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Standard Name	grxC
Gene Synonym(s)	ECK3600, b3610, JW3585, yibM^[1], yibM
Product Desc.	glutaredoxin 3^[2]^[3] Glutaredoxin 3^[4]
Product Synonyms(s)	glutaredoxin 3^[1], B3610^[2]^[1], YibM^[2]^[1] , ECK3600, JW3585, yibM, b3610
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): grxC^[2]
Regulation/Activity
Quick Links
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	grxC
Mnemonic	Glutaredoxin
Synonyms	ECK3600, b3610, JW3585, yibM^[1], yibM
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	81.52 minutes	MG1655: 3782465..3782214 <gbrowseImage> name=NC_000913:3782214..3782465 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 3725208..3724957 <gbrowseImage> name=NC_012967:3724957..3725208 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 3670540..3670791 <gbrowseImage> name=NC_012759:3670540..3670791 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 3855973..3856224 <gbrowseImage> name=NC_007779:3855973..3856224 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 3880042..3879791 <gbrowseImage> name=NC_010473:3879791..3880042 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
Coding Start (SO:0000323)	MG1655	3782217	Edman degradation	PMID:7937896
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability
ΔgrxC (Keio:JW3585)	deletion	deletion	PMID:16738554	Shigen CGSC10641^[5]
ΔgrxC722::kan			PMID:16738554	CGSC:101258
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW3585	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCGCCAATGTTGAAATCTATAC Primer 2:CCTTTCAGCAGGGGATCCAGTCC
5D2	Kohara Phage	Genobase	PMID:3038334
zhg-50::Tn10	Linked marker	CAG18450 = CGSC7450^[5]	est. P1 cotransduction: % ^[6] Synonyms:zhf-50::Tn10, zhf-5::Tn10
zic-4901::Tn10	Linked marker	CAG18492 = CGSC7457^[5]	est. P1 cotransduction: 13% ^[6]
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG12294	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG12294	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002175	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:948132	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2202	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0011801	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	GrxC
Synonyms	glutaredoxin 3^[1], B3610^[2]^[1], YibM^[2]^[1] , ECK3600, JW3585, yibM, b3610
Product description	glutaredoxin 3^[2]^[3] Glutaredoxin 3^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0006810	transport	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009055	electron carrier activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002109	F	Seeded from EcoCyc (v14.0)	complete
	GO:0009055	electron carrier activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011767	F	Seeded from EcoCyc (v14.0)	complete
	GO:0009263	deoxyribonucleotide biosynthetic process	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0215	P	Seeded from EcoCyc (v14.0)	complete
	GO:0015035	protein disulfide oxidoreductase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002109	F	Seeded from EcoCyc (v14.0)	complete
	GO:0022900	electron transport chain	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0249	P	Seeded from EcoCyc (v14.0)	complete
	GO:0045454	cell redox homeostasis	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002109	P	Seeded from EcoCyc (v14.0)	complete
	GO:0045454	cell redox homeostasis	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011767	P	Seeded from EcoCyc (v14.0)	complete
	GO:0045454	cell redox homeostasis	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011900	P	Seeded from EcoCyc (v14.0)	complete
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Interactions

See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MANVEIYTKE TCPYCHRAKA LLSSKGVSFQ ELPIDGNAAK REEMIKRSGR TTVPQIFIDA QHIGGCDDLY ALDARGGLDP LLK
Length	83
Mol. Wt	9.137 kDa
pI	7.2 (calculated)
Extinction coefficient	4,470 - 4,845 (calc based on 3 Y, 0 W, and 3 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Initiator Methionine	1	Removed	UniProt:P0AC62
Domain	4..63	PF00462 Glutaredoxin		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=grxC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16131481	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:948132	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0011801	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P0AC62	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG12294	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG12294	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:948132	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002175	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2202	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MG1655	7668	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	2978	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	2864	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
grxC
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:3782445..3782485 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b3610 (EcoliWiki Page)	NCBI GEO profiles for grxC
microarray	GenExpDB:b3610 (EcoliWiki Page)	Summary of data for grxC from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
	GFP Fusion	Intergenic region (3781984..3782221) fused to gfpmut2.	OpenBioSystems	GFP fusion described in Zaslaver, et al. Plate:109-AZ17; Well:E9^[7]
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Notes

Accessions Related to grxC Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG12294	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2202	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b3610
EcoGene	EcoGene:EG12294	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002175	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0011801	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Apis mellifera	ENSAPMP00000026176 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Arabidopsis thaliana	AT5G63030 (score: 1.000; bootstrap: 100%) AT5G40370 (score: 0.463) AT5G20500 (score: 0.144) AT2G20270 (score: 0.144) AT4G28730 (score: 0.128) AT1G77370 (score: 0.085) AT1G03020 (score: 0.074) AT5G18600 (score: 0.069) AT4G15700 (score: 0.053)	From Inparanoid:20070104
Bos taurus	ENSBTAP00000001575 (score: 1.000; bootstrap: 100%) ENSBTAP00000015500 (score: 0.963) ENSBTAP00000018314 (score: 0.931) ENSBTAP00000008637 (score: 0.806) ENSBTAP00000028695 (score: 0.787) ENSBTAP00000015063 (score: 0.775) ENSBTAP00000021249 (score: 0.050)	From Inparanoid:20070104
Caenorhabditis elegans	WBGene00017340 (score: 1.000; bootstrap: 69%)	From Inparanoid:20070104
Canis familiaris	ENSCAFP00000011683 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Danio rerio	ZDB-GENE-040718-101 (score: 1.000; bootstrap: 61%) ZDB-CDNA-040718-122 (score: 1.000; bootstrap: 61%) ZDB-CDNA-050612-210 (score: 0.090) ZDB-GENE-041010-11 (score: 0.090) ZDB-CDNA-041010-11 (score: 0.076)	From Inparanoid:20070104
Dictyostelium discoideum	DDB0188682 (score: 1.000; bootstrap: 100%) DDB0216771 (score: 0.193)	From Inparanoid:20070104
Monodelphis domestica	ENSMODP00000015289 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Oryza gramene	P55142 (score: 1.000; bootstrap: 100%) Q7FA28 (score: 1.000; bootstrap: 100%) Q7XY25 (score: 0.753) Q94JS9 (score: 0.693) Q6K953 (score: 0.613) Q84Z96 (score: 0.167) Q67U24 (score: 0.147) Q6H628 (score: 0.087)	From Inparanoid:20070104
Schizosaccharomyces pombe	SPAC4F100 (score: 1.000; bootstrap: 100%) SPAC15E19 (score: 0.186)	From Inparanoid:20070104
Takifugu rubripes	NEWSINFRUP00000155411 (score: 1.000; bootstrap: 65%)	From Inparanoid:20070104
Tetraodon nigroviridis	GSTENP00030436001 (score: 1.000; bootstrap: 55%)	From Inparanoid:20070104
Shigella flexneri	GRXC	From SHIGELLACYC
E. coli O157	GRXC	From ECOO157CYC
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Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF00462 Glutaredoxin
Superfamily (EcoliWiki Page)	SUPERFAMILY:52833
EcoCyc	EcoCyc:EG12294	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG12294	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120002175	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2202	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0011801	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ Zaslaver, A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat. Methods 3 623-8 PubMed

grxC:On One Page

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Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to grxC Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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