plsB:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

PlsB

Synonyms

glycerol-3-phosphate O-acyltransferase[1], B4041[2][1], PlsB[2][1] , ECK4033, JW4001, b4041

Product description

GLYCEROL-3-P- Glycerol-3-phosphate acyltransferase[3]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0004366

glycerol-3-phosphate O-acyltransferase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00393

F

Seeded from EcoCyc (v14.0)

complete

GO:0004366

glycerol-3-phosphate O-acyltransferase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.3.1.15

F

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00393

C

Seeded from EcoCyc (v14.0)

complete

GO:0004366

glycerol-3-phosphate O-acyltransferase activity

PMID:6251087[4]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0005887

integral to plasma membrane

PMID:6997313[5]

IDA: Inferred from Direct Assay

C

complete

GO:0008654

phospholipid biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00393

P

Seeded from EcoCyc (v14.0)

complete

GO:0008654

phospholipid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0594

P

Seeded from EcoCyc (v14.0)

complete

GO:0019898

extrinsic to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9903

C

Seeded from EcoCyc (v14.0)

complete

GO:0006631

fatty acid metabolic process

PMID:3542964[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008654

phospholipid biosynthetic process

PMID:3294813[7]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005887

integral to plasma membrane

PMID:10074094[8]

IDA: Inferred from Direct Assay

C

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

lpdA

PMID:15690043[9]

Experiment(s):EBI-884968

Protein

rho

PMID:15690043[9]

Experiment(s):EBI-884968

Protein

rplC

PMID:15690043[9]

Experiment(s):EBI-884968, EBI-891798

Protein

rplD

PMID:15690043[9]

Experiment(s):EBI-884968

Protein

rpsC

PMID:15690043[9]

Experiment(s):EBI-884968, EBI-891798

Protein

rpsD

PMID:15690043[9]

Experiment(s):EBI-884968, EBI-891798

Protein

srmB

PMID:15690043[9]

Experiment(s):EBI-884968

Protein

tufA

PMID:15690043[9]

Experiment(s):EBI-884968

Protein

rplB

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rplF

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rplI

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rpsE

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rpsH

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rpsI

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rpsJ

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rluB

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rplK

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rplL

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rplM

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rplO

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rplS

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rplV

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rplX

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rpmB

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rpmG

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

rpsB

PMID:15690043[9]

Experiment(s):EBI-891798

Protein

dnaE

PMID:16606699[10]

Experiment(s):EBI-1147321

Protein

groL

PMID:16606699[10]

Experiment(s):EBI-1147321

Protein

rpsD

PMID:19402753[11]

LCMS(ID Probability):99.0 MALDI(Z-score):17.053160

Protein

rpsC

PMID:19402753[11]

LCMS(ID Probability):99.0 MALDI(Z-score):17.053160

Protein

ispA

PMID:19402753[11]

MALDI(Z-score):38.419024

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MTFCYPCRAF ALLTRGFTSF MSGWPRIYYK LLNLPLSILV KSKSIPADPA PELGLDTSRP
IMYVLPYNSK ADLLTLRAQC LAHDLPDPLE PLEIDGTLLP RYVFIHGGPR VFTYYTPKEE
SIKLFHDYLD LHRSNPNLDV QMVPVSVMFG RAPGREKGEV NPPLRMLNGV QKFFAVLWLG
RDSFVRFSPS VSLRRMADEH GTDKTIAQKL ARVARMHFAR QRLAAVGPRL PARQDLFNKL
LASRAIAKAV EDEARSKKIS HEKAQQNAIA LMEEIAANFS YEMIRLTDRI LGFTWNRLYQ
GINVHNAERV RQLAHDGHEL VYVPCHRSHM DYLLLSYVLY HQGLVPPHIA AGINLNFWPA
GPIFRRLGAF FIRRTFKGNK LYSTVFREYL GELFSRGYSV EYFVEGGRSR TGRLLDPKTG
TLSMTIQAML RGGTRPITLI PIYIGYEHVM EVGTYAKELR GATKEKESLP QMLRGLSKLR
NLGQGYVNFG EPMPLMTYLN QHVPDWRESI DPIEAVRPAW LTPTVNNIAA DLMVRINNAG
AANAMNLCCT ALLASRQRSL TREQLTEQLN CYLDLMRNVP YSTDSTVPSA SASELIDHAL
QMNKFEVEKD TIGDIIILPR EQAVLMTYYR NNIAHMLVLP SLMAAIVTQH RHISRDVLME
HVNVLYPMLK AELFLRWDRD ELPDVIDALA NEMQRQGLIT LQDDELHINP AHSRTLQLLA
AGARETLQRY AITFWLLSAN PSINRGTLEK ESRTVAQRLS VLHGINAPEF FDKAVFSSLV
LTLRDEGYIS DSGDAEPAET MKVYQLLAEL ITSDVRLTIE SATQGEG
Length

827

Mol. Wt

93.699 kDa

pI

8.7 (calculated)

Extinction coefficient

91,680 - 92,555 (calc based on 32 Y, 8 W, and 7 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0A7A7

Domain

281..426

PF01553 Acyltransferase

PMID:19920124[12]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=plsB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111678

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948541

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013232

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A7A7

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10740

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10740

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948541

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000731

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0733

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ Lightner, VA et al. (1980) Membrane phospholipid synthesis in Escherichia coli. Cloning of a structural gene (plsB) of the sn-glycerol-3-phosphate acyl/transferase. J. Biol. Chem. 255 9413-20 PubMed
  5. ↑ Larson, TJ et al. (1980) Membrane phospholipid synthesis in Escherichia coli. Identification of the sn-glycerol-3-phosphate acyltransferase polypeptide as the plsB gene product. J. Biol. Chem. 255 9421-6 PubMed
  6. ↑ Cooper, CL et al. (1987) Fatty acid metabolism in sn-glycerol-3-phosphate acyltransferase (plsB) mutants. J. Bacteriol. 169 605-11 PubMed
  7. ↑ Ray, TK & Cronan, JE Jr (1987) Acylation of glycerol 3-phosphate is the sole pathway of de novo phospholipid synthesis in Escherichia coli. J. Bacteriol. 169 2896-8 PubMed
  8. ↑ Heath, RJ & Rock, CO (1999) A missense mutation accounts for the defect in the glycerol-3-phosphate acyltransferase expressed in the plsB26 mutant. J. Bacteriol. 181 1944-6 PubMed
  9. ↑ 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 9.11 9.12 9.13 9.14 9.15 9.16 9.17 9.18 9.19 9.20 9.21 9.22 9.23 9.24 9.25 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  10. ↑ 10.0 10.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  11. ↑ 11.0 11.1 11.2 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  12. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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