Category:Complex:glutamate-5-semialdehyde dehydrogenase
About
Description (originally from EcoCyc[1][2]) glutamate-5-semialdehyde dehydrogenase
Comments (originally from EcoCyc[1][2]) Glutamate 5-kinase catalyzes the first reaction in the synthesis of proline and is coded for by the gene proB. The second reaction is catalyzed by glutamate-5-semialdehyde dehydrogenase, coded for by the proA gene. It has been determined that these two enzymes form a complex and that the presence of GSA dehydrogenase is necessary for the glutamate 5-kinase activity. [3]
Glutamic acid 5-semialdehyde is unstable and cyclizes spontaneously
to pyrroline-5'-carboxylate. Inhibition and kinetic studies deal with the overall reaction including the spontaneous production of pyrroline-5'-carboxylate.
References
- ↑ 1.0 1.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 2.0 2.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ Smith, CJ et al. (1984) Purification and characteristics of a gamma-glutamyl kinase involved in Escherichia coli proline biosynthesis. J. Bacteriol. 157 545-51 PubMed
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