fbp:On One Page

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Quickview | Gene | Product(s) | Expression| Evolution | References |

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Standard Name

fbp

Gene Synonym(s)

ECK4227, b4232, JW4191, fdp[1], fdp

Product Desc.

fructose 1,6 bisphosphatase monomer[2]; fructose-1,6-bisphosphatase monomer[3];

Component of fructose 1,6 bisphosphatase[2]; fructose-1,6-bisphosphatase I[3]

Fructose-1,6-bisphosphatase; allosteric: inhibited by AMP[4]

Product Synonyms(s)

fructose-1,6-bisphosphatase I[1], B4232[2][1], Fdp[2][1], Fbp[2][1] , ECK4227, fdp, JW4191, b4232

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): fbp[2]

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

fbp

Mnemonic

Fructose-bisphosphatase

Synonyms

ECK4227, b4232, JW4191, fdp[1], fdp

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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain Map location Genome coordinates Genome browsers Sequence links

MG1655

95.97 minutes, 95.97 minutes 

MG1655: 4453632..4452634
<gbrowseImage> name=NC_000913:4452634..4453632 source=MG1655 preset=GeneLocation </gbrowseImage>

REL606

NC_012967: 4438859..4437861
<gbrowseImage> name=NC_012967:4437861..4438859 source=REL606 preset=GeneLocation </gbrowseImage>

BW2952

NC_012759: 4391369..4392367
<gbrowseImage> name=NC_012759:4391369..4392367 source=BW2952 preset=GeneLocation </gbrowseImage>

W3110

 

W3110: 4460289..4459291
<gbrowseImage> name=NC_007779:4459291..4460289 source=W3110 preset=GeneLocation </gbrowseImage>

DH10B

DH10B: 4555440..4554442
<gbrowseImage> name=NC_010473:4554442..4555440 source=DH10B preset=GeneLocation </gbrowseImage>

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type Strain Genomic Location Evidence Reference Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele Nt change(s) AA change(s) Phenotype: Type Phenotype: Description Reference Availability Comments

Δfbp (Keio:JW4191)

deletion

deletion

PMID:16738554

Shigen
CGSC11014[5]

Δfbp::kan

deletion

Biolog:respiration

unable to respire Glycerol

PMID:16095938

Δfbp::kan

deletion

Biolog:respiration

unable to respire D-Galactoniate

PMID:16095938

Δfbp::kan

deletion

Biolog:respiration

unable to respire D-Glucuronate

PMID:16095938

Δfbp::kan

deletion

Biolog:respiration

unable to respire Acetate

PMID:16095938

Δfbp::kan

deletion

Biolog:respiration

unable to respire a-Ketoglutarate

PMID:16095938

Δfbp::kan

deletion

Biolog:respiration

unable to respire Succinate

PMID:16095938

Δfbp::kan

deletion

Biolog:respiration

unable to respire L-Alanine

PMID:16095938

Δfbp::kan

deletion

Biolog:respiration

unable to respire L-Alanyl-glycine

PMID:16095938

Δfbp::kan

deletion

Biolog:respiration

unable to respire L-Asparagine

PMID:16095938

Δfbp::kan

deletion

Biolog:respiration

unable to respire L-Aspartate

PMID:16095938

Δfbp::kan

deletion

Biolog:respiration

unable to respire L-Serine

PMID:16095938

Δfbp-287

CGSC:11279

fbp-5

CGSC:11723

Δfbp-779::kan

PMID:16738554

CGSC:100792


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Notes

Genetic Interactions

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Interactor Interaction Allele Score(s) Reference(s) Accessions Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource Resource Type Source Notes/Reference

JW4191

Plasmid clone

Shigen

PMID:16769691

Status:Clone OK

Primer 1:GCCAAAACGTTAGGTGAATTTAT

Primer 2:CCgGCGTCCGGGAACTCACGGAT

E1H3

Kohara Phage

Genobase

PMID:3038334

zjf-920::Tn10

Linked marker

CAG12019 = CGSC7484[5]

est. P1 cotransduction: 77% [6]
Synonyms:zjh-901::Tn10, zjg-920::Tn10

mdoB202::Tn10

Linked marker

CAG18430 = CGSC7488[5]

est. P1 cotransduction: % [6]
Synonyms:zjj-202::Tn10, zji-202::Tn10

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:EG10283

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10283

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000277

Escherichia coli str. K-12 substr. MG1655

NCBI (EcoliWiki Page)

GeneID:948753

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0279

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013842

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Fbp

Synonyms

fructose-1,6-bisphosphatase I[1], B4232[2][1], Fdp[2][1], Fbp[2][1] , ECK4227, fdp, JW4191, b4232

Product description

fructose 1,6 bisphosphatase monomer[2]; fructose-1,6-bisphosphatase monomer[3];

Component of fructose 1,6 bisphosphatase[2]; fructose-1,6-bisphosphatase I[3]

Fructose-1,6-bisphosphatase; allosteric: inhibited by AMP[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status

GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01855

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0042132

fructose 1,6-bisphosphate 1-phosphatase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01855

F

Seeded from EcoCyc (v14.0)

complete

GO:0042132

fructose 1,6-bisphosphate 1-phosphatase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.1.3.11

F

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of fructose 1,6 bisphosphatase

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKTLGEFIVE KQHEFSHATG ELTALLSAIK LGAKIIHRDI NKAGLVDILG ASGAENVQGE
VQQKLDLFAN EKLKAALKAR DIVAGIASEE EDEIVVFEGC EHAKYVVLMD PLDGSSNIDV
NVSVGTIFSI YRRVTPVGTP VTEEDFLQPG NKQVAAGYVV YGSSTMLVYT TGCGVHAFTY
DPSLGVFCLC QERMRFPEKG KTYSINEGNY IKFPNGVKKY IKFCQEEDKS TNRPYTSRYI
GSLVADFHRN LLKGGIYLYP STASHPDGKL RLLYECNPMA FLAEQAGGKA SDGKERILDI
IPETLHQRRS FFVGNDHMVE DVERFIREFP DA
Length

332

Mol. Wt

36.834 kDa

pI

5.8 (calculated)

Extinction coefficient

20,860 - 21,610 (calc based on 14 Y, 0 W, and 6 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

2..329

PF00316 Fructose-1-6-bisphosphatase

PMID:19920124

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=fbp taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16132054

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948753

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013842

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A993

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10283

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10283

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948753

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000277

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0279

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

Molecule Organism or Strain Value Units Experimental Conditions Assay used Notes Reference(s)

Protein

E. coli K-12 MG1655

5367

molecules/cell/generation

  • Medium: MOPS Complete
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Protein

E. coli K-12 MG1655

1028

molecules/cell/generation

  • Medium: MOPS Minimal
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Protein

E. coli K-12 MG1655

3390

molecules/cell/generation

  • Medium: MOPS Complete without Methionine
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

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Notes

Transcription and Transcriptional Regulation

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<protect>

See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

fbp

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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:4453612..4453652 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name Mutation Phenotype Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type Reference Notes

microarray

GEO Profiles:b4232 (EcoliWiki Page)

NCBI GEO profiles for fbp

microarray

GenExpDB:b4232 (EcoliWiki Page)

Summary of data for fbp from multiple microarray studies

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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name Resource Type Description Source Notes
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Notes

Accessions Related to fbp Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:EG10283

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0279

Escherichia coli str. K-12 substr. MG1655

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b4232

EcoGene

EcoGene:EG10283

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000277

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013842

Escherichia coli str. K-12 substr. MG1655

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Notes

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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism Homologs (Statistics) Comments

Anopheles gambiae

  • ENSANGP00000016841 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Apis mellifera

  • ENSAPMP00000022879 (score: 1.000; bootstrap: 90%)

From Inparanoid:20070104

Arabidopsis thaliana

  • AT1G43670 (score: 1.000; bootstrap: 98%)
  • AT3G54050 (score: 0.105)

From Inparanoid:20070104

Bos taurus

  • ENSBTAP00000012835 (score: 1.000; bootstrap: 100%)
  • ENSBTAP00000026056 (score: 0.629)

From Inparanoid:20070104

Caenorhabditis briggsae

  • WBGene00026892 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Caenorhabditis elegans

  • WBGene00001404 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Canis familiaris

  • ENSCAFP00000001871 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Danio rerio

  • ZDB-GENE-040822-23 (score: 1.000; bootstrap: 100%)
  • ZDB-CDNA-040822-23 (score: 1.000; bootstrap: 100%)
  • ZDB-CDNA-040425-1587 (score: 0.560)
  • ZDB-GENE-030131-7171 (score: 0.560)
  • ZDB-CDNA-040425-3092 (score: 0.541)
  • ZDB-GENE-021206-11 (score: 0.541)

From Inparanoid:20070104

Dictyostelium discoideum

  • DDB0216231 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Drosophila melanogaster

  • FBgn0032820 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Drosophila pseudoobscura

  • GA16400-PA (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Gallus gallus

  • ENSGALP00000020563 (score: 1.000; bootstrap: 100%)
  • ENSGALP00000020562 (score: 0.647)

From Inparanoid:20070104

Homo sapiens

  • ENSP00000253266 (score: 1.000; bootstrap: 100%)
  • ENSP00000253269 (score: 0.641)

From Inparanoid:20070104

Macaca mulatta

  • ENSMMUP00000029667 (score: 1.000; bootstrap: 100%)
  • ENSMMUP00000029668 (score: 0.342)

From Inparanoid:20070104

Monodelphis domestica

  • ENSMODP00000003412 (score: 1.000; bootstrap: 100%)
  • ENSMODP00000003429 (score: 0.664)

From Inparanoid:20070104

Mus musculus

  • MGI:95491 (score: 1.000; bootstrap: 100%)
  • MGI:95492 (score: 0.613)

From Inparanoid:20070104

Oryza gramene

  • O64421 (score: 1.000; bootstrap: 99%)
  • Q5N9E2 (score: 1.000; bootstrap: 99%)
  • Q9SDL8 (score: 0.997)
  • Q43139 (score: 0.851)
  • Q75HX2 (score: 0.813)
  • Q94JN1 (score: 0.154)
  • P09195 (score: 0.119)
  • Q7G5R1 (score: 0.109)
  • O64422 (score: 0.109)

From Inparanoid:20070104

Pan troglodytes

  • ENSPTRP00000036128 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Rattus norvegicus

  • ENSRNOP00000023865 (score: 1.000; bootstrap: 100%)
  • ENSRNOP00000023685 (score: 0.339)

From Inparanoid:20070104

Saccharomyces cerevisiae

  • YLR377C (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Schizosaccharomyces pombe

  • SPBC11984c (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Takifugu rubripes

  • NEWSINFRUP00000139771 (score: 1.000; bootstrap: 100%)
  • NEWSINFRUP00000168356 (score: 0.515)

From Inparanoid:20070104

Tetraodon nigroviridis

  • GSTENP00025164001 (score: 1.000; bootstrap: 100%)
  • GSTENP00029094001 (score: 0.719)
  • GSTENP00029093001 (score: 0.552)

From Inparanoid:20070104

Xenopus tropicalis

  • ENSXETP00000038177 (score: 1.000; bootstrap: 71%)
  • ENSXETP00000038182 (score: 0.435)
  • ENSXETP00000005220 (score: 0.415)
  • ENSXETP00000005238 (score: 0.373)

From Inparanoid:20070104

Shigella flexneri

FBP

From SHIGELLACYC

E. coli O157

FBP

From ECOO157CYC

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Do-It-Yourself Web Tools

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Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

Pfam (EcoliWiki Page)

PF00316 Fructose-1-6-bisphosphatase

Superfamily (EcoliWiki Page)

SUPERFAMILY:56655

EcoCyc

EcoCyc:EG10283

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10283

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000277

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0279

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013842

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 CGSC: The Coli Genetics Stock Center
  6. ↑ 6.0 6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

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