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Gene |

Product(s) |

Expression|

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Standard Name	accA
Gene Synonym(s)	ECK0184, b0185, JW0180^[1], JW0180
Product Desc.	AccA^[2]^[3]; Component of carboxyl transferase subunit α^[2]^[3]; acetyl-CoA carboxyltransferase^[2]^[3]; acetyl CoA carboxylase^[2]^[3] Acetyl-CoA carboxylase, carboxyltransferase alpha subunit^[4]
Product Synonyms(s)	acetyl-CoA carboxylase, carboxytransferase, alpha subunit^[1], B0185^[2]^[1], AccA^[2]^[1] , ECK0184, JW0180, b0185
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): accA^[2]
Regulation/Activity
Quick Links
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</protect> See Help:Quickview for help with entering information in the Quickview table. <protect></protect>

Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	accA
Mnemonic	Acetyl-CoA carboxylase
Synonyms	ECK0184, b0185, JW0180^[1], JW0180
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	4.5 minutes	MG1655: 208621..209580 <gbrowseImage> name=NC_000913:208621..209580 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 211463..212422 <gbrowseImage> name=NC_012967:211463..212422 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 208620..209579 <gbrowseImage> name=NC_012759:208620..209579 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 208621..209580 <gbrowseImage> name=NC_007779:208621..209580 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 182725..183684 <gbrowseImage> name=NC_010473:182725..183684 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
Coding Start (SO:0000323)	MG1655	208624	Edman degradation	PMID:1355089 PMID:9298646
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
accA⁺⁺			Overexpression	Increase Acetyle COA Carboxylase activity upon over expression.	PMID:10893421		See Table 1.
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW0180	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCAGTCTGAATTTCCTTGATTT Primer 2:CCCGCGTAACCGTAGCTCATCAG
E2B8	Kohara Phage	Genobase	PMID:3038334
6F5	Kohara Phage	Genobase	PMID:3038334
10F9	Kohara Phage	Genobase	PMID:3038334
zad-220::Tn10	Linked marker	CAG12025 = CGSC7326^[5]	est. P1 cotransduction: 4% ^[6]
yafC502::Tn10	Linked marker	CAG18436 = CGSC7328^[5]	est. P1 cotransduction: 42% ^[6] Synonyms:zae-502::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11647	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11647	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001591	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:944895	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1600	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0000630	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	AccA
Synonyms	acetyl-CoA carboxylase, carboxytransferase, alpha subunit^[1], B0185^[2]^[1], AccA^[2]^[1] , ECK0184, JW0180, b0185
Product description	AccA^[2]^[3]; Component of carboxyl transferase subunit α^[2]^[3]; acetyl-CoA carboxyltransferase^[2]^[3]; acetyl CoA carboxylase^[2]^[3] Acetyl-CoA carboxylase, carboxyltransferase alpha subunit^[4]
EC number (for enzymes)	6.4.1.2^[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000166	nucleotide binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded from EcoCyc (v14.0)	complete
	GO:0003989	acetyl-CoA carboxylase activity	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_00823	F	Seeded from EcoCyc (v14.0)	complete
	GO:0003989	acetyl-CoA carboxylase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001095	F	Seeded from EcoCyc (v14.0)	complete
	GO:0003989	acetyl-CoA carboxylase activity	GOA:spec GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:6.4.1.2	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005515	protein binding	PMID:15690043	IPI: Inferred from Physical Interaction	UniProtKB:P0A9Q5	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded from EcoCyc (v14.0)	complete
	GO:0006633	fatty acid biosynthetic process	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_00823	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006633	fatty acid biosynthetic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001095	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006633	fatty acid biosynthetic process	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0275	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006633	fatty acid biosynthetic process	PMID:10893421	IMP: Inferred from Mutant Phenotype		P	Seeded from EcoCyc (v14.0)	complete
	GO:0009329	acetate CoA-transferase complex	PMID:1355089	IDA: Inferred from Direct Assay		C	Seeded from EcoCyc (v14.0)	complete
	GO:0016874	ligase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011763	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016874	ligase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0436	F	Seeded from EcoCyc (v14.0)	complete
	GO:0006633	fatty acid biosynthetic process	PMID:10893421	IGI: Inferred from Genetic Interaction	EcoliWiki:accB EcoliWiki:accC EcoliWiki:accD	P		complete
	GO:0042759	long-chain fatty acid biosynthetic process	PMID:18156466	NAS: Non-traceable Author Statement		P		complete
	GO:0005737	cytoplasm	PMID:10893421	IC: Inferred by Curator	GO:0006633	C		complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of carboxyl transferase subunit α	could be indirect
Protein	accD		PMID:15690043	Experiment(s):EBI-882405, EBI-882574, EBI-889915, EBI-890114
Protein	rplC		PMID:15690043	Experiment(s):EBI-882405
Protein	accD		PMID:16606699	Experiment(s):EBI-1135857
Protein	hemF		PMID:16606699	Experiment(s):EBI-1135857
Protein	groL		PMID:16606699	Experiment(s):EBI-1135857
Protein	prs		PMID:16606699	Experiment(s):EBI-1135857
Protein	lysU		PMID:15690043	Experiment(s):EBI-889915
Protein	rplR		PMID:15690043	Experiment(s):EBI-889915
Protein	rplV		PMID:15690043	Experiment(s):EBI-889915
Protein	rplW		PMID:15690043	Experiment(s):EBI-889915
Protein	dnaK		PMID:15690043	Experiment(s):EBI-889915
Protein	infB		PMID:15690043	Experiment(s):EBI-889915
Protein	Subunits of acetyl-CoA carboxyltransferase	could be indirect
Protein	Subunits of acetyl CoA carboxylase	could be indirect
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MSLNFLDFEQ PIAELEAKID SLTAVSRQDE KLDINIDEEV HRLREKSVEL TRKIFADLGA WQIAQLARHP QRPYTLDYVR LAFDEFDELA GDRAYADDKA IVGGIARLDG RPVMIIGHQK GRETKEKIRR NFGMPAPEGY RKALRLMQMA ERFKMPIITF IDTPGAYPGV GAEERGQSEA IARNLREMSR LGVPVVCTVI GEGGSGGALA IGVGDKVNML QYSTYSVISP EGCASILWKS ADKAPLAAEA MGIIAPRLKE LKLIDSIIPE PLGGAHRNPE AMAASLKAQL LADLADLDVL STEDLKNRRY QRLMSYGYA
Length	319
Mol. Wt	35.242 kDa
pI	5.8 (calculated)
Extinction coefficient	25,900 - 26,150 (calc based on 10 Y, 2 W, and 2 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Initiator Methionine	1	Removed	UniProt:P0ABD5
Domain	4..151	PF03255 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=accA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16128178	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:944895	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0000630	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P0ABD5	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG11647	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11647	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:944895	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001591	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1600	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MC4100	1.04E+03	molecules/cell	Medium: median data from rich and minimal media Temperature (°C): 37 Doubling time (min): Growth Rate(min): Growth phase: other:	emPAI		PMID:18304323
Protein	E. coli K-12 EMG2	180	molecules/cell	Medium: MOPS glucose minimal Temperature (°C): 37 Doubling time (min): Growth phase: Exponential OD: OD600 = 0.2 to 0.25 other: aerated	Quantitative protein sequencing	Spot ID: MlOO	PMID: 9298646
Protein	E. coli K-12 MG1655	10155	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	1800	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	4753	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
accA
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:208601..208641 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

</protect>

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b0185 (EcoliWiki Page)	NCBI GEO profiles for accA
microarray	GenExpDB:b0185 (EcoliWiki Page)	Summary of data for accA from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to accA Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11647	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1600	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b0185
EcoGene	EcoGene:EG11647	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001591	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0000630	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Arabidopsis thaliana	AT2G38040 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Macaca mulatta	ENSMMUP00000004348 (score: 1.000; bootstrap: 100%) ENSMMUP00000019905 (score: 0.123)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000046385 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Shigella flexneri	ACCA	From SHIGELLACYC
E. coli O157	ACCA	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF03255 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
Superfamily (EcoliWiki Page)	SUPERFAMILY:52096
Panther (EcoliWiki Page)	PTHR22855:SF3
EcoCyc	EcoCyc:EG11647	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11647	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001591	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1600	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0000630	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

accA:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to accA Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

Categories

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