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Expression|

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Standard Name	cutC
Gene Synonym(s)	ECK1875, b1874, JW1863, dinY?^[1]^[2], dinY?
Product Desc.	copper homeostasis protein^[2]^[3] Copper sensitivity^[4]
Product Synonyms(s)	copper homeostasis protein^[1], B1874^[2]^[1], CutC^[2]^[1] , dinY?, ECK1875, JW1863, b1874
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s):
Regulation/Activity
Quick Links
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	cutC
Mnemonic	Cu tolerance
Synonyms	ECK1875, b1874, JW1863, dinY?^[1]^[2], dinY?
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655		MG1655: 1957290..1956544 <gbrowseImage> name=NC_000913:1956544..1957290 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 1937730..1937290 <gbrowseImage> name=NC_012967:1937290..1937730 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 1848603..1849349 <gbrowseImage> name=NC_012759:1848603..1849349 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 1960980..1960234 <gbrowseImage> name=NC_007779:1960234..1960980 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
MG1655	42.17 minutes	MG1655: 1956984..1956544 <gbrowseImage> name=NC_000913:1956544..1956984 source=ecoli preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse (MG1655)	FASTA Dump
DH10B		DH10B: 2047861..2047115 <gbrowseImage> name=NC_010473:2047115..2047861 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
ΔcutC (Keio:JW1863)	deletion	deletion			PMID:16738554	Shigen CGSC9553^[5]
ΔcutC728::kan					PMID:16738554	CGSC:100452
cutC (Strain: GME111)	bp 146 (from A to G) in cutC Mutations in cutF also: bp 32 of (from C to T) & bp 301 (from A to T)	substitution of Lys-49 by Arg-49 in cutC AND: first mutation in cutF: Ala-10 to Val-10 (in signal peptide) & second mutation in cutF (in mature protein): Thr-81 by Ser-81	Sensitivity to	Copper Additionally, resistant to P1 infection	PMID:7635807		Note that this cutC strain contains additional mutations in cutF.
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW1863	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCGCATTACTGGAAATTTGCTG Primer 2:CCTTTGGCCTGATGGCGTTCAAT
20H4	Kohara Phage	Genobase	PMID:3038334
12C7	Kohara Phage	Genobase	PMID:3038334
thrA34::Tn10	Linked marker	CAG18442 = CGSC7320^[5]	est. P1 cotransduction: % ^[6] Synonyms:thr-34::Tn10
carB96::Tn10	Linked marker	CAG12093 = CGSC7322^[5]	est. P1 cotransduction: 27% ^[6] Synonyms:car-96::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G7024	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG12956	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003611	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:2847756	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2790	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0006252	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	CutC
Synonyms	copper homeostasis protein^[1], B1874^[2]^[1], CutC^[2]^[1] , dinY?, ECK1875, JW1863, b1874
Product description	copper homeostasis protein^[2]^[3] Copper sensitivity^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005507	copper ion binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005627	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005507	copper ion binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0186	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005737	cytoplasm	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_00795	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005737	cytoplasm	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C	Seeded from EcoCyc (v14.0)	complete
Deprecated	GO:0046688	response to copper ion	PMID:7635807	IGI: Inferred from Genetic Interaction		P	The Cu-related phenotypes of cutC(del) were later shown to be due to the loss of micL, a sRNA that is encoded within the 3' end of cutC (^[7]).	complete
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C	Seeded from EcoCyc (v14.0)	complete
Deprecated	GO:0055070	copper ion homeostasis	PMID:7635807	IGI: Inferred from Genetic Interaction		P	The Cu-related phenotypes of cutC(del) were later shown to be due to the loss of micL, a sRNA that is encoded within the 3' end of cutC (^[7]).	complete
	GO:0006878	cellular copper ion homeostasis	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_00795	P	Seeded from EcoCyc (v14.0)	complete
Deprecated	GO:0006878	cellular copper ion homeostasis	PMID:7635807	IGI: Inferred from Genetic Interaction		P	The Cu-related phenotypes of cutC(del) were later shown to be due to the loss of micL, a sRNA that is encoded within the 3' end of cutC (^[7]).	complete
Deprecated	GO:0006878	cellular copper ion homeostasis	PMID:7635807	IGI: Inferred from Genetic Interaction		P	The Cu-related phenotypes of cutC(del) were later shown to be due to the loss of micL, a sRNA that is encoded within the 3' end of cutC (^[7]).	complete
Deprecated	GO:0046688	response to copper ion	PMID:7635807	IGI: Inferred from Genetic Interaction		P	The Cu-related phenotypes of cutC(del) were later shown to be due to the loss of micL, a sRNA that is encoded within the 3' end of cutC (^[7]).	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	ygeY	PMID:16606699	Experiment(s):EBI-1141140
Protein	proC	PMID:16606699	Experiment(s):EBI-1141140
Protein	uvrY	PMID:16606699	Experiment(s):EBI-1141140
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MPRMEKIMAA AGPLAVTFHR AFDMCANPLY TLNNLAELGI ARVLTSGQKS DALQGLSKIM ELIAHRDAPI IMAGAGVRAE NLHHFLDAGV LEVHSSAGAW QASPMRYRNQ GLSMSSDEHA DEYSRYIVDG AAVAEMKGII ERHQAK
Length	146
Mol. Wt	15.873 kDa
pI	6.8 (calculated)
Extinction coefficient	11,460 - 11,585 (calc based on 4 Y, 1 W, and 1 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	2..201	PF03932 CutC family		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=cutC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:90111351	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:2847756	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0006252	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P67826	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G7024	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG12956	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:2847756	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003611	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2790	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MG1655	470	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	194	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	201	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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Transcription unit(s)
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:1957270..1957310 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b1874 (EcoliWiki Page)	NCBI GEO profiles for cutC
microarray	GenExpDB:b1874 (EcoliWiki Page)	Summary of data for cutC from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to cutC Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G7024	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2790	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b1874
EcoGene	EcoGene:EG12956	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003611	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0006252	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Shigella flexneri	CUTC	From SHIGELLACYC
E. coli O157	CUTC	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF03932 CutC family
Panther (EcoliWiki Page)	PTHR12598:SF0
Superfamily (EcoliWiki Page)	SUPERFAMILY:110395
EcoCyc	EcoCyc:G7024	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG12956	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003611	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2790	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0006252	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Guo, MS et al. (2014) MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein. Genes Dev. 28 1620-34 PubMed

cutC:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

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Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to cutC Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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