accA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

AccA

Synonyms

acetyl-CoA carboxylase, carboxytransferase, alpha subunit[1], B0185[2][1], AccA[2][1] , ECK0184, JW0180, b0185

Product description

AccA[2][3];

Component of carboxyl transferase subunit α[2][3]; acetyl-CoA carboxyltransferase[2][3]; acetyl CoA carboxylase[2][3]

Acetyl-CoA carboxylase, carboxyltransferase alpha subunit[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0003989

acetyl-CoA carboxylase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00823

F

Seeded from EcoCyc (v14.0)

complete

GO:0003989

acetyl-CoA carboxylase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001095

F

Seeded from EcoCyc (v14.0)

complete

GO:0003989

acetyl-CoA carboxylase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:6.4.1.2

F

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

PMID:15690043[5]

IPI: Inferred from Physical Interaction

UniProtKB:P0A9Q5

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00823

P

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001095

P

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0275

P

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

PMID:10893421[6]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc (v14.0)

complete

GO:0009329

acetate CoA-transferase complex

PMID:1355089[7]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0016874

ligase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011763

F

Seeded from EcoCyc (v14.0)

complete

GO:0016874

ligase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0436

F

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

PMID:10893421[6]

IGI: Inferred from Genetic Interaction

EcoliWiki:accB EcoliWiki:accC EcoliWiki:accD


P

complete

GO:0042759

long-chain fatty acid biosynthetic process

PMID:18156466[8]

NAS: Non-traceable Author Statement

P

complete

GO:0005737

cytoplasm

PMID:10893421[6]

IC: Inferred by Curator

GO:0006633


C

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of carboxyl transferase subunit α

could be indirect

Protein

accD

PMID:15690043[5]

Experiment(s):EBI-882405, EBI-882574, EBI-889915, EBI-890114

Protein

rplC

PMID:15690043[5]

Experiment(s):EBI-882405

Protein

accD

PMID:16606699[9]

Experiment(s):EBI-1135857

Protein

hemF

PMID:16606699[9]

Experiment(s):EBI-1135857

Protein

groL

PMID:16606699[9]

Experiment(s):EBI-1135857

Protein

prs

PMID:16606699[9]

Experiment(s):EBI-1135857

Protein

lysU

PMID:15690043[5]

Experiment(s):EBI-889915

Protein

rplR

PMID:15690043[5]

Experiment(s):EBI-889915

Protein

rplV

PMID:15690043[5]

Experiment(s):EBI-889915

Protein

rplW

PMID:15690043[5]

Experiment(s):EBI-889915

Protein

dnaK

PMID:15690043[5]

Experiment(s):EBI-889915

Protein

infB

PMID:15690043[5]

Experiment(s):EBI-889915

Protein

Subunits of acetyl-CoA carboxyltransferase

could be indirect

Protein

Subunits of acetyl CoA carboxylase

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSLNFLDFEQ PIAELEAKID SLTAVSRQDE KLDINIDEEV HRLREKSVEL TRKIFADLGA
WQIAQLARHP QRPYTLDYVR LAFDEFDELA GDRAYADDKA IVGGIARLDG RPVMIIGHQK
GRETKEKIRR NFGMPAPEGY RKALRLMQMA ERFKMPIITF IDTPGAYPGV GAEERGQSEA
IARNLREMSR LGVPVVCTVI GEGGSGGALA IGVGDKVNML QYSTYSVISP EGCASILWKS
ADKAPLAAEA MGIIAPRLKE LKLIDSIIPE PLGGAHRNPE AMAASLKAQL LADLADLDVL
STEDLKNRRY QRLMSYGYA
Length

319

Mol. Wt

35.242 kDa

pI

5.8 (calculated)

Extinction coefficient

25,900 - 26,150 (calc based on 10 Y, 2 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0ABD5

Domain

4..151

PF03255 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit

PMID:19920124[10]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=accA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128178

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:944895

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000630

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0ABD5

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11647

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11647

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:944895

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001591

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1600

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. ↑ 6.0 6.1 6.2 Davis, MS et al. (2000) Overproduction of acetyl-CoA carboxylase activity increases the rate of fatty acid biosynthesis in Escherichia coli. J. Biol. Chem. 275 28593-8 PubMed
  7. ↑ Li, SJ & Cronan, JE Jr (1992) The genes encoding the two carboxyltransferase subunits of Escherichia coli acetyl-CoA carboxylase. J. Biol. Chem. 267 16841-7 PubMed
  8. ↑ Benson, BK et al. (2008) DNA inhibits catalysis by the carboxyltransferase subunit of acetyl-CoA carboxylase: implications for active site communication. Protein Sci. 17 34-42 PubMed
  9. ↑ 9.0 9.1 9.2 9.3 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  10. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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