ftsK:On One Page

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Quickview | Gene | Product(s) | Expression| Evolution | References |

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Standard Name

ftsK

Gene Synonym(s)

ECK0881, b0890, JW0873, dinH[1], dinH, usoM [2]

Product Desc.

essential cell division protein FtsK [3][4][5];

Component of Xer site-specific recombination system[5][6]

DNA translocase at septal ring sorting daughter chromsomes[7][6]

Couples cell division and chromosome segregation. [8]

Required at an early step in septation. [3]

Product Synonyms(s)

DNA-binding membrane protein required for chromosome resolution and partitioning[1], B0890[4][1], DinH[4][1], FtsK[4][1] , dinH, ECK0881, JW0873, b0890

Function from GO

<GO_nr />

Knock-Out Phenotype

ts mutants filament

Regulation/Expression

transcription unit(s): ftsK[4], dinH

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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FtsK is required for resolution of chromosome dimers at dif by XerCD. FtsK helps keep the nucleoids properly localized, recognizing opposing replichores by using FtsK orienting polar sequences (KOPS). The N-terminal domain is membrane-anchored, localizes to the division septum and is required for cell division. The C-terminal domain has the non-essential translocase activity, which becomes essential for replicating the asymmetric replichores produced by chromosome inversion (Lesterlin, 2008). LexA regulon. Homologous to B. subtilis SpoIIIE protein. The ftsK gene is essential. The filamentous growth of mutants is suppressed by dacA deletions. ftsK44(ts) can be suppressed by an ftsA R286W mutation or by an ftsQAZ plasmid. Divisome.[7]



Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

ftsK

Mnemonic

filamentation temperature sensitive Filamentation, temperature sensitive

Synonyms

ECK0881, b0890, JW0873, dinH[1], dinH, usoM [2]

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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain Map location Genome coordinates Genome browsers Sequence links

MG1655

20.1 minutes 

MG1655: 932447..936436
<gbrowseImage> name=NC_000913:932447..936436 source=MG1655 preset=GeneLocation </gbrowseImage>

REL606

NC_012967: 950282..954310
<gbrowseImage> name=NC_012967:950282..954310 source=REL606 preset=GeneLocation </gbrowseImage>

BW2952

NC_012759: 835415..839404
<gbrowseImage> name=NC_012759:835415..839404 source=BW2952 preset=GeneLocation </gbrowseImage>

W3110

 

W3110: 933646..937635
<gbrowseImage> name=NC_007779:933646..937635 source=W3110 preset=GeneLocation </gbrowseImage>

DH10B

DH10B: 986375..990364
<gbrowseImage> name=NC_010473:986375..990364 source=DH10B preset=GeneLocation </gbrowseImage>

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type Strain Genomic Location Evidence Reference Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele Nt change(s) AA change(s) Phenotype: Type Phenotype: Description Reference Availability Comments

LC(del)

PMID:15522074

Carries a deletion of FtsK L and FtsK C

ftsKG80A

G80A

In Toe44; loss of function under extreme conditions

seeded from UniProt:P46889

ftsKE58A

E58A

Loss of function

seeded from UniProt:P46889

NC

PMID:15522074

Barre

Deletion of the FtsK Linker

NL hi C

PMID:15522074

Barre

Carries swaps b/t E.coli and H. influenzae FtsK regions

ftsK A

K997A

PMID:15522074

Barre

Carries a single point mutation in the walker A motif of FtsK C

NLC hi

PMID:15522074

Barre

Carries swaps b/t E.coli and H.influenzae FtsK regions

ftsk::cat1

PMID:9721304

Donachie Sheratt

only expresses the NTD due to a Cm resistance cassette at nt 678 of ftsK

ftsk44

missense mutation

G80A

Growth Phenotype

temperature sensitive late stage block in division, but does not affect chromosome replication or segregation

forms long filamentous cells at 42C

PMID:7592387

PMID:9721304

Donachie

this is the allele from the TOE44 strain listed in this table.

ftsK1::cat

abnormal nucleoid segregation- asymmetrically positioned nucleoids and large anucleate regions

inhibited cell-cell separation

  • PMID:9294448
  • PMID:9829960

defect in the C-terminus of FtsK

ftsK1::cat mukB(del)

Growth Phenotype

synthetically lethal

PMID:9829960

shown that it must be complemented in trans

ftsK::cat-2

Δ54-2201

PMID:9721304

almost the entire N-terminal membrane-spanning domain is deleted, and the C-terminal fragment is out of frame with the cat gene. Lethal- must be complemented in trans

ftsK::cat-Δ5

Δ54-3651

PMID:9721304

this is a deletion of 90% of ftsK

ftsK3531

missense mutation

Growth Phenotype

same phenotype as ftsK44- temperature sensitive late stage block in division, but does not affect chromosome replication or segregation

PMID:9721304

suppressed by high salt (1% NaCl) in the medium or by insertional inactivation of the dacA gene, encoding PBP5.

ftsK::cat-2(del) dacA(del)::kan

Cell Shape

  • forms small colonies on plates grows well
  • produces a population of misshapen cells in liquid culture

PMID:9721304

ftsK::cat-5(del) dac(del)::kan

synthetically lethal

PMID:9721304

ftsKC priA2::kan

Growth Phenotype

synthetically lethal

PMID:11459954

ftsK1::cat minB(del)

Growth Phenotype

chains of minicells generated (many of which contained DNA)

PMID:9829960

ftsK100

K997A

ATP mutant

PMID:18363794

ftsK10

Growth Phenotype

affects expression form the uspA promoter, results in salt sensitivity, stationary-phase survival is impaired, and cell-cell separation is blocked

PMID:9294449

Also called usoM10

ftsK

deletion in the c-terminal

Growth Phenotype

inhibits FtsK activity and increases recombination near dif

PMID:15916604 PMID:9294449


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Notes

Deletions that leave the membrane segments intact are viable[9]. Suppressors of the ftsK chaining/filamentation phenotype are discussed in Geissler and Margolin (2005)[10].


Genetic Interactions

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Interactor Interaction Allele Score(s) Reference(s) Accessions Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource Resource Type Source Notes/Reference

JW0873

Plasmid clone

Shigen

PMID:16769691

Status:Clone OK

Primer 1:GCCAGCCAGGAATACATTGAAGA

Primer 2:CCGTCAAACGGCGGTGGGGCCAG

1F10

Kohara Phage

Genobase

PMID:3038334

E6H3

Kohara Phage

Genobase

PMID:3038334

zbh-29::Tn10

Linked marker

CAG18493 = CGSC7353[11]

est. P1 cotransduction: % [12]
Synonyms:zbi-29::Tn10

zca-1230::Tn10

Linked marker

CAG18478 = CGSC7356[11]

est. P1 cotransduction: 61% [12]
Synonyms:zbj-1230::Tn10

W3110::Plac-ftsK

Strain

Depletion Strain[3]

pWL71

Plasmid Clone

Pbad-FtsK(1-202)-GFP

Successfully complements the W3110::Plac-ftsK depletion strain[3]

pWL72

Plasmid Clone

Pbad-FtsK(1-211)-GFP

Successfully complements the W3110::Plac-ftsK depletion strain [3]

pWL73

Plasmid Clone

Pbad-FtsK(1-251)-GFP

Successfully complements the W3110::Plac-ftsK depletion strain [3]

pWL74

Plasmid Clone

Pbad-FtsK(1-644)

Successfully complements the W3110::Plac-ftsK depletion strain [3]

pWL75

Plasmid Clone

Pbad-FtsK(1-1329)

Successfully complements the W3110::Plac-ftsK depletion strain [3]

pWL76

Plasmid Clone

Pbad-FtsK(1-19 and 637-1329)- N-terminal 19 amino acids fused in phase to amino acid residue 637 of FtsK

Cannot complement the W3110::Plac-ftsK depletion strain [3]

pFtsK-PhoA plasmids

Plasmid Clone

This represents multiple plasmids with phoA inserted at various positions[13].

pFtsK-LacZ plasmids

Plasmid Clone

This represents multiple plasmids with lacZ inserted at various positions[13].

pFLAG-FtsK plasmids

Plasmid Clone

This reference describes plasmids with various FtsK truncations N-terminally tagged to FLAG[14].

MA3

Strain

AB1157ftsK

PMID:10523315

GR51

Strain

AB1157xerCftsK

PMID:10523315

GR59

Strain

AB1157ftsK recA56 srl::Tn10

PMID:10523315

FC1

Strain

AB1157, ftsK100 K997A (ATP mutant), CmR

PMID:18363794

FtsK-YFP

Plasmid Clone

  • low-copy expression vectors derived from pSC101
  • Spectinomycin resistance gene

PMID:18363794

FtsKΔγ

Plasmid Clone

FtsK50C deleted from residue 1248

PMID:19854947

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:G6464

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13226

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003064

Escherichia coli str. K-12 substr. MG1655

NCBI (EcoliWiki Page)

GeneID:945102

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3016

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0003027

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

FtsK

Synonyms

DNA-binding membrane protein required for chromosome resolution and partitioning[1], B0890[4][1], DinH[4][1], FtsK[4][1] , dinH, ECK0881, JW0873, b0890

Product description

essential cell division protein FtsK [3][4][5];

Component of Xer site-specific recombination system[5][6]

DNA translocase at septal ring sorting daughter chromsomes[7][6]

Couples cell division and chromosome segregation. [8]

Required at an early step in septation. [3]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status

GO:0051301

cell division

PMID:9721304

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007059

chromosome segregation

PMID:12034757

IMP: Inferred from Mutant Phenotype

P

complete

GO:0051301

cell division

PMID:7592387

IMP: Inferred from Mutant Phenotype

P

complete

GO:0000166

nucleotide binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002543

F

Seeded from EcoCyc (v14.0)

complete

GO:0007059

chromosome segregation

PMID:17805344

IMP: Inferred from Mutant Phenotype

P

expression of the cytoplasmic domain of FtsK facilitates chromosome segregation in parC(ts) and parE(ts) cells

complete

GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

PMID:10922461

EXP: Inferred from Experiment

C

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002543

F

Seeded from EcoCyc (v14.0)

complete

GO:0051301

cell division

PMID:9294448

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0006970

response to osmotic stress

PMID:9294448

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005887

integral to plasma membrane

PMID:10922461

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

PMID:18722176

IDA: Inferred from Direct Assay

F

complete

GO:0007049

cell cycle

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002543

P

Seeded from EcoCyc (v14.0)

complete

GO:0016887

ATPase activity

PMID:18722176

IDA: Inferred from Direct Assay

F

complete

GO:0007049

cell cycle

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0131

P

Seeded from EcoCyc (v14.0)

complete

GO:0007059

chromosome segregation

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002543

P

Seeded from EcoCyc (v14.0)

complete

GO:0007059

chromosome segregation

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0159

P

Seeded from EcoCyc (v14.0)

complete

GO:0007059

chromosome segregation

PMID:12034757

IGI: Inferred from Genetic Interaction

P

Seeded from EcoCyc (v14.0)

Missing: with/from

GO:0007059

chromosome segregation

PMID:12034757

IGI: Inferred from Genetic Interaction

UniProtKB:P0A734 UniProtKB:P0AEZ3 UniProtKB:P18196


P

Seeded from EcoCyc (v14.0)

complete

GO:0015616

DNA translocase activity

PMID:16301526

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0043565

sequence-specific DNA binding

PMID:17041598

IMP: Inferred from Mutant Phenotype

F

Seeded from EcoCyc (v14.0)

complete

GO:0043565

sequence-specific DNA binding

PMID:17057717

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0045941

positive regulation of transcription

PMID:9294448

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

PMID:9723913

IDA: Inferred from Direct Assay

C

complete

GO:0016020

membrane

PMID:10922461

IDA: Inferred from Direct Assay

C

complete

GO:0071236

cellular response to antibiotic

PMID:9723913

IMP: Inferred from Mutant Phenotype

P

mitomycin C

complete

GO:0007059

chromosome segregation

PMID:9829960

IMP: Inferred from Mutant Phenotype

P

complete

GO:0015616

DNA translocase activity

PMID:19854947

IDA: Inferred from Direct Assay

F

complete

GO:0016887

ATPase activity

PMID:19854947

IDA: Inferred from Direct Assay

F

complete

GO:0007059

chromosome segregation

PMID:19854947

IDA: Inferred from Direct Assay

P

complete

GO:0051301

cell division

PMID:9829960

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007059

chromosome segregation

PMID:19854947

IPI: Inferred from Physical Interaction

UniProtKB:P0A8P6 UniProtKB:P0A8P8


P

complete

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:9294448

IMP: Inferred from Mutant Phenotype

P

increases PuspA activity in stationary phase

complete

Contributes to

GO:0006265

DNA topological change

PMID:20081205

IDA: Inferred from Direct Assay

P

stimulates Topo IV's ability to relax positively supercoiled DNA

complete

GO:0009651

response to salt stress

PMID:9294448

IMP: Inferred from Mutant Phenotype

P

complete

Contributes to

GO:0007059

chromosome segregation

PMID:20081205

IDA: Inferred from Direct Assay

P

stimulates Topo IV's decatenation ability

complete

GO:0000920

cytokinetic cell separation

PMID:9294448

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007059

chromosome segregation

PMID:12034757

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007059

chromosome segregation

PMID:12034757

IGI: Inferred from Genetic Interaction

UniProtKB:P0A734 UniProtKB:P0AEZ3 UniProtKB:P18196


P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of Xer site-specific recombination system

could be indirect

Protein

aceE

PMID:15690043

Experiment(s):EBI-888719

Protein

rpsJ

PMID:19402753

LCMS(ID Probability):99.6

Protein

yfiD

PMID:19402753

LCMS(ID Probability):99.6

Protein

ParC subunit of Topo IV

PMID:12939258

Protein

Either subunit of the XerCD Recombinase

PMID:19854947

Triplex Displacement Assays

Protein

FtsZ and FtsA

FtsK localization depends on FtsZ and FtsA prior localization

PMID:9723913


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

C-terminus localized in the cytoplasm with 6 predicted transmembrane domains

Daley et al. (2005) [15]

Inner membrane

GFP fusion localization

PMID:9495771

Signal sequence in the N-terminal domain of the protein

Inner membrane

PhoA and beta-gal assays

PMID:10922461

Cytosol

FtsK (818-1329)

Microscopy

PMID:11114887


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSQEYIEDKE VTLTKLSSGR RLLEALLILI VLFAVWLMAA LLSFNPSDPS WSQTAWHEPI
HNLGGMPGAW LADTLFFIFG VMAYTIPVII VGGCWFAWRH QSSDEYIDYF AVSLRIIGVL
ALILTSCGLA AINADDIWYF ASGGVIGSLL STTLQPLLHS SGGTIALLCV WAAGLTLFTG
WSWVTIAEKL GGWILNILTF ASNRTRRDDT WVDEDEYEDD EEYEDENHGK QHESRRARIL
RGALARRKRL AEKFINPMGR QTDAALFSGK RMDDDEEITY TARGVAADPD DVLFSGNRAT
QPEYDEYDPL LNGAPITEPV AVAAAATTAT QSWAAPVEPV TQTPPVASVD VPPAQPTVAW
QPVPGPQTGE PVIAPAPEGY PQQSQYAQPA VQYNEPLQQP VQPQQPYYAP AAEQPAQQPY
YAPAPEQPVA GNAWQAEEQQ STFAPQSTYQ TEQTYQQPAA QEPLYQQPQP VEQQPVVEPE
PVVEETKPAR PPLYYFEEVE EKRAREREQL AAWYQPIPEP VKEPEPIKSS LKAPSVAAVP
PVEAAAAVSP LASGVKKATL ATGAAATVAA PVFSLANSGG PRPQVKEGIG PQLPRPKRIR
VPTRRELASY GIKLPSQRAA EEKAREAQRN QYDSGDQYND DEIDAMQQDE LARQFAQTQQ
QRYGEQYQHD VPVNAEDADA AAEAELARQF AQTQQQRYSG EQPAGANPFS LDDFEFSPMK
ALLDDGPHEP LFTPIVEPVQ QPQQPVAPQQ QYQQPQQPVP PQPQYQQPQQ PVAPQPQYQQ
PQQPVAPQQQ YQQPQQPVAP QQQYQQPQQP VAPQPQDTLL HPLLMRNGDS RPLHKPTTPL
PSLDLLTPPP SEVEPVDTFA LEQMARLVEA RLADFRIKAD VVNYSPGPVI TRFELNLAPG
VKAARISNLS RDLARSLSTV AVRVVEVIPG KPYVGLELPN KKRQTVYLRE VLDNAKFRDN
PSPLTVVLGK DIAGEPVVAD LAKMPHLLVA GTTGSGKSVG VNAMILSMLY KAQPEDVRFI
MIDPKMLELS VYEGIPHLLT EVVTDMKDAA NALRWCVNEM ERRYKLMSAL GVRNLAGYNE
KIAEADRMMR PIPDPYWKPG DSMDAQHPVL KKEPYIVVLV DEFADLMMTV GKKVEELIAR
LAQKARAAGI HLVLATQRPS VDVITGLIKA NIPTRIAFTV SSKIDSRTIL DQAGAESLLG
MGDMLYSGPN STLPVRVHGA FVRDQEVHAV VQDWKARGRP QYVDGITSDS ESEGGAGGFD
GAEELDPLFD QAVQFVTEKR KASISGVQRQ FRIGYNRAAR IIEQMEAQGI VSEQGHNGNR
EVLAPPPFD
Length

1,329

Mol. Wt

146.661 kDa

pI

4.8 (calculated)

Extinction coefficient

173,040 - 173,540 (calc based on 46 Y, 19 W, and 4 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

947..1161

PF01580 FtsK/SpoIIIE family

PMID:19920124

Domain

1261..1327

PF09397 Ftsk gamma domain

PMID:19920124

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<motif_map/>

tmhmm.php?gene=ftsK&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=ftsK taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

  • Membrane topology studies using phoA and lacZ fusions are described in Dorazi et al.(2000)[13]
  • Crystal structure of P. aeruginosa FtsK complexed with KOPS with a putative molecular mechanism for loading and translocation may be found in Lowe et al. (2008)[16].
  • FtsK links chromosome segregation to septation via its domain structure. The N-terminal domain is required for septation and its C-terminal domain is required for chromosome segregation[17].

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

Antibody

raised against FtsK(447-729)

isolated from rabbit [3]

Purification protocol

  • PMID:18722176
  • PMID:20081205
  • PMID:12939258
  • PMID:11832210
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128857

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945102

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0003027

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P46889

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6464

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13226

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945102

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003064

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3016

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

Molecule Organism or Strain Value Units Experimental Conditions Assay used Notes Reference(s)

Protein

E. coli K-12 MC4100

1.64E+02

molecules/cell

  • Medium: median data from rich and minimal media
  • Temperature (°C): 37
  • Doubling time (min): Growth Rate(min):
  • Growth phase: other:

emPAI

PMID:18304323

Protein

Ecoli K-12

4.585+/-0.025

Molecules/cell

  • Medium:
  • Temperature (°C):
  • Doubling time (min): Growth Rate(min): *
  • Growth phase: other: *

Single Molecule Fluorescence

PMID:20671182

mRNA

Ecoli K-12

0.030458762

Molecules/cell

  • Medium:
  • Temperature (°C):
  • Doubling time (min): Growth Rate(min): *
  • Growth phase: other: *

by RNA_Seq

PMID:20671182

Protein

E. coli K-12 MG1655

508

molecules/cell/generation

  • Medium: MOPS Complete
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Protein

E. coli K-12 MG1655

213

molecules/cell/generation

  • Medium: MOPS Minimal
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

Protein

E. coli K-12 MG1655

376

molecules/cell/generation

  • Medium: MOPS Complete without Methionine
  • Temperature (°C): 37
  • Doubling time (min):
  • *Growth phase:
  • OD:
  • other:

Ribosome Profiling

PMID: 24766808

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Notes

Transcription and Transcriptional Regulation

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<protect>

See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

ftsK

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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Protection from DNA damage is increased when FtsK is overexpressed. [3]

Filaments lacking constrictions are produced when FtsK is depleted.[3]

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:932427..932467 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name Mutation Phenotype Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type Reference Notes

microarray

GEO Profiles:b0890 (EcoliWiki Page)

NCBI GEO profiles for ftsK

microarray

GenExpDB:b0890 (EcoliWiki Page)

Summary of data for ftsK from multiple microarray studies

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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name Resource Type Description Source Notes

GFP Fusion

Intergenic region (932236..932512) fused to gfpmut2.

OpenBioSystems

GFP fusion described in Zaslaver, et al.
Plate:109-AZ12; Well:G9[18]

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Notes

Accessions Related to ftsK Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:G6464

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3016

Escherichia coli str. K-12 substr. MG1655

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b0890

EcoGene

EcoGene:EG13226

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003064

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0003027

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism Homologs (Statistics) Comments

Apis mellifera

  • ENSAPMP00000011742 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Caenorhabditis briggsae

  • WBGene00032775 (score: 1.000; bootstrap: 84%)

From Inparanoid:20070104

Caenorhabditis elegans

  • WBGene00004120 (score: 1.000; bootstrap: 61%)

From Inparanoid:20070104

Ciona intestinalis

  • ENSCINP00000006114 (score: 1.000; bootstrap: 100%)
  • ENSCINP00000009221 (score: 0.082)
  • ENSCINP00000019637 (score: 0.053)

From Inparanoid:20070104

Danio rerio

  • ZDB-GENE-040426-2032 (score: 1.000; bootstrap: 100%)
  • ZDB-CDNA-040425-2979 (score: 1.000; bootstrap: 100%)

From Inparanoid:20070104

Dictyostelium discoideum

  • DDB0220598 (score: 1.000; bootstrap: 59%)
  • DDB0220698 (score: 0.241)
  • DDB0219424 (score: 0.232)
  • DDB0204496 (score: 0.232)
  • DDB0202465 (score: 0.232)
  • DDB0220473 (score: 0.223)
  • DDB0186879 (score: 0.214)
  • DDB0220092 (score: 0.207)
  • DDB0191294 (score: 0.206)
  • DDB0220695 (score: 0.204)
  • DDB0206355 (score: 0.203)
  • DDB0191586 (score: 0.203)
  • DDB0188286 (score: 0.201)
  • DDB0231210 (score: 0.196)
  • DDB0217693 (score: 0.191)
  • DDB0202946 (score: 0.191)
  • DDB0192024 (score: 0.190)
  • DDB0216864 (score: 0.188)
  • DDB0215257 (score: 0.180)
  • DDB0190401 (score: 0.180)
  • DDB0205029 (score: 0.178)
  • DDB0205680 (score: 0.177)
  • DDB0220086 (score: 0.177)
  • DDB0201626 (score: 0.177)
  • DDB0189741 (score: 0.177)
  • DDB0167841 (score: 0.175)
  • DDB0217027 (score: 0.175)
  • DDB0220518 (score: 0.174)
  • DDB0220120 (score: 0.174)
  • DDB0220085 (score: 0.174)
  • DDB0217746 (score: 0.174)
  • DDB0190773 (score: 0.172)
  • DDB0190924 (score: 0.172)
  • DDB0186048 (score: 0.170)
  • DDB0219997 (score: 0.167)
  • DDB0189801 (score: 0.167)
  • DDB0216409 (score: 0.167)
  • DDB0218010 (score: 0.167)
  • DDB0216189 (score: 0.166)
  • DDB0218446 (score: 0.162)
  • DDB0231755 (score: 0.162)
  • DDB0230050 (score: 0.162)
  • DDB0217416 (score: 0.162)
  • DDB0218812 (score: 0.159)
  • DDB0218153 (score: 0.159)
  • DDB0167208 (score: 0.158)
  • DDB0217222 (score: 0.158)
  • DDB0184424 (score: 0.158)
  • DDB0168158 (score: 0.158)
  • DDB0232248 (score: 0.156)
  • DDB0189892 (score: 0.156)
  • DDB0216341 (score: 0.154)
  • DDB0217895 (score: 0.154)
  • DDB0191073 (score: 0.153)
  • DDB0169513 (score: 0.153)
  • DDB0220491 (score: 0.153)
  • DDB0232328 (score: 0.153)
  • DDB0218472 (score: 0.151)
  • DDB0217365 (score: 0.150)
  • DDB0229362 (score: 0.150)
  • DDB0232322 (score: 0.150)
  • DDB0215670 (score: 0.150)
  • DDB0218258 (score: 0.150)
  • DDB0217236 (score: 0.150)
  • DDB0220481 (score: 0.150)
  • DDB0217043 (score: 0.148)
  • DDB0204126 (score: 0.148)
  • DDB0190492 (score: 0.146)
  • DDB0217593 (score: 0.145)
  • DDB0206180 (score: 0.143)
  • DDB0217417 (score: 0.140)
  • DDB0215378 (score: 0.140)
  • DDB0185465 (score: 0.140)
  • DDB0167981 (score: 0.140)
  • DDB0216921 (score: 0.138)
  • DDB0218621 (score: 0.138)
  • DDB0191191 (score: 0.137)
  • DDB0192193 (score: 0.137)
  • DDB0231700 (score: 0.137)
  • DDB0167801 (score: 0.137)
  • DDB0191361 (score: 0.135)
  • DDB0220001 (score: 0.135)
  • DDB0229382 (score: 0.135)
  • DDB0202354 (score: 0.132)
  • DDB0190606 (score: 0.132)
  • DDB0188826 (score: 0.132)
  • DDB0191409 (score: 0.132)
  • DDB0188175 (score: 0.130)
  • DDB0218306 (score: 0.130)
  • DDB0202163 (score: 0.130)
  • DDB0216403 (score: 0.130)
  • DDB0190785 (score: 0.129)
  • DDB0184127 (score: 0.129)
  • DDB0218626 (score: 0.129)
  • DDB0186751 (score: 0.127)
  • DDB0220704 (score: 0.127)
  • DDB0188246 (score: 0.125)
  • DDB0205385 (score: 0.125)
  • DDB0184207 (score: 0.125)
  • DDB0203776 (score: 0.125)
  • DDB0188933 (score: 0.125)
  • DDB0218594 (score: 0.125)
  • DDB0206066 (score: 0.124)
  • DDB0220467 (score: 0.124)
  • DDB0219334 (score: 0.122)
  • DDB0185803 (score: 0.122)
  • DDB0205043 (score: 0.122)
  • DDB0232321 (score: 0.119)
  • DDB0219621 (score: 0.119)
  • DDB0186491 (score: 0.119)
  • DDB0191321 (score: 0.119)
  • DDB0217237 (score: 0.119)
  • DDB0217138 (score: 0.119)
  • DDB0218866 (score: 0.117)
  • DDB0169488 (score: 0.117)
  • DDB0167087 (score: 0.116)
  • DDB0217187 (score: 0.116)
  • DDB0220097 (score: 0.116)
  • DDB0218566 (score: 0.114)
  • DDB0204506 (score: 0.114)
  • DDB0231554 (score: 0.113)
  • DDB0191385 (score: 0.113)
  • DDB0216544 (score: 0.113)
  • DDB0204403 (score: 0.113)
  • DDB0220494 (score: 0.113)
  • DDB0189822 (score: 0.111)
  • DDB0232928 (score: 0.111)
  • DDB0232160 (score: 0.109)
  • DDB0206051 (score: 0.109)
  • DDB0185056 (score: 0.108)
  • DDB0189620 (score: 0.108)
  • DDB0232078 (score: 0.108)
  • DDB0220595 (score: 0.108)
  • DDB0189968 (score: 0.108)
  • DDB0216392 (score: 0.108)
  • DDB0167764 (score: 0.106)
  • DDB0205713 (score: 0.106)
  • DDB0188213 (score: 0.106)
  • DDB0190152 (score: 0.106)
  • DDB0217700 (score: 0.105)
  • DDB0217078 (score: 0.105)
  • DDB0218867 (score: 0.105)
  • DDB0190271 (score: 0.105)
  • DDB0192215 (score: 0.103)
  • DDB0216943 (score: 0.101)
  • DDB0218236 (score: 0.100)
  • DDB0229429 (score: 0.100)
  • DDB0216342 (score: 0.100)
  • DDB0218050 (score: 0.100)
  • DDB0218102 (score: 0.100)
  • DDB0190787 (score: 0.100)
  • DDB0191116 (score: 0.100)
  • DDB0216260 (score: 0.100)
  • DDB0205150 (score: 0.100)
  • DDB0219211 (score: 0.098)
  • DDB0229845 (score: 0.098)
  • DDB0218256 (score: 0.096)
  • DDB0188369 (score: 0.096)
  • DDB0216546 (score: 0.096)
  • DDB0220499 (score: 0.095)
  • DDB0216391 (score: 0.095)
  • DDB0205447 (score: 0.095)
  • DDB0169529 (score: 0.095)
  • DDB0220471 (score: 0.095)
  • DDB0192199 (score: 0.093)
  • DDB0218196 (score: 0.093)
  • DDB0205871 (score: 0.093)
  • DDB0217649 (score: 0.093)
  • DDB0202340 (score: 0.093)
  • DDB0192013 (score: 0.093)
  • DDB0187983 (score: 0.093)
  • DDB0183969 (score: 0.092)
  • DDB0220492 (score: 0.092)
  • DDB0205687 (score: 0.092)
  • DDB0218037 (score: 0.092)
  • DDB0189487 (score: 0.092)
  • DDB0217708 (score: 0.092)
  • DDB0183931 (score: 0.090)
  • DDB0189893 (score: 0.090)
  • DDB0220516 (score: 0.088)
  • DDB0220683 (score: 0.088)
  • DDB0185762 (score: 0.088)
  • DDB0206470 (score: 0.088)
  • DDB0167229 (score: 0.087)
  • DDB0218840 (score: 0.087)
  • DDB0232152 (score: 0.087)
  • DDB0231001 (score: 0.085)
  • DDB0231454 (score: 0.085)
  • DDB0218029 (score: 0.085)
  • DDB0217451 (score: 0.085)
  • DDB0220441 (score: 0.085)
  • DDB0191499 (score: 0.085)
  • DDB0215388 (score: 0.085)
  • DDB0218154 (score: 0.085)
  • DDB0205961 (score: 0.084)
  • DDB0220630 (score: 0.084)
  • DDB0186352 (score: 0.084)
  • DDB0186385 (score: 0.084)
  • DDB0192130 (score: 0.082)
  • DDB0190674 (score: 0.082)
  • DDB0167294 (score: 0.082)
  • DDB0188687 (score: 0.080)
  • DDB0167538 (score: 0.080)
  • DDB0218210 (score: 0.080)
  • DDB0220136 (score: 0.080)
  • DDB0185453 (score: 0.080)
  • DDB0189561 (score: 0.080)
  • DDB0205575 (score: 0.079)
  • DDB0203240 (score: 0.079)
  • DDB0202718 (score: 0.079)
  • DDB0168645 (score: 0.079)
  • DDB0167751 (score: 0.079)
  • DDB0216935 (score: 0.079)
  • DDB0219636 (score: 0.077)
  • DDB0189138 (score: 0.077)
  • DDB0218235 (score: 0.077)
  • DDB0191806 (score: 0.077)
  • DDB0218069 (score: 0.077)
  • DDB0217843 (score: 0.077)
  • DDB0190877 (score: 0.077)
  • DDB0191498 (score: 0.077)
  • DDB0220490 (score: 0.077)
  • DDB0191753 (score: 0.076)
  • DDB0201966 (score: 0.076)
  • DDB0231197 (score: 0.076)
  • DDB0186448 (score: 0.076)
  • DDB0185180 (score: 0.074)
  • DDB0229364 (score: 0.074)
  • DDB0217360 (score: 0.074)
  • DDB0168034 (score: 0.074)
  • DDB0203430 (score: 0.074)
  • DDB0220705 (score: 0.072)
  • DDB0220087 (score: 0.072)
  • DDB0219309 (score: 0.071)
  • DDB0217883 (score: 0.071)
  • DDB0220624 (score: 0.071)
  • DDB0187027 (score: 0.069)
  • DDB0188637 (score: 0.069)
  • DDB0229847 (score: 0.069)
  • DDB0220678 (score: 0.069)
  • DDB0218171 (score: 0.069)
  • DDB0184423 (score: 0.069)
  • DDB0219954 (score: 0.069)
  • DDB0218341 (score: 0.069)
  • DDB0186697 (score: 0.069)
  • DDB0204418 (score: 0.068)
  • DDB0233011 (score: 0.068)
  • DDB0219396 (score: 0.068)
  • DDB0220608 (score: 0.068)
  • DDB0220623 (score: 0.066)
  • DDB0217977 (score: 0.066)
  • DDB0217507 (score: 0.066)
  • DDB0185296 (score: 0.066)
  • DDB0218242 (score: 0.066)
  • DDB0231340 (score: 0.066)
  • DDB0231692 (score: 0.066)
  • DDB0184080 (score: 0.066)
  • DDB0185964 (score: 0.066)
  • DDB0168602 (score: 0.066)
  • DDB0190902 (score: 0.066)
  • DDB0190200 (score: 0.066)
  • DDB0206023 (score: 0.064)
  • DDB0185671 (score: 0.064)
  • DDB0220477 (score: 0.064)
  • DDB0220094 (score: 0.064)
  • DDB0206169 (score: 0.064)
  • DDB0191859 (score: 0.063)
  • DDB0186434 (score: 0.063)
  • DDB0205093 (score: 0.063)
  • DDB0215408 (score: 0.063)
  • DDB0231506 (score: 0.063)
  • DDB0218398 (score: 0.061)
  • DDB0218173 (score: 0.061)
  • DDB0205432 (score: 0.061)
  • DDB0184253 (score: 0.061)
  • DDB0184153 (score: 0.061)
  • DDB0219903 (score: 0.061)
  • DDB0204566 (score: 0.061)
  • DDB0167634 (score: 0.061)
  • DDB0216146 (score: 0.061)
  • DDB0218526 (score: 0.061)
  • DDB0190114 (score: 0.059)
  • DDB0185095 (score: 0.059)
  • DDB0216369 (score: 0.059)
  • DDB0220029 (score: 0.059)
  • DDB0231774 (score: 0.058)
  • DDB0220507 (score: 0.058)
  • DDB0167013 (score: 0.058)
  • DDB0220438 (score: 0.058)
  • DDB0187840 (score: 0.058)
  • DDB0191512 (score: 0.058)
  • DDB0220118 (score: 0.056)
  • DDB0217915 (score: 0.056)
  • DDB0220095 (score: 0.056)
  • DDB0169210 (score: 0.056)
  • DDB0167912 (score: 0.056)
  • DDB0190500 (score: 0.056)
  • DDB0220643 (score: 0.056)
  • DDB0188671 (score: 0.056)
  • DDB0203640 (score: 0.055)
  • DDB0167082 (score: 0.055)
  • DDB0184018 (score: 0.055)
  • DDB0186991 (score: 0.055)
  • DDB0215968 (score: 0.055)
  • DDB0204798 (score: 0.055)
  • DDB0204588 (score: 0.055)
  • DDB0191514 (score: 0.055)
  • DDB0185224 (score: 0.055)
  • DDB0219308 (score: 0.053)
  • DDB0185366 (score: 0.053)
  • DDB0205039 (score: 0.053)
  • DDB0216052 (score: 0.053)
  • DDB0230104 (score: 0.053)
  • DDB0184005 (score: 0.053)
  • DDB0220493 (score: 0.053)
  • DDB0231216 (score: 0.053)
  • DDB0215091 (score: 0.051)
  • DDB0184166 (score: 0.051)
  • DDB0186147 (score: 0.051)
  • DDB0220693 (score: 0.051)
  • DDB0190296 (score: 0.051)
  • DDB0220509 (score: 0.051)
  • DDB0232331 (score: 0.051)
  • DDB0204114 (score: 0.051)
  • DDB0217783 (score: 0.051)
  • DDB0167741 (score: 0.051)
  • DDB0220697 (score: 0.051)
  • DDB0206012 (score: 0.051)
  • DDB0168793 (score: 0.051)

From Inparanoid:20070104

Drosophila melanogaster

  • FBgn0030541 (score: 1.000; bootstrap: 56%)
  • FBgn0051626 (score: 0.068)
  • FBgn0010218 (score: 0.051)

From Inparanoid:20070104

Gallus gallus

  • ENSGALP00000010284 (score: 1.000; bootstrap: 57%)

From Inparanoid:20070104

Homo sapiens

  • ENSP00000344579 (score: 1.000; bootstrap: 55%)
  • ENSP00000311997 (score: 0.050)

From Inparanoid:20070104

Macaca mulatta

  • ENSMMUP00000015589 (score: 1.000; bootstrap: 54%)

From Inparanoid:20070104

Mus musculus

  • MGI:1919670 (score: 1.000; bootstrap: 51%)

From Inparanoid:20070104

Pan troglodytes

  • ENSPTRP00000016262 (score: 1.000; bootstrap: 100%)
  • ENSPTRP00000015748 (score: 0.495)
  • ENSPTRP00000015205 (score: 0.450)
  • ENSPTRP00000015475 (score: 0.115)

From Inparanoid:20070104

Xenopus tropicalis

  • ENSXETP00000051723 (score: 1.000; bootstrap: 69%)
  • ENSXETP00000039820 (score: 0.059)
  • ENSXETP00000040556 (score: 0.057)

From Inparanoid:20070104

Shigella flexneri

FTSK

From SHIGELLACYC

E. coli O157

FTSK

From ECOO157CYC

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Do-It-Yourself Web Tools

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Notes

The N-terminal domain sequence of FtsK is conserved only in proteobacteria while the C-terminus DNA translocation domain in conserved in most bacterial species[10][19][20].

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

Pfam (EcoliWiki Page)

PF01580 FtsK/SpoIIIE family

Superfamily (EcoliWiki Page)

SUPERFAMILY:46785

Panther (EcoliWiki Page)

PTHR22683:SF1

Superfamily (EcoliWiki Page)

SUPERFAMILY:52540

Pfam (EcoliWiki Page)

PF09397 Ftsk gamma domain

EcoCyc

EcoCyc:G6464

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13226

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003064

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3016

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0003027

Escherichia coli str. K-12 substr. MG1655

edit table

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 Arnau, J et al. (1997) Cloning, expression, and characterization of the Lactococcus lactis pfl gene, encoding pyruvate formate-lyase. J. Bacteriol. 179 5884-91 PubMed
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 Wang, L & Lutkenhaus, J (1998) FtsK is an essential cell division protein that is localized to the septum and induced as part of the SOS response. Mol. Microbiol. 29 731-40 PubMed
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  5. ↑ 5.0 5.1 5.2 5.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  6. ↑ 6.0 6.1 6.2 6.3 Capiaux, H et al. (2002) A dual role for the FtsK protein in Escherichia coli chromosome segregation. EMBO Rep. 3 532-6 PubMed
  7. ↑ 7.0 7.1 7.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  8. ↑ 8.0 8.1 Robertson, S (1992) Putting pen to paper. Aust Crit Care 5 2 PubMed
  9. ↑ Draper, GC et al. (1998) Only the N-terminal domain of FtsK functions in cell division. J. Bacteriol. 180 4621-7 PubMed
  10. ↑ 10.0 10.1 Geissler, B & Margolin, W (2005) Evidence for functional overlap among multiple bacterial cell division proteins: compensating for the loss of FtsK. Mol. Microbiol. 58 596-612 PubMed
  11. ↑ 11.0 11.1 CGSC: The Coli Genetics Stock Center
  12. ↑ 12.0 12.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
  13. ↑ 13.0 13.1 13.2 Dorazi, R & Dewar, SJ (2000) Membrane topology of the N-terminus of the Escherichia coli FtsK division protein. FEBS Lett. 478 13-8 PubMed
  14. ↑ Barre, FX et al. (2000) FtsK functions in the processing of a Holliday junction intermediate during bacterial chromosome segregation. Genes Dev. 14 2976-88 PubMed
  15. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
  16. ↑ Löwe, J et al. (2008) Molecular mechanism of sequence-directed DNA loading and translocation by FtsK. Mol. Cell 31 498-509 PubMed
  17. ↑ Bigot, S et al. (2007) FtsK, a literate chromosome segregation machine. Mol. Microbiol. 64 1434-41 PubMed
  18. ↑ Zaslaver, A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat. Methods 3 623-8 PubMed
  19. ↑ Barre, FX et al. (2001) Circles: the replication-recombination-chromosome segregation connection. Proc. Natl. Acad. Sci. U.S.A. 98 8189-95 PubMed
  20. ↑ Barre, FX (2007) FtsK and SpoIIIE: the tale of the conserved tails. Mol. Microbiol. 66 1051-5 PubMed

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