mutL:On One Page

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Quickview | Gene | Product(s) | Expression| Evolution | References |

Quickview

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Standard Name

mutL

Gene Synonym(s)

ECK4166, b4170, JW4128[1], JW4128

Product Desc.

MutL[2][3];

Component of MutHLS complex, methyl-directed mismatch repair[2][3]

Methyl-directed mismatch repair; matchmaker protein; weak DNA-stimulated ATPase[4]

Product Synonyms(s)

methyl-directed mismatch repair protein[1], B4170[2][1], MutL[2][1] , ECK4166, JW4128, b4170

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): yjeFE-amiB-mutL-miaA-hfq-hflXKC[2], ORF55-ORF17-amiB-mutL-miaA-hfq-hflXKC

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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MutL DNA-binding is required for methyl-directed mismatch repair (Robertson, 2006). The ATPase activity of MutL is essential for mismatch repair (Ban, 1998; Ban, 1999; Spampinato, 2000; Robertson, 2006). MutL binds UvrD, stimulates UvrD unwinding activity and is required for UvrD loading onto DNA (Hall, 1998; Yamaguchi, 1998; Mechanic, 2000). MutL stimulates MutS and Vsr binding to mismatched DNA (Drotschmann, 1998).[4]



Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

mutL

Mnemonic

Mutator

Synonyms

ECK4166, b4170, JW4128[1], JW4128

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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain Map location Genome coordinates Genome browsers Sequence links

MG1655

94.74 minutes 

MG1655: 4395435..4397282
<gbrowseImage> name=NC_000913:4395435..4397282 source=MG1655 preset=GeneLocation </gbrowseImage>

REL606

NC_012967: 4375567..4377414
<gbrowseImage> name=NC_012967:4375567..4377414 source=REL606 preset=GeneLocation </gbrowseImage>

BW2952

NC_012759: 4334170..4336017
<gbrowseImage> name=NC_012759:4334170..4336017 source=BW2952 preset=GeneLocation </gbrowseImage>

W3110

 

W3110: 4402092..4403939
<gbrowseImage> name=NC_007779:4402092..4403939 source=W3110 preset=GeneLocation </gbrowseImage>

DH10B

DH10B: 4495797..4497644
<gbrowseImage> name=NC_010473:4495797..4497644 source=DH10B preset=GeneLocation </gbrowseImage>

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type Strain Genomic Location Evidence Reference Notes

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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele Nt change(s) AA change(s) Phenotype: Type Phenotype: Description Reference Availability Comments

mutL(del) (Keio:JW4128)

deletion

deletion

PMID:16738554

Shigen
CGSC10971[5]

mutL218::Tn10

CGSC:7799

mutL13

PMID:4919752

CGSC:8030

mutL720(del)::kan

PMID:16738554

CGSC:101974

mutL::KmMlu

GC To AT and AT to GC transition Mutation

Mutation Frequency

Insertion caused GC to AT and AT to GC transition mutation to increase. Table 2.

PMID:1999389

Strain: NU1521 (AT to GC) Strain: NU1509 (GC to AT)

mutL:omega(Kmr OR Cmr);BsaAI

Auxotrophies

The polar omega cassettes blocked mutL-miaA transcription and caused the full-lengthened protected species to disappear, Fig. 2 lanes 3 and 4.

PMID:7748952

Strains: TX2568 (Cmr) & TX2569 (Kmr)

MutL(del)335N

deletion of N terminus

excision activity

Truncation mutant was inefficient as wild type MutL in promoting the excision activity of ExoX. Interaction between MutL and ExoX was also reduced. figure 4. These data suggest that the 335 N-terminal amoni acids of MutL are essential for both the interaction and stimulation of ExoX.

PMID:20638361

MutL-E29A

replacement of Glutamic acid to Alanine at position 29.

DNA repair

mutant form of MutL is inactive in ATP hydrolysis but still has a physical interaction with RecA. Mutation had an inhibitory effect on RecA's ATPase activity, Figure 4B.

PMID:22001225

Parent Strain:MG1655


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Notes

Genetic Interactions

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Interactor Interaction Allele Score(s) Reference(s) Accessions Notes

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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource Resource Type Source Notes/Reference

JW4128

Plasmid clone

Shigen

PMID:16769691

Status:Clone OK

Primer 1:GCCCCAATTCAGGTCTTACCGCC

Primer 2:CCtTCATCTTTCAGGGCTTTTAT

3A1

Kohara Phage

Genobase

PMID:3038334

cadB2231::Tn10

Linked marker

CAG18488 = CGSC7479[5]

est. P1 cotransduction: 20% [6]
Synonyms:zjd-2231::Tn10

cycA30::Tn10

Linked marker

CAG12073 = CGSC7482[5]

est. P1 cotransduction: 30% [6]

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:EG11281

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11281

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001254

Escherichia coli str. K-12 substr. MG1655

NCBI (EcoliWiki Page)

GeneID:948691

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1258

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013655

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MutL

Synonyms

methyl-directed mismatch repair protein[1], B4170[2][1], MutL[2][1] , ECK4166, JW4128, b4170

Product description

MutL[2][3];

Component of MutHLS complex, methyl-directed mismatch repair[2][3]

Methyl-directed mismatch repair; matchmaker protein; weak DNA-stimulated ATPase[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status

GO:0006298

mismatch repair

PMID:6987663

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005524

ATP binding

PMID:9827806

IDA: Inferred from Direct Assay

F

complete

GO:0006298

mismatch repair

PMID:2665076

IDA: Inferred from Direct Assay

P

complete

GO:0032300

mismatch repair complex

PMID:6987663

IGI: Inferred from Genetic Interaction

UniProtKB:P06722|UniProtKB:P23909

C

With MutH (P06722) and MutS (P23909).

complete

GO:0005515

protein binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020667

F

Seeded from EcoCyc (v14.0)

complete

GO:0016887

ATPase activity

PMID:9827806

IDA: Inferred from Direct Assay

F

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002099

F

Seeded from EcoCyc (v14.0)

complete

GO:0016887

ATPase activity

PMID:9827806

IMP: Inferred from Mutant Phenotype

F

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003594

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013507

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0006298

mismatch repair

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00149

P

Seeded from EcoCyc (v14.0)

complete

GO:0006298

mismatch repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002099

P

Seeded from EcoCyc (v14.0)

complete

GO:0006298

mismatch repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013507

P

Seeded from EcoCyc (v14.0)

complete

GO:0006298

mismatch repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020667

P

Seeded from EcoCyc (v14.0)

complete

GO:0030983

mismatched DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002099

F

Seeded from EcoCyc (v14.0)

complete

GO:0030983

mismatched DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013507

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

PMID:12606120

IDA: Inferred from Direct Assay

F

complete

GO:0003677

DNA binding

PMID:12606120

IDA: Inferred from Direct Assay

F

complete

GO:0016887

ATPase activity

PMID:9827806

IDA: Inferred from Direct Assay

F

complete

GO:0005524

ATP binding

PMID:9827806

IDA: Inferred from Direct Assay

F

complete

GO:0000018

regulation of DNA recombination

PMID:2555716

IMP: Inferred from Mutant Phenotype

P

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of MutHLS complex, methyl-directed mismatch repair

PMID:6987663

Inferred from genetic interaction

Protein

tufA

PMID:15690043

Experiment(s):EBI-880976

Protein

dnaK

PMID:15690043

Experiment(s):EBI-887579

Protein

rpsA

PMID:15690043

Experiment(s):EBI-887579

Protein

rpsA

PMID:19402753

LCMS(ID Probability):99.6

Protein

Vsr

PMID:19376855

Protein

DnaN: beta sliding clamp of DNA Pol III

MutL only binds to the beta subunit in the presence of ss DNA.

PMID:16546997

native gel electrophoresis

Protein

MutH

data suggest the ATPase fragment of MutL directly contacts MutH

PMID:9827806

Chemical crosslinking

Protein

MutS

PMID:9250691

Visualized using EM

Protein

UvrD

PMID:9880500

2-Hybrid Screen

Protein

MutH

The C-terminal 218 amino acids of MutL were sufficient for the two-hybrid interaction with MutH

PMID:9880500

2 Hybrid Screen

Protein

UvrD

Both the N- and C-termini of UvrD were required for interaction with MutL

PMID:9482750

2 Hybrid Screen

Protein

RecA

The N-terminal fragment of MutL (residues 1-349) was sufficient to bind RecA.

MutL inhibits the ssDNA-dependent ATPase activity of RecA (Fig. 4)

PMID:22001225

Far-Western and pull-down assays.

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MPIQVLPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIDIERGG AKLIRIRDNG
CGIKKDELAL ALARHATSKI ASLDDLEAII SLGFRGEALA SISSVSRLTL TSRTAEQQEA
WQAYAEGRDM NVTVKPAAHP VGTTLEVLDL FYNTPARRKF LRTEKTEFNH IDEIIRRIAL
ARFDVTINLS HNGKIVRQYR AVPEGGQKER RLGAICGTAF LEQALAIEWQ HGDLTLRGWV
ADPNHTTPAL AEIQYCYVNG RMMRDRLINH AIRQACEDKL GADQQPAFVL YLEIDPHQVD
VNVHPAKHEV RFHQSRLVHD FIYQGVLSVL QQQLETPLPL DDEPQPAPRS IPENRVAAGR
NHFAEPAARE PVAPRYTPAP ASGSRPAAPW PNAQPGYQKQ QGEVYRQLLQ TPAPMQKLKA
PEPQEPALAA NSQSFGRVLT IVHSDCALLE RDGNISLLSL PVAERWLRQA QLTPGEAPVC
AQPLLIPLRL KVSAEEKSAL EKAQSALAEL GIDFQSDAQH VTIRAVPLPL RQQNLQILIP
ELIGYLAKQS VFEPGNIAQW IARNLMSEHA QWSMAQAITL LADVERLCPQ LVKTPPGGLL
QSVDLHPAIK ALKDE
Length

615

Mol. Wt

67.924 kDa

pI

6.8 (calculated)

Extinction coefficient

54,890 - 55,765 (calc based on 11 Y, 7 W, and 7 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

18..147

PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

PMID:19920124

Domain

212..331

PF01119 DNA mismatch repair protein, C-terminal domain

PMID:19920124

Domain

434..576

PF08676 MutL C terminal dimerisation domain

PMID:19920124

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=mutL taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

Purified protein

MutL R266E[7]

  • Behaves like ΔmutL
  • Reduced DNA binding activity
  • Is completely inactive in MMR and in blocking homologous recombination in vivo
  • Activates MutH ~50% better than wt MutL
  • Basal level ATPase activity similar to wt MutL, which no longer responds to DNA stimulation

Purified protein

MutL R95F[7]

  • Mildly defective ATPase activity
  • Defective MutH activation in vitro
  • Moderately elevated mutation and DNA recombination rates in vivo

Purified protein

MutL N302A[7]

  • Mildly defective ATPase activity
  • Defective MutH activation in vitro
  • Moderately elevated mutation and DNA recombination rates in vivo

Purified protein

MutL R261H[7]

  • Reduced ATP binding
  • Exhibit a 20-80% reduction in the ATP-dependent activation of MutH endonuclease activity

Purified protein

MutL K307A[7]

  • Reduced ATP binding
  • Exhibit a 20-80% reduction in the ATP-dependent activation of MutH endonuclease activity

Purified protein

MutL E29A[7]

  • Binds ATP well, but hydrolyzes it poorly
  • Activates MutH well, but fails to mediate the mismatch-dependent MutH activation by MutS in the MMR initiation assays

Purified protein

MutL R95F/N302A[7]

  • Binds ATP well, but hydrolyzes it poorly
  • Activates MutH well, but fails to mediate the mismatch-dependent MutH activation by MutS in the MMR initiation assays

Purified protein

MutL I90R[7]

  • Behave like wt MutL in vitro and in vivo

Purified protein

MutL I90E[7]

  • Behave like wt MutL in vitro and in vivo

Purified protein

MutL R237E[7]

  • Behave like wt MutL in vitro and in vivo

Purified protein

MutL G238A[7]

  • Appears to have no in vivo defect
  • Insolubility issues prevented in vitro assays

Purified protein

MutL K159E[7]

  • Alters the residues around the DNA binding cleft
  • ~10-fold reduction in ATP hydrolysis
  • Defective in DNA binding
  • Fails to activate MMR and block homologous recombination

Purified protein

MutL G238D[7]

  • Confers a dominant mutator phenotype
  • Insolubility issues prevented in vitro assays

Purified protein

MutL R177E[7]

  • Alters the residues around the DNA binding cleft
  • Exhibits reduced catalytic efficiency
  • Mediates the mismatch-dependent activation of MutH in vitro
  • Exhibits a mutator phenotype and increased homologous recombination in vivo

Purification protocol

Single-step purification of His6-MutL

PMID:8747662

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131992

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948691

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013655

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P23367

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11281

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11281

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948691

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001254

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1258

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

Molecule Organism or Strain Value Units Experimental Conditions Assay used Notes Reference(s)

Protein

Ecoli K-12

6.625+/-0.086

Molecules/cell

  • Medium:
  • Temperature (°C):
  • Doubling time (min): Growth Rate(min): *
  • Growth phase: other: *

Single Molecule Fluorescence

PMID:20671182

mRNA

Ecoli K-12

0.027070926

Molecules/cell

  • Medium:
  • Temperature (°C):
  • Doubling time (min): Growth Rate(min): *
  • Growth phase: other: *

by RNA_Seq

PMID:20671182

Protein

E. coli K-12 MG1655

160

molecules/cell/generation

  • Medium: MOPS Complete
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Protein

E. coli K-12 MG1655

77

molecules/cell/generation

  • Medium: MOPS Minimal
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Protein

E. coli K-12 MG1655

118

molecules/cell/generation

  • Medium: MOPS Complete without Methionine
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Notes

Transcription and Transcriptional Regulation

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<protect>

See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

yjeFE-amiB-mutL-miaA-hfq-hflXKC

Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:4395415..4395455 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name Mutation Phenotype Reference


Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type Reference Notes

microarray

GEO Profiles:b4170 (EcoliWiki Page)

NCBI GEO profiles for mutL

microarray

GenExpDB:b4170 (EcoliWiki Page)

Summary of data for mutL from multiple microarray studies


Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name Resource Type Description Source Notes

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Notes

Accessions Related to mutL Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:EG11281

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1258

Escherichia coli str. K-12 substr. MG1655

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b4170

EcoGene

EcoGene:EG11281

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001254

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013655

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism Homologs (Statistics) Comments

Anopheles gambiae

  • ENSANGP00000014016 (score: 1.000; bootstrap: 93%)
  • ENSANGP00000013484 (score: 0.509)

From Inparanoid:20070104

Apis mellifera

  • ENSAPMP00000003921 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Arabidopsis thaliana

  • AT4G09140 (score: 1.000; bootstrap: 88%)

From Inparanoid:20070104

Bos taurus

  • ENSBTAP00000022288 (score: 1.000; bootstrap: 97%)

From Inparanoid:20070104

Caenorhabditis briggsae

  • WBGene00041694 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Caenorhabditis elegans

  • WBGene00004064 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Canis familiaris

  • ENSCAFP00000007136 (score: 1.000; bootstrap: 93%)

From Inparanoid:20070104

Ciona intestinalis

  • ENSCINP00000007598 (score: 1.000; bootstrap: 100%)
  • ENSCINP00000005453 (score: 0.056)

From Inparanoid:20070104

Danio rerio

  • ZDB-GENE-040426-1600 (score: 1.000; bootstrap: 93%)
  • ZDB-CDNA-040425-2534 (score: 1.000; bootstrap: 92%)

From Inparanoid:20070104

Dictyostelium discoideum

  • DDB0232418 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Drosophila melanogaster

  • FBgn0011659 (score: 1.000; bootstrap: 98%)

From Inparanoid:20070104

Drosophila pseudoobscura

  • GA11026-PA (score: 1.000; bootstrap: 96%)

From Inparanoid:20070104

Gallus gallus

  • ENSGALP00000019676 (score: 1.000; bootstrap: 98%)

From Inparanoid:20070104

Homo sapiens

  • ENSP00000231790 (score: 1.000; bootstrap: 93%)

From Inparanoid:20070104

Macaca mulatta

  • ENSMMUP00000029671 (score: 1.000; bootstrap: 99%)

From Inparanoid:20070104

Monodelphis domestica

  • ENSMODP00000016697 (score: 1.000; bootstrap: 96%)

From Inparanoid:20070104

Mus musculus

  • MGI:101938 (score: 1.000; bootstrap: 90%)

From Inparanoid:20070104

Oryza gramene

  • Q5JN46 (score: 1.000; bootstrap: 96%)

From Inparanoid:20070104

Pan troglodytes

  • ENSPTRP00000032283 (score: 1.000; bootstrap: 80%)

From Inparanoid:20070104

Rattus norvegicus

  • ENSRNOP00000043097 (score: 1.000; bootstrap: 86%)

From Inparanoid:20070104

Saccharomyces cerevisiae

  • YMR167W (score: 1.000; bootstrap: 97%)

From Inparanoid:20070104

Schizosaccharomyces pombe

  • SPBC17034 (score: 1.000; bootstrap: 86%)

From Inparanoid:20070104

Takifugu rubripes

  • NEWSINFRUP00000142652 (score: 1.000; bootstrap: 77%)

From Inparanoid:20070104

Tetraodon nigroviridis

  • GSTENP00029221001 (score: 1.000; bootstrap: 90%)

From Inparanoid:20070104

Xenopus tropicalis

  • ENSXETP00000010905 (score: 1.000; bootstrap: 94%)

From Inparanoid:20070104

Shigella flexneri

MUTL

From SHIGELLACYC

E. coli O157

MUTL

From ECOO157CYC


Do-It-Yourself Web Tools

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Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

Pfam (EcoliWiki Page)

PF01119 DNA mismatch repair protein, C-terminal domain

Pfam (EcoliWiki Page)

PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

Panther (EcoliWiki Page)

PTHR10073:SF12

Superfamily (EcoliWiki Page)

SUPERFAMILY:54211

Superfamily (EcoliWiki Page)

SUPERFAMILY:55874

Superfamily (EcoliWiki Page)

SUPERFAMILY:118116

Pfam (EcoliWiki Page)

PF08676 MutL C terminal dimerisation domain

EcoCyc

EcoCyc:EG11281

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11281

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001254

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1258

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013655

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.0 5.1 5.2 CGSC: The Coli Genetics Stock Center
  6. 6.0 6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
  7. 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 Junop, MS et al. (2003) In vitro and in vivo studies of MutS, MutL and MutH mutants: correlation of mismatch repair and DNA recombination. DNA Repair (Amst.) 2 387-405 PubMed

Categories

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