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On One Page

Quickview |

Gene |

Product(s) |

Expression|

Evolution |

References |

Quickview

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Standard Name	thyA
Gene Synonym(s)	ECK2823, b2827, JW2795^[1], JW2795
Product Desc.	thymidylate synthase^[2]^[3]; Component of thymidylate synthase^[2]^[3] Thymidylate synthase; aminopterin, trimethoprim resistance; homodimer^[4]
Product Synonyms(s)	thymidylate synthetase^[1], B2827^[2]^[1], ThyA^[2]^[1], 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase^[2]^[1] , ECK2823, JW2795, b2827
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): lgt-thyA^[2]
Regulation/Activity
Quick Links
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Notes

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Thymidylate synthase (TS) catalytic mechanism order: TS + dUMP --> TS x dUMP + (6R)-5,10-CH2-H4folate --> TS x dUMP x (6R)-5,10-CH2H4folate --> TS x dTMP x H2folate --> TS x dTMP --> TS.^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	thyA
Mnemonic	Thymine
Synonyms	ECK2823, b2827, JW2795^[1], JW2795
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	63.85 minutes	MG1655: 2963177..2962383 <gbrowseImage> name=NC_000913:2962383..2963177 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 2859775..2858981 <gbrowseImage> name=NC_012967:2858981..2859775 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 2849531..2850325 <gbrowseImage> name=NC_012759:2849531..2850325 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 2963811..2963017 <gbrowseImage> name=NC_007779:2963017..2963811 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 3057047..3056253 <gbrowseImage> name=NC_010473:3056253..3057047 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
Coding Start (SO:0000323)	MG1655	2962383	Edman degradation	PMID:6308660
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Description	Reference	Availability
thyA(del) (Keio:JW2795)	deletion	deletion		PMID:16738554	Shigen
thyA751					CGSC:4790
thyA25					CGSC:4870
thyA715					CGSC:5108
thyA36					CGSC:5214
thyA6					CGSC:5229
thyA47					CGSC:5247
thyA52					CGSC:5930
thyA12					CGSC:6324
thyA704					CGSC:6454
thyA3					CGSC:6456
thyA81					CGSC:6550
thyA82					CGSC:6553
thyA56					CGSC:6624
thyA117					CGSC:6693
thyA61					CGSC:6774
thyA144					CGSC:6965
thyA54					CGSC:6984
thyA42					CGSC:7046
thyA748::Tn10					CGSC:7146
thyA147					CGSC:7435
thyA148					CGSC:7441
thyA45					CGSC:7744
thyA702					CGSC:7782
thyA55					CGSC:8013
thyA43					CGSC:8047
thyA11					CGSC:8289
thyA24					CGSC:8317
thyA305					CGSC:8415
thyA14					CGSC:8453
thyA33					CGSC:8524
thyA114(Stable)::Mu					CGSC:8530
thyA20					CGSC:8680
thyA707					CGSC:8791
thyA111					CGSC:8970
thyA16					CGSC:9232
thyA15					CGSC:9246
thyA705					CGSC:9518
thyA48					CGSC:9636
thyA714					CGSC:9655
thyA95					CGSC:9679
thyA44					CGSC:9739
thyA710					CGSC:9829
thyA0					CGSC:9977
thyA299					CGSC:10047
thyA59					CGSC:10129
thyA746					CGSC:10313
thyA752(del)					CGSC:10675
thyA719					CGSC:10685
thyA755					CGSC:10854
thyA756					CGSC:10867
thyA57(del)					CGSC:10899
thyA758					CGSC:10937
thyA38					CGSC:11040
thyA26					CGSC:11309
thyA41					CGSC:11313
thyA23					CGSC:11395
thyA325					CGSC:11630
thyA46					CGSC:11771
thyA2					CGSC:13565
thyA18					CGSC:13591
thyA34					CGSC:13776
thyA10					CGSC:13932
thyA39					CGSC:13966
thyA29					CGSC:14002
thyA27					CGSC:14007
thyA53					CGSC:14054
thyA28					CGSC:14170
thyA30					CGSC:14178
thyA31					CGSC:14184
thyA49					CGSC:14623
thyA709					CGSC:14678
thyA17					CGSC:16221
thyA51					CGSC:16360
thyA321					CGSC:16724
thyA58					CGSC:16920
thyA50					CGSC:16936
thyA40					CGSC:17076
thyA333					CGSC:19205
thyA9999(ts)::Mud(Ap,lac)			temperature sensitive		CGSC:19260
thyA149					CGSC:19317
thyA101					CGSC:19651
thyA9					CGSC:23655
thyA326					CGSC:27048
thyA753					CGSC:29474
thyA281					CGSC:66486
thyA294					CGSC:72642
thyA119					CGSC:74742
thyA760					CGSC:79050
thyA749					CGSC:80478
thyA750					CGSC:80480
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW2795	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCAAACAGTATTTAGAACTGAT Primer 2:CCGATAGCCACCGGCGCTTTAAT
3G11	Kohara Phage	Genobase	PMID:3038334
5A10	Kohara Phage	Genobase	PMID:3038334
recD1901::Tn10	Linked marker	CAG12135 = CGSC7429^[5]	est. P1 cotransduction: 67% ^[6]
speA210::Tn10	Linked marker	CAG12168 = CGSC7431^[5]	est. P1 cotransduction: % ^[6] Synonyms:zgd-210::Tn10, zgf-210::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11002	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11002	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000991	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:949035	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0995	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0009268	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	ThyA
Synonyms	thymidylate synthetase^[1], B2827^[2]^[1], ThyA^[2]^[1], 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase^[2]^[1] , ECK2823, JW2795, b2827
Product description	thymidylate synthase^[2]^[3]; Component of thymidylate synthase^[2]^[3] Thymidylate synthase; aminopterin, trimethoprim resistance; homodimer^[4]
EC number (for enzymes)	2.1.1.45^[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0003723	RNA binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0694	F	Seeded from EcoCyc (v14.0)	complete
	GO:0004799	thymidylate synthase activity	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_00008	F	Seeded from EcoCyc (v14.0)	complete
	GO:0004799	thymidylate synthase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000398	F	Seeded from EcoCyc (v14.0)	complete
	GO:0004799	thymidylate synthase activity	GOA:spec GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.1.1.45	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005737	cytoplasm	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_00008	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005737	cytoplasm	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C	Seeded from EcoCyc (v14.0)	complete
	GO:0006231	dTMP biosynthetic process	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_00008	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006231	dTMP biosynthetic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000398	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006417	regulation of translation	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0810	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009165	nucleotide biosynthetic process	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0545	P	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of thymidylate synthase	could be indirect
Protein	ybiB		PMID:16606699	Experiment(s):EBI-1144077
Protein	rplB		PMID:16606699	Experiment(s):EBI-1144077
Protein	yhbJ		PMID:16606699	Experiment(s):EBI-1144077
Protein	ygdL		PMID:16606699	Experiment(s):EBI-1144077
Protein	thrS		PMID:19402753	MALDI(Z-score):26.246830
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MKQYLELMQK VLDEGTQKND RTGTGTLSIF GHQMRFNLQD GFPLVTTKRC HLRSIIHELL WFLQGDTNIA YLHENNVTIW DEWADENGDL GPVYGKQWRA WPTPDGRHID QITTVLNQLK NDPDSRRIIV SAWNVGELDK MALAPCHAFF QFYVADGKLS CQLYQRSCDV FLGLPFNIAS YALLVHMMAQ QCDLEVGDFV WTGGDTHLYS NHMDQTHLQL SREPRPLPKL IIKRKPESIF DYRFEDFEIE GYDPHPGIKA PVAI
Length	264
Mol. Wt	30.479 kDa
pI	5.9 (calculated)
Extinction coefficient	51,910 - 52,535 (calc based on 9 Y, 7 W, and 5 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	1..264	PF00303 Thymidylate synthase		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=thyA taxon=562,83333 </beststructure>

Models

View models at:

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</protect>

Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16130731	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:949035	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0009268	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P0A884	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG11002	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11002	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:949035	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000991	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0995	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MC4100	4.53E+02	molecules/cell	Medium: median data from rich and minimal media Temperature (°C): 37 Doubling time (min): Growth Rate(min): Growth phase: other:	emPAI		PMID:18304323
Protein	Ecoli K-12	46.834+/-0.467	Molecules/cell	Medium: Temperature (°C): Doubling time (min): Growth Rate(min): * Growth phase: other: *		Single Molecule Fluorescence	PMID:20671182
mRNA	Ecoli K-12	0.086901763	Molecules/cell	Medium: Temperature (°C): Doubling time (min): Growth Rate(min): * Growth phase: other: *		by RNA_Seq	PMID:20671182
Protein	E. coli K-12 MG1655	3089	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	651	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	1071	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
lgt-thyA
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:2963157..2963197 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

</protect>

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b2827 (EcoliWiki Page)	NCBI GEO profiles for thyA
microarray	GenExpDB:b2827 (EcoliWiki Page)	Summary of data for thyA from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to thyA Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11002	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0995	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b2827
EcoGene	EcoGene:EG11002	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000991	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0009268	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Anopheles gambiae	ENSANGP00000013700 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Arabidopsis thaliana	AT4G34570 (score: 1.000; bootstrap: 100%) AT2G16370 (score: 0.743) AT2G21550 (score: 0.331)	From Inparanoid:20070104
Bos taurus	ENSBTAP00000009213 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Caenorhabditis briggsae	WBGene00039295 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Caenorhabditis elegans	WBGene00022455 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Canis familiaris	ENSCAFP00000006268 (score: 1.000; bootstrap: 100%) ENSCAFP00000027096 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Ciona intestinalis	ENSCINP00000010823 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Danio rerio	ZDB-GENE-040426-59 (score: 1.000; bootstrap: 100%) ZDB-CDNA-040425-950 (score: 1.000; bootstrap: 100%) ZDB-CDNA-040425-951 (score: 0.979)	From Inparanoid:20070104
Drosophila melanogaster	FBgn0024920 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Drosophila pseudoobscura	GA16493-PA (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Gallus gallus	ENSGALP00000023982 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Homo sapiens	ENSP00000315644 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Macaca mulatta	ENSMMUP00000005405 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Monodelphis domestica	ENSMODP00000026836 (score: 1.000; bootstrap: 100%) ENSMODP00000025810 (score: 0.105)	From Inparanoid:20070104
Mus musculus	MGI:98878 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Oryza gramene	O81395 (score: 1.000; bootstrap: 59%)	From Inparanoid:20070104
Pan troglodytes	ENSPTRP00000016716 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Saccharomyces cerevisiae	YOR074C (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Schizosaccharomyces pombe	SPAC15E14 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Takifugu rubripes	NEWSINFRUP00000142407 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000006860 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Shigella flexneri	THYA	From SHIGELLACYC
E. coli O157	THYA	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Panther (EcoliWiki Page)	PTHR11549:SF2
Superfamily (EcoliWiki Page)	SUPERFAMILY:55831
Pfam (EcoliWiki Page)	PF00303 Thymidylate synthase
EcoCyc	EcoCyc:EG11002	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11002	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000991	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0995	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0009268	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

thyA:On One Page

Quickview

Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to thyA Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

Categories

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