qorA:On One Page

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Quickview | Gene | Product(s) | Expression| Evolution | References |

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Standard Name

qorA

Gene Synonym(s)

ECK4043, b4051, JW4011, hcz, hzc, qor[1], hzc, qor

Product Desc.

Qor[2][3];

Component of quinone oxidoreductase[2][3]

Quinone oxidoreductase, NADPH dependent[4]

Product Synonyms(s)

quinone oxidoreductase, NADPH-dependent[1], B4051[2][1], Hzc[2][1], Hcz[2][1], Qor[2][1] , ECK4043, hcz, hzc, JW4011, qor, b4051

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): qorA[2]

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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N-terminal sequencing of a novel E. coli mRNA-binding protein gives best match to Qor and may verify its start.[4]



Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

qorA

Mnemonic

Quinone oxidoreductase

Synonyms

ECK4043, b4051, JW4011, hcz, hzc, qor[1], hzc, qor

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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain Map location Genome coordinates Genome browsers Sequence links

MG1655

91.84 minutes, 91.84 minutes 

MG1655: 4262254..4261271
<gbrowseImage> name=NC_000913:4261271..4262254 source=MG1655 preset=GeneLocation </gbrowseImage>

BW2952

NC_012759: 4200116..4201099
<gbrowseImage> name=NC_012759:4200116..4201099 source=BW2952 preset=GeneLocation </gbrowseImage>

W3110

 

W3110: 4267821..4266838
<gbrowseImage> name=NC_007779:4266838..4267821 source=W3110 preset=GeneLocation </gbrowseImage>

DH10B

DH10B: 4361950..4360967
<gbrowseImage> name=NC_010473:4360967..4361950 source=DH10B preset=GeneLocation </gbrowseImage>

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type Strain Genomic Location Evidence Reference Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele Nt change(s) AA change(s) Phenotype: Type Phenotype: Description Reference Availability Comments

Δqor (Keio:JW4011)

deletion

deletion

PMID:16738554

Shigen
CGSC8315[5]

Δqor-745::kan

PMID:16738554

CGSC:99830


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Notes

Genetic Interactions

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Interactor Interaction Allele Score(s) Reference(s) Accessions Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource Resource Type Source Notes/Reference

JW4011

Plasmid clone

Shigen

PMID:16769691

Status:Clone OK

Primer 1:GCCGCAACACGAATTGAATTTCA

Primer 2:CCTGGAATCAGCAGGCTGGAACC

1E4

Kohara Phage

Genobase

PMID:3038334

malF3089::Tn10

Linked marker

CAG12164 = CGSC7476[5]

est. P1 cotransduction: 47% [6]

zje-2241::Tn10

Linked marker

CAG18427 = CGSC7481[5]

est. P1 cotransduction: 14% [6]

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:EG11492

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1455

Escherichia coli str. K-12 substr. MG1655

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b4051

ECOL199310CYC (EcoliWiki Page)

ECOL199310CYC:C5020

EcoGene

EcoGene:EG11492

Escherichia coli str. K-12 substr. MG1655

ECOO157CYC (EcoliWiki Page)

ECOO157CYC:QOR

CGSC (EcoliWiki Page)

CGSC:36654

ASAP

ASAP:ABE-0013262

Escherichia coli str. K-12 substr. MG1655

EcoCyc (EcoliWiki Page)

ECOCYC:EG11492

Escherichia coli str. K-12 substr. MG1655

NCBI (EcoliWiki Page)

GeneID:948556

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001448

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Qor

Synonyms

quinone oxidoreductase, NADPH-dependent[1], B4051[2][1], Hzc[2][1], Hcz[2][1], Qor[2][1] , ECK4043, hcz, hzc, JW4011, qor, b4051

Product description

Qor[2][3];

Component of quinone oxidoreductase[2][3]

Quinone oxidoreductase, NADPH dependent[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status

GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016040

F

Seeded from EcoCyc (v14.0)

complete

GO:0003960

NADPH:quinone reductase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.6.5.5

F

Seeded from EcoCyc (v14.0)

complete

GO:0008152

metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016040

P

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002085

F

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002364

F

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013149

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002085

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002364

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013149

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

PMID:8046753

IDA: Inferred from Direct Assay

C

complete

GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013154

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

F

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002085

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013149

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of quinone oxidoreductase

could be indirect

Protein

dnaK

PMID:15690043

Experiment(s):EBI-884439

Protein

groL

PMID:16606699

Experiment(s):EBI-1147338

Protein

rdgC

PMID:16606699

Experiment(s):EBI-1147338
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MATRIEFHKH GGPEVLQAVE FTPADPAENE IQVENKAIGI NFIDTYIRSG LYPPPSLPSG
LGTEAAGIVS KVGSGVKHIK AGDRVVYAQS ALGAYSSVHN IIADKAAILP AAISFEQAAA
SFLKGLTVYY LLRKTYEIKP DEQFLFHAAA GGVGLIACQW AKALGAKLIG TVGTAQKAQS
ALKAGAWQVI NYREEDLVER LKEITGGKKV RVVYDSVGRD TWERSLDCLQ RRGLMVSFGN
SSGAVTGVNL GILNQKGSLY VTRPSLQGYI TTREELTEAS NELFSLIASG VIKVDVAEQQ
KYPLKDAQRA HEILESRATQ GSSLLIP
Length

327

Mol. Wt

35.172 kDa

pI

8.5 (calculated)

Extinction coefficient

34,380 - 34,630 (calc based on 12 Y, 3 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

152..285

PF00107 Zinc-binding dehydrogenase

PMID:19920124

Domain

28..97

PF08240 Alcohol dehydrogenase GroES-like domain

PMID:19920124

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=qor taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131877

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948556

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013262

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P28304

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11492

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11492

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948556

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001448

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1455

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

Molecule Organism or Strain Value Units Experimental Conditions Assay used Notes Reference(s)

Protein

Ecoli K-12

39.459+/-0.277

Molecules/cell

  • Medium:
  • Temperature (°C):
  • Doubling time (min): Growth Rate(min): *
  • Growth phase: other: *

Single Molecule Fluorescence

PMID:20671182

mRNA

Ecoli K-12

0.092065107

Molecules/cell

  • Medium:
  • Temperature (°C):
  • Doubling time (min): Growth Rate(min): *
  • Growth phase: other: *

by RNA_Seq

PMID:20671182

Protein

E. coli K-12 MG1655

217

molecules/cell/generation

  • Medium: MOPS Complete
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Protein

E. coli K-12 MG1655

643

molecules/cell/generation

  • Medium: MOPS Minimal
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Protein

E. coli K-12 MG1655

225

molecules/cell/generation

  • Medium: MOPS Complete without Methionine
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

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Notes

Transcription and Transcriptional Regulation

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<protect>

See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

qor

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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:4262234..4262274 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name Mutation Phenotype Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type Reference Notes

microarray

GEO Profiles:b4051 (EcoliWiki Page)

NCBI GEO profiles for qor

microarray

GenExpDB:b4051 (EcoliWiki Page)

Summary of data for qor from multiple microarray studies

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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name Resource Type Description Source Notes
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Notes

Accessions Related to qorA Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:EG11492

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1455

Escherichia coli str. K-12 substr. MG1655

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b4051

EcoGene

EcoGene:EG11492

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001448

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013262

Escherichia coli str. K-12 substr. MG1655

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Notes

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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism Homologs (Statistics) Comments

Anopheles gambiae

  • ENSANGP00000000280 (score: 1.000; bootstrap: 73%)

From Inparanoid:20070104

Apis mellifera

  • ENSAPMP00000029534 (score: 1.000; bootstrap: 95%)

From Inparanoid:20070104

Arabidopsis thaliana

  • AT5G61510 (score: 1.000; bootstrap: 99%)

From Inparanoid:20070104

Bos taurus

  • ENSBTAP00000004109 (score: 1.000; bootstrap: 55%)

From Inparanoid:20070104

Caenorhabditis briggsae

  • WBGene00038883 (score: 1.000; bootstrap: 83%)

From Inparanoid:20070104

Caenorhabditis elegans

  • WBGene00009554 (score: 1.000; bootstrap: 86%)

From Inparanoid:20070104

Canis familiaris

  • ENSCAFP00000005896 (score: 1.000; bootstrap: 54%)

From Inparanoid:20070104

Ciona intestinalis

  • ENSCINP00000008400 (score: 1.000; bootstrap: 68%)

From Inparanoid:20070104

Danio rerio

  • ZDB-GENE-050306-24 (score: 1.000; bootstrap: 92%)
  • ZDB-CDNA-050306-24 (score: 1.000; bootstrap: 90%)

From Inparanoid:20070104

Dictyostelium discoideum

  • DDB0216934 (score: 1.000; bootstrap: 98%)

From Inparanoid:20070104

Drosophila melanogaster

  • FBgn0033883 (score: 1.000; bootstrap: 74%)

From Inparanoid:20070104

Gallus gallus

  • ENSGALP00000018510 (score: 1.000; bootstrap: 54%)

From Inparanoid:20070104

Homo sapiens

  • ENSP00000263416 (score: 1.000; bootstrap: 74%)

From Inparanoid:20070104

Macaca mulatta

  • ENSMMUP00000019158 (score: 1.000; bootstrap: 83%)

From Inparanoid:20070104

Monodelphis domestica

  • ENSMODP00000023817 (score: 1.000; bootstrap: 72%)

From Inparanoid:20070104

Mus musculus

  • MGI:88527 (score: 1.000; bootstrap: 93%)

From Inparanoid:20070104

Oryza gramene

  • Q8SBA7 (score: 1.000; bootstrap: 99%)
  • Q7XC60 (score: 1.000; bootstrap: 99%)
  • Q9AUT6 (score: 0.847)

From Inparanoid:20070104

Pan troglodytes

  • ENSPTRP00000001500 (score: 1.000; bootstrap: 80%)

From Inparanoid:20070104

Rattus norvegicus

  • ENSRNOP00000038188 (score: 1.000; bootstrap: 96%)

From Inparanoid:20070104

Saccharomyces cerevisiae

  • YBR046C (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Schizosaccharomyces pombe

  • SPCC14426c (score: 1.000; bootstrap: 99%)

From Inparanoid:20070104

Takifugu rubripes

  • NEWSINFRUP00000143800 (score: 1.000; bootstrap: 91%)

From Inparanoid:20070104

Tetraodon nigroviridis

  • GSTENP00004955001 (score: 1.000; bootstrap: 81%)

From Inparanoid:20070104

Xenopus tropicalis

  • ENSXETP00000006542 (score: 1.000; bootstrap: 56%)

From Inparanoid:20070104

Shigella flexneri

QOR

From SHIGELLACYC

E. coli O157

QOR

From ECOO157CYC

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Do-It-Yourself Web Tools

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Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

Pfam (EcoliWiki Page)

PF00107 Zinc-binding dehydrogenase

Superfamily (EcoliWiki Page)

SUPERFAMILY:50129

Superfamily (EcoliWiki Page)

SUPERFAMILY:51735

Panther (EcoliWiki Page)

PTHR11695:SF31

Pfam (EcoliWiki Page)

PF08240 Alcohol dehydrogenase GroES-like domain

EcoCyc

EcoCyc:EG11492

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11492

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001448

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1455

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013262

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 CGSC: The Coli Genetics Stock Center
  6. ↑ 6.0 6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

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