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Standard Name	malY
Gene Synonym(s)	ECK1617, b1622, JW1614^[1], JW1614
Product Desc.	bifunctional: repressor of maltose regulon^[2]^[3] Antagonist of MalT transcriptional activator of maltose regulon, binds MalT in absence of maltotriose; cysteine desulfhydrase^[4]
Product Synonyms(s)	bifunctional beta-cystathionase, PLP-dependent and regulator of maltose regulon^[1], B1622^[2]^[1], MalY^[2]^[1] , ECK1617, JW1614, b1622
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): malXY^[2], OP00176
Regulation/Activity
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	malY
Mnemonic	Maltose
Synonyms	ECK1617, b1622, JW1614^[1], JW1614
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	36.62 minutes	MG1655: 1698981..1700153 <gbrowseImage> name=NC_000913:1698981..1700153 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 1678151..1679323 <gbrowseImage> name=NC_012967:1678151..1679323 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 1591040..1592212 <gbrowseImage> name=NC_012759:1591040..1592212 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 1702671..1703843 <gbrowseImage> name=NC_007779:1702671..1703843 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 1789942..1791114 <gbrowseImage> name=NC_010473:1789942..1791114 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Description	Reference	Availability	Comments
ΔmalY (Keio:JW1614)	deletion	deletion		PMID:16738554	Shigen CGSC9375^[5]
malY::Tn5KAN-2 (FB20395)	Insertion at nt 678 in Minus orientation			PMID:15262929	E. coli Genome Project:FB20395	contains pKD46
malY::Tn5KAN-2 (FB20396)	Insertion at nt 678 in Minus orientation			PMID:15262929	E. coli Genome Project:FB20396	does not contain pKD46
malYK233I		K233I	Loss of enzymatic activity; but no loss of repression function			seeded from UniProt:P23256
ΔmalY770::kan				PMID:16738554	CGSC:101750
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW1614	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCTTCGATTTTTCAAAGGTCGT Primer 2:CCACGAACAGCGCGGATGGCGTT
6A5	Kohara Phage	Genobase	PMID:3038334
9A1	Kohara Phage	Genobase	PMID:3038334
20B5	Kohara Phage	Genobase	PMID:3038334
zdd-235::Tn10	Linked marker	CAG18461 = CGSC7378^[5]	est. P1 cotransduction: % ^[6] Synonyms:zdc-235::Tn10
zdi-925::Tn10	Linked marker	CAG12151 = CGSC7385^[5]	est. P1 cotransduction: % ^[6] Synonyms:zdh-925::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10564	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10564	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000557	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:945937	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0559	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0005432	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	MalY
Synonyms	bifunctional beta-cystathionase, PLP-dependent and regulator of maltose regulon^[1], B1622^[2]^[1], MalY^[2]^[1] , ECK1617, JW1614, b1622
Product description	bifunctional: repressor of maltose regulon^[2]^[3] Antagonist of MalT transcriptional activator of maltose regulon, binds MalT in absence of maltotriose; cysteine desulfhydrase^[4]
EC number (for enzymes)	4.4.1.8^[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0003824	catalytic activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015421	F	Seeded from EcoCyc (v14.0)	complete
	GO:0004121	cystathionine beta-lyase activity	GOA:spec GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:4.4.1.8	F	Seeded from EcoCyc (v14.0)	complete
	GO:0006350	transcription	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P	Seeded from EcoCyc (v14.0)	complete
	GO:0008652	cellular amino acid biosynthetic process	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0028	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009058	biosynthetic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004839	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009086	methionine biosynthetic process	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0486	P	Seeded from EcoCyc (v14.0)	complete
	GO:0016769	transferase activity, transferring nitrogenous groups	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004839	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016829	lyase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0456	F	Seeded from EcoCyc (v14.0)	complete
	GO:0030170	pyridoxal phosphate binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004839	F	Seeded from EcoCyc (v14.0)	complete
	GO:0030170	pyridoxal phosphate binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015421	F	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	mpl	PMID:16606699	Experiment(s):EBI-1140303
Protein	gatZ	PMID:16606699	Experiment(s):EBI-1140303
Protein	mqo	PMID:16606699	Experiment(s):EBI-1140303
Protein	nuoF	PMID:16606699	Experiment(s):EBI-1140303
Protein	rhsD	PMID:16606699	Experiment(s):EBI-1140303
Protein	rplB	PMID:16606699	Experiment(s):EBI-1140303
Protein	matC	PMID:16606699	Experiment(s):EBI-1140303
Protein	aaeB	PMID:16606699	Experiment(s):EBI-1140303
Protein	ompL	PMID:16606699	Experiment(s):EBI-1140303
Protein	uidA	PMID:16606699	Experiment(s):EBI-1140303
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MFDFSKVVDR HGTWCTQWDY VADRFGTADL LPFTISDMDF ATAPCIIEAL NQRLMHGVFG YSRWKNDEFL AAIAHWFSTQ HYTAIDSQTV VYGPSVIYMV SELIRQWSET GEGVVIHTPA YDAFYKAIEG NQRTVMPVAL EKQADGWFCD MGKLEAVLAK PECKIMLLCS PQNPTGKVWT CDELEIMADL CERHGVRVIS DEIHMDMVWG EQPHIPWSNV ARGDWALLTS GSKSFNIPAL TGAYGIIENS SSRDAYLSAL KGRDGLSSPS VLALTAHIAA YQQGAPWLDA LRIYLKDNLT YIADKMNAAF PELNWQIPQS TYLAWLDLRP LNIDDNALQK ALIEQEKVAI MPGYTYGEEG RGFVRLNAGC PRSKLEKGVA GLINAIRAVR
Length	390
Mol. Wt	43.642 kDa
pI	5.2 (calculated)
Extinction coefficient	93,850 - 94,850 (calc based on 15 Y, 13 W, and 8 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	28..382	PF00155 Aminotransferase class I and II		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=malY taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16129580	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:945937	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0005432	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P23256	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG10564	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10564	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:945937	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000557	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0559	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MG1655	179	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	124	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	128	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
malXY
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:1698961..1699001 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b1622 (EcoliWiki Page)	NCBI GEO profiles for malY
microarray	GenExpDB:b1622 (EcoliWiki Page)	Summary of data for malY from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to malY Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10564	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0559	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b1622
EcoGene	EcoGene:EG10564	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000557	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0005432	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Apis mellifera	ENSAPMP00000026240 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000023584 (score: 1.000; bootstrap: 99%)	From Inparanoid:20070104
Shigella flexneri	MALY	From SHIGELLACYC
E. coli O157	MALY	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF00155 Aminotransferase class I and II
Panther (EcoliWiki Page)	PTHR11751:SF21
Superfamily (EcoliWiki Page)	SUPERFAMILY:53383
EcoCyc	EcoCyc:EG10564	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10564	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000557	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0559	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0005432	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

malY:On One Page

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Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to malY Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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