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Gene |

Product(s) |

Expression|

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Standard Name	gpr
Gene Synonym(s)	ECK2995, b3001, JW2970, mgrA, yghZ^[1], mgrA, yghZ
Product Desc.	methylglyoxal reductase^[2]^[3] l-Glyceraldehyde 3-phosphate reductase, NADPH-dependent; weak methylglyoxal reductase; overexpression confers increased resistance to methylglyoxal; aldo-keto reductase^[4]
Product Synonyms(s)	aldo-keto reductase^[1], B3001^[2]^[1], MgrA^[2]^[1], Gpr^[2]^[1] , ECK2995, JW2970, mgrA, yghZ, b3001
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): gpr^[2]
Regulation/Activity
Quick Links
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Notes

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AKR14 family.^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	gpr
Mnemonic
Synonyms	ECK2995, b3001, JW2970, mgrA, yghZ^[1], mgrA, yghZ
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	67.8 minutes	MG1655: 3145919..3146959 <gbrowseImage> name=NC_000913:3145919..3146959 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 3082069..3083109 <gbrowseImage> name=NC_012967:3082069..3083109 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 3033067..3034107 <gbrowseImage> name=NC_012759:3033067..3034107 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 3146553..3147593 <gbrowseImage> name=NC_007779:3146553..3147593 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 3243664..3244704 <gbrowseImage> name=NC_010473:3243664..3244704 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability
ΔyghZ (Keio:JW2970)	deletion	deletion	PMID:16738554	Shigen CGSC10282^[5]
ΔyghZ775::kan			PMID:16738554	CGSC:105038
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW2970	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCGTCTGGTTAGCGAATCCCGA Primer 2:CCTTTATCGGAAGACGCCTGCCA
5C10	Kohara Phage	Genobase	PMID:3038334
nupG511::Tn10	Linked marker	CAG18472 = CGSC7433^[5]	est. P1 cotransduction: 16% ^[6]
metC162::Tn10	Linked marker	CAG18475 = CGSC7435^[5]	est. P1 cotransduction: 86% ^[6]
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G7558	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2831	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b3001
ECOL199310CYC (EcoliWiki Page)	ECOL199310CYC:C3737
EcoGene	EcoGene:EG13010	Escherichia coli str. K-12 substr. MG1655
ECOO157CYC (EcoliWiki Page)	ECOO157CYC:Z4354
ASAP	ASAP:ABE-0009848	Escherichia coli str. K-12 substr. MG1655
EcoCyc (EcoliWiki Page)	ECOCYC:G7558	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:947480	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120004118	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	Gpr
Synonyms	aldo-keto reductase^[1], B3001^[2]^[1], MgrA^[2]^[1], Gpr^[2]^[1] , ECK2995, JW2970, mgrA, yghZ, b3001
Product description	methylglyoxal reductase^[2]^[3] l-Glyceraldehyde 3-phosphate reductase, NADPH-dependent; weak methylglyoxal reductase; overexpression confers increased resistance to methylglyoxal; aldo-keto reductase^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0006813	potassium ion transport	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005399	P	Seeded from EcoCyc (v14.0)	complete
	GO:0055085	transmembrane transport	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005399	P	Seeded from EcoCyc (v14.0)	complete
	GO:0055114	oxidation reduction	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001395	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006974	response to DNA damage stimulus	PMID:11967071	IEP: Inferred from Expression Pattern		P		complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	groL	PMID:16606699	Experiment(s):EBI-1144533
Protein	yfbN	PMID:19402753	LCMS(ID Probability):99.2
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MVWLANPERY GQMQYRYCGK SGLRLPALSL GLWHNFGHVN ALESQRAILR KAFDLGITHF DLANNYGPPP GSAEENFGRL LREDFAAYRD ELIISTKAGY DMWPGPYGSG GSRKYLLASL DQSLKRMGLE YVDIFYSHRV DENTPMEETA SALAHAVQSG KALYVGISSY SPERTQKMVE LLREWKIPLL IHQPSYNLLN RWVDKSGLLD TLQNNGVGCI AFTPLAQGLL TGKYLNGIPQ DSRMHREGNK VRGLTPKMLT EANLNSLRLL NEMAQQRGQS MAQMALSWLL KDDRVTSVLI GASRAEQLEE NVQALNNLTF STKELAQIDQ HIADGELNLW QASSDK
Length	346
Mol. Wt	38.833 kDa
pI	7.2 (calculated)
Extinction coefficient	59,360 - 59,610 (calc based on 14 Y, 7 W, and 2 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	27..333	PF00248 Aldo/keto reductase family		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=yghZ taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16130899	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:947480	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0009848	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:Q46851	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G7558	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13010	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:947480	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120004118	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2831	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MG1655	83	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	114	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	21^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
yghZ
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:3145899..3145939 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b3001 (EcoliWiki Page)	NCBI GEO profiles for yghZ
microarray	GenExpDB:b3001 (EcoliWiki Page)	Summary of data for yghZ from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to gpr Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G7558	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2831	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b3001
EcoGene	EcoGene:EG13010	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120004118	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0009848	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Anopheles gambiae	ENSANGP00000006086 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Apis mellifera	ENSAPMP00000017335 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Arabidopsis thaliana	AT1G04690 (score: 1.000; bootstrap: 98%)	From Inparanoid:20070104
Bos taurus	ENSBTAP00000024576 (score: 1.000; bootstrap: 97%) ENSBTAP00000010684 (score: 0.725) ENSBTAP00000019888 (score: 0.450)	From Inparanoid:20070104
Canis familiaris	ENSCAFP00000028868 (score: 1.000; bootstrap: 98%) ENSCAFP00000013013 (score: 0.584) ENSCAFP00000024848 (score: 0.523)	From Inparanoid:20070104
Ciona intestinalis	ENSCINP00000005427 (score: 1.000; bootstrap: 97%)	From Inparanoid:20070104
Danio rerio	ZDB-GENE-050327-79 (score: 1.000; bootstrap: 99%) ZDB-CDNA-050327-79 (score: 1.000; bootstrap: 98%) ZDB-CDNA-050612-257 (score: 0.671)	From Inparanoid:20070104
Drosophila melanogaster	FBgn0001203 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Drosophila pseudoobscura	GA17075-PA (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Gallus gallus	ENSGALP00000001339 (score: 1.000; bootstrap: 99%) ENSGALP00000032335 (score: 0.607)	From Inparanoid:20070104
Homo sapiens	ENSP00000340824 (score: 1.000; bootstrap: 99%) ENSP00000273475 (score: 0.704) ENSP00000302719 (score: 0.604)	From Inparanoid:20070104
Macaca mulatta	ENSMMUP00000022317 (score: 1.000; bootstrap: 96%) ENSMMUP00000022138 (score: 0.549)	From Inparanoid:20070104
Monodelphis domestica	ENSMODP00000019658 (score: 1.000; bootstrap: 99%) ENSMODP00000007916 (score: 0.673) ENSMODP00000009371 (score: 0.589)	From Inparanoid:20070104
Mus musculus	MGI:109239 (score: 1.000; bootstrap: 99%) MGI:109155 (score: 0.734) MGI:1336208 (score: 0.289)	From Inparanoid:20070104
Oryza gramene	Q6K697 (score: 1.000; bootstrap: 99%) Q40648 (score: 0.744)	From Inparanoid:20070104
Pan troglodytes	ENSPTRP00000014856 (score: 1.000; bootstrap: 99%) ENSPTRP00000026786 (score: 1.000; bootstrap: 98%) ENSPTRP00000044762 (score: 1.000; bootstrap: 99%)	From Inparanoid:20070104
Rattus norvegicus	ENSRNOP00000015840 (score: 1.000; bootstrap: 99%) ENSRNOP00000051084 (score: 0.734) ENSRNOP00000011523 (score: 0.595)	From Inparanoid:20070104
Schizosaccharomyces pombe	SPCC9656 (score: 1.000; bootstrap: 97%)	From Inparanoid:20070104
Takifugu rubripes	NEWSINFRUP00000167043 (score: 1.000; bootstrap: 99%) NEWSINFRUP00000159386 (score: 0.582) NEWSINFRUP00000155538 (score: 0.582) NEWSINFRUP00000133544 (score: 0.535) NEWSINFRUP00000159387 (score: 0.376)	From Inparanoid:20070104
Tetraodon nigroviridis	GSTENP00019063001 (score: 1.000; bootstrap: 99%) GSTENP00003421001 (score: 0.393) GSTENP00027578001 (score: 0.335) GSTENP00028447001 (score: 0.149) GSTENP00004469001 (score: 0.068)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000006343 (score: 1.000; bootstrap: 100%) ENSXETP00000019882 (score: 0.573) ENSXETP00000026821 (score: 0.558)	From Inparanoid:20070104
Shigella flexneri	S3249	From SHIGELLACYC
E. coli O157	Z4354	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF00248 Aldo/keto reductase family
Superfamily (EcoliWiki Page)	SUPERFAMILY:51430
Panther (EcoliWiki Page)	PTHR11732:SF14
EcoCyc	EcoCyc:G7558	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13010	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120004118	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2831	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0009848	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

gpr:On One Page

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Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to gpr Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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