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Standard Name	typA
Gene Synonym(s)	bipA, ECK3864, b3871, JW5571, yihK^[1]^[2], yihK
Product Desc.	protein possibly involved in LPS biosynthesis and host colonization^[2]^[3] GTPase, regulatory, ribosome-associated; phosphorylated protein involved in global gene regulation; non-essential gene^[4]
Product Synonyms(s)	GTP-binding protein^[1], B3871^[2]^[1], YihK^[2]^[1], BipA^[2]^[1], TypA^[2]^[1] , bipA, ECK3864, JW5571, yihK, b3871
Function from GO	<GO_nr />
Knock-Out Phenotype	failure to grow at low temperatures^[5]
Regulation/Expression	transcription unit(s): bipA^[2]
Regulation/Activity	test2
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	typA
Mnemonic	Tyrosine phosphoprotein
Synonyms	bipA, ECK3864, b3871, JW5571, yihK^[1]^[2], yihK
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	87.43 minutes	MG1655: 4056430..4058253 <gbrowseImage> name=NC_000913:4056430..4058253 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 4036665..4038488 <gbrowseImage> name=NC_012967:4036665..4038488 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 3946099..3947922 <gbrowseImage> name=NC_012759:3946099..3947922 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 3578274..3576451 <gbrowseImage> name=NC_007779:3576451..3578274 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
Coding Start (SO:0000323)	MG1655	4056430	Edman degradation	PMID:7783627 PMID:9298646
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Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
typAV497A	V497A		(in strain: MAR001)			Strain variation; seeded from UniProt:P32132
typAI489T	I489T		(in strain: MAR001)			Strain variation; seeded from UniProt:P32132
ΔbipA733::kan				PMID:16738554	CGSC:100204
∆bipA::kan		Growth Phenotype	MG1655 ∆bipA::kan doesn't form isolated colonies on LB medium at 20°C (plates were incubated for 4 days). In liquid LB medium, the mutant grows more slowly than the bipA+ parent strain.	PMID:11683274		The growth phenotypes were complemented by a plasmid clone of bipA.
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Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
	Plasmid clone	Shigen	PMID:16769691 Status: Primer 1: Primer 2:
9H1	Kohara Phage	Genobase	PMID:3038334
10F1	Kohara Phage	Genobase	PMID:3038334
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11837	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11837	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001768	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:948369	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1783	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012648	Escherichia coli str. K-12 substr. MG1655
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Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	BipA
Synonyms	GTP-binding protein^[1], B3871^[2]^[1], YihK^[2]^[1], BipA^[2]^[1], TypA^[2]^[1] , bipA, ECK3864, JW5571, yihK, b3871
Product description	protein possibly involved in LPS biosynthesis and host colonization^[2]^[3] GTPase, regulatory, ribosome-associated; phosphorylated protein involved in global gene regulation; non-essential gene^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000166	nucleotide binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded from EcoCyc (v14.0)	complete
	GO:0003924	GTPase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000795	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005525	GTP binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000640	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005525	GTP binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000795	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005525	GTP binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004161	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005525	GTP binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005225	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005525	GTP binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006298	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005525	GTP binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0342	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005622	intracellular	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006298	C	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MIEKLRNIAI IAHVDHGKTT LVDKLLQQSG TFDSRAETQE RVMDSNDLEK ERGITILAKN TAIKWNDYRI NIVDTPGHAD FGGEVERVMS MVDSVLLVVD AFDGPMPQTR FVTKKAFAYG LKPIVVINKV DRPGARPDWV VDQVFDLFVN LDATDEQLDF PIVYASALNG IAGLDHEDMA EDMTPLYQAI VDHVPAPDVD LDGPFQMQIS QLDYNSYVGV IGIGRIKRGK VKPNQQVTII DSEGKTRNAK VGKVLGHLGL ERIETDLAEA GDIVAITGLG ELNISDTVCD TQNVEALPAL SVDEPTVSMF FCVNTSPFCG KEGKFVTSRQ ILDRLNKELV HNVALRVEET EDADAFRVSG RGELHLSVLI ENMRREGFEL AVSRPKVIFR EIDGRKQEPY ENVTLDVEEQ HQGSVMQALG ERKGDLKNMN PDGKGRVRLD YVIPSRGLIG FRSEFMTMTS GTGLLYSTFS HYDDVRPGEV GQRQNGVLIS NGQGKAVAFA LFGLQDRGKL FLGHGAEVYE GQIIGIHSRS NDLTVNCLTG KKLTNMRASG TDEAVVLVPP IRMTLEQALE FIDDDELVEV TPTSIRIRKR HLTENDRRRA NRAPKDD
Length	607
Mol. Wt	67.355 kDa
pI	5.1 (calculated)
Extinction coefficient	27,390 - 27,890 (calc based on 11 Y, 2 W, and 4 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	References
Domain	395..483	PF00679 Elongation factor G C-terminus	PMID:19920124
Domain	3..196	PF00009 Elongation factor Tu GTP binding domain	PMID:19920124
Domain	219..289	PF03144 Elongation factor Tu domain 2	PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=typA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:49176434	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:948369	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012648	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P32132	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG11837	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11837	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:948369	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001768	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1783	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MC4100	2.92E+03	molecules/cell	Medium: median data from rich and minimal media Temperature (°C): 37 Doubling time (min): Growth Rate(min): Growth phase: other:	emPAI		PMID:18304323
Protein	Ecoli K-12	89.635+/-0.328	Molecules/cell	Medium: Temperature (°C): Doubling time (min): Growth Rate(min): * Growth phase: other: *		Single Molecule Fluorescence	PMID:20671182
Protein	E. coli K-12 MG1655	17233	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	3215	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	7754	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
bipA
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:4056410..4056450 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b3871 (EcoliWiki Page)	NCBI GEO profiles for typA
microarray	GenExpDB:b3871 (EcoliWiki Page)	Summary of data for typA from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to typA Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11837	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1783	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b3871
EcoGene	EcoGene:EG11837	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001768	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012648	Escherichia coli str. K-12 substr. MG1655
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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Shigella flexneri	YIHK	From SHIGELLACYC
E. coli O157	YIHK	From ECOO157CYC
Sinorhizobium melilotii		Required for symbiosis with Medicago truncatula and survival of certain stresses ^[6]
Salmonella enterica serovar Typhimurium		^[7]
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF03144 Elongation factor Tu domain 2
Pfam (EcoliWiki Page)	PF00009 Elongation factor Tu GTP binding domain
Pfam (EcoliWiki Page)	PF00679 Elongation factor G C-terminus
Superfamily (EcoliWiki Page)	SUPERFAMILY:50447
Panther (EcoliWiki Page)	PTHR23115:SF14
Superfamily (EcoliWiki Page)	SUPERFAMILY:52540
Superfamily (EcoliWiki Page)	SUPERFAMILY:54980
Superfamily (EcoliWiki Page)	SUPERFAMILY:54980
EcoCyc	EcoCyc:EG11837	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11837	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001768	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1783	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012648	Escherichia coli str. K-12 substr. MG1655
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Notes

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ Pfennig, PL & Flower, AM (2001) BipA is required for growth of Escherichia coi K12 at low temperature. Mol. Genet. Genomics 266 313-7 PubMed
↑ Kiss, E et al. (2004) The typA gene is required for stress adaptation as well as for symbiosis of Sinorhizobium meliloti 1021 with certain Medicago truncatula lines. Mol. Plant Microbe Interact. 17 235-44 PubMed
↑ deLivron, MA & Robinson, VL (2008) Salmonella enterica serovar Typhimurium BipA exhibits two distinct ribosome binding modes. J. Bacteriol. 190 5944-52 PubMed

typA:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to typA Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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