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On One Page

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Gene |

Product(s) |

Expression|

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Standard Name	cvrA
Gene Synonym(s)	ECK1179, b1191, JW5184, ycgO^[1], ycgO
Product Desc.	YcgO CPA1 Transporter^[2]^[3] Required for growth at low osmolarity; similar to eukaryotic Na+/H+ exchangers, but not involved in Na+ extrusion; proposed to be involved in the regulation of cell volume^[4]
Product Synonyms(s)	predicted cation/proton antiporter^[1], B1191^[2]^[1], CvrA^[2]^[1], YcgO^[2]^[1] , ECK1179, JW5184, ycgO, b1191
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): cvrA^[2]
Regulation/Activity
Quick Links
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	cvrA
Mnemonic	Cell volume regulation
Synonyms	ECK1179, b1191, JW5184, ycgO^[1], ycgO
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	26.72 minutes	MG1655: 1241294..1239558 <gbrowseImage> name=NC_000913:1239558..1241294 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 1240485..1242221 <gbrowseImage> name=NC_012967:1240485..1242221 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 1128279..1130015 <gbrowseImage> name=NC_012759:1128279..1130015 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 1243648..1241912 <gbrowseImage> name=NC_007779:1241912..1243648 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 1281535..1279799 <gbrowseImage> name=NC_010473:1279799..1281535 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
ΔcvrA (Keio:JW5184)	deletion	deletion			PMID:16738554	Shigen
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW5184	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCGATGCCACAACAATAATTAG Primer 2:CCAGATTCAGCTTCCTCTTCAGC
11G8	Kohara Phage	Genobase	PMID:3038334
7C10	Kohara Phage	Genobase	PMID:3038334
fadR13::Tn10	Linked marker	CAG18497 = CGSC7365^[5]	est. P1 cotransduction: 84% ^[6]
oppC506::Tn10	Linked marker	CAG12169 = CGSC7369^[5]	est. P1 cotransduction: 3% ^[6] Synonyms:zch-506::Tn10, zci-506::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G6620	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13896	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003215	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:945755	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3655	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003999	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	CvrA
Synonyms	predicted cation/proton antiporter^[1], B1191^[2]^[1], CvrA^[2]^[1], YcgO^[2]^[1] , ECK1179, JW5184, ycgO, b1191
Product description	YcgO CPA1 Transporter^[2]^[3] Required for growth at low osmolarity; similar to eukaryotic Na+/H+ exchangers, but not involved in Na+ extrusion; proposed to be involved in the regulation of cell volume^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MLAGVDGVGG IPFDNYPFAY MVSNLALAII LLDGGMRTQA SSFRVALGPA LSLATLGVLI TSGLTGMMAA WLFNLDLIEG LLIGAIVGST DAAAVFSLLG GKGLNERVGS TLEIESGSND PMAVFLTITL IAMIQHHESN ISWMFIVDIL QQFGLGIVIG LGGGYLLLQM INRIALPAGL YPLLALSGGI LIFSLTTALE GSGILAVYLC GFLLGNRPIR NRYGILQNFD GLAWLAQIAM FLVLGLLVNP SDLLPIAIPA LILSAWMIFF ARPLSVFAGL LPFRGFNLRE RVFISWVGLR GAVPIILAVF PMMAGLENAR LFFNVAFFVV LVSLLLQGTS LSWAAKKAKV VVPPVGRPVS RVGLDIHPEN PWEQFVYQLS ADKWCVGAAL RDLHMPKETR IAALFRDNQL LHPTGSTRLR EGDVLCVIGR ERDLPALGKL FSQSPPVALD QRFFGDFILE ASAKYADVAL IYGLEDGREY RDKQQTLGEI VQQLLGAAPV VGDQVEFAGM IWTVAEKEDN EVLKIGVRVA EEEAES
Length	536
Mol. Wt	57.911 kDa
pI	5.1 (calculated)
Extinction coefficient	64,400 - 64,775 (calc based on 10 Y, 9 W, and 3 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	References
Domain	492..573	PF03471 Transporter associated domain	PMID:19920124
Domain	10..389	PF00999 Sodium/hydrogen exchanger family	PMID:19920124
Domain	417..484	PF02080 TrkA-C domain	PMID:19920124
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<motif_map/>

Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=cvrA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:90111230	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:945755	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003999	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P76007	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G6620	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13896	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:945755	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003215	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3655	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MG1655	66	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	55	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	31	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
cvrA
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:1241274..1241314 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b1191 (EcoliWiki Page)	NCBI GEO profiles for cvrA
microarray	GenExpDB:b1191 (EcoliWiki Page)	Summary of data for cvrA from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to cvrA Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G6620	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3655	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b1191
EcoGene	EcoGene:EG13896	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003215	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003999	Escherichia coli str. K-12 substr. MG1655
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Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Apis mellifera	ENSAPMP00000020875 (score: 1.000; bootstrap: 100%) ENSAPMP00000011331 (score: 0.164)	From Inparanoid:20070104
Schizosaccharomyces pombe	SPAC15A106 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Shigella flexneri	S1269	From SHIGELLACYC
E. coli O157	Z1954	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF00999 Sodium/hydrogen exchanger family
Pfam (EcoliWiki Page)	PF03471 Transporter associated domain
Superfamily (EcoliWiki Page)	SUPERFAMILY:116726
Pfam (EcoliWiki Page)	PF02080 TrkA-C domain
EcoCyc	EcoCyc:G6620	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13896	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003215	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3655	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003999	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

cvrA:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to cvrA Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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