recQ:On One Page

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Quickview | Gene | Product(s) | Expression| Evolution | References |

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Standard Name

recQ

Gene Synonym(s)

ECK3816, b3822, JW5855[1], JW5855

Product Desc.

ATP-dependent DNA helicase[2][3]

DNA helicase involved in recombination, replication, repair; ATP-dependent; monomeric[4]

Product Synonyms(s)

ATP-dependent DNA helicase[1], B3822[2][1], RecQ[2][1] , ECK3816, JW5855, b3822

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): recQ[2]

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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Helicases generally separate duplex nucleic acids into separate strands. RecQ helicase couples the energy of ATP hydrolysis in order to unwind double-stranded DNA and RNA molecules. RecQ is involved with recombinational repair within the RecF pathway. Specifically, recQ is used for double stranded DNA break (DSB) repair by generating the single stranded DNA. This ssDNA is then processed by other enzymes in the RecF pathway, which manipulate the ssDNA so it will be competent for recombination. [5]

Associated syndromes with mutations on the recQ gene include Werner's, Bloom's, and Rothmund-Thomson Syndrome, which are all autosomal recessive disorders. Werner's Syndrome occurs due to a mutation on the WRN gene and causes loss of skin elasticity, osteoporosis, and atherosclerosis in humans. Bloom's occurs on the BLM gene and is associated with immuno-deficiency, male infertility, and predisposition to all types of cancer. Rothmund-Thomson syndrome is due to a mutation on the RECQ4 gene and causes growth deficiency, early graying and hair loss, and increased cancer incidence in humans. [6]

SSB binds to RecQ and stimulates DNA unwinding (Shereda, 2007). LexA regulon.[4]



Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

recQ

Mnemonic

Recombination

Synonyms

ECK3816, b3822, JW5855[1], JW5855

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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain Map location Genome coordinates Genome browsers Sequence links

MG1655

86.3 minutes 

MG1655: 4003887..4005716
<gbrowseImage> name=NC_000913:4003887..4005716 source=MG1655 preset=GeneLocation </gbrowseImage>

REL606

NC_012967: 3970285..3972120
<gbrowseImage> name=NC_012967:3970285..3972120 source=REL606 preset=GeneLocation </gbrowseImage>

BW2952

NC_012759: 3893556..3895385
<gbrowseImage> name=NC_012759:3893556..3895385 source=BW2952 preset=GeneLocation </gbrowseImage>

W3110

 

W3110: 3630817..3628988
<gbrowseImage> name=NC_007779:3628988..3630817 source=W3110 preset=GeneLocation </gbrowseImage>

DH10B

DH10B: 4102807..4104636
<gbrowseImage> name=NC_010473:4102807..4104636 source=DH10B preset=GeneLocation </gbrowseImage>

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type Strain Genomic Location Evidence Reference Notes

Coding Start (SO:0000323)

MG1655

4003890

Edman degradation

PMID:2164680


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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele Nt change(s) AA change(s) Phenotype: Type Phenotype: Description Reference Availability Comments

ΔrecQ (Keio:JW5855)

deletion

deletion

PMID:16738554

Shigen

recQ1803::Tn3

PMID:2993821

CGSC:65458

recQ1 (HN15)

Resistant to

Mutation causes partial resistance to thymineless death (TLD), figure 1.

PMID:6381965

Parent Strain: AB2497

Mutant previously designated tld-1

recQ1 (HN15)

Sensitivity to

Mutation causes increased UV sensitivity in a recBC sbcB background. (Data not shown)

PMID:6381965

Parent Strain: AB2497

Mutant previously designated tld-1

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Notes

Genetic Interactions

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Interactor Interaction Allele Score(s) Reference(s) Accessions Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource Resource Type Source Notes/Reference

JW5855

Plasmid clone

Shigen

PMID:16769691

Status:Clone OK

Primer 1:GCCGCGCAGGCGGAAGTGTTGAA

Primer 2:CCtTCTTCGTCATCGCCATCAAC

1C10

Kohara Phage

Genobase

PMID:3038334

7G3

Kohara Phage

Genobase

PMID:3038334

ilvD500::Tn10

Linked marker

CAG18431 = CGSC7462[7]

est. P1 cotransduction: 9% [8]
Synonyms:ilv500::Tn10

metEo-3079::Tn10

Linked marker

CAG18491 = CGSC7464[7]

est. P1 cotransduction: 85% [8]
Synonyms:metE3079::Tn10 nnnThe Tn10 in CAG13491 is inserted in the metE regulatory region, but causes a Met- phenotype.

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:EG10833

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10833

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000824

Escherichia coli str. K-12 substr. MG1655

NCBI (EcoliWiki Page)

GeneID:948318

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0826

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0012483

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

RecQ

Synonyms

ATP-dependent DNA helicase[1], B3822[2][1], RecQ[2][1] , ECK3816, JW5855, b3822

Product description

ATP-dependent DNA helicase[2][3]

DNA helicase involved in recombination, replication, repair; ATP-dependent; monomeric[4]

EC number (for enzymes)
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Notes

  • A mutant of the human homolog of RecQ, known as BLM, is responsible for Bloom syndrome. See BLM on GONUTS.

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status

GO:0000166

nucleotide binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010997

F

Seeded from EcoCyc (v14.0)

complete

GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0003676

nucleic acid binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001650

F

Seeded from EcoCyc (v14.0)

complete

GO:0003676

nucleic acid binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002121

F

Seeded from EcoCyc (v14.0)

complete

GO:0046914

transition metal ion binding

PMID:2164680

IDA: Inferred from Direct Assay

F

complete

GO:0003676

nucleic acid binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011545

F

Seeded from EcoCyc (v14.0)

complete

GO:0016887

ATPase activity

PMID:2164680

IDA: Inferred from Direct Assay

F

complete

GO:0003677

DNA binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded from EcoCyc (v14.0)

complete

GO:0008094

DNA-dependent ATPase activity

PMID:2164680

IDA: Inferred from Direct Assay

F

complete

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010997

F

Seeded from EcoCyc (v14.0)

complete

GO:0004003

ATP-dependent DNA helicase activity

PMID:2164680

IDA: Inferred from Direct Assay

F

complete

GO:0004003

ATP-dependent DNA helicase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006293

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

PMID:2164680

IDA: Inferred from Direct Assay

C

complete

GO:0005515

protein binding

PMID:19150358

IPI: Inferred from Physical Interaction

UniProtKB:P0AGE0

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

PMID:14665634

IDA: Inferred from Direct Assay

F

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001650

F

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

PMID:15292213

IMP: Inferred from Mutant Phenotype

F

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011545

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

PMID:15292213

IPI: Inferred from Physical Interaction

F

Missing: with/from

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0017116

single-stranded DNA-dependent ATP-dependent DNA helicase activity

PMID:12805371

IDA: Inferred from Direct Assay

F

complete

GO:0005622

intracellular

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002121

C

Seeded from EcoCyc (v14.0)

complete

GO:0017117

single-stranded DNA-dependent ATP-dependent DNA helicase complex

PMID:12805371

IDA: Inferred from Direct Assay

C

complete

GO:0006260

DNA replication

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018982

P

Seeded from EcoCyc (v14.0)

complete

GO:0006310

DNA recombination

PMID:7868608

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006281

DNA repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018982

P

Seeded from EcoCyc (v14.0)

complete

GO:0006281

DNA repair

PMID:7868608

IGI: Inferred from Genetic Interaction

EcoliWiki:recB|EcoliWiki:recC|EcoliWiki:sbcB|EcoliWiki:sbcC

P

complete

GO:0006281

DNA repair

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0234

P

Seeded from EcoCyc (v14.0)

complete

GO:0006974

response to DNA damage stimulus

PMID:7868608

IGI: Inferred from Genetic Interaction

EcoliWiki:recB|EcoliWiki:recC|EcoliWiki:sbcB|EcoliWiki:sbcC

P

complete

GO:0006281

DNA repair

PMID:7868608

IGI: Inferred from Genetic Interaction

P

Seeded from EcoCyc (v14.0)

Missing: with/from

GO:0006310

DNA recombination

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004589

P

Seeded from EcoCyc (v14.0)

complete

GO:0006310

DNA recombination

PMID:9553043

IDA: Inferred from Direct Assay

P

With RecA & SSB.

complete

GO:0005515

protein binding

PMID:19150358

IPI: Inferred from Physical Interaction

UniProtKB:P0AGE0

F

SSB (Single-stranded DNA-binding protein)

complete

GO:0006310

DNA recombination

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006293

P

Seeded from EcoCyc (v14.0)

complete

GO:0006310

DNA recombination

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018329

P

Seeded from EcoCyc (v14.0)

complete

GO:0006310

DNA recombination

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0233

P

Seeded from EcoCyc (v14.0)

complete

GO:0006310

DNA recombination

PMID:9553043

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0009432

SOS response

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006293

P

Seeded from EcoCyc (v14.0)

complete

GO:0009432

SOS response

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0742

P

Seeded from EcoCyc (v14.0)

complete

GO:0030894

replisome

PMID:16385024

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0043140

ATP-dependent 3'-5' DNA helicase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018982

F

Seeded from EcoCyc (v14.0)

complete

GO:0043590

bacterial nucleoid

PMID:16385024

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

ssb

PMID:15690043

Experiment(s):EBI-882208, EBI-885071, EBI-889737

Protein

aceE

PMID:15690043

Experiment(s):EBI-882208

Protein

aceF

PMID:15690043

Experiment(s):EBI-882208, EBI-889737

Protein

lpdA

PMID:15690043

Experiment(s):EBI-882208, EBI-889737

Protein

topA

PMID:15690043

Experiment(s):EBI-882208, EBI-888130

Protein

rpmB

PMID:15690043

Experiment(s):EBI-889737

Protein

rpsN

PMID:15690043

Experiment(s):EBI-889737

Protein

rpmB

PMID:19402753

LCMS(ID Probability):99.6

Protein

topA

PMID:19402753

LCMS(ID Probability):98.5 MALDI(Z-score):28.250265

Protein

ssb

PMID:19402753

LCMS(ID Probability):99.6 MALDI(Z-score):35.825787

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MAQAEVLNLE SGAKQVLQET FGYQQFRPGQ EEIIDTVLSG RDCLVVMPTG GGKSLCYQIP
ALLLNGLTVV VSPLISLMKD QVDQLQANGV AAACLNSTQT REQQLEVMTG CRTGQIRLLY
IAPERLMLDN FLEHLAHWNP VLLAVDEAHC ISQWGHDFRP EYAALGQLRQ RFPTLPFMAL
TATADDTTRQ DIVRLLGLND PLIQISSFDR PNIRYMLMEK FKPLDQLMRY VQEQRGKSGI
IYCNSRAKVE DTAARLQSKG ISAAAYHAGL ENNVRADVQE KFQRDDLQIV VATVAFGMGI
NKPNVRFVVH FDIPRNIESY YQETGRAGRD GLPAEAMLFY DPADMAWLRR CLEEKPQGQL
QDIERHKLNA MGAFAEAQTC RRLVLLNYFG EGRQEPCGNC DICLDPPKQY DGSTDAQIAL
STIGRVNQRF GMGYVVEVIR GANNQRIRDY GHDKLKVYGM GRDKSHEHWV SVIRQLIHLG
LVTQNIAQHS ALQLTEAARP VLRGESSLQL AVPRIVALKP KAMQKSFGGN YDRKLFAKLR
KLRKSIADES NVPPYVVFND ATLIEMAEQM PITASEMLSV NGVGMRKLER FGKPFMALIR
AHVDGDDEE
Length

609

Mol. Wt

68.364 kDa

pI

7.3 (calculated)

Extinction coefficient

48,820 - 50,195 (calc based on 18 Y, 4 W, and 11 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P15043

Domain

27..192

PF00270 DEAD/DEAH box helicase

PMID:19920124

Domain

254..331

PF00271 Helicase conserved C-terminal domain

PMID:19920124

Domain

532..599

PF00570 HRDC domain

PMID:19920124

Domain

411..514

PF09382 RQC domain

PMID:19920124

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=recQ taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:162135918

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948318

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0012483

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P15043

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10833

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10833

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948318

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000824

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0826

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

Molecule Organism or Strain Value Units Experimental Conditions Assay used Notes Reference(s)

Protein

Ecoli K-12

1.937+/-0.103

Molecules/cell

  • Medium:
  • Temperature (°C):
  • Doubling time (min): Growth Rate(min): *
  • Growth phase: other: *

Single Molecule Fluorescence

PMID:20671182

mRNA

Ecoli K-12

0.024056862

Molecules/cell

  • Medium:
  • Temperature (°C):
  • Doubling time (min): Growth Rate(min): *
  • Growth phase: other: *

by RNA_Seq

PMID:20671182

Protein

E. coli K-12 MG1655

155

molecules/cell/generation

  • Medium: MOPS Complete
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Protein

E. coli K-12 MG1655

63

molecules/cell/generation

  • Medium: MOPS Minimal
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Protein

E. coli K-12 MG1655

87

molecules/cell/generation

  • Medium: MOPS Complete without Methionine
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

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Notes

Transcription and Transcriptional Regulation

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<protect>

See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

recQ

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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:4003867..4003907 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name Mutation Phenotype Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type Reference Notes

microarray

GEO Profiles:b3822 (EcoliWiki Page)

NCBI GEO profiles for recQ

microarray

GenExpDB:b3822 (EcoliWiki Page)

Summary of data for recQ from multiple microarray studies

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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name Resource Type Description Source Notes
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Notes

Accessions Related to recQ Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:EG10833

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0826

Escherichia coli str. K-12 substr. MG1655

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b3822

EcoGene

EcoGene:EG10833

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000824

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0012483

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism Homologs (Statistics) Comments

Shigella flexneri

RECQ

From SHIGELLACYC

E. coli O157

RECQ

From ECOO157CYC

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Do-It-Yourself Web Tools

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Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

Pfam (EcoliWiki Page)

PF00570 HRDC domain

Pfam (EcoliWiki Page)

PF00271 Helicase conserved C-terminal domain

Pfam (EcoliWiki Page)

PF00270 DEAD/DEAH box helicase

Superfamily (EcoliWiki Page)

SUPERFAMILY:47819

Panther (EcoliWiki Page)

PTHR13710:SF11

Superfamily (EcoliWiki Page)

SUPERFAMILY:52540

Superfamily (EcoliWiki Page)

SUPERFAMILY:52540

Pfam (EcoliWiki Page)

PF09382 RQC domain

EcoCyc

EcoCyc:EG10833

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10833

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000824

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0826

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0012483

Escherichia coli str. K-12 substr. MG1655

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References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Killoran, MP & Keck, JL (2006) Sit down, relax and unwind: structural insights into RecQ helicase mechanisms. Nucleic Acids Res. 34 4098-105 PubMed
  6. ↑ Mohaghegh, P & Hickson, ID (2001) DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders. Hum. Mol. Genet. 10 741-6 PubMed
  7. ↑ 7.0 7.1 CGSC: The Coli Genetics Stock Center
  8. ↑ 8.0 8.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

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