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Gene |

Product(s) |

Expression|

Evolution |

References |

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Standard Name	pta
Gene Synonym(s)	ECK2291, b2297, JW2294^[1], JW2294
Product Desc.	Pta^[2]^[3]; Component of phosphate acetyltransferase^[2]^[3]
Product Synonyms(s)	phosphate acetyltransferase^[1], B2297^[2]^[1], Pta^[2]^[1] , ECK2291, JW2294, b2297
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): pta^[2], ackA-pta^[2]
Regulation/Activity
Quick Links
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	pta
Mnemonic	Phosphotransacetylase
Synonyms	ECK2291, b2297, JW2294^[1], JW2294
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	52 minutes	MG1655: 2412769..2414913 <gbrowseImage> name=NC_000913:2412769..2414913 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 2358339..2360483 <gbrowseImage> name=NC_012967:2358339..2360483 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 2298574..2300718 <gbrowseImage> name=NC_012759:2298574..2300718 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 2420193..2422337 <gbrowseImage> name=NC_007779:2420193..2422337 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 2504534..2506678 <gbrowseImage> name=NC_010473:2504534..2506678 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
Coding Start (SO:0000323)	MG1655	2412772	Edman degradation	PMID:7883769 PMID:7918659
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability	Comments
Δpta (Keio:JW2294)	deletion	deletion	PMID:16738554	Shigen CGSC9844^[4]
pta::Tn5KAN-2 (FB20752)	Insertion at nt 1310 in Minus orientation		PMID:15262929	E. coli Genome Project:FB20752	does not contain pKD46
pta::Tn5KAN-2 (FB20753)	Insertion at nt 1310 in Minus orientation		PMID:15262929	E. coli Genome Project:FB20753	contains pKD46
pta-39				CGSC:7369
pta-200			PMID:6259116	CGSC:25449
Δpta-779::kan			PMID:16738554	CGSC:102512
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW2294	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCTCCCGTATTATTATGCTGAT Primer 2:CCtTGCTGCTGTGCAGACTGAAT
E9C9	Kohara Phage	Genobase	PMID:3038334
9D2	Kohara Phage	Genobase	PMID:3038334
zfb-223::Tn10	Linked marker	CAG18484 = CGSC7406^[4]	est. P1 cotransduction: 42% ^[5] Synonyms:zej-223::Tn10
zfd-1::Tn10	Linked marker	CAG18467 = CGSC7408^[4]	est. P1 cotransduction: % ^[5] Synonyms:zfb-1::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG20173	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG20173	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002445	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:946778	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB4147	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007582	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	Pta
Synonyms	phosphate acetyltransferase^[1], B2297^[2]^[1], Pta^[2]^[1] , ECK2291, JW2294, b2297
Product description	Pta^[2]^[3]; Component of phosphate acetyltransferase^[2]^[3]
EC number (for enzymes)	2.3.1.8^[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C	Seeded from EcoCyc (v14.0)	complete
	GO:0008152	metabolic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002505	P	Seeded from EcoCyc (v14.0)	complete
	GO:0008415	acyltransferase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002505	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008415	acyltransferase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0012	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008959	phosphate acetyltransferase activity	GOA:spec GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.3.1.8	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016407	acetyltransferase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004614	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016740	transferase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008270	zinc ion binding	PMID:11985624	IDA: Inferred from Direct Assay		F		complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of phosphate acetyltransferase	could be indirect
Protein	dnaJ		PMID:15690043	Experiment(s):EBI-878661
Protein	tufA		PMID:15690043	Experiment(s):EBI-878661
Protein	chpS		PMID:15690043	Experiment(s):EBI-881405
Protein	nuoE		PMID:16606699	Experiment(s):EBI-1142480
Protein	ygcM		PMID:16606699	Experiment(s):EBI-1142480
Protein	nadE		PMID:16606699	Experiment(s):EBI-1142480
Protein	yneK		PMID:16606699	Experiment(s):EBI-1142480
Protein	rhsC		PMID:16606699	Experiment(s):EBI-1142480
Protein	nrdI		PMID:16606699	Experiment(s):EBI-1142480
Protein	yddB		PMID:16606699	Experiment(s):EBI-1142480
Protein	rplF		PMID:16606699	Experiment(s):EBI-1142480
Protein	argG		PMID:16606699	Experiment(s):EBI-1142480
Protein	napC		PMID:16606699	Experiment(s):EBI-1142480
Protein	putA		PMID:16606699	Experiment(s):EBI-1142480
Protein	tig		PMID:16606699	Experiment(s):EBI-1142480
Protein	tufB		PMID:19402753	MALDI(Z-score):18.848927
Protein	dnaJ		PMID:19402753	MALDI(Z-score):19.745213
Protein	chpS		PMID:19402753	LCMS(ID Probability):99.6
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Notes

Localization

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Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MSRIIMLIPT GTSVGLTSVS LGVIRAMERK GVRLSVFKPI AQPRTGGDAP DQTTTIVRAN SSTTTAAEPL KMSYVEGLLS SNQKDVLMEE IVANYHANTK DAEVVLVEGL VPTRKHQFAQ SLNYEIAKTL NAEIVFVMSQ GTDTPEQLKE RIELTRNSFG GAKNTNITGV IVNKLNAPVD EQGRTRPDLS EIFDDSSKAK VNNVDPAKLQ ESSPLPVLGA VPWSFDLIAT RAIDMARHLN ATIINEGDIN TRRVKSVTFC ARSIPHMLEH FRAGSLLVTS ADRPDVLVAA CLAAMNGVEI GALLLTGGYE MDARISKLCE RAFATGLPVF MVNTNTWQTS LSLQSFNLEV PVDDHERIEK VQEYVANYIN ADWIESLTAT SERSRRLSPP AFRYQLTELA RKAGKRIVLP EGDEPRTVKA AAICAERGIA TCVLLGNPAE INRVAASQGV ELGAGIEIVD PEVVRESYVG RLVELRKNKG MTETVAREQL EDNVVLGTLM LEQDEVDGLV SGAVHTTANT IRPPLQLIKT APGSSLVSSV FFMLLPEQVY VYGDCAINPD PTAEQLAEIA IQSADSAAAF GIEPRVAMLS YSTGTSGAGS DVEKVREATR LAQEKRPDLM IDGPLQYDAA VMADVAKSKA PNSPVAGRAT VFIFPDLNTG NTTYKAVQRS ADLISIGPML QGMRKPVNDL SRGALVDDIV YTIALTAIQS AQQQ
Length	714
Mol. Wt	77.172 kDa
pI	5.2 (calculated)
Extinction coefficient	37,360 - 38,110 (calc based on 14 Y, 3 W, and 6 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Initiator Methionine	1	Removed	UniProt:P0A9M8
Modification Site	691	phosphorylation site at S691	probability greater than 75%	PMID:17938405
Domain	391..707	PF01515 Phosphate acetyl/butaryl transferase		PMID:19920124
Domain	234..346	PF07085 DRTGG domain		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=pta taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16130232	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:946778	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007582	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P0A9M8	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG20173	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG20173	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:946778	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002445	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB4147	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MC4100	2.38E+03	molecules/cell	Medium: median data from rich and minimal media Temperature (°C): 37 Doubling time (min): Growth Rate(min): Growth phase: other:	emPAI		PMID:18304323
Protein	Ecoli K-12	62.472+/-0.362	Molecules/cell	Medium: Temperature (°C): Doubling time (min): Growth Rate(min): * Growth phase: other: *		Single Molecule Fluorescence	PMID:20671182
mRNA	Ecoli K-12	0.06926306	Molecules/cell	Medium: Temperature (°C): Doubling time (min): Growth Rate(min): * Growth phase: other: *		by RNA_Seq	PMID:20671182
Protein	E. coli K-12 MG1655	13861	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	1157	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	6999	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
pta
ackA-pta
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:2412749..2412789 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b2297 (EcoliWiki Page)	NCBI GEO profiles for pta
microarray	GenExpDB:b2297 (EcoliWiki Page)	Summary of data for pta from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to pta Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG20173	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB4147	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b2297
EcoGene	EcoGene:EG20173	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002445	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007582	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Shigella flexneri	PTA	From SHIGELLACYC
E. coli O157	PTA	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Superfamily (EcoliWiki Page)	SUPERFAMILY:52540
Superfamily (EcoliWiki Page)	SUPERFAMILY:53659
Pfam (EcoliWiki Page)	PF01515 Phosphate acetyl/butaryl transferase
Pfam (EcoliWiki Page)	PF07085 DRTGG domain
EcoCyc	EcoCyc:EG20173	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG20173	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002445	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB4147	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007582	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 CGSC: The Coli Genetics Stock Center
↑ ^5.0 ^5.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

pta:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to pta Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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