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Standard Name	osmC
Gene Synonym(s)	ECK1476, b1482, JW1477^[1], JW1477
Product Desc.	osmotically inducible peroxidase OsmC^[2]^[3] Osmotically inducible, stress-inducible membrane protein; involved in defense against oxidative compounds; required for long-term survival in stationary phase^[4]
Product Synonyms(s)	osmotically inducible, stress-inducible membrane protein^[1], B1482^[2]^[1], OsmC^[2]^[1], osmotically inducible protein^[2]^[1] , ECK1476, JW1477, b1482
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): osmC^[2]
Regulation/Activity
Quick Links
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Notes

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OsmC contains a conserved CxxS redox motif. Regulated by NhaR, RcsBDC, Lrp, Hns and RpoS. Nonessential gene.^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	osmC
Mnemonic	Osmotically inducible
Synonyms	ECK1476, b1482, JW1477^[1], JW1477
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	33.51 minutes	MG1655: 1554649..1555080 <gbrowseImage> name=NC_000913:1554649..1555080 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 1530563..1530994 <gbrowseImage> name=NC_012967:1530563..1530994 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 1446708..1447139 <gbrowseImage> name=NC_012759:1446708..1447139 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 1558339..1558770 <gbrowseImage> name=NC_007779:1558339..1558770 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 1645244..1645675 <gbrowseImage> name=NC_010473:1645244..1645675 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
Coding Start (SO:0000323)	MG1655	1554652	Edman degradation	PMID:9298646
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability	Comments
ΔosmC (Keio:JW1477)	deletion	deletion	PMID:16738554	Shigen CGSC9283^[5]
osmC::Tn5KAN-2 (FB20335)	Insertion at nt 303 in Plus orientation		PMID:15262929	E. coli Genome Project:FB20335	contains pKD46
osmC::Tn5KAN-2 (FB20336)	Insertion at nt 303 in Plus orientation		PMID:15262929	E. coli Genome Project:FB20336	does not contain pKD46
ΔosmC775::kan			PMID:16738554	CGSC:102202
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW1477	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCACAATCCATAAGAAAGGTCA Primer 2:CCaGATTTCAACTGGTAATCCAG
1G9	Kohara Phage	Genobase	PMID:3038334
9B8	Kohara Phage	Genobase	PMID:3038334
10C7	Kohara Phage	Genobase	PMID:3038334
zdd-235::Tn10	Linked marker	CAG18461 = CGSC7378^[5]	est. P1 cotransduction: 50% ^[6] Synonyms:zdc-235::Tn10
zdi-925::Tn10	Linked marker	CAG12151 = CGSC7385^[5]	est. P1 cotransduction: % ^[6] Synonyms:zdh-925::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10680	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10680	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000673	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:946043	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0674	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004944	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	OsmC
Synonyms	osmotically inducible, stress-inducible membrane protein^[1], B1482^[2]^[1], OsmC^[2]^[1], osmotically inducible protein^[2]^[1] , ECK1476, JW1477, b1482
Product description	osmotically inducible peroxidase OsmC^[2]^[3] Osmotically inducible, stress-inducible membrane protein; involved in defense against oxidative compounds; required for long-term survival in stationary phase^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0004601	peroxidase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0575	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005737	cytoplasm	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C	Seeded from EcoCyc (v14.0)	complete
	GO:0006950	response to stress	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003718	P	Seeded from EcoCyc (v14.0)	complete
	GO:0016209	antioxidant activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0049	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016491	oxidoreductase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F	Seeded from EcoCyc (v14.0)	complete
	GO:0051920	peroxiredoxin activity	GOA:spec GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.11.1.15	F	Seeded from EcoCyc (v14.0)	complete
	GO:0055114	oxidation reduction	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	lacZ	PMID:16606699	Experiment(s):EBI-1139950
Protein	torR	PMID:16606699	Experiment(s):EBI-1139950
Protein	ptrA	PMID:16606699	Experiment(s):EBI-1139950
Protein	yjiG	PMID:16606699	Experiment(s):EBI-1139950
Protein	yebS	PMID:16606699	Experiment(s):EBI-1139950
Protein	fdoG	PMID:16606699	Experiment(s):EBI-1139950
Protein	yjeH	PMID:16606699	Experiment(s):EBI-1139950
Protein	malE	PMID:16606699	Experiment(s):EBI-1139950
Protein	mngB	PMID:16606699	Experiment(s):EBI-1139950
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MTIHKKGQAH WEGDIKRGKG TVSTESGVLN QQPYGFNTRF EGEKGTNPEE LIGAAHAACF SMALSLMLGE AGFTPTSIDT TADVSLDKVD AGFAITKIAL KSEVAVPGID ASTFDGIIQK AKAGCPVSQV LKAEITLDYQ LKS
Length	143
Mol. Wt	15.087 kDa
pI	5.7 (calculated)
Extinction coefficient	8,480 - 8,730 (calc based on 2 Y, 1 W, and 2 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Initiator Methionine	1	Removed	UniProt:P0C0L2
Domain	41..140	PF02566 OsmC-like protein		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=osmC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16129441	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:946043	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004944	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P0C0L2	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG10680	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10680	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:946043	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000673	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0674	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MC4100	1.04E+03	molecules/cell	Medium: median data from rich and minimal media Temperature (°C): 37 Doubling time (min): Growth Rate(min): Growth phase: other:	emPAI		PMID:18304323
Protein	Ecoli K-12	1.205+/-0.034	Molecules/cell	Medium: Temperature (°C): Doubling time (min): Growth Rate(min): * Growth phase: other: *		Single Molecule Fluorescence	PMID:20671182
mRNA	Ecoli K-12	0.981438515	Molecules/cell	Medium: Temperature (°C): Doubling time (min): Growth Rate(min): * Growth phase: other: *		by RNA_Seq	PMID:20671182
Protein	E. coli K-12 MG1655	431	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	4306	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	515	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
osmC
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:1554629..1554669 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b1482 (EcoliWiki Page)	NCBI GEO profiles for osmC
microarray	GenExpDB:b1482 (EcoliWiki Page)	Summary of data for osmC from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
	GFP Fusion	Intergenic region (1554269..1554722) fused to gfpmut2.	OpenBioSystems	GFP fusion described in Zaslaver, et al. Plate:109-AZ04; Well:H7^[7]
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Notes

Accessions Related to osmC Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10680	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0674	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b1482
EcoGene	EcoGene:EG10680	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000673	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004944	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Dictyostelium discoideum	DDB0190102 (score: 1.000; bootstrap: 100%) DDB0190245 (score: 0.114)	From Inparanoid:20070104
Shigella flexneri	OSMC	From SHIGELLACYC
E. coli O157	OSMC	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF02566 OsmC-like protein
Superfamily (EcoliWiki Page)	SUPERFAMILY:82784
EcoCyc	EcoCyc:EG10680	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10680	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000673	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0674	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004944	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ Zaslaver, A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat. Methods 3 623-8 PubMed

osmC:On One Page

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Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to osmC Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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