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Standard Name	mglA
Gene Synonym(s)	ECK2142, b2149, JW2136, mglP, PMG, mgl^[1]
Product Desc.	MglA^[2]^[3]; Component of galactose ABC transporter^[2]^[3] Methyl-galactoside transporter^[4]
Product Synonyms(s)	fused methyl-galactoside transporter subunits of ABC superfamily: ATP-binding components^[1], B2149^[2]^[1], MglP^[2]^[1], Mgl^[2]^[1], MglA^[2]^[1] , ECK2142, JW2136, mglP, b2149
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): mglAC^[2], mglBAC^[2], OP00230, mglBAK
Regulation/Activity
Quick Links
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</protect> See Help:Quickview for help with entering information in the Quickview table. <protect></protect>

Notes

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Binds TrxA (Kumar, 2004).^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	mglA
Mnemonic	Methyl-galactoside
Synonyms	ECK2142, b2149, JW2136, mglP, PMG, mgl^[1]
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	48.19 minutes	MG1655: 2237311..2235791 <gbrowseImage> name=NC_000913:2235791..2237311 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 2190527..2189007 <gbrowseImage> name=NC_012967:2189007..2190527 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 2128274..2129794 <gbrowseImage> name=NC_012759:2128274..2129794 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 2242623..2241103 <gbrowseImage> name=NC_007779:2241103..2242623 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability	Comments
ΔmglA (Keio:JW2136)	deletion	deletion	PMID:16738554	Shigen CGSC9731^[5]
mglA::Tn5KAN-2 (FB20651)	Insertion at nt 123 in Plus orientation		PMID:15262929	E. coli Genome Project:FB20651	does not contain pKD46
mglA::Tn5KAN-2 (FB20652)	Insertion at nt 123 in Plus orientation		PMID:15262929	E. coli Genome Project:FB20652	contains pKD46
mgl-51				CGSC:4507
mgl-50				CGSC:5278
mgl-2				CGSC:9752
mgl-500::Tn10				CGSC:15615
mgl-15				CGSC:19380
ΔmglA776::kan			PMID:16738554	CGSC:101848
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW2136	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCGTCAGCTCAACGACTCCGTC Primer 2:CCAAGGTGCAAAGACGCAAGACG
7F1	Kohara Phage	Genobase	PMID:3038334
7H12	Kohara Phage	Genobase	PMID:3038334
zbd-3104::Tn10	Linked marker	CAG12021 = CGSC7344^[5]	est. P1 cotransduction: 5% ^[6] Synonyms:zbc-3105::Tn10, zbd-3105::Tn10
napA722::Tn10	Linked marker	CAG12098 = CGSC7400^[5]	est. P1 cotransduction: 3% ^[6] Synonyms:zeg-722, zei-722::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10592	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10592	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000585	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:949036	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0587	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007103	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	MglA
Synonyms	fused methyl-galactoside transporter subunits of ABC superfamily: ATP-binding components^[1], B2149^[2]^[1], MglP^[2]^[1], Mgl^[2]^[1], MglA^[2]^[1] , ECK2142, JW2136, mglP, b2149
Product description	MglA^[2]^[3]; Component of galactose ABC transporter^[2]^[3] Methyl-galactoside transporter^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0006974	response to DNA damage stimulus	PMID:11967071	IEP: Inferred from Expression Pattern		P		complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of galactose ABC transporter	could be indirect
Protein	mutM		PMID:16606699	Experiment(s):EBI-1142018
Protein	groL		PMID:16606699	Experiment(s):EBI-1142018
Protein	yifB		PMID:16606699	Experiment(s):EBI-1142018
Protein	degP		PMID:16606699	Experiment(s):EBI-1142018
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
cytoplasm			From EcoCyc^[3]
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MVSSTTPSSG EYLLEMSGIN KSFPGVKALD NVNLKVRPHS IHALMGENGA GKSTLLKCLF GIYQKDSGTI LFQGKEIDFH SAKEALENGI SMVHQELNLV LQRSVMDNMW LGRYPTKGMF VDQDKMYRET KAIFDELDID IDPRARVGTL SVSQMQMIEI AKAFSYNAKI VIMDEPTSSL TEKEVNHLFT IIRKLKERGC GIVYISHKME EIFQLCDEVT VLRDGQWIAT EPLAGLTMDK IIAMMVGRSL NQRFPDKENK PGEVILEVRN LTSLRQPSIR DVSFDLHKGE ILGIAGLVGA KRTDIVETLF GIREKSAGTI TLHGKQINNH NANEAINHGF ALVTEERRST GIYAYLDIGF NSLISNIRNY KNKVGLLDNS RMKSDTQWVI DSMRVKTPGH RTQIGSLSGG NQQKVIIGRW LLTQPEILML DEPTRGIDVG AKFEIYQLIA ELAKKGKGII IISSEMPELL GITDRILVMS NGLVSGIVDT KTTTQNEILR LASLHL
Length	506
Mol. Wt	56.417 kDa
pI	7.7 (calculated)
Extinction coefficient	36,900 - 37,275 (calc based on 10 Y, 4 W, and 3 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	References
Domain	53..178	PF00005 ABC transporter	PMID:19920124
Domain	303..435	PF00005 ABC transporter	PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=mglA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16130087	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:949036	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007103	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P0AAG8	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG10592	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10592	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:949036	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000585	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0587	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MC4100	9.79E+01	molecules/cell	Medium: median data from rich and minimal media Temperature (°C): 37 Doubling time (min): Growth Rate(min): Growth phase: other:	emPAI		PMID:18304323
Protein	E. coli K-12 MG1655	52	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	83	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	21^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
mglAC
mglBAC
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:2237291..2237331 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b2149 (EcoliWiki Page)	NCBI GEO profiles for mglA
microarray	GenExpDB:b2149 (EcoliWiki Page)	Summary of data for mglA from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
	GFP Fusion	Intergenic region (2237226..2237446) fused to gfpmut2.	OpenBioSystems	GFP fusion described in Zaslaver, et al. Plate:109-AZ14; Well:C12^[7]
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Notes

Accessions Related to mglA Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10592	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0587	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b2149
EcoGene	EcoGene:EG10592	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000585	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007103	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Anopheles gambiae	ENSANGP00000029065 (score: 1.000; bootstrap: 100%) YP_026286 (score: 0.089)	From Inparanoid:20070104
Drosophila pseudoobscura	YP_026286 (score: 0.230) GA14368-PA (score: 1.000; bootstrap: 87%) GA13367-PA (score: 0.116)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000027009 (score: 1.000; bootstrap: 92%)	From Inparanoid:20070104
Shigella flexneri	MGLA	From SHIGELLACYC
E. coli O157	MGLA	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF00005 ABC transporter
Pfam (EcoliWiki Page)	PF00005 ABC transporter
Panther (EcoliWiki Page)	PTHR24220:SF114
Superfamily (EcoliWiki Page)	SUPERFAMILY:52540
Superfamily (EcoliWiki Page)	SUPERFAMILY:52540
EcoCyc	EcoCyc:EG10592	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10592	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000585	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0587	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007103	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ Zaslaver, A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat. Methods 3 623-8 PubMed

mglA:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to mglA Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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