hisG:On One Page

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Quickview | Gene | Product(s) | Expression| Evolution | References |

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Standard Name

hisG

Gene Synonym(s)

ECK2014, b2019, JW2001[1], JW2001

Product Desc.

ATP phosphoribosyltransferase[2][3];

Component of ATP phosphoribosyltransferase[2][3]

ATP-phosphoribosyltransferase[4]

Product Synonyms(s)

ATP phosphoribosyltransferase[1], B2019[2][1], HisG[2][1] , ECK2014, JW2001, b2019

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): hisLGDCBHAFI[2]

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

hisG

Mnemonic

Histidine

Synonyms

ECK2014, b2019, JW2001[1], JW2001

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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain Map location Genome coordinates Genome browsers Sequence links

MG1655

45.01 minutes 

MG1655: 2088216..2089115
<gbrowseImage> name=NC_000913:2088216..2089115 source=MG1655 preset=GeneLocation </gbrowseImage>

REL606

NC_012967: 2020194..2021093
<gbrowseImage> name=NC_012967:2020194..2021093 source=REL606 preset=GeneLocation </gbrowseImage>

BW2952

NC_012759: 1980699..1981598
<gbrowseImage> name=NC_012759:1980699..1981598 source=BW2952 preset=GeneLocation </gbrowseImage>

W3110

 

W3110: 2092329..2093228
<gbrowseImage> name=NC_007779:2092329..2093228 source=W3110 preset=GeneLocation </gbrowseImage>

DH10B

DH10B: 2179224..2180123
<gbrowseImage> name=NC_010473:2179224..2180123 source=DH10B preset=GeneLocation </gbrowseImage>

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type Strain Genomic Location Evidence Reference Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele Nt change(s) AA change(s) Phenotype: Type Phenotype: Description Reference Availability Comments

ΔhisG (Keio:JW2001)

deletion

deletion

Auxotrophies

Requires histidine for growth

PMID:16738554

Shigen

CGSC9647[5]

hisG::Tn5KAN-2 (FB20583)

Insertion at position 466 in Minus orientation, contains pKD46

Auxotrophies

Requires Histidine for growth

PMID:15262929

E. coli Genome Project FB20575

hisG::Tn5KAN-2 (FB20583)

Insertion at position 466 in Minus orientation, does not contain pKD46

Auxotrophies

Requires Histidine for growth

PMID:15262929

E. coli Genome Project FB20576

hisG4(Oc)

Auxotrophies

Requires Histidine for growth

PMID:5324068 PMID:6450870

CGSC:4501

ochre (UAA) mutation

hisG1(Fs)

Auxotrophies

requires Histidine for growth

PMID:4934197

CGSC:4886

can't find allele in the reference provided

hisG213::Tn10

Auxotrophies

Requires Histidine for growth

CGSC:8789

ΔhisG788::kan

deletion

deletion

Auxotrophies

Requires Histidine for growth

PMID:16738554

CGSC:101370

hisG::Tn5KAN-2 (FB20576)

Insertion at nt 466 in Minus orientation

PMID:15262929

E. coli Genome Project:FB20576

does not contain pKD46

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Notes

Genetic Interactions

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Interactor Interaction Allele Score(s) Reference(s) Accessions Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource Resource Type Source Notes/Reference

JW2001

Plasmid clone

Shigen

PMID:16769691

Status:Clone OK

Primer 1:GCCACAGACAACACTCGTTTACG

Primer 2:CCtTCCATCATCTTCTCAATCGG

6D9

Kohara Phage

Genobase

PMID:3038334

zef-3129::Tn10

Linked marker

CAG12099 = CGSC7397[5]

est. P1 cotransduction: 85% [6]
Synonyms:zee-3129::Tn10

zbd-3104::Tn10

Linked marker

CAG12021 = CGSC7344[5]

est. P1 cotransduction: % [6]
Synonyms:zbc-3105::Tn10, zbd-3105::Tn10

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:EG10449

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10449

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000442

Escherichia coli str. K-12 substr. MG1655

NCBI (EcoliWiki Page)

GeneID:946549

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0444

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006713

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

HisG

Synonyms

ATP phosphoribosyltransferase[1], B2019[2][1], HisG[2][1] , ECK2014, JW2001, b2019

Product description

ATP phosphoribosyltransferase[2][3];

Component of ATP phosphoribosyltransferase[2][3]

ATP-phosphoribosyltransferase[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status

GO:0000105

histidine biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00079

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001348

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013115

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013820

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020621

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0368

P

Seeded from EcoCyc (v14.0)

complete

GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00079

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013115

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460

F

Seeded from EcoCyc (v14.0)

complete

GO:0003879

ATP phosphoribosyltransferase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00079

F

Seeded from EcoCyc (v14.0)

complete

GO:0003879

ATP phosphoribosyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001348

F

Seeded from EcoCyc (v14.0)

complete

GO:0003879

ATP phosphoribosyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013115

F

Seeded from EcoCyc (v14.0)

complete

GO:0003879

ATP phosphoribosyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013820

F

Seeded from EcoCyc (v14.0)

complete

GO:0003879

ATP phosphoribosyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020621

F

Seeded from EcoCyc (v14.0)

complete

GO:0003879

ATP phosphoribosyltransferase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.4.2.17

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00079

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013115

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013820

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of ATP phosphoribosyltransferase

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MTDNTRLRIA MQKSGRLSDD SRELLARCGI KINLHTQRLI AMAENMPIDI LRVRDDDIPG
LVMDGVVDLG IIGENVLEEE LLNRRAQGED PRYFTLRRLD FGGCRLSLAT PVDEAWDGPL
SLNGKRIATS YPHLLKRYLD QKGISFKSCL LNGSVEVAPR AGLADAICDL VSTGATLEAN
GLREVEVIYR SKACLIQRDG EMEESKQQLI DKLLTRIQGV IQARESKYIM MHAPTERLDE
VIALLPGAER PTILPLAGDQ QRVAMHMVSS ETLFWETMEK LKALGASSIL VLPIEKMME
Length

299

Mol. Wt

33.367 kDa

pI

5.4 (calculated)

Extinction coefficient

18,450 - 19,075 (calc based on 5 Y, 2 W, and 5 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

53..221

PF01634 ATP phosphoribosyltransferase

PMID:19920124

Domain

222..297

PF08029 HisG, C-terminal domain

PMID:19920124

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=hisG taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129960

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946549

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006713

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P60757

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10449

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10449

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946549

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000442

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0444

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

Molecule Organism or Strain Value Units Experimental Conditions Assay used Notes Reference(s)

Protein

E. coli K-12 MC4100

6.40E+02

molecules/cell

  • Medium: median data from rich and minimal media
  • Temperature (°C): 37
  • Doubling time (min): Growth Rate(min):
  • Growth phase: other:

emPAI

PMID:18304323

Protein

E. coli K-12 MG1655

2848

molecules/cell/generation

  • Medium: MOPS Complete
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Protein

E. coli K-12 MG1655

2567

molecules/cell/generation

  • Medium: MOPS Minimal
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Protein

E. coli K-12 MG1655

2659

molecules/cell/generation

  • Medium: MOPS Complete without Methionine
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

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Notes

Transcription and Transcriptional Regulation

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<protect>

See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

hisLGDCBHAFI

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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:2088196..2088236 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name Mutation Phenotype Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type Reference Notes

microarray

GEO Profiles:b2019 (EcoliWiki Page)

NCBI GEO profiles for hisG

microarray

GenExpDB:b2019 (EcoliWiki Page)

Summary of data for hisG from multiple microarray studies

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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name Resource Type Description Source Notes
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Notes

Accessions Related to hisG Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:EG10449

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0444

Escherichia coli str. K-12 substr. MG1655

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b2019

EcoGene

EcoGene:EG10449

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000442

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006713

Escherichia coli str. K-12 substr. MG1655

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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism Homologs (Statistics) Comments

Apis mellifera

  • ENSAPMP00000022248 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Arabidopsis thaliana

  • AT1G09795 (score: 1.000; bootstrap: 100%)
  • AT1G58080 (score: 0.770)

From Inparanoid:20070104

Saccharomyces cerevisiae

  • YER055C (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Schizosaccharomyces pombe

  • SPAC25G105c (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Shigella flexneri

HISG

From SHIGELLACYC

E. coli O157

HISG

From ECOO157CYC

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Do-It-Yourself Web Tools

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Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

Pfam (EcoliWiki Page)

PF01634 ATP phosphoribosyltransferase

Superfamily (EcoliWiki Page)

SUPERFAMILY:53850

Panther (EcoliWiki Page)

PTHR21403:SF0

Superfamily (EcoliWiki Page)

SUPERFAMILY:54913

Pfam (EcoliWiki Page)

PF08029 HisG, C-terminal domain

EcoCyc

EcoCyc:EG10449

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10449

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000442

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0444

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006713

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 CGSC: The Coli Genetics Stock Center
  6. ↑ 6.0 6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

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