ftsN:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

FtsN

Synonyms

essential cell division protein[1], B3933[2][1], MsgA[2][1], FtsN[2][1] , ECK3925, JW3904, msgA, b3933

Product description

essential cell division protein FtsN[2][3]

Cell division and growth; multicopy suppresses ftsA12[4]

Enhances the integrity and activity of Z ring. [5]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000910

cytokinesis

PMID:9282742[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0051301

cell division

PMID:9282742[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0000917

barrier septum formation

PMID:9282742[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005886

plasma membrane

PMID:8509333[7]

IDA: Inferred from Direct Assay

C

complete

GO:0005515

protein binding

PMID:18165305[8]

IGI: Inferred from Genetic Interaction

F

Seeded from EcoCyc (v14.0)

Missing: with/from

GO:0005624

membrane fraction

PMID:8509333[7]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

PMID:18165305[8]

IGI: Inferred from Genetic Interaction

EcoliWiki:mtgA


F

complete

GO:0016020

membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc (v14.0)

complete

GO:0000917

barrier septum formation

P

Missing: evidence, reference

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9906

C

Seeded from EcoCyc (v14.0)

complete

GO:0033205

cell cycle cytokinesis

PMID:8509333[7]

IGI: Inferred from Genetic Interaction

P

Seeded from EcoCyc (v14.0)

Missing: with/from

GO:0044457

cell septum part

PMID:9282742[6]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

PMID:20497333[9]

IPI: Inferred from Physical Interaction

EcoliWiki:ftsN


F

complete

GO:0005515

protein binding

PMID:20497333[9]

IPI: Inferred from Physical Interaction

EcoliWiki:zapA


F

complete

GO:0005515

protein binding

PMID:20497333[9]

IPI: Inferred from Physical Interaction

EcoliWiki:ftsW


F

complete

GO:0005515

protein binding

PMID:20497333[9]

IPI: Inferred from Physical Interaction

EcoliWiki:ftsI


F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

ynaE

PMID:16606699[10]

Experiment(s):EBI-1147095

Protein

rpsI

PMID:16606699[10]

Experiment(s):EBI-1147095

Protein

rraA

PMID:16606699[10]

Experiment(s):EBI-1147095

Protein

yhaJ

PMID:16606699[10]

Experiment(s):EBI-1147095

Protein

ydfK

PMID:16606699[10]

Experiment(s):EBI-1147095

Protein

rhaD

PMID:16606699[10]

Experiment(s):EBI-1147095

Protein

gadW

PMID:16606699[10]

Experiment(s):EBI-1147095

Protein

rplQ

PMID:16606699[10]

Experiment(s):EBI-1147095

Protein

ftsA12(ts), ftsQ1(ts), and ftsI23(ts)

FtsN suppresses these mutations suggesting that FtsN interacts and stabilizes these parts of division

PMID:8631709[11] PMID:9282742[6] PMID:8509333[7]

Protein

ftsK

FtsN suppresses mutations of ftsK allowing cell division to occur

PMID:9721304[12]

Protein

FtsI and FtsQ

these proteins are required for the recruiting of FtsN

Septal ring localization depends on FtsI

PMID:9282742[6]


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MAQRDYVRRS QPAPSRRKKS TSRKKQRNLP AVSPAMVAIA AAVLVTFIGG LYFITHHKKE
ESETLQSQKV TGNGLPPKPE ERWRYIKELE SRQPGVRAPT EPSAGGEVKT PEQLTPEQRQ
LLEQMQADMR QQPTQLVEVP WNEQTPEQRQ QTLQRQRQAQ QLAEQQRLAQ QSRTTEQSWQ
QQTRTSQAAP VQAQPRQSKP ASSQQPYQDL LQTPAHTTAQ SKPQQAAPVA RAADAPKPTA
EKKDERRWMV QCGSFRGAEQ AETVRAQLAF EGFDSKITTN NGWNRVVIGP VKGKENADST
LNRLKMAGHT NCIRLAAGG
Length

319

Mol. Wt

35.791 kDa

pI

10.6 (calculated)

Extinction coefficient

33,460 - 33,710 (calc based on 4 Y, 5 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

244..315

PF05036 Sporulation related domain

PMID:19920124[13]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=ftsN taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131771

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948428

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0012850

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P29131

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11529

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11529

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948428

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001483

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1491

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Bernard, CS et al. (2007) An altered FtsA can compensate for the loss of essential cell division protein FtsN in Escherichia coli. Mol. Microbiol. 64 1289-305 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Addinall, SG et al. (1997) FtsN, a late recruit to the septum in Escherichia coli. Mol. Microbiol. 25 303-9 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 Dai, K et al. (1993) Cloning and characterization of ftsN, an essential cell division gene in Escherichia coli isolated as a multicopy suppressor of ftsA12(Ts). J. Bacteriol. 175 3790-7 PubMed
  8. ↑ 8.0 8.1 Derouaux, A et al. (2008) The monofunctional glycosyltransferase of Escherichia coli localizes to the cell division site and interacts with penicillin-binding protein 3, FtsW, and FtsN. J. Bacteriol. 190 1831-4 PubMed
  9. ↑ 9.0 9.1 9.2 9.3 Alexeeva, S et al. (2010) Direct interactions of early and late assembling division proteins in Escherichia coli cells resolved by FRET. Mol. Microbiol. 77 384-98 PubMed
  10. ↑ 10.0 10.1 10.2 10.3 10.4 10.5 10.6 10.7 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  11. ↑ Dai, K et al. (1996) Topological characterization of the essential Escherichia coli cell division protein FtsN. J. Bacteriol. 178 1328-34 PubMed
  12. ↑ Draper, GC et al. (1998) Only the N-terminal domain of FtsK functions in cell division. J. Bacteriol. 180 4621-7 PubMed
  13. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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