein	yjgA	PMID:19402753	LCMS(ID Probability):99.6
Protein	rplA	PMID:19402753	LCMS(ID Probability):99.6
Protein	yicC	PMID:19402753	MALDI(Z-score):38.150360
Protein	thrS	PMID:19402753	LCMS(ID Probability):99.6
edit table

</protect>

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
plasma membrane	C-terminus localized in the cytoplasm with 2 predicted transmembrane domains	Daley et al. (2005) ^[7]
edit table

Notes

Structure and Physical Properties

[back to top]

<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MSHRARHQLL ALPGIIFLVL FPIILSLWIA FLWAKSEVNN QLRTFAQLAL DKSELVIRQA DLVSDAAERY QGQVCTPAHQ KRMLNIIRGY LYINELIYAR DNHFLCSSLI APVNGYTIAP ADYKREPNVS IYYYRDTPFF SGYKMTYMQR GNYVAVINPL FWSEVMSDDP TLQWGVYDTV TKTFFSLSKE ASAATFSPLI HLKDLTVQRN GYLYATVYST KRPIAAIVAT SYQRLITHFY NHLIFALPAG ILGSLVLLLL WLRIRQNYLS PKRKLQRALE KHQLCLYYQP IIDIKTEKCI GAEALLRWPG EQGQIMNPAE FIPLAEKEGM IEQITDYVID NVFRDLGDYL ATHADRYVSI NLSASDFHTS RLIARINQKT EQYAVRPQQI KFEVTEHAFL DVDKMTPIIL AFRQAGYEVA IDDFGIGYSN LHNLKSLNVD ILKIDKSFVE TLTTHKTSHL IAEHIIELAH SLGLKTIAEG VETEEQVNWL RKRGVRYCQG WFFAKAMPPQ VFMQWMEQLP ARELTRGQ
Length	528
Mol. Wt	60.803 kDa
pI	8.6 (calculated)
Extinction coefficient	91,220 - 91,845 (calc based on 28 Y, 9 W, and 5 C residues)
edit table

Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	272..506	PF00563 EAL domain		PMID:19920124
edit table

<motif_map/>

Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=yjcC taxon=562,83333 </beststructure>

Models

View models at:

edit table

</protect>

Structure figures

</protect>

Notes

Gene Product Resources

[back to top]

See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
edit table

Notes

Accessions in Other Databases

[back to top]

See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16131887	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:948568	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0013309	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P32701	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG11938	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11938	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:948568	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001866	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1882	Escherichia coli str. K-12 substr. MG1655
edit table

Notes

Links

[back to top]

Name	URL	Comments
edit table

Expression

[back to top]

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

[back to top]

See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MG1655	13	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	21	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	5^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
edit table

Notes

Transcription and Transcriptional Regulation

[back to top]

See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
yjcC
edit table

Figure courtesy of RegulonDB

</protect>

Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

[back to top]

<protect><gbrowseImage> name=NC_000913:4273474..4273514 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

</protect>

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

</protect>

Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

[back to top]

<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
edit table

Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b4061 (EcoliWiki Page)	NCBI GEO profiles for yjcC
microarray	GenExpDB:b4061 (EcoliWiki Page)	Summary of data for yjcC from multiple microarray studies
edit table

Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
edit table

Notes

Accessions Related to yjcC Expression

[back to top]

See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11938	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1882	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b4061
EcoGene	EcoGene:EG11938	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001866	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0013309	Escherichia coli str. K-12 substr. MG1655
edit table

Notes

Links

[back to top]

Name	URL	Comments
edit table

Evolution

[back to top]

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Homologs in Other Organisms

[back to top]

See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Xenopus tropicalis	ENSXETP00000013944 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
E. coli O157	YJCC	From ECOO157CYC
edit table

Do-It-Yourself Web Tools

Notes

Families

[back to top]

See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF00563 EAL domain
Superfamily (EcoliWiki Page)	SUPERFAMILY:141868
EcoCyc	EcoCyc:EG11938	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11938	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001866	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1882	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0013309	Escherichia coli str. K-12 substr. MG1655
edit table

Notes

Links

[back to top]

Name	URL	Comments
edit table

References

[back to top]

See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed

yjcC:On One Page

Quickview

Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to yjcC Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

Categories

Navigation menu

Search