glvC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

GlvC

Synonyms

arbutin sp ecific enzyme IIC component of PTS[1], B3683[2][1], YidO[2][1], GlvC[2][1], PtiC[3][1] , ECK3674, glvB, JW3659, yidN, yidO, b3683

Product description

GlvC[2][3];

Component of EIIBCGlv[3]

EC number (for enzymes)

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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005351

sugar:hydrogen symporter activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003352

F

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0006810

transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc (v14.0)

complete

GO:0008643

carbohydrate transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0762

P

Seeded from EcoCyc (v14.0)

complete

GO:0008982

protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003352

F

Seeded from EcoCyc (v14.0)

complete

GO:0008982

protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004719

F

Seeded from EcoCyc (v14.0)

complete

GO:0008982

protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010975

F

Seeded from EcoCyc (v14.0)

complete

GO:0009401

phosphoenolpyruvate-dependent sugar phosphotransferase system

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003352

P

Seeded from EcoCyc (v14.0)

complete

GO:0009401

phosphoenolpyruvate-dependent sugar phosphotransferase system

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004719

P

Seeded from EcoCyc (v14.0)

complete

GO:0009401

phosphoenolpyruvate-dependent sugar phosphotransferase system

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010975

P

Seeded from EcoCyc (v14.0)

complete

GO:0009401

phosphoenolpyruvate-dependent sugar phosphotransferase system

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0598

P

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003352

C

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004719

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9909

C

Seeded from EcoCyc (v14.0)

complete

GO:0003674

molecular function

127.0.0.1 15:06, 17 February 2015 (CST)

ND: No biological Data available

F

Is notGO:0016740 (transferase activity) as suggested. PMID:8019415[4] infersGO:0004557 (alpha galactosidase activity) andGO:0008706 (phospho-beta-glucosidase activity) in abstract but did not document any evidence to support terms. Gene is compared to MalX, which is not sufficiently annotated to warrant sequence comparison as evidence.

Strongly suggestGO:0008982 (protein-N(PI)-phosphohistidine-sugar phosphotransferase activity); no sequence comparison fully supports term.

Missing: reference

GO:0008643

carbohydrate transport

PMID:8019415[4]

TAS: Traceable Author Statement

P

complete

GO:0005575

cellular component

127.0.0.1 15:06, 17 February 2015 (CST)

ND: No biological Data available

C

Presumed function from sequence data, no data from wet experiments could be found on C subunit. Ecocyc presumes subunit B on cytoplasmic side of membrane but does not provide citation or mention C subunit localization.

Missing: reference

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of EIIBCGlv

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

C-terminus localized to the periplasm with 8 predicted transmembrane domains

Daley et al. (2005) [5]

plasma membrane

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MRTQVLLNRL KKHLFFKDVF DAVYLCSQRS TFSRKRRSLP PNEKHESDHE SHWVVMFCRS
HLPILAPGLP HNQSGFLLTE LRKEDVEMLS QIQRFGGAMF TPVLLFPFAG IVVGLAILLQ
NPMFVGESLT DPNSLFAQIV HIIEEGGWTV FRNMPLIFAV GLPIGLAKQA QGRACLAVMV
SFLTWNYFIN AMGMTWGSYF GVDFTQDAVA GSGLTMMAGI KTLDTSIIGA IIISGIVTAL
HNRLFDKKLP VFLGIFQGTS YVVIIAFLVM IPCAWLTLLG WPKVQMGIES LQAFLRSAGA
LGVWVYTFLE RILIPTGLHH FIYGQFIFGP AAVEGGIQMY WAQHLQEFSL SAEPLKSLFP
EGGFALHGNS KIFGAVGISL AMYFTAAPEN RVKVAGLLIP ATLTAMLVGI TEPLEFTFLF
ISPLLFAVHA VLAASMSTVM YLFGVVGNMG GGLID
Length

455

Mol. Wt

50.005 kDa

pI

8.0 (calculated)

Extinction coefficient

57,410 - 57,910 (calc based on 9 Y, 8 W, and 4 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

9..347

PF02378 Phosphotransferase system, EIIC

PMID:19920124[6]

<motif_map/>

tmhmm.php?gene=glvC&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=glvC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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</protect>

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

ASAP

ASAP:ABE-0012043

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:2847721

Escherichia coli str. K-12 substr. MG1655

ASAP (EcoliWiki Page)

[https://asap.ahabs.wisc.edu/asap/feature_info.php?FeatureID=ABE-0012043 ASAP:ABE-0012043]

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P31452

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11710

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11710

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:2847721

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001653

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1661

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 Reizer, J et al. (1994) Novel phosphotransferase system genes revealed by bacterial genome analysis: unique, putative fructose- and glucoside-specific systems. Protein Sci. 3 440-50 PubMed
  5. Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
  6. Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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