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Product(s) |

Expression|

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Standard Name	ftsQ
Gene Synonym(s)	ECK0094, b0093, JW0091^[1], JW0091
Product Desc.	essential cell division protein FtsQ^[2]^[3] Cell division and growth of wall at septum^[4]
Product Synonyms(s)	membrane anchored protein involved in growth of wall at septum^[1], B0093^[2]^[1], FtsQ^[2]^[1] , ECK0094, JW0091, b0093
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): ftsQ^[2], mraZW-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ^[2], ftsQAZ^[2], OP00295
Regulation/Activity
Quick Links
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Notes

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Overexpression causes filamentous biofilm formation. Although FtsQ co-precipiates with FtsL and FtsB, it does not require the presence of FtsLB for mid-cell localization. Single transmembrane helix inner membrane protein; 25 N-terminal aa in cytoplasm; last 225 aa in periplasm. Essential gene. Localized to septum by periplasmic domain. Targeted by SRP/FtsY to Sec/YidC for membrane insertion. Divisome.^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	ftsQ
Mnemonic	Filamentation, temperature sensitive
Synonyms	ECK0094, b0093, JW0091^[1], JW0091
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	2.22 minutes	MG1655: 103155..103985 <gbrowseImage> name=NC_000913:103155..103985 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 105959..106789 <gbrowseImage> name=NC_012967:105959..106789 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 103154..103984 <gbrowseImage> name=NC_012759:103154..103984 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 103155..103985 <gbrowseImage> name=NC_007779:103155..103985 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 77259..78089 <gbrowseImage> name=NC_010473:77259..78089 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability
ftsQ1(ts)				temperature sensitive	PMID:3894330 PMID:11790739	CGSC:91091
ftsQ6	TTC to TTA and CTG to CGG	Phe145 to Leu and Leu181 to Arg	Growth Phenotype	unless WT FtsQ is diminished, this allele is unable to localize at division site poorly competes for septal targeting (similar to ftsQ15)	PMID:11790739
FtsQ15	CAG to CTG and GTC to GGC and TAT to GAT	Gln108 to Leu and Val111 to Gly and Tyr227 to Asp	Growth Phenotype	unless WT FtsQ is diminished, this allele is unable to localize at division site poorly competes for septal targeting (similar to ftsQ6)	PMID:11790739
ftsQ2	TAT to TAA (nonsense) and GAC to GGC	TYR248 to ochre and Asp 249 to Gly	Growth Phenotype	produces a truncated protein filamented phenotype is exacerbated dominant-negative effects at permissive temperature	PMID:11790739
ftsQ65	ATT to TTT, CAG to CGG, GTT to GAT, and TTG to TCG	Ile207 to Phe, Gln232 to Arg, Val244 to Asp, and Le259 to Ser	Growth Phenotype	Similar to ftsQ2 cannot recruit downstream cell division proteins to suptum	PMID:11790739
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW0091	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCTCGCAGGCTGCTCTGAACAC Primer 2:CCTTGTTGTTCTGCCTGTGCCTG
6F3	Kohara Phage	Genobase	PMID:3038334
15B8	Kohara Phage	Genobase	PMID:3038334
leuO3051::Tn10	Linked marker	CAG12095 = CGSC7324^[5]	est. P1 cotransduction: 49% ^[6] Synonyms:zab-3051::Tn10 nnnThe start of leuO was reannotated by Riley et al. (2006).
zad-220::Tn10	Linked marker	CAG12025 = CGSC7326^[5]	est. P1 cotransduction: 13% ^[6]
pLMG161	Plasmid Clone	ftsQ gene cloned into pBAD18	PMID:7608087
pLMG160	Plasmid Clone	ftsQ gene cloned into pBAD18s	PMID:7608087
pLMG163	Plasmid Clone	ftsQ-TnphoA91 cloned into pBAD18	PMID:7608087
pLMG160	Plasmid Clone	ftsQ gene cloned into pBAD18s	PMID;7608087
pLMG162	Plasmid Clone	ftsQ-TnphoA91 cloned into pBAD18s	PMID:7608087
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10342	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10342	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000336	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:944823	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0338	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0000329	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	FtsQ
Synonyms	membrane anchored protein involved in growth of wall at septum^[1], B0093^[2]^[1], FtsQ^[2]^[1] , ECK0094, JW0091, b0093
Product description	essential cell division protein FtsQ^[2]^[3] Cell division and growth of wall at septum^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000917	barrier septum formation	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0717	P	Seeded from EcoCyc (v14.0)	complete
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0997	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C	Seeded from EcoCyc (v14.0)	complete
	GO:0007049	cell cycle	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0131	P	Seeded from EcoCyc (v14.0)	complete
	GO:0051301	cell division	PMID:2007547	IMP: Inferred from Mutant Phenotype		P		complete
	GO:0016021	integral to membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded from EcoCyc (v14.0)	complete
	GO:0000917	barrier septum formation	PMID:2007547	IMP: Inferred from Mutant Phenotype		P		complete
	GO:0016021	integral to membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-9906	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005886	plasma membrane	PMID:2007547	IMP: Inferred from Mutant Phenotype		C		complete
	GO:0016021	integral to membrane	PMID:2007547	IDA: Inferred from Direct Assay		C		complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	FtsB	depletion of FtsQ leads to decreased amounts of full-length FtsB; when FtsQ is depleted, C-terminal domain of FtsB is degraded	PMID:19233928
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
plasma membrane
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MSQAALNTRN SEEEVSSRRN NGTRLAGILF LLTVLTTVLV SGWVVLGWME DAQRLPLSKL VLTGERHYTR NDDIRQSILA LGEPGTFMTQ DVNIIQTQIE QRLPWIKQVS VRKQWPDELK IHLVEYVPIA RWNDQHMVDA EGNTFSVPPE RTSKQVLPML YGPEGSANEV LQGYREMGQM LAKDRFTLKE AAMTARRSWQ LTLNNDIKLN LGRGDTMKRL ARFVELYPVL QQQAQTDGKR ISYVDLRYDS GAAVGWAPLP PEESTQQQNQ AQAEQQ
Length	276
Mol. Wt	31.433 kDa
pI	6.9 (calculated)
Extinction coefficient	48,930 (calc based on 7 Y, 7 W, and 0 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	References
Domain	129..247	PF03799 Cell division protein FtsQ	PMID:19920124
Domain	55..126	PF08478 POTRA domain, FtsQ-type	PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=ftsQ taxon=562,83333 </beststructure>

Models

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Structure figures

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16128086	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:944823	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0000329	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P06136	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG10342	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10342	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:944823	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000336	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0338	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Enzyme activity	E. coli MJC252 and MJC251 (see Table 1)	~22	molecules/cell	Medium: M63 minimal glycerol medium Temperature (°C): 34 Doubling time (min): Growth Rate(min): Growth phase: other:	enzyme activity	Chromosomal ftsQ-phoA fusions were assayed for alkaline phosphatase activity & compared to activity of MotB-PhoA fusions	PMID:2007547
Protein	E. coli K-12 MG1655	336	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	147	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	172	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
ftsQ
mraZW-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ
ftsQAZ
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:103135..103175 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b0093 (EcoliWiki Page)	NCBI GEO profiles for ftsQ
microarray	GenExpDB:b0093 (EcoliWiki Page)	Summary of data for ftsQ from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to ftsQ Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10342	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0338	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b0093
EcoGene	EcoGene:EG10342	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000336	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0000329	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Shigella flexneri	FTSQ	From SHIGELLACYC
E. coli O157	FTSQ	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF03799 Cell division protein FtsQ
Pfam (EcoliWiki Page)	PF08478 POTRA domain, FtsQ-type
EcoCyc	EcoCyc:EG10342	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10342	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000336	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0338	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0000329	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

ftsQ:On One Page

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Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

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Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to ftsQ Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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