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Standard Name	glpQ
Gene Synonym(s)	ECK2231, b2239, JW2233^[1], JW2233
Product Desc.	GlpQ^[2]^[3]; Component of glycerophosphoryl diester phosphodiesterase, periplasmic^[2]^[3] Glycerophosphodiester phosphodiesterase, periplasmic; tetrameric^[4]
Product Synonyms(s)	periplasmic glycerophosphodiester phosphodiesterase^[1], B2239^[2]^[1], GlpQ^[2]^[1] , ECK2231, JW2233, b2239
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): glpTQ^[2], OP00304
Regulation/Activity
Quick Links
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	glpQ
Mnemonic	Glycerol phosphate
Synonyms	ECK2231, b2239, JW2233^[1], JW2233
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	50.61 minutes	MG1655: 2349033..2347957 <gbrowseImage> name=NC_000913:2347957..2349033 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 2297719..2296643 <gbrowseImage> name=NC_012967:2296643..2297719 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 2233762..2234838 <gbrowseImage> name=NC_012759:2233762..2234838 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 2355681..2354605 <gbrowseImage> name=NC_007779:2354605..2355681 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 2440021..2438945 <gbrowseImage> name=NC_010473:2438945..2440021 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
Coding Start (SO:0000323)	MG1655	2347960	Edman degradation	PMID:1851953
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability
ΔglpQ (Keio:JW2233)	deletion	deletion	PMID:16738554	Shigen CGSC9800^[5]
ΔglpQ790::kan			PMID:16738554	CGSC:101190
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW2233	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCAAATTGACGCTGAAAAACCT Primer 2:CCtTCTTTATTAAGAAATTTTAC
2E8	Kohara Phage	Genobase	PMID:3038334
22C4	Kohara Phage	Genobase	PMID:3038334
zfa-723::Tn10	Linked marker	CAG12178 gyrA+ = CGSC7526^[5]	est. P1 cotransduction: 85% ^[6] Synonyms:zei-723::Tn10, zfa-723::Tn10 nnnThe original CAG12178 was NalR. This is a NalS derivative constructed by S. McAteer (CGSC).
zfb-223::Tn10	Linked marker	CAG18484 = CGSC7406^[5]	est. P1 cotransduction: 17% ^[6] Synonyms:zej-223::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10399	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10399	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000392	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:946725	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0394	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007399	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	GlpQ
Synonyms	periplasmic glycerophosphodiester phosphodiesterase^[1], B2239^[2]^[1], GlpQ^[2]^[1] , ECK2231, JW2233, b2239
Product description	GlpQ^[2]^[3]; Component of glycerophosphoryl diester phosphodiesterase, periplasmic^[2]^[3] Glycerophosphodiester phosphodiesterase, periplasmic; tetrameric^[4]
EC number (for enzymes)	3.1.4.46^[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0030288	outer membrane-bounded periplasmic space				C	Seeded from Riley et al 2006 ^[1].	Missing: evidence, reference
	GO:0005509	calcium ion binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0106	F	Seeded from EcoCyc (v14.0)	complete
	GO:0006071	glycerol metabolic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004129	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006071	glycerol metabolic process	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0319	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006629	lipid metabolic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017946	P	Seeded from EcoCyc (v14.0)	complete
	GO:0008081	phosphoric diester hydrolase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017946	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008889	glycerophosphodiester phosphodiesterase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004129	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008889	glycerophosphodiester phosphodiesterase activity	GOA:spec GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.1.4.46	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016787	hydrolase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F	Seeded from EcoCyc (v14.0)	complete
	GO:0042597	periplasmic space	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0574	C	Seeded from EcoCyc (v14.0)	complete
	GO:0042597	periplasmic space	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0200	C	Seeded from EcoCyc (v14.0)	complete
	GO:0046872	metal ion binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of glycerophosphoryl diester phosphodiesterase, periplasmic	could be indirect
Protein	nrdB		PMID:16606699	Experiment(s):EBI-1142297
Protein	rplF		PMID:16606699	Experiment(s):EBI-1142297
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Evidence	Reference/Source
periplasm		From EcoCyc^[3]
Periplasm	PMID:1851953	EchoLocation:glpQ
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MKLTLKNLSM AIMMSTIVMG SSAMAADSNE KIVIAHRGAS GYLPEHTLPA KAMAYAQGAD YLEQDLVMTK DDNLVVLHDH YLDRVTDVAD RFPDRARKDG RYYAIDFTLD EIKSLKFTEG FDIENGKKVQ TYPGRFPMGK SDFRVHTFEE EIEFVQGLNH STGKNIGIYP EIKAPWFHHQ EGKDIAAKTL EVLKKYGYTG KDDKVYLQCF DADELKRIKN ELEPKMGMEL NLVQLIAYTD WNETQQKQPD GSWVNYNYDW MFKPGAMKQV AEYADGIGPD YHMLIEETSQ PGNIKLTGMV QDAQQNKLVV HPYTVRSDKL PEYTPDVNQL YDALYNKAGV NGLFTDFPDK AVKFLNKE
Length	358
Mol. Wt	40.844 kDa
pI	5.4 (calculated)
Extinction coefficient	51,800 - 51,925 (calc based on 20 Y, 4 W, and 1 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
motif	1-25	UniProt Manual:Signal Peptides	UniProt:P09394
Domain	36..350	PF03009 Glycerophosphoryl diester phosphodiesterase family		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=glpQ taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16130174	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:946725	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007399	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P09394	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG10399	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10399	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:946725	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000392	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0394	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MG1655	56	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	31	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	24^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
glpTQ
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:2349013..2349053 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b2239 (EcoliWiki Page)	NCBI GEO profiles for glpQ
microarray	GenExpDB:b2239 (EcoliWiki Page)	Summary of data for glpQ from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to glpQ Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10399	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0394	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b2239
EcoGene	EcoGene:EG10399	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000392	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007399	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Anopheles gambiae	ENSANGP00000016319 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Arabidopsis thaliana	AT5G08030 (score: 1.000; bootstrap: 100%) AT1G74210 (score: 0.703)	From Inparanoid:20070104
Bos taurus	ENSBTAP00000017095 (score: 1.000; bootstrap: 100%) ENSBTAP00000001177 (score: 0.066)	From Inparanoid:20070104
Ciona intestinalis	ENSCINP00000008396 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Oryza gramene	Q6AUZ6 (score: 1.000; bootstrap: 94%) Q8LR39 (score: 0.644) Q6YVY7 (score: 0.502)	From Inparanoid:20070104
Takifugu rubripes	NEWSINFRUP00000172553 (score: 1.000; bootstrap: 100%) NEWSINFRUP00000157334 (score: 0.360) NEWSINFRUP00000159609 (score: 0.275)	From Inparanoid:20070104
Tetraodon nigroviridis	GSTENP00008368001 (score: 1.000; bootstrap: 100%) GSTENP00031233001 (score: 0.290)	From Inparanoid:20070104
Shigella flexneri	GLPQ	From SHIGELLACYC
E. coli O157	GLPQ	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF03009 Glycerophosphoryl diester phosphodiesterase family
Superfamily (EcoliWiki Page)	SUPERFAMILY:51695
Panther (EcoliWiki Page)	PTHR23344:SF0
EcoCyc	EcoCyc:EG10399	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10399	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000392	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0394	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007399	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

glpQ:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to glpQ Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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