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Gene |

Product(s) |

Expression|

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Standard Name	galT
Gene Synonym(s)	ECK0747, b0758, JW0741, galB^[1], galB
Product Desc.	GalT^[2]^[3]; Component of GALACTURIDYLYLTRANS-CPLX^[2] Galactose-1-phosphate uridylyltransferase; Rob regulon, repressed^[4]
Product Synonyms(s)	galactose-1-phosphate uridylyltransferase^[1], B0758^[2]^[1], GalB^[2]^[1], GalT^[2]^[1] , ECK0747, galB, JW0741, b0758
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): galETKM^[2], OP00032, galETK
Regulation/Activity
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	galT
Mnemonic	Galactose
Synonyms	ECK0747, b0758, JW0741, galB^[1], galB
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	17.01 minutes	MG1655: 790252..789206 <gbrowseImage> name=NC_000913:789206..790252 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 771658..770612 <gbrowseImage> name=NC_012967:770612..771658 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 692174..693220 <gbrowseImage> name=NC_012759:692174..693220 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 791451..790405 <gbrowseImage> name=NC_007779:790405..791451 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 844180..843134 <gbrowseImage> name=NC_010473:843134..844180 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
Coding Start (SO:0000323)	MG1655	789209	Edman degradation	PMID:384209
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Description	Reference	Availability	Comments
ΔgalT (Keio:JW0741)	deletion	deletion		PMID:16738554	Shigen CGSC8804^[5]
galTC160S,A		C160S,A	Slight inhibition of enzymatic activity			seeded from UniProt:P09148
galTS161A		S161A	7000-fold reduction in specific activity			seeded from UniProt:P09148
galTH166G		H166G	Abolishes enzymatic activity			seeded from UniProt:P09148
galT22					CGSC:4537
galT23					CGSC:5507
galT118					CGSC:7946
galT12					CGSC:8234
galT27					CGSC:8462
galT1					CGSC:9855
galT47					CGSC:11992
ΔgalT730::kan				PMID:16738554	CGSC:101088
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW0741	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCACGCAATTTAATCCCGTTGA Primer 2:CCCACTCCGGATTCGCGAAAATG
4H1	Kohara Phage	Genobase	PMID:3038334
nadA57::Tn10	Linked marker	CAG12147 = CGSC7351^[5]	est. P1 cotransduction: 72% ^[6]
zbh-29::Tn10	Linked marker	CAG18493 = CGSC7353^[5]	est. P1 cotransduction: 28% ^[6] Synonyms:zbi-29::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10366	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10366	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000359	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:945357	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0361	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0002573	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	GalT
Synonyms	galactose-1-phosphate uridylyltransferase^[1], B0758^[2]^[1], GalB^[2]^[1], GalT^[2]^[1] , ECK0747, galB, JW0741, b0758
Product description	GalT^[2]^[3]; Component of GALACTURIDYLYLTRANS-CPLX^[2] Galactose-1-phosphate uridylyltransferase; Rob regulon, repressed^[4]
EC number (for enzymes)	2.7.7.10^[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0006012	galactose metabolic process	PMID:13914787	IMP: Inferred from Mutant Phenotype		P	Seeded from EcoCyc (v14.0)	complete
	GO:0008108	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001937	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008108	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005849	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008108	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005850	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008108	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019779	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008108	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	GOA:spec GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.7.12	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008270	zinc ion binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001937	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008270	zinc ion binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019779	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008270	zinc ion binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0862	F	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of GALACTURIDYLYLTRANS-CPLX	could be indirect
Protein	nadE		PMID:16606699	Experiment(s):EBI-1137877
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MTQFNPVDHP HRRYNPLTGQ WILVSPHRAK RPWQGAQETP AKQVLPAHDP DCFLCAGNVR VTGDKNPDYT GTYVFTNDFA ALMSDTPDAP ESHDPLMRCQ SARGTSRVIC FSPDHSKTLP ELSVAALTEI VKTWQEQTAE LGKTYPWVQV FENKGAAMGC SNPHPHGQIW ANSFLPNEAE REDRLQKEYF AEQKSPMLVD YVQRELADGS RTVVETEHWL AVVPYWAAWP FETLLLPKAH VLRITDLTDA QRSDLALALK KLTSRYDNLF QCSFPYSMGW HGAPFNGEEN QHWQLHAHFY PPLLRSATVR KFMVGYEMLA ETQRDLTAEQ AAERLRAVSD IHFRESGV
Length	348
Mol. Wt	39.644 kDa
pI	6.5 (calculated)
Extinction coefficient	71,390 - 72,140 (calc based on 11 Y, 10 W, and 6 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	References
Domain	182..347	PF02744 Galactose-1-phosphate uridyl transferase, C-terminal domain	PMID:19920124
Domain	2..176	PF01087 Galactose-1-phosphate uridyl transferase, N-terminal domain	PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=galT taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16128726	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:945357	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0002573	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P09148	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG10366	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10366	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:945357	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000359	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0361	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MC4100	2.12E+02	molecules/cell	Medium: median data from rich and minimal media Temperature (°C): 37 Doubling time (min): Growth Rate(min): Growth phase: other:	emPAI	PMID:18304323
Protein	E. coli K-12 MG1655	335	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	135	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	163	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
galETKM
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:790232..790272 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b0758 (EcoliWiki Page)	NCBI GEO profiles for galT
microarray	GenExpDB:b0758 (EcoliWiki Page)	Summary of data for galT from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to galT Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10366	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0361	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b0758
EcoGene	EcoGene:EG10366	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000359	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0002573	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Anopheles gambiae	ENSANGP00000017622 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Apis mellifera	ENSAPMP00000007384 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Arabidopsis thaliana	AT5G18200 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Bos taurus	ENSBTAP00000020997 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Caenorhabditis briggsae	WBGene00026433 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Caenorhabditis elegans	WBGene00014203 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Canis familiaris	ENSCAFP00000002867 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Drosophila melanogaster	FBgn0031845 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Drosophila pseudoobscura	GA21629-PA (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Gallus gallus	ENSGALP00000003412 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Homo sapiens	ENSP00000319899 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Macaca mulatta	ENSMMUP00000027360 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Monodelphis domestica	ENSMODP00000009839 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Mus musculus	MGI:95638 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Oryza gramene	Q69LB9 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Pan troglodytes	ENSPTRP00000035725 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Rattus norvegicus	ENSRNOP00000019886 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Saccharomyces cerevisiae	YBR018C (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Schizosaccharomyces pombe	SPBPB2B20c (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Takifugu rubripes	NEWSINFRUP00000133840 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Tetraodon nigroviridis	GSTENP00008246001 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000028909 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Shigella flexneri	GALT	From SHIGELLACYC
E. coli O157	GALT	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF02744 Galactose-1-phosphate uridyl transferase, C-terminal domain
Pfam (EcoliWiki Page)	PF01087 Galactose-1-phosphate uridyl transferase, N-terminal domain
Panther (EcoliWiki Page)	PTHR11943:SF0
Superfamily (EcoliWiki Page)	SUPERFAMILY:54197
Superfamily (EcoliWiki Page)	SUPERFAMILY:54197
EcoCyc	EcoCyc:EG10366	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10366	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000359	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0361	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0002573	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

galT:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to galT Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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