proA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

ProA

Synonyms

gamma-glutamylphosphate reductase[1], B0243[2][1], ProA[2][1] , ECK0244, JW0233, pro, b0243

Product description

ProA[2][3];

Component of glutamate-5-semialdehyde dehydrogenase[2][3]; γ-glutamyl kinase-GP-reductase multienzyme complex[2][3]

gamma-Glutamyl phosphate reductase, proline biosynthesis[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004350

glutamate-5-semialdehyde dehydrogenase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00412

F

Seeded from EcoCyc (v14.0)

complete

GO:0004350

glutamate-5-semialdehyde dehydrogenase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000965

F

Seeded from EcoCyc (v14.0)

complete

GO:0004350

glutamate-5-semialdehyde dehydrogenase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012134

F

Seeded from EcoCyc (v14.0)

complete

GO:0004350

glutamate-5-semialdehyde dehydrogenase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020593

F

Seeded from EcoCyc (v14.0)

complete

GO:0004350

glutamate-5-semialdehyde dehydrogenase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.2.1.41

F

Seeded from EcoCyc (v14.0)

complete

GO:0004350

glutamate-5-semialdehyde dehydrogenase activity

PMID:6337636[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0004350

glutamate-5-semialdehyde dehydrogenase activity

PMID:7034716[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0004350

glutamate-5-semialdehyde dehydrogenase activity

PMID:7035170[7]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00412

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0006561

proline biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00412

P

Seeded from EcoCyc (v14.0)

complete

GO:0006561

proline biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000965

P

Seeded from EcoCyc (v14.0)

complete

GO:0006561

proline biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012134

P

Seeded from EcoCyc (v14.0)

complete

GO:0006561

proline biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020593

P

Seeded from EcoCyc (v14.0)

complete

GO:0006561

proline biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0641

P

Seeded from EcoCyc (v14.0)

complete

GO:0006561

proline biosynthetic process

PMID:6089111[8]

IGI: Inferred from Genetic Interaction

P

Seeded from EcoCyc (v14.0)

Missing: with/from

GO:0050661

NADP or NADPH binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012134

F

Seeded from EcoCyc (v14.0)

complete

GO:0050661

NADP or NADPH binding

PMID:7034716[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012134

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015590

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016161

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016162

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of glutamate-5-semialdehyde dehydrogenase

could be indirect

Protein

aceE

PMID:15690043[9]

Experiment(s):EBI-888834

Protein

dnaN

PMID:15690043[9]

Experiment(s):EBI-888834

Protein

rapA

PMID:16606699[10]

Experiment(s):EBI-1136008

Protein

yhhH

PMID:16606699[10]

Experiment(s):EBI-1136008

Protein

ptrA

PMID:16606699[10]

Experiment(s):EBI-1136008

Protein

iscS

PMID:16606699[10]

Experiment(s):EBI-1136008

Protein

yghO

PMID:15690043[9]

Experiment(s):EBI-893980

Protein

cysA

PMID:15690043[9]

Experiment(s):EBI-893980

Protein

lpxD

PMID:15690043[9]

Experiment(s):EBI-893980

Protein

proS

PMID:15690043[9]

Experiment(s):EBI-893980

Protein

sfsA

PMID:15690043[9]

Experiment(s):EBI-893980

Protein

ugpB

PMID:15690043[9]

Experiment(s):EBI-893980

Protein

yehT

PMID:15690043[9]

Experiment(s):EBI-893980

Protein

proS

PMID:19402753[11]

LCMS(ID Probability):99.0

Protein

cysA

PMID:19402753[11]

LCMS(ID Probability):99.0

Protein

yehT

PMID:19402753[11]

LCMS(ID Probability):99.0

Protein

sfsA

PMID:19402753[11]

LCMS(ID Probability):99.0

Protein

Subunits of γ-glutamyl kinase-GP-reductase multienzyme complex

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MLEQMGIAAK QASYKLAQLS SREKNRVLEK IADELEAQSE IILNANAQDV ADARANGLSE
AMLDRLALTP ARLKGIADDV RQVCNLADPV GQVIDGGVLD SGLRLERRRV PLGVIGVIYE
ARPNVTVDVA SLCLKTGNAV ILRGGKETCR TNAATVAVIQ DALKSCGLPA GAVQAIDNPD
RALVSEMLRM DKYIDMLIPR GGAGLHKLCR EQSTIPVITG GIGVCHIYVD ESVEIAEALK
VIVNAKTQRP STCNTVETLL VNKNIADSFL PALSKQMAES GVTLHADAAA LAQLQAGPAK
VVAVKAEEYD DEFLSLDLNV KIVSDLDDAI AHIREHGTQH SDAILTRDMR NAQRFVNEVD
SSAVYVNAST RFTDGGQFGL GAEVAVSTQK LHARGPMGLE ALTTYKWIGI GDYTIRA
Length

417

Mol. Wt

44.629 kDa

pI

5.4 (calculated)

Extinction coefficient

17,420 - 18,295 (calc based on 8 Y, 1 W, and 7 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

2..304

PF00171 Aldehyde dehydrogenase family

PMID:19920124[12]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=proA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128229

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946680

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000832

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P07004

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10767

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10767

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946680

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000758

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0760

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Hayzer, DJ & Leisinger, T (1983) Proline biosynthesis in Escherichia coli. Kinetic and mechanistic properties of glutamate semialdehyde dehydrogenase. Biochim. Biophys. Acta 742 391-8 PubMed
  6. ↑ 6.0 6.1 Hayzer, DJ & Leisinger, T (1981) Proline biosynthesis in Escherichia coli. Stoichiometry and end-product identification of the reaction catalysed by glutamate semialdehyde dehydrogenase. Biochem. J. 197 269-74 PubMed
  7. ↑ Hayzer, DJ & Leisinger, T (1982) Proline biosynthesis in Escherichia coli. Purification and characterisation of glutamate-semialdehyde dehydrogenase. Eur. J. Biochem. 121 561-5 PubMed
  8. ↑ Deutch, AH et al. (1984) Analysis of the Escherichia coli proBA locus by DNA and protein sequencing. Nucleic Acids Res. 12 6337-55 PubMed
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 9.8 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  10. ↑ 10.0 10.1 10.2 10.3 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  11. ↑ 11.0 11.1 11.2 11.3 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  12. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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