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On One Page

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Product(s) |

Expression|

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Standard Name	ftsB
Gene Synonym(s)	ECK2743, b2748, JW2718, ygbQ^[1], ygbQ
Product Desc.	essential cell division protein FtsB^[2]^[3] Membrane protein required for cell division; septum localization dependent on Ftsl and FtsQ^[4]
Product Synonyms(s)	cell division protein^[1], B2748^[2]^[1], FtsB^[2]^[1], YgbQ^[2]^[1] , ECK2743, JW2718, ygbQ, b2748
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s):
Regulation/Activity
Quick Links
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Notes

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ftsB is an essential gene. FtsB forms a complex with FtsL prior to mid-cell localization; this complex formation requires FtsQ, but not FtsK. Divisome.^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	ftsB
Mnemonic	Filamentation, temperature sensitive
Synonyms	ECK2743, b2748, JW2718, ygbQ^[1], ygbQ
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	61.87 minutes	MG1655: 2870842..2870531 <gbrowseImage> name=NC_000913:2870531..2870842 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 2767681..2767370 <gbrowseImage> name=NC_012967:2767370..2767681 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 2756343..2756654 <gbrowseImage> name=NC_012759:2756343..2756654 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 2871476..2871165 <gbrowseImage> name=NC_007779:2871165..2871476 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 2963384..2963073 <gbrowseImage> name=NC_010473:2963073..2963384 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW2718	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCGGTAAACTAACGCTGCTGTT Primer 2:CCTCGATTGTTTTGCCCCGCAGA
1B5	Kohara Phage	Genobase	PMID:3038334
6C8	Kohara Phage	Genobase	PMID:3038334
srlD3131::Tn10	Linked marker	CAG18642 = CGSC7423^[5]	est. P1 cotransduction: 14% ^[6] Synonyms:zfh-3131::Tn10, zfi-3131::Tn10
cysI95::Tn10	Linked marker	CAG12173 = CGSC7425^[5]	est. P1 cotransduction: 58% ^[6] Synonyms:cysC95::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G7424	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13111	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003989	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:946033	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2914	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0009019	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	FtsB
Synonyms	cell division protein^[1], B2748^[2]^[1], FtsB^[2]^[1], YgbQ^[2]^[1] , ECK2743, JW2718, ygbQ, b2748
Product description	essential cell division protein FtsB^[2]^[3] Membrane protein required for cell division; septum localization dependent on Ftsl and FtsQ^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005886	plasma membrane	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_00599	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0997	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C	Seeded from EcoCyc (v14.0)	complete
	GO:0051301	cell division	PMID:11972052	IMP: Inferred from Mutant Phenotype		P		complete
	GO:0007049	cell cycle	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007060	P	Seeded from EcoCyc (v14.0)	complete
	GO:0030428	cell septum	PMID:11972052	IDA: Inferred from Direct Assay		C	Changed from GO:0000935 barrier septum.127.0.0.1 14:55, 17 February 2015 (CST)	complete
	GO:0007049	cell cycle	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0131	P	Seeded from EcoCyc (v14.0)	complete
Deprecated	GO:0051301	cell division	PMID:4583216	IMP: Inferred from Mutant Phenotype		P	The mutant (MFT84) described in this paper was later found to be an allele of nrdB.^[7] ^[8]	complete
	GO:0016020	membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-9906	C	Seeded from EcoCyc (v14.0)	complete
	GO:0051301	cell division	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0132	P	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References
Protein	FtsL	n-terminal of FtsB is required for interaction with FtsL; in the absence of FtsQ, FtsL and FtsB can still interact	PMID:19233928
Protein	FtsQ	C-terminal of FtsB is required for interaction with FtsQ	PMID:19233928
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Reference/Source	Notes
plasma membrane	From EcoCyc^[3]
Septum	PMID:11972052	localization depends on FtsL and FtsQ
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MGKLTLLLLA ILVWLQYSLW FGKNGIHDYT RVNDDVAAQQ ATNAKLKARN DQLFAEIDDL NGGQEALEER ARNELSMTRP GETFYRLVPD ASKRAQSAGQ NNR
Length	103
Mol. Wt	11.622 kDa
pI	7.3 (calculated)
Extinction coefficient	15,470 (calc based on 3 Y, 2 W, and 0 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	11..90	PF04977 Septum formation initiator		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=ftsB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16130655	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:946033	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0009019	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P0A6S5	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G7424	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13111	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:946033	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003989	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2914	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MG1655	487	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	140	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	173	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:2870822..2870862 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b2748 (EcoliWiki Page)	NCBI GEO profiles for ftsB
microarray	GenExpDB:b2748 (EcoliWiki Page)	Summary of data for ftsB from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to ftsB Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G7424	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2914	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b2748
EcoGene	EcoGene:EG13111	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003989	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0009019	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Shigella flexneri	S2964	From SHIGELLACYC
E. coli O157	Z4056	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF04977 Septum formation initiator
EcoCyc	EcoCyc:G7424	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13111	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003989	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2914	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0009019	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ Kren, B & Fuchs, JA (1987) Characterization of the ftsB gene as an allele of the nrdB gene in Escherichia coli. J. Bacteriol. 169 14-8 PubMed
↑ Taschner, PE et al. (1987) Genetic and morphological characterization of ftsB and nrdB mutants of Escherichia coli. J. Bacteriol. 169 19-25 PubMed

ftsB:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to ftsB Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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