lldR:On One Page
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Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
Quickview | | Gene | | Product(s) | | Expression| | Evolution | | References | |
Quickview
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Standard Name |
lldR |
---|---|
Gene Synonym(s) |
ECK3594, b3604, JW3579, lctR, lct[1], lct |
Product Desc. |
LldR transcriptional repressor[2][3] Dual role activator/repressor for lldPRD operon[4] |
Product Synonyms(s) |
DNA-binding transcriptional repressor[1], Lct[2][1], B3604[2][1], LldR[2][1], LctR[2][1] , ECK3594, JW3579, lct, lctR, b3604 |
Function from GO |
<GO_nr /> |
Knock-Out Phenotype | |
Regulation/Expression | |
Regulation/Activity | |
Quick Links | |
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</protect> See Help:Quickview for help with entering information in the Quickview table. <protect></protect>
Notes
LldR is a HTH GntR-type DNA-binding transcriptional regulator.[4]
Gene
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Nomenclature
See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.
Standard name |
lldR |
---|---|
Mnemonic |
L-Lactose dehydrogenase |
Synonyms |
ECK3594, b3604, JW3579, lctR, lct[1], lct |
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Notes
Location(s) and DNA Sequence
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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.
Strain | Map location | Genome coordinates | Genome browsers | Sequence links |
---|---|---|---|---|
MG1655 |
81.41 minutes, 81.41 minutes |
MG1655: 3777077..3777853 |
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NC_012967: 3719864..3720640 |
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NC_012759: 3665403..3666179 |
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W3110 |
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W3110: 3861361..3860585 |
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DH10B: 3874654..3875430 |
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Notes
Sequence Features
See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.
Feature Type | Strain | Genomic Location | Evidence | Reference | Notes |
---|---|---|---|---|---|
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Notes
Alleles and Phenotypes
See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.
Allele | Nt change(s) | AA change(s) | Phenotype: Type | Phenotype: Description | Reference | Availability | Comments |
---|---|---|---|---|---|---|---|
ΔlldR (Keio:JW3579) |
deletion |
deletion |
PMID:16738554 |
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lldR::Tn5KAN-I-SceI (FB21334) |
Insertion at nt 186 in Plus orientation |
PMID:15262929 |
does not contain pKD46 | ||||
lldR::Tn5KAN-I-SceI (FB21335) |
Insertion at nt 186 in Plus orientation |
PMID:15262929 |
contains pKD46 | ||||
ΔlldR788::kan |
PMID:16738554 |
| |||||
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Notes
Genetic Interactions
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Interactor | Interaction | Allele | Score(s) | Reference(s) | Accessions | Notes |
---|---|---|---|---|---|---|
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Notes
Genetic Resources
See Help:Gene_resources for help entering information into the Genetic Resources table.
Resource | Resource Type | Source | Notes/Reference |
---|---|---|---|
JW3579 |
Plasmid clone |
PMID:16769691 Status:Clone OK Primer 1:GCCATTGTTTTACCCAGACGCCT Primer 2:CCTGCGTTTTTCTCCCTCGAATG | |
Kohara Phage |
PMID:3038334 | ||
zhg-50::Tn10 |
Linked marker |
est. P1 cotransduction: % [6] | |
zic-4901::Tn10 |
Linked marker |
est. P1 cotransduction: 9% [6] | |
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Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
Database | Accession | Notes |
---|---|---|
EcoCyc:EG11962 |
Escherichia coli str. K-12 substr. MG1655 | |
EcoGene:EG11962 |
Escherichia coli str. K-12 substr. MG1655 | |
RegulonDB:ECK120001888 |
Escherichia coli str. K-12 substr. MG1655 | |
Escherichia coli str. K-12 substr. MG1655 | ||
EchoBASE:EB1905 |
Escherichia coli str. K-12 substr. MG1655 | |
ASAP:ABE-0011782 |
Escherichia coli str. K-12 substr. MG1655 | |
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Notes
Links
Name | URL | Comments |
---|---|---|
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Product(s)
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Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
Standard name |
LldR |
---|---|
Synonyms |
DNA-binding transcriptional repressor[1], Lct[2][1], B3604[2][1], LldR[2][1], LctR[2][1] , ECK3594, JW3579, lct, lctR, b3604 |
Product description |
LldR transcriptional repressor[2][3] Dual role activator/repressor for lldPRD operon[4] |
EC number (for enzymes) |
|
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Notes
Function
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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
---|---|---|---|---|---|---|---|---|
GO:0003677 |
DNA binding |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
SP_KW:KW-0238 |
F |
Seeded from EcoCyc (v14.0) |
complete | |
GO:0003700 |
transcription factor activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000524 |
F |
Seeded from EcoCyc (v14.0) |
complete | |
GO:0005622 |
intracellular |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000524 |
C |
Seeded from EcoCyc (v14.0) |
complete | |
GO:0006350 |
transcription |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
SP_KW:KW-0804 |
P |
Seeded from EcoCyc (v14.0) |
complete | |
GO:0006355 |
regulation of transcription, DNA-dependent |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000524 |
P |
Seeded from EcoCyc (v14.0) |
complete | |
GO:0006974 |
response to DNA damage stimulus |
PMID:11967071 |
IEP: Inferred from Expression Pattern |
P |
complete | |||
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
Partner Type | Partner | Notes | References | Evidence |
---|---|---|---|---|
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Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
Compartment | Description | Evidence | Reference/Source | Notes |
---|---|---|---|---|
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Notes
Structure and Physical Properties
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Physical Properties
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
Name | |
---|---|
Sequence |
MIVLPRRLSD EVADRVRALI DEKNLEAGMK LPAERQLAMQ LGVSRNSLRE ALAKLVSEGV LLSRRGGGTF IRWRHDTWSE QNIVQPLKTL MADDPDYSFD ILEARYAIEA STAWHAAMRA TPGDKEKIQL CFEATLSEDP DIASQADVRF HLAIAEASHN IVLLQTMRGF FDVLQSSVKH SRQRMYLVPP VFSQLTEQHQ AVIDAIFAGD ADGARKAMMA HLSFVHTTMK RFDEDQARHA RITRLPGEHN EHSREKNA |
Length |
258 |
Mol. Wt |
29.166 kDa |
pI |
6.9 (calculated) |
Extinction coefficient |
20,970 - 21,095 (calc based on 3 Y, 3 W, and 1 C residues) |
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Domains/Motifs/Modification Sites
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
|
<motif_map/> |
Structure
| </protect>
Structure figures<protect> | ||||||
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
Resource type | Source | Notes/Reference |
---|---|---|
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Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
Database | Accession | Notes |
---|---|---|
Escherichia coli str. K-12 substr. MG1655 | ||
Escherichia coli str. K-12 substr. MG1655 | ||
ASAP:ABE-0011782 |
Escherichia coli str. K-12 substr. MG1655 | |
Escherichia coli str. K-12 substr. MG1655 | ||
EcoCyc:EG11962 |
Escherichia coli str. K-12 substr. MG1655 | |
EcoGene:EG11962 |
Escherichia coli str. K-12 substr. MG1655 | |
Escherichia coli str. K-12 substr. MG1655 | ||
RegulonDB:ECK120001888 |
Escherichia coli str. K-12 substr. MG1655 | |
EchoBASE:EB1905 |
Escherichia coli str. K-12 substr. MG1655 | |
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Notes
Links
Name | URL | Comments |
---|---|---|
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Expression
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Overview
This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.
Cellular Levels
Molecule | Organism or Strain | Value | Units | Experimental Conditions | Assay used | Notes | Reference(s) |
---|---|---|---|---|---|---|---|
Protein |
E. coli K-12 MG1655 |
61 |
molecules/cell/generation |
|
Ribosome Profiling |
PMID: 24766808 | |
Protein |
E. coli K-12 MG1655 |
26 |
molecules/cell/generation |
|
Ribosome Profiling |
PMID: 24766808 | |
Protein |
E. coli K-12 MG1655 |
26a |
molecules/cell/generation |
|
Ribosome Profiling |
Low confidence in the sequencing data set. |
PMID: 24766808 |
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Notes
Transcription and Transcriptional Regulation
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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.
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Notes
This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.
Translation and Regulation of Translation
<protect><gbrowseImage>
name=NC_000913:3777057..3777097
source=MG1655
type=Gene+DNA_+Protein
preset=Nterminus
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This picture shows the sequence around the N-terminus.
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Notes
This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.
Turnover and Regulation of Turnover
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Notes
This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.
Experimental
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Mutations Affecting Expression
See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.
Allele Name | Mutation | Phenotype | Reference |
---|---|---|---|
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Expression Studies
See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.
Type | Reference | Notes |
---|---|---|
microarray |
NCBI GEO profiles for lldR | |
microarray |
Summary of data for lldR from multiple microarray studies | |
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Expression Resources
See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.
Resource Name | Resource Type | Description | Source | Notes |
---|---|---|---|---|
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Notes
Accessions Related to lldR Expression
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
Database | Accession | Notes |
---|---|---|
EcoCyc:EG11962 |
Escherichia coli str. K-12 substr. MG1655 | |
EchoBASE:EB1905 |
Escherichia coli str. K-12 substr. MG1655 | |
EcoGene:EG11962 |
Escherichia coli str. K-12 substr. MG1655 | |
RegulonDB:ECK120001888 |
Escherichia coli str. K-12 substr. MG1655 | |
ASAP:ABE-0011782 |
Escherichia coli str. K-12 substr. MG1655 | |
edit table |
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Notes
Links
Name | URL | Comments |
---|---|---|
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Evolution
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Homologs in Other Organisms
See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.
Organism | Homologs (Statistics) | Comments |
---|---|---|
Xenopus tropicalis |
|
From Inparanoid:20070104 |
Shigella flexneri |
LLDR |
From SHIGELLACYC |
E. coli O157 |
LLDR |
From ECOO157CYC |
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Do-It-Yourself Web Tools
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Notes
Families
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
Database | Accession | Notes |
---|---|---|
EcoCyc:EG11962 |
Escherichia coli str. K-12 substr. MG1655 | |
EcoGene:EG11962 |
Escherichia coli str. K-12 substr. MG1655 | |
RegulonDB:ECK120001888 |
Escherichia coli str. K-12 substr. MG1655 | |
EchoBASE:EB1905 |
Escherichia coli str. K-12 substr. MG1655 | |
ASAP:ABE-0011782 |
Escherichia coli str. K-12 substr. MG1655 | |
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Notes
Links
Name | URL | Comments |
---|---|---|
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References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.0 5.1 5.2 CGSC: The Coli Genetics Stock Center
- ↑ 6.0 6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
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