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On One Page

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Gene |

Product(s) |

Expression|

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Standard Name	yfgC
Gene Synonym(s)	ECK2490, b2494, JW2479^[1], JW2479
Product Desc.	predicted peptidase^[2]^[3] Putative periplasmic metalloprotease, function unknown; M48 family^[4]
Product Synonyms(s)	predicted peptidase^[1], B2494^[2]^[1], YfgC^[2]^[1] , ECK2490, JW2479, b2494
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): yfgCD^[2]
Regulation/Activity
Quick Links
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Notes

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Overexpression causes abnormal biofilm architecture. The first 27 residues are predicted to be a signal peptide. Gene disruption does not cause growth defect (unpublished data Y. Akiyama cited in Sakoh, 2005). htpX, yggG, yfgC and ycaL are paralogs.^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	yfgC
Mnemonic	Systematic nomenclature
Synonyms	ECK2490, b2494, JW2479^[1], JW2479
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	56.34 minutes	MG1655: 2614116..2615579 <gbrowseImage> name=NC_000913:2614116..2615579 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 2536914..2538377 <gbrowseImage> name=NC_012967:2536914..2538377 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 2499921..2501384 <gbrowseImage> name=NC_012759:2499921..2501384 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 2614750..2616213 <gbrowseImage> name=NC_007779:2614750..2616213 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 2705881..2707344 <gbrowseImage> name=NC_010473:2705881..2707344 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability
ΔyfgC (Keio:JW2479)	deletion	deletion	PMID:16738554	Shigen CGSC9979^[5]
ΔyfgC742::kan			PMID:16738554	CGSC:104756
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW2479	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCTTCAGGCAGTTGAAAAAAAA Primer 2:ccCATCTTGGTATAAGGCTTAAAGCGTTCCTGC
10H6	Kohara Phage	Genobase	PMID:3038334
5A11	Kohara Phage	Genobase	PMID:3038334
purC80::Tn10	Linked marker	CAG18470 = CGSC7413^[5]	est. P1 cotransduction: 47% ^[6]
zfh-208::Tn10	Linked marker	CAG18481 = CGSC7417^[5]	est. P1 cotransduction: 10% ^[6] Synonyms:zff-208::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G7311	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG14199	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003883	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:947029	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3951	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0008212	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	YfgC
Synonyms	predicted peptidase^[1], B2494^[2]^[1], YfgC^[2]^[1] , ECK2490, JW2479, b2494
Product description	predicted peptidase^[2]^[3] Putative periplasmic metalloprotease, function unknown; M48 family^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0004222	metalloendopeptidase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001915	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005488	binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011990	F	Seeded from EcoCyc (v14.0)	complete
	GO:0006508	proteolysis	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001915	P	Seeded from EcoCyc (v14.0)	complete
	GO:0016020	membrane	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001915	C	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	ydfG	PMID:19402753	LCMS(ID Probability):99.6
Protein	rpmB	PMID:19402753	LCMS(ID Probability):99.6
Protein	rplA	PMID:19402753	LCMS(ID Probability):99.6
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MFRQLKKNLV ATLIAAMTIG QVAPAFADSA DTLPDMGTSA GSTLSIGQEM QMGDYYVRQL RGSAPLINDP LLTQYINSLG MRLVSHANSV KTPFHFFLIN NDEINAFAFF GGNVVLHSAL FRYSDNESQL ASVMAHEISH VTQRHLARAM EDQQRSAPLT WVGALGSILL AMASPQAGMA ALTGTLAGTR QGMISFTQQN EQEADRIGIQ VLQRSGFDPQ AMPTFLEKLL DQARYSSRPP EILLTHPLPE SRLADARNRA NQMRPMVVQS SEDFYLAKAR TLGMYNSGRN QLTSDLLDEW AKGNVRQQRA AQYGRALQAM EANKYDEARK TLQPLLAAEP GNAWYLDLAT DIDLGQNKAN EAINRLKNAR DLRTNPVLQL NLANAYLQGG QPQEAANILN RYTFNNKDDS NGWDLLAQAE AALNNRDQEL AARAEGYALA GRLDQAISLL SSASSQVKLG SLQQARYDAR IDQLRQLQER FKPYTKM
Length	487
Mol. Wt	53.909 kDa
pI	7.7 (calculated)
Extinction coefficient	44,350 (calc based on 15 Y, 4 W, and 0 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
motif	1-27	UniProt Manual:Signal Peptides	UniProt:P66948
Domain	42..255	PF01435 Peptidase family M48		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=yfgC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16130419	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:947029	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0008212	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P66948	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G7311	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG14199	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:947029	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003883	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3951	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MG1655	181	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	228	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	188	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
yfgCD
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:2614096..2614136 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b2494 (EcoliWiki Page)	NCBI GEO profiles for yfgC
microarray	GenExpDB:b2494 (EcoliWiki Page)	Summary of data for yfgC from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to yfgC Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G7311	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3951	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b2494
EcoGene	EcoGene:EG14199	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003883	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0008212	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Schizosaccharomyces pombe	SPAP14E84 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000051684 (score: 1.000; bootstrap: 99%)	From Inparanoid:20070104
Shigella flexneri	S2687	From SHIGELLACYC
E. coli O157	Z3757	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Superfamily (EcoliWiki Page)	SUPERFAMILY:48452
Pfam (EcoliWiki Page)	PF01435 Peptidase family M48
EcoCyc	EcoCyc:G7311	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG14199	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003883	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3951	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0008212	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

yfgC:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to yfgC Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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