PMID:10074094
| Citation |
Heath, RJ and Rock, CO (1999) A missense mutation accounts for the defect in the glycerol-3-phosphate acyltransferase expressed in the plsB26 mutant. J. Bacteriol. 181:1944-6 |
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| Abstract |
The sn-glycerol-3-phosphate acyltransferase (plsB) catalyzes the first step in membrane phospholipid formation. A conditional Escherichia coli mutant (plsB26) has a single missense mutation (G1045A) predicting the expression of an acyltransferase with an Ala349Thr substitution. The PlsB26 protein had a significantly reduced glycerol-3-phosphate acyltransferase specific activity coupled with an elevated Km for glycerol-3-phosphate. |
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| Keywords |
Alleles; Base Sequence; DNA Primers/genetics; DNA, Bacterial/genetics; Escherichia coli/enzymology; Escherichia coli/genetics; Gene Expression; Genes, Bacterial; Glycerol-3-Phosphate O-Acyltransferase/genetics; Glycerol-3-Phosphate O-Acyltransferase/metabolism; Kinetics; Molecular Sequence Data; Mutation, Missense |
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