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Standard Name	glvC
Gene Synonym(s)	ECK3675, b3683, JW3660, yidO, ptiC^[1]^[2]^[3], ECK3674, glvB, JW3659, yidN
Product Desc.	GlvC^[2]^[3]; Component of EIIBCGlv^[3]
Product Synonyms(s)	arbutin sp ecific enzyme IIC component of PTS^[1], B3683^[2]^[1], YidO^[2]^[1], GlvC^[2]^[1], PtiC^[3]^[1] , ECK3674, glvB, JW3659, yidN, yidO, b3683
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): ysdC^[2]
Regulation/Activity
Quick Links
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	glvC
Mnemonic
Synonyms	ECK3675, b3683, JW3660, yidO, ptiC^[1]^[2]^[3], ECK3674, glvB, JW3659, yidN
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	83.21 minutes	MG1655: 3861626..3860520 <gbrowseImage> name=NC_000913:3860520..3861626 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 3822427..3824043 <gbrowseImage> name=NC_012967:3822427..3824043 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
W3110		W3110: 3776812..3777918 <gbrowseImage> name=NC_007779:3776812..3777918 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 3959210..3957594 <gbrowseImage> name=NC_010473:3957594..3959210 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability
ΔglvC (Keio:JW3660)	deletion	deletion	PMID:16738554	Shigen CGSC10686^[4]
ΔglvC790::kan			PMID:16738554	CGSC:101214
ΔglvC789::kan			PMID:16738554	CGSC:106200
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW3660	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCCTCAGTCAAATTCAACGCTT Primer 2:CCGTCAATCAGACCTCCGCCCAT
3D1	Kohara Phage	Genobase	PMID:3038334
8E8	Kohara Phage	Genobase	PMID:3038334
zic-4901::Tn10	Linked marker	CAG18492 = CGSC7457^[4]	est. P1 cotransduction: 27% ^[5]
zid-501::Tn10	Linked marker	CAG18499 = CGSC7458^[4]	est. P1 cotransduction: 62% ^[5]
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11710	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11710	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001653	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:2847721	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1661	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012043	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	GlvC
Synonyms	arbutin sp ecific enzyme IIC component of PTS^[1], B3683^[2]^[1], YidO^[2]^[1], GlvC^[2]^[1], PtiC^[3]^[1] , ECK3674, glvB, JW3659, yidN, yidO, b3683
Product description	GlvC^[2]^[3]; Component of EIIBCGlv^[3]
EC number (for enzymes)	2.7.1.69^[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005351	sugar:hydrogen symporter activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003352	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0997	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C	Seeded from EcoCyc (v14.0)	complete
	GO:0006810	transport	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P	Seeded from EcoCyc (v14.0)	complete
	GO:0008643	carbohydrate transport	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0762	P	Seeded from EcoCyc (v14.0)	complete
	GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003352	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004719	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010975	F	Seeded from EcoCyc (v14.0)	complete
	GO:0009401	phosphoenolpyruvate-dependent sugar phosphotransferase system	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003352	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009401	phosphoenolpyruvate-dependent sugar phosphotransferase system	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004719	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009401	phosphoenolpyruvate-dependent sugar phosphotransferase system	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010975	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009401	phosphoenolpyruvate-dependent sugar phosphotransferase system	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0598	P	Seeded from EcoCyc (v14.0)	complete
	GO:0016020	membrane	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003352	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016020	membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004719	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-9909	C	Seeded from EcoCyc (v14.0)	complete
	GO:0003674	molecular function	127.0.0.1 15:06, 17 February 2015 (CST)	ND: No biological Data available		F	Is not GO:0016740 (transferase activity) as suggested. PMID:8019415 infers GO:0004557 (alpha galactosidase activity) and GO:0008706 (phospho-beta-glucosidase activity) in abstract but did not document any evidence to support terms. Gene is compared to MalX, which is not sufficiently annotated to warrant sequence comparison as evidence. Strongly suggest GO:0008982 (protein-N(PI)-phosphohistidine-sugar phosphotransferase activity); no sequence comparison fully supports term.	Missing: reference
	GO:0008643	carbohydrate transport	PMID:8019415	TAS: Traceable Author Statement		P		complete
	GO:0005575	cellular component	127.0.0.1 15:06, 17 February 2015 (CST)	ND: No biological Data available		C	Presumed function from sequence data, no data from wet experiments could be found on C subunit. Ecocyc presumes subunit B on cytoplasmic side of membrane but does not provide citation or mention C subunit localization.	Missing: reference
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of EIIBCGlv	could be indirect
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source
plasma membrane	C-terminus localized to the periplasm with 8 predicted transmembrane domains	Daley et al. (2005) ^[6]
plasma membrane			From EcoCyc^[3]
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MRTQVLLNRL KKHLFFKDVF DAVYLCSQRS TFSRKRRSLP PNEKHESDHE SHWVVMFCRS HLPILAPGLP HNQSGFLLTE LRKEDVEMLS QIQRFGGAMF TPVLLFPFAG IVVGLAILLQ NPMFVGESLT DPNSLFAQIV HIIEEGGWTV FRNMPLIFAV GLPIGLAKQA QGRACLAVMV SFLTWNYFIN AMGMTWGSYF GVDFTQDAVA GSGLTMMAGI KTLDTSIIGA IIISGIVTAL HNRLFDKKLP VFLGIFQGTS YVVIIAFLVM IPCAWLTLLG WPKVQMGIES LQAFLRSAGA LGVWVYTFLE RILIPTGLHH FIYGQFIFGP AAVEGGIQMY WAQHLQEFSL SAEPLKSLFP EGGFALHGNS KIFGAVGISL AMYFTAAPEN RVKVAGLLIP ATLTAMLVGI TEPLEFTFLF ISPLLFAVHA VLAASMSTVM YLFGVVGNMG GGLID
Length	455
Mol. Wt	50.005 kDa
pI	8.0 (calculated)
Extinction coefficient	57,410 - 57,910 (calc based on 9 Y, 8 W, and 4 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	9..347	PF02378 Phosphotransferase system, EIIC		PMID:19920124
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<motif_map/>

Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=glvC taxon=562,83333 </beststructure>

Models

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Structure figures

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
ASAP	ASAP:ABE-0012043	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:2847721	Escherichia coli str. K-12 substr. MG1655
ASAP (EcoliWiki Page)	ASAP:ABE-0012043	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P31452	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG11710	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11710	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:2847721	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001653	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1661	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
ysdC
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:3861606..3861646 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

</protect>

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b3683 (EcoliWiki Page)	NCBI GEO profiles for glvC
microarray	GenExpDB:b3683 (EcoliWiki Page)	Summary of data for glvC from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to glvC Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11710	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1661	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b3683
EcoGene	EcoGene:EG11710	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001653	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012043	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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<protect> See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF02378 Phosphotransferase system, EIIC
EcoCyc	EcoCyc:EG11710	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11710	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001653	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1661	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012043	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 CGSC: The Coli Genetics Stock Center
↑ ^5.0 ^5.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed

glvC:On One Page

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Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to glvC Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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