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On One Page

Quickview |

Gene |

Product(s) |

Expression|

Evolution |

References |

Quickview

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Standard Name	argI
Gene Synonym(s)	ECK4247, b4254, JW4211^[1], JW4211
Product Desc.	ArgI^[2]^[3]; Component of ornithine carbamoyltransferase^[2]^[3] Ornithine carbamoyltransferase; ornithine transcarbamylase; OTCase^[4]
Product Synonyms(s)	ornithine carbamoyltransferase 1^[1], B4254^[2]^[1], ArgI^[2]^[1] , ECK4247, JW4211, b4254
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): argI^[2], OP00008
Regulation/Activity
Quick Links
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Notes

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argI and argF have same enzyme activity. ArgF and ArgI form both homotrimers and heterotrimers (Legrain, 1972).^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	argI
Mnemonic	Arginine
Synonyms	ECK4247, b4254, JW4211^[1], JW4211
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	96.46 minutes	MG1655: 4476334..4475330 <gbrowseImage> name=NC_000913:4475330..4476334 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 4461443..4460439 <gbrowseImage> name=NC_012967:4460439..4461443 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 4414065..4415069 <gbrowseImage> name=NC_012759:4414065..4415069 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 4482991..4481987 <gbrowseImage> name=NC_007779:4481987..4482991 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 4578142..4577138 <gbrowseImage> name=NC_010473:4577138..4578142 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
Coding Start (SO:0000323)	MG1655	4475333	Edman degradation	PMID:9298646
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Reference	Availability	Comments
ΔargI (Keio:JW4211)	deletion	deletion	Auxotrophies	PMID:16738554	Shigen CGSC11031^[5]
argI44			Auxotrophies		CGSC:5159
argI60			Auxotrophies		CGSC:5176
argI61			Auxotrophies		CGSC:5177
argI67			Auxotrophies		CGSC:5183
ΔargI68	deletion	deletion	Auxotrophies		CGSC:5184
ΔargI74	deletion	deletion	Auxotrophies		CGSC:5190
argI82			Auxotrophies		CGSC:5198
argI140(Am)			Auxotrophies	PMID:4942757	CGSC:5208	amber (UAG) mutation
ΔargI728::kan	deletion	deletion	Auxotrophies	PMID:16738554	CGSC:100048
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW4211	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCTCCGGGTTTTATCATAAGCA Primer 2:CCTTTACTGAGCGTCGCGACCAT
E1F5	Kohara Phage	Genobase	PMID:3038334
5C4	Kohara Phage	Genobase	PMID:3038334
zjf-920::Tn10	Linked marker	CAG12019 = CGSC7484^[5]	est. P1 cotransduction: 30% ^[6] Synonyms:zjh-901::Tn10, zjg-920::Tn10
mdoB202::Tn10	Linked marker	CAG18430 = CGSC7488^[5]	est. P1 cotransduction: % ^[6] Synonyms:zjj-202::Tn10, zji-202::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10069	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10069	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000065	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:948774	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0067	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0013927	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	ArgI
Synonyms	ornithine carbamoyltransferase 1^[1], B4254^[2]^[1], ArgI^[2]^[1] , ECK4247, JW4211, b4254
Product description	ArgI^[2]^[3]; Component of ornithine carbamoyltransferase^[2]^[3] Ornithine carbamoyltransferase; ornithine transcarbamylase; OTCase^[4]
EC number (for enzymes)	2.1.3.3^[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0004585	ornithine carbamoyltransferase activity	PMID:4873401	IGI: Inferred from Genetic Interaction		F	Table 4 shows specific activity of ornithine transcarbamylase in argI.	Missing: with/from
	GO:0004585	ornithine carbamoyltransferase activity	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_01109	F	Seeded from EcoCyc (v14.0)	complete
	GO:0004585	ornithine carbamoyltransferase activity	PMID:4558857	IGI: Inferred from Genetic Interaction		F	Activity of enzyme presented in Fig. 3. Table 1 displays quantification of enzyme protocol.	Missing: with/from
	GO:0004585	ornithine carbamoyltransferase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002292	F	Seeded from EcoCyc (v14.0)	complete
	GO:0004585	ornithine carbamoyltransferase activity	GOA:spec GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.1.3.3	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005737	cytoplasm	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_01109	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005737	cytoplasm	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C	Seeded from EcoCyc (v14.0)	complete
	GO:0006520	cellular amino acid metabolic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002292	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006520	cellular amino acid metabolic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006130	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006520	cellular amino acid metabolic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006131	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006520	cellular amino acid metabolic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006132	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006526	arginine biosynthetic process	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0055	P	Seeded from EcoCyc (v14.0)	complete
	GO:0008652	cellular amino acid biosynthetic process	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0028	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009348	ornithine carbamoyltransferase complex	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002292	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016597	amino acid binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006130	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016597	amino acid binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006131	F	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of ornithine carbamoyltransferase	arg I is able to produce a functional ornithine carbamoyltransferase	PMID:4558857
Protein	nadE		PMID:16606699	Experiment(s):EBI-1147760
Protein	ahpF		PMID:16606699	Experiment(s):EBI-1147760
Protein	pepA		PMID:16606699	Experiment(s):EBI-1147760
Protein	tyrR		PMID:16606699	Experiment(s):EBI-1147760
Protein	yfbU		PMID:16606699	Experiment(s):EBI-1147760
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MSGFYHKHFL KLLDFTPAEL NSLLQLAAKL KADKKSGKEE AKLTGKNIAL IFEKDSTRTR CSFEVAAYDQ GARVTYLGPS GSQIGHKESI KDTARVLGRM YDGIQYRGYG QEIVETLAEY ASVPVWNGLT NEFHPTQLLA DLLTMQEHLP GKAFNEMTLV YAGDARNNMG NSMLEAAALT GLDLRLVAPQ ACWPEAALVT ECRALAQQNG GNITLTEDVA KGVEGADFIY TDVWVSMGEA KEKWAERIAL LREYQVNSKM MQLTGNPEVK FLHCLPAFHD DQTTLGKKMA EEFGLHGGME VTDEVFESAA SIVFDQAENR MHTIKAVMVA TLSK
Length	334
Mol. Wt	36.907 kDa
pI	5.5 (calculated)
Extinction coefficient	36,900 - 37,400 (calc based on 10 Y, 4 W, and 4 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Initiator Methionine	1	Removed	UniProt:P04391
Domain	155..331	PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain		PMID:19920124
Domain	7..148	PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=argI taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16132076	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:948774	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0013927	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P04391	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG10069	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10069	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:948774	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000065	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0067	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MG1655	63	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	2562	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	19^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
argI
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:4476314..4476354 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

</protect>

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b4254 (EcoliWiki Page)	NCBI GEO profiles for argI
microarray	GenExpDB:b4254 (EcoliWiki Page)	Summary of data for argI from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
	GFP Fusion	Intergenic region (4475783..4476040) fused to gfpmut2.	OpenBioSystems	GFP fusion described in Zaslaver, et al. Plate:109-AZ01; Well:E1^[7]
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Notes

Accessions Related to argI Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10069	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0067	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b4254
EcoGene	EcoGene:EG10069	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000065	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0013927	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Apis mellifera	ENSAPMP00000022451 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Arabidopsis thaliana	AT1G75330 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Bos taurus	ENSBTAP00000001947 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Canis familiaris	ENSCAFP00000020690 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Gallus gallus	ENSGALP00000029680 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Homo sapiens	ENSP00000039007 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Macaca mulatta	ENSMMUP00000017738 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Monodelphis domestica	ENSMODP00000026385 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Mus musculus	MGI:97448 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Oryza gramene	Q6YVI0 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Pan troglodytes	ENSPTRP00000037399 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Rattus norvegicus	ENSRNOP00000004686 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Saccharomyces cerevisiae	YJL088W (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Schizosaccharomyces pombe	SPAC4G90 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Takifugu rubripes	NEWSINFRUP00000176157 (score: 1.000; bootstrap: 100%) NEWSINFRUP00000172677 (score: 0.621)	From Inparanoid:20070104
Tetraodon nigroviridis	GSTENP00025982001 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000018777 (score: 1.000; bootstrap: 99%)	From Inparanoid:20070104
Shigella flexneri	ARGI	From SHIGELLACYC
E. coli O157	ARGI	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
Pfam (EcoliWiki Page)	PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
Superfamily (EcoliWiki Page)	SUPERFAMILY:53671
EcoCyc	EcoCyc:EG10069	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10069	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000065	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0067	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0013927	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ Zaslaver, A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat. Methods 3 623-8 PubMed

argI:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to argI Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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