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Standard Name	pabC
Gene Synonym(s)	ECK1082, b1096, JW1082^[1], JW1082
Product Desc.	pabC^[2]^[3]; Component of aminodeoxychorismate lyase^[2]^[3]; para-aminobenzoate synthase multi-enzyme complex^[2]^[3] Sulfonamide resistance; aminodeoxychorismate lyase^[4]
Product Synonyms(s)	4-amino-4-deoxychorismate lyase component of para-aminobenzoate synthase multienzyme complex^[1], B1096^[2]^[1], PabC^[2]^[1] , ECK1082, JW1082, b1096
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): pabC^[2]
Regulation/Activity
Quick Links
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	pabC
Mnemonic	Para-Aminobenzoate
Synonyms	ECK1082, b1096, JW1082^[1], JW1082
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	24.84 minutes	MG1655: 1152523..1153332 <gbrowseImage> name=NC_000913:1152523..1153332 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 1167869..1168678 <gbrowseImage> name=NC_012967:1167869..1168678 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 1056448..1057257 <gbrowseImage> name=NC_012759:1056448..1057257 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 1154877..1155686 <gbrowseImage> name=NC_007779:1154877..1155686 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 1207968..1208777 <gbrowseImage> name=NC_010473:1207968..1208777 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
Coding Start (SO:0000323)	MG1655	1152523	Edman degradation	PMID:1644759 PMID:2071583
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
ΔpabC (Keio:JW1082)	deletion	deletion			PMID:16738554	Shigen
pabC in strain IB3			Resistant to	Resistant to Sulfonamide	PMID:6392473	Strain: IB3	table 2
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW1082	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCTTCTTAATTAACGGTCATAA Primer 2:CCATTCGGGCGCTCACAAAGTGG
14C1	Kohara Phage	Genobase	PMID:3038334
E9G1	Kohara Phage	Genobase	PMID:3038334
zcc-282::Tn10	Linked marker	CAG18466 = CGSC7359^[5]	est. P1 cotransduction: % ^[6]
zce-726::Tn10	Linked marker	CAG12078 = CGSC7361^[5]	est. P1 cotransduction: 91% ^[6]
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11493	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11493	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001449	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:946647	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1456	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003709	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	PabC
Synonyms	4-amino-4-deoxychorismate lyase component of para-aminobenzoate synthase multienzyme complex^[1], B1096^[2]^[1], PabC^[2]^[1] , ECK1082, JW1082, b1096
Product description	pabC^[2]^[3]; Component of aminodeoxychorismate lyase^[2]^[3]; para-aminobenzoate synthase multi-enzyme complex^[2]^[3] Sulfonamide resistance; aminodeoxychorismate lyase^[4]
EC number (for enzymes)	4.1.3.38^[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm				C	Seeded from Riley et al 2006 ^[1].	Missing: evidence, reference
	GO:0003824	catalytic activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001544	F	Seeded from EcoCyc (v14.0)	complete
	GO:0003824	catalytic activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018300	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008152	metabolic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001544	P	Seeded from EcoCyc (v14.0)	complete
	GO:0008152	metabolic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018300	P	Seeded from EcoCyc (v14.0)	complete
	GO:0008696	4-amino-4-deoxychorismate lyase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017824	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008696	4-amino-4-deoxychorismate lyase activity	GOA:spec GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:4.1.3.38	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016829	lyase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0456	F	Seeded from EcoCyc (v14.0)	complete
	GO:0030170	pyridoxal phosphate binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017824	F	Seeded from EcoCyc (v14.0)	complete
	GO:0046656	folic acid biosynthetic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017824	P	Seeded from EcoCyc (v14.0)	complete
	GO:0046656	folic acid biosynthetic process	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0289	P	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of aminodeoxychorismate lyase	could be indirect
Protein	talA		PMID:16606699	Experiment(s):EBI-1138845
Protein	tmk		PMID:16606699	Experiment(s):EBI-1138845
Protein	pflA		PMID:16606699	Experiment(s):EBI-1138845
Protein	ydfE		PMID:16606699	Experiment(s):EBI-1138845
Protein	rpsD		PMID:16606699	Experiment(s):EBI-1138845
Protein	eno		PMID:19402753	LCMS(ID Probability):99.5
Protein	Subunits of para-aminobenzoate synthase multi-enzyme complex	could be indirect
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MFLINGHKQE SLAVSDRATQ FGDGCFTTAR VIDGKVSLLS AHIQRLQDAC QRLMISCDFW PQLEQEMKTL AAEQQNGVLK VVISRGSGGR GYSTLNSGPA TRILSVTAYP AHYDRLRNEG ITLALSPVRL GRNPHLAGIK HLNRLEQVLI RSHLEQTNAD EALVLDSEGW VTECCAANLF WRKGNVVYTP RLDQAGVNGI MRQFCIRLLA QSSYQLVEVQ ASLEESLQAD EMVICNALMP VMPVCACGDV SFSSATLYEY LAPLCERPN
Length	269
Mol. Wt	29.714 kDa
pI	6.5 (calculated)
Extinction coefficient	26,930 - 28,180 (calc based on 7 Y, 3 W, and 10 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	37..267	PF01063 Aminotransferase class IV		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=pabC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16129059	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:946647	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003709	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P28305	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG11493	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11493	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:946647	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001449	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1456	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MG1655	82	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	75	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	153	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
pabC
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:1152503..1152543 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b1096 (EcoliWiki Page)	NCBI GEO profiles for pabC
microarray	GenExpDB:b1096 (EcoliWiki Page)	Summary of data for pabC from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
	GFP Fusion	Intergenic region (1152311..1152543) fused to gfpmut2.	OpenBioSystems	GFP fusion described in Zaslaver, et al. Plate:109-AZ07; Well:F4^[7]
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Notes

Accessions Related to pabC Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11493	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1456	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b1096
EcoGene	EcoGene:EG11493	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001449	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003709	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Oryza gramene	Q5W706 (score: 1.000; bootstrap: 100%) Q5NAM3 (score: 0.640) Q6K7U8 (score: 0.432)	From Inparanoid:20070104
Shigella flexneri	PABC	From SHIGELLACYC
E. coli O157	PABC	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF01063 Aminotransferase class IV
Panther (EcoliWiki Page)	PTHR11825:SF4
Superfamily (EcoliWiki Page)	SUPERFAMILY:56752
EcoCyc	EcoCyc:EG11493	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11493	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001449	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1456	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003709	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ Zaslaver, A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat. Methods 3 623-8 PubMed

pabC:On One Page

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Gene

Nomenclature

Notes

Location(s) and DNA Sequence

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Sequence Features

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Alleles and Phenotypes

Notes

Genetic Interactions

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Genetic Resources

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Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to pabC Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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