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Standard Name	tatC
Gene Synonym(s)	ECK3832, b3839, JW3815, mttA2, mttB, yigUV, ysgB, yigU, yigV^[1], yigV
Product Desc.	TatC^[2]^[3]; Component of TatABCE protein export complex^[2]^[3] Protein translocase, Sec-independent; mediates export of folded and ligand-bound proteins^[4]
Product Synonyms(s)	TatABCE protein translocation system subunit^[1], YigV^[2]^[1], YigU^[2]^[1], MttB^[2]^[1], TatC^[2]^[1], B3839^[2]^[1] , ECK3832, JW3815, mttB, yigU, yigV, b3839
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): tatA^[2]
Regulation/Activity
Quick Links
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Notes

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Topology mapped using protein fusions. Forms a complex with TatAB. Mutants have elevated OM vesiculation (McBroom, 2006).^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	tatC
Mnemonic	Twin arginine translocation
Synonyms	ECK3832, b3839, JW3815, mttA2, mttB, yigUV, ysgB, yigU, yigV^[1], yigV
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	86.66 minutes	MG1655: 4020759..4021535 <gbrowseImage> name=NC_000913:4020759..4021535 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 4001207..4001983 <gbrowseImage> name=NC_012967:4001207..4001983 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 3910428..3911204 <gbrowseImage> name=NC_012759:3910428..3911204 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 3613945..3613169 <gbrowseImage> name=NC_007779:3613169..3613945 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 4119679..4120455 <gbrowseImage> name=NC_010473:4119679..4120455 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
tatC(del) (Keio:JW3815)	deletion	deletion			PMID:16738554	Shigen CGSC10761^[5]
tatCD211E,N		D211E,N		Decrease in torA export activity			seeded from UniProt:P69423
tatCR17A		R17A		No anaerobic growth and no torA export			seeded from UniProt:P69423
tatC							Deletion
tatCL20A		L20A		25% decrease in anaerobic growth and 75% decrease in torA export			seeded from UniProt:P69423
tatCE103Q		E103Q		Severely retard but does not abolish activity			seeded from UniProt:P69423
tatCD211A		D211A		Export activity of torA blocked. Export of torA restored; when associated with A-94 or A-103			seeded from UniProt:P69423
tatCF94A,L		F94A,L		Loss of function			seeded from UniProt:P69423
tatCF94A		F94A		Export of torA restored; when associated with A-211			seeded from UniProt:P69423
tatCE103A,D,R		E103A,D,R		Loss of function			seeded from UniProt:P69423
tatCE103A		E103A		Export of torA restored; when associated with A-211			seeded from UniProt:P69423
tatC781(del)::kan					PMID:16738554	CGSC:103096
tatC(del)			Sensitivity to	Strain carrying deletion at tatC locus which encodes a subunit of the twin argenine translocation complex (tat)used for protein secretion, exhibited increased susceptibility to protamine, Alpha helical CAMPs magainin 2 and melittin. Fig 1 and 2	PMID:21149452	Parent strain: BW25113
tatC781(del)::FRTKanFRT	deletion		Mutagenesis rate	Decrease in Stress Induced Mutagenesis (SIM)	PMID:23224554	Parent Strain: SMR4562 Experimental Stain: SMR12008	The mutation caused a significant decrease in SIM with mutant frequency reduced by 68 t0 89 percent of the wild type. See table S3 for full experimental data.
tatC781(del)::FRTKanFRT	deletion		Sensitivity to	SDS-EDTA Sensitivity	PMID:23224554	Parent Strain: SMR4562 Experimental Stain: SMR12008	The mutation conferred an increase in SDS-EDTA sensitivity. See table S7 and S1 for a summary of experimental data.
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW3815	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCTCTGTAGAAGATACTCAACC Primer 2:CCTTCTTCAGTTTTTTCGCTTTC
16G1	Kohara Phage	Genobase	PMID:3038334
1C10	Kohara Phage	Genobase	PMID:3038334
metEo-3079::Tn10	Linked marker	CAG18491 = CGSC7464^[5]	est. P1 cotransduction: 66% ^[6] Synonyms:metE3079::Tn10 nnnThe Tn10 in CAG13491 is inserted in the metE regulatory region, but causes a Met- phenotype.
fad-751::Tn10	Linked marker	CAG18496 = CGSC7465^[5]	est. P1 cotransduction: 80% ^[6] Synonyms:fadAB101::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11479	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11479	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001438	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:948328	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1445	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012547	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	TatC
Synonyms	TatABCE protein translocation system subunit^[1], YigV^[2]^[1], YigU^[2]^[1], MttB^[2]^[1], TatC^[2]^[1], B3839^[2]^[1] , ECK3832, JW3815, mttB, yigU, yigV, b3839
Product description	TatC^[2]^[3]; Component of TatABCE protein export complex^[2]^[3] Protein translocase, Sec-independent; mediates export of folded and ligand-bound proteins^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	Aspect	Notes	Status
	GO:0009977	proton motive force dependent protein transmembrane transporter activity	PMID:11350936	IMP: Inferred from Mutant Phenotype	F	Seeded from EcoCyc (v14.0)	complete
	GO:0033281	TAT protein transport complex	PMID:11279240	IDA: Inferred from Direct Assay	C	Seeded from EcoCyc (v14.0)	complete
	GO:0065002	intracellular protein transmembrane transport	PMID:11279240	IDA: Inferred from Direct Assay	P	Seeded from EcoCyc (v14.0)	complete
	GO:0065002	intracellular protein transmembrane transport	PMID:9546395	IMP: Inferred from Mutant Phenotype	P	Seeded from EcoCyc (v14.0)	complete
	GO:0016020	membrane	PMID:10747959	IDA: Inferred from Direct Assay	C		complete
	GO:0008320	protein transmembrane transporter activity	PMID:9660752	IMP: Inferred from Mutant Phenotype	F	replaced original annotation to GO:0008565 because that term was made obsolete	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of TatABCE protein export complex	could be indirect
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence
plasma membrane	C-terminus localized in the cytoplasm with 6 predicted transmembrane domains	Daley et al. (2005) ^[7]
membrane
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MSVEDTQPLI THLIELRKRL LNCIIAVIVI FLCLVYFAND IYHLVSAPLI KQLPQGSTMI ATDVASPFFT PIKLTFMVSL ILSAPVILYQ VWAFIAPALY KHERRLVVPL LVSSSLLFYI GMAFAYFVVF PLAFGFLANT APEGVQVSTD IASYLSFVMA LFMAFGVSFE VPVAIVLLCW MGITSPEDLR KKRPYVLVGA FVVGMLLTPP DVFSQTLLAI PMYCLFEIGV FFSRFYVGKG RNREEENDAE AESEKTEE
Length	258
Mol. Wt	28.876 kDa
pI	5.2 (calculated)
Extinction coefficient	25,900 - 26,400 (calc based on 10 Y, 2 W, and 4 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Initiator Methionine	1	Removed	UniProt:P69423
Domain	10..221	PF00902 Sec-independent protein translocase protein (TatC)		PMID:19920124
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<motif_map/>

Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=tatC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16131687	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:948328	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012547	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P69423	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG11479	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11479	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:948328	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001438	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1445	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MG1655	1148	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	189	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	393	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
tatA
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:4020739..4020779 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b3839 (EcoliWiki Page)	NCBI GEO profiles for tatC
microarray	GenExpDB:b3839 (EcoliWiki Page)	Summary of data for tatC from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to tatC Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11479	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1445	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b3839
EcoGene	EcoGene:EG11479	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001438	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012547	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Arabidopsis thaliana	AT2G01110 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Shigella flexneri	YIGU	From SHIGELLACYC
E. coli O157	TATC	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF00902 Sec-independent protein translocase protein (TatC)
EcoCyc	EcoCyc:EG11479	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11479	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001438	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1445	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012547	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed

tatC:On One Page

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Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to tatC Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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