PMID:3294813
| Citation |
Ray, TK and Cronan, JE Jr (1987) Acylation of glycerol 3-phosphate is the sole pathway of de novo phospholipid synthesis in Escherichia coli. J. Bacteriol. 169:2896-8 |
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| Abstract |
The inhibition of phospholipid synthesis engendered by starving glycerol 3-phosphate (G3P) auxotrophs of Escherichia coli (plsB or gpsA) for G3P is incomplete; 5 to 10% of the normal rate of phospholipid synthesis remains, even after prolonged starvation. We report that G3P starvation of a strain having lesions in both the gpsA and plsB genes resulted in essentially complete (greater than 98.5%) inhibition of phospholipid synthesis, indicating that all de novo glycerolipid synthesis in E. coli proceeds by acylation of G3P. |
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| Keywords |
Acetates/metabolism; Acylation; Diglycerides/metabolism; Escherichia coli/metabolism; Glyceraldehyde-3-Phosphate Dehydrogenases/metabolism; Glycerol/metabolism; Glycerophosphates/metabolism; Phosphatidic Acids/biosynthesis; Phospholipids/biosynthesis |
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