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Standard Name	ftsN
Gene Synonym(s)	ECK3925, b3933, JW3904, msgA^[1], msgA
Product Desc.	essential cell division protein FtsN^[2]^[3] Cell division and growth; multicopy suppresses ftsA12^[4] Enhances the integrity and activity of Z ring. ^[5]
Product Synonyms(s)	essential cell division protein^[1], B3933^[2]^[1], MsgA^[2]^[1], FtsN^[2]^[1] , ECK3925, JW3904, msgA, b3933
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s):
Regulation/Activity
Quick Links
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Notes

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The ftsN gene is essential. Divisome.^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	ftsN
Mnemonic	Filamentation, temperature sensitive
Synonyms	ECK3925, b3933, JW3904, msgA^[1], msgA
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	88.81 minutes, 88.81 minutes	MG1655: 4121362..4120403 <gbrowseImage> name=NC_000913:4120403..4121362 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 4102822..4101863 <gbrowseImage> name=NC_012967:4101863..4102822 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 4010072..4011031 <gbrowseImage> name=NC_012759:4010072..4011031 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 3513342..3514301 <gbrowseImage> name=NC_007779:3513342..3514301 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 4221059..4220100 <gbrowseImage> name=NC_010473:4220100..4221059 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
ftsN110::kan			Growth Phenotype		PMID:8509333	CGSC:91096	produces less stable Z rings after exposed to non-permissive temperature
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW3904	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCGCACAACGAGATTATGTACG Primer 2:CCACCCCCGGCGGCGAGCCGAAT
12E3	Kohara Phage	Genobase	PMID:3038334
4H12	Kohara Phage	Genobase	PMID:3038334
zih-35::Tn10	Linked marker	CAG18495 = CGSC7467^[6]	est. P1 cotransduction: 6% ^[7]
pflD501::Tn10	Linked marker	CAG18477 = CGSC7470^[6]	est. P1 cotransduction: 43% ^[7] Synonyms:zij-501::Tn10 nnnCAG18477 also carries metF79(Am) (CGSC).
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11529	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11529	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001483	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:948428	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1491	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012850	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	FtsN
Synonyms	essential cell division protein^[1], B3933^[2]^[1], MsgA^[2]^[1], FtsN^[2]^[1] , ECK3925, JW3904, msgA, b3933
Product description	essential cell division protein FtsN^[2]^[3] Cell division and growth; multicopy suppresses ftsA12^[4] Enhances the integrity and activity of Z ring. ^[5]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000910	cytokinesis	PMID:9282742	IMP: Inferred from Mutant Phenotype		P		complete
	GO:0051301	cell division	PMID:9282742	IMP: Inferred from Mutant Phenotype		P		complete
	GO:0000917	barrier septum formation	PMID:9282742	IMP: Inferred from Mutant Phenotype		P		complete
	GO:0005886	plasma membrane	PMID:8509333	IDA: Inferred from Direct Assay		C		complete
	GO:0005515	protein binding	PMID:18165305	IGI: Inferred from Genetic Interaction		F	Seeded from EcoCyc (v14.0)	Missing: with/from
	GO:0005624	membrane fraction	PMID:8509333	IDA: Inferred from Direct Assay		C	Seeded from EcoCyc (v14.0)	complete
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0997	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005515	protein binding	PMID:18165305	IGI: Inferred from Genetic Interaction	EcoliWiki:mtgA	F		complete
	GO:0016020	membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded from EcoCyc (v14.0)	complete
	GO:0000917	barrier septum formation				P		Missing: evidence, reference
	GO:0016021	integral to membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-9906	C	Seeded from EcoCyc (v14.0)	complete
	GO:0033205	cell cycle cytokinesis	PMID:8509333	IGI: Inferred from Genetic Interaction		P	Seeded from EcoCyc (v14.0)	Missing: with/from
	GO:0044457	cell septum part	PMID:9282742	IDA: Inferred from Direct Assay		C	Seeded from EcoCyc (v14.0)	complete
	GO:0005515	protein binding	PMID:20497333	IPI: Inferred from Physical Interaction	EcoliWiki:ftsN	F		complete
	GO:0005515	protein binding	PMID:20497333	IPI: Inferred from Physical Interaction	EcoliWiki:zapA	F		complete
	GO:0005515	protein binding	PMID:20497333	IPI: Inferred from Physical Interaction	EcoliWiki:ftsW	F		complete
	GO:0005515	protein binding	PMID:20497333	IPI: Inferred from Physical Interaction	EcoliWiki:ftsI	F		complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	ynaE		PMID:16606699	Experiment(s):EBI-1147095
Protein	rpsI		PMID:16606699	Experiment(s):EBI-1147095
Protein	rraA		PMID:16606699	Experiment(s):EBI-1147095
Protein	yhaJ		PMID:16606699	Experiment(s):EBI-1147095
Protein	ydfK		PMID:16606699	Experiment(s):EBI-1147095
Protein	rhaD		PMID:16606699	Experiment(s):EBI-1147095
Protein	gadW		PMID:16606699	Experiment(s):EBI-1147095
Protein	rplQ		PMID:16606699	Experiment(s):EBI-1147095
Protein	ftsA12(ts), ftsQ1(ts), and ftsI23(ts)	FtsN suppresses these mutations suggesting that FtsN interacts and stabilizes these parts of division	PMID:8631709 PMID:9282742 PMID:8509333
Protein	ftsK	FtsN suppresses mutations of ftsK allowing cell division to occur	PMID:9721304
Protein	FtsI and FtsQ	these proteins are required for the recruiting of FtsN Septal ring localization depends on FtsI	PMID:9282742
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
plasma membrane
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MAQRDYVRRS QPAPSRRKKS TSRKKQRNLP AVSPAMVAIA AAVLVTFIGG LYFITHHKKE ESETLQSQKV TGNGLPPKPE ERWRYIKELE SRQPGVRAPT EPSAGGEVKT PEQLTPEQRQ LLEQMQADMR QQPTQLVEVP WNEQTPEQRQ QTLQRQRQAQ QLAEQQRLAQ QSRTTEQSWQ QQTRTSQAAP VQAQPRQSKP ASSQQPYQDL LQTPAHTTAQ SKPQQAAPVA RAADAPKPTA EKKDERRWMV QCGSFRGAEQ AETVRAQLAF EGFDSKITTN NGWNRVVIGP VKGKENADST LNRLKMAGHT NCIRLAAGG
Length	319
Mol. Wt	35.791 kDa
pI	10.6 (calculated)
Extinction coefficient	33,460 - 33,710 (calc based on 4 Y, 5 W, and 2 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	244..315	PF05036 Sporulation related domain		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=ftsN taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16131771	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:948428	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012850	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P29131	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG11529	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11529	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:948428	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001483	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1491	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MG1655	871	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	269	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	405	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Inactivation of ftsN results in filamentation and cell death. ^[8]

Supressed cells lacking ftsN had a higher average length at 42C than those containing ftsN. ^[5]

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:4121342..4121382 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b3933 (EcoliWiki Page)	NCBI GEO profiles for ftsN
microarray	GenExpDB:b3933 (EcoliWiki Page)	Summary of data for ftsN from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
	GFP Fusion	Intergenic region (4120828..4121062) fused to gfpmut2.	OpenBioSystems	GFP fusion described in Zaslaver, et al. Plate:109-AZ11; Well:C8^[9]
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Notes

Accessions Related to ftsN Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11529	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1491	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b3933
EcoGene	EcoGene:EG11529	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001483	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012850	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Danio rerio	ZDB-GENE-050706-185 (score: 1.000; bootstrap: 100%) ZDB-CDNA-050706-68 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Rattus norvegicus	ENSRNOP00000018507 (score: 1.000; bootstrap: 48%)	From Inparanoid:20070104
Shigella flexneri	FTSN	From SHIGELLACYC
E. coli O157	FTSN	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Panther (EcoliWiki Page)	PTHR11064:SF5
Superfamily (EcoliWiki Page)	SUPERFAMILY:110997
Pfam (EcoliWiki Page)	PF05036 Sporulation related domain
EcoCyc	EcoCyc:EG11529	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11529	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001483	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1491	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012850	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 Bernard, CS et al. (2007) An altered FtsA can compensate for the loss of essential cell division protein FtsN in Escherichia coli. Mol. Microbiol. 64 1289-305 PubMed
↑ ^6.0 ^6.1 CGSC: The Coli Genetics Stock Center
↑ ^7.0 ^7.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ Dai, K et al. (1993) Cloning and characterization of ftsN, an essential cell division gene in Escherichia coli isolated as a multicopy suppressor of ftsA12(Ts). J. Bacteriol. 175 3790-7 PubMed
↑ Zaslaver, A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat. Methods 3 623-8 PubMed

ftsN:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to ftsN Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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